{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:21:25Z","timestamp":1791238885344,"version":"4.1.0"},"reference-count":195,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:p>This paper introduces the hypothesis of Psychedelic Iatrogenic Structural Dissociation (PISD), proposing that psychedelics may reactivate dissociated traumatic material, increasing the risk of psychological destabilization in trauma-exposed individuals. Grounded in structural dissociation theory, this framework suggests that psychedelics can disrupt the balance between daily functioning (the Apparently Normal Personality, ANP) and trauma-related responses (the Emotional Personality, EP), leading to the resurfacing of unintegrated memories. A review of recent studies highlights persistent adverse effects associated with psychedelic use, including emotional dysregulation, identity fragmentation, derealization, and perceptual disturbances, particularly among individuals with early trauma histories. To mitigate these risks and facilitate trauma processing, integration practices, body-focused therapies, and structured social support systems are proposed as key interventions. Additionally, emerging neurophysiological models suggest that psychedelics may reconfigure dissociative processes through the modulation of entrenched patterns, potentially facilitating trauma integration or increasing vulnerability to destabilization, depending on individual and contextual factors. These findings underscore the necessity of trauma-informed screening, preparation, and integration protocols to enhance the safety and efficacy of psychedelic therapies, particularly for vulnerable populations.<\/jats:p>","DOI":"10.3389\/fpsyg.2025.1528253","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T12:39:41Z","timestamp":1741091981000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Psychedelic iatrogenic structural dissociation: an exploratory hypothesis on dissociative risks in psychedelic use"],"prefix":"10.3389","volume":"16","author":[{"given":"Steven","family":"Elfrink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"Bergin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.jpsychires.2022.04.037","article-title":"Real-world effectiveness of ketamine in treatment-resistant depression: a systematic review & meta-analysis","volume":"151","author":"Alnefeesi","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"ref2","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-5 (Vol. 5, No. 5)","year":"2013"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/j.1476-5381.1983.tb11031.x","article-title":"The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate","volume":"79","author":"Anis","year":"1983","journal-title":"Br. J. Pharmacol."},{"key":"ref4","volume-title":"Beyond despair: Three lectures and a conversation with Philip Roth","author":"Apelfeld","year":"1994"},{"key":"ref5","volume-title":"Navigating groundlessness: an interview study on dealing with ontological shock and existential distress following psychedelic experiences","author":"Argyri","year":"2024"},{"key":"ref6","article-title":"Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: Observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial","author":"Barba","year":"2024","journal-title":"eClinicalMedicine"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089\/psymed.2023.0027","article-title":"Perceived risk of trying lysergic acid diethylamide in the United States from 2015 to 2019: are Americans assessing lysergic acid Diethylamide's risk profile more favorably?","author":"Barnett","year":"","journal-title":"Psych. Med."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/psymed.2023.0036","article-title":"American Psychiatrists' opinions about classic hallucinogens and their potential therapeutic applications: a 7-year follow-up survey","volume":"2","author":"Barnett","year":"","journal-title":"Psych. Med."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1097\/NMD.0000000000000828","article-title":"A survey of American psychiatrists' attitudes toward classic hallucinogens","volume":"206","author":"Barnett","year":"2018","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1177\/0269881116678781","article-title":"The challenging experience questionnaire: characterization of challenging experiences with psilocybin mushrooms","volume":"30","author":"Barrett","year":"2016","journal-title":"J. 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Psych."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1001\/jamapsychiatry.2022.2096","article-title":"Percentage of heavy drinking days following psilocybin-assisted psychotherapy vs placebo in the treatment of adult patients with alcohol use disorder: a randomized clinical trial","volume":"79","author":"Bogenschutz","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.2139\/ssrn.2558742","article-title":"Seasonalities in anomalies","volume-title":"Social Science Research Network","author":"Bogousslavsky","year":"2015"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1176\/ajp.150.3.489","article-title":"Multiple personality disorder in the Netherlands","volume":"1","author":"Boon","year":"1993","journal-title":"A m J Psychiatry"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e0000438","DOI":"10.1371\/journal.pgph.0000438","article-title":"Adverse effects of ayahuasca: results from the global Ayahuasca survey","volume":"2","author":"Bouso","year":"2022","journal-title":"PLOS Glob. Public Health"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1097\/NMD.0b013e318288d2ee","article-title":"Disinformation about dissociation: Dr Joel Paris\u2019s notions about dissociative identity disorder","volume":"201","author":"Brand","year":"2013","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1521\/psyc.2014.77.2.169","article-title":"Dispelling myths about dissociative identity disorder treatment: an empirically based approach","volume":"77","author":"Brand","year":"2014","journal-title":"Psychiatry Interpers. Biolog. Processes"},{"key":"ref19","volume-title":"First person plural: Multiple personality and the philosophy of mind","author":"Braude","year":"1995"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"15998","DOI":"10.1038\/s41598-023-41145-x","article-title":"Case analysis of long-term negative psychological responses to psychedelics","volume":"13","author":"Bremler","year":"2023","journal-title":"Sci. Rep."},{"key":"ref21","first-page":"3","article-title":"What is trauma","volume-title":"Principles of trauma therapy: A guide to symptoms, evaluation, and treatment","author":"Briere","year":"2006"},{"key":"ref22","first-page":"21","article-title":"Psychological trauma, or unexperienced experience","volume":"12","author":"Browne","year":"1990","journal-title":"Re Vis. J."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3928\/0279-3695-19950901-04","article-title":"Memory presentations of childhood sexual abuse","volume":"33","author":"Burgess","year":"1995","journal-title":"J. Psychosoc. Nurs. Ment. Health Serv."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1746-4269-2-47","article-title":"Traditional medicinal plant use in northern Peru: tracking two thousand years of healing culture","volume":"2","author":"Bussmann","year":"2006","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1177\/0269881116662634","article-title":"Survey study of challenging experiences after ingesting psilocybin mushrooms: acute and enduring positive and negative consequences","volume":"30","author":"Carbonaro","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S2215-0366(16)30065-7","article-title":"Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study","volume":"3","author":"Carhart-Harris","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"109398","DOI":"10.1016\/j.neuropharm.2022.109398","article-title":"Canalization and plasticity in psychopathology","volume":"226","author":"Carhart-Harris","year":"2023","journal-title":"Neuropharmacology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1124\/pr.118.017160","article-title":"REBUS and the anarchic brain: toward a unified model of the brain action of psychedelics","volume":"71","author":"Carhart-Harris","year":"2019","journal-title":"Pharmacol. 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Allied Sci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e0154667","DOI":"10.1371\/journal.pone.0154667","article-title":"Switch function and pathological dissociation in acute psychiatric inpatients","volume":"11","author":"Chiu","year":"2016","journal-title":"PLoS One"},{"key":"ref34","volume-title":"Beyond boredom and anxiety: Experiencing flow in work and play","author":"Csikszentmihalyi","year":"1975"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1037\/a0027447","article-title":"Evaluation of the evidence for the trauma and fantasy models of dissociation","volume":"138","author":"Dalenberg","year":"2012","journal-title":"Psychol. Bull."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0301-2115(96)02605-X","article-title":"Rape-related psychotraumatic syndromes","volume":"71","author":"Darves-Bornoz","year":"1997","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1080\/02791072.2021.1971343","article-title":"Attitudes and beliefs about the therapeutic use of psychedelic drugs among psychologists in the United States","volume":"54","author":"Davis","year":"2022","journal-title":"J. Psychoactive Drugs"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1001\/jamapsychiatry.2020.3285","article-title":"Effects of psilocybin-assisted therapy on major depressive disorder: a randomized clinical trial","volume":"78","author":"Davis","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"4305","DOI":"10.1017\/S0033291723001058","article-title":"Reporting of harms in clinical trials of esketamine in depression: a systematic review","volume":"53","author":"de Laportali\u00e8re","year":"2023","journal-title":"Psychol. 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Psychol."},{"key":"ref9001","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102799","article-title":"Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial","volume":"76","author":"Erritzoe","year":"2024","journal-title":"EClinicalMedicine"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e0293349","DOI":"10.1371\/journal.pone.0293349","article-title":"Extended difficulties following the use of psychedelic drugs: a mixed methods study","volume":"18","author":"Evans","year":"2023","journal-title":"PLoS One"},{"key":"ref45","first-page":"185","article-title":"A functional behavioristic approach to aversively motivated behavior: predatory imminence as a determinant of the topography of defensive behavior","volume-title":"Evolution and learning","author":"Fanselow","year":"2013"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.pnpbp.2018.03.003","article-title":"MDMA-assisted psychotherapy for PTSD: are memory reconsolidation and fear extinction underlying mechanisms?","volume":"84","author":"Feduccia","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1017\/CBO9780511777042.010","article-title":"The relationship of adverse childhood experiences to adult medical disease, psychiatric disorders, and sexual behavior: implications for healthcare","volume-title":"The impact of early life trauma on health and disease: The hidden epidemic","author":"Felitti","year":"2010"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15299732.2018.1502568","article-title":"What mindfulness can learn about dissociation and what dissociation can learn from mindfulness","volume":"20","author":"Forner","year":"2019","journal-title":"J. Trauma Dissociation"},{"key":"ref49","first-page":"295","volume-title":"Project for a scientific psychology. Standard edition","author":"Freud","year":"1895"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.1177\/15248380221120835","article-title":"The relationship between dissociation and complex post-traumatic stress disorder: a scoping review","volume":"24","author":"Fung","year":"2023","journal-title":"Trauma Violence Abuse"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1360-0443.2006.01652.x","article-title":"Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids","volume":"102","author":"Gable","year":"2007","journal-title":"Addiction"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00213-020-05719-1","article-title":"Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants","volume":"238","author":"Galv\u00e3o-Coelho","year":"2021","journal-title":"Psychopharmacology"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"102997","DOI":"10.1016\/j.drugpo.2020.102997","article-title":"Making \u201cbad trips\u201d good: how users of psychedelics narratively transform challenging trips into valuable experiences","volume":"87","author":"Gashi","year":"2021","journal-title":"Int. J. Drug Policy"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/ijnp\/pyac074","article-title":"Default mode network modulation by psychedelics: a systematic review","volume":"26","author":"Gattuso","year":"2023","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1037\/0033-2909.134.5.617","article-title":"Cognitive processes in dissociation: an analysis of core theoretical assumptions","volume":"134","author":"Giesbrecht","year":"2008","journal-title":"Psychol. Bull."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1056\/NEJMoa2206443","article-title":"Single-dose psilocybin for a treatment-resistant episode of major depression","volume":"387","author":"Goodwin","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"645246","DOI":"10.3389\/fpsyg.2021.645246","article-title":"Psychedelic harm reduction and integration: a transtheoretical model for clinical practice","volume":"12","author":"Gorman","year":"2021","journal-title":"Front. Psychol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1080\/14616734.2017.1354040","article-title":"Disorganized attachment in infancy: a review of the phenomenon and its implications for clinicians and policy-makers","volume":"19","author":"Granqvist","year":"2017","journal-title":"Attach Hum. Dev."},{"key":"ref59","first-page":"163","volume-title":"Psychedelic drugs reconsidered","author":"Grinspoon","year":"1979"},{"key":"ref60","volume-title":"Beyond the brain: Birth, death, and transcendence in psychotherapy","author":"Grof","year":"1985"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s12231-008-9033-8","article-title":"Hallucinogenic mushrooms in Mexico: an overview","volume":"62","author":"Guzm\u00e1n","year":"2008","journal-title":"Econ. Bot."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.pharmthera.2004.03.003","article-title":"Hallucinogens and dissociative agents naturally growing in the United States","volume":"102","author":"Halpern","year":"2004","journal-title":"Pharmacol. Ther."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/7854_2016_457","article-title":"A review of hallucinogen persisting perception disorder (HPPD) and an exploratory study of subjects claiming symptoms of HPPD","volume":"36","author":"Halpern","year":"2018","journal-title":"Behav. Neurobiol. Psych. Drugs"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1177\/0269881116677852","article-title":"Set and setting, psychedelics and the placebo response: an extra-pharmacological perspective on psychopharmacology","volume":"30","author":"Hartogsohn","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1023\/A:1024773202939","article-title":"Dissociative symptoms in acute stress disorder","volume":"12","author":"Harvey","year":"1999","journal-title":"J. Trauma. Stress."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.jad.2020.12.116","article-title":"Foster children's complex psychopathology in the context of cumulative childhood trauma: the interplay of ICD-11 complex PTSD, dissociation, depression, and emotion regulation","volume":"282","author":"Haselgruber","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref67","volume-title":"Trauma and recovery: The aftermath of violence--from domestic abuse to political terror","author":"Herman","year":"2015"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.1021\/acschemneuro.0c00608","article-title":"Dark classics in chemical neuroscience: Salvinorin a","volume":"11","author":"Hern\u00e1ndez-Alvarado","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/02791072.1979.10472092","article-title":"How LSD originated","volume":"11","author":"Hofmann","year":"1979","journal-title":"J. Psychedelic Drugs"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/BF02159243","article-title":"Psilocybin, a psychotropic substance from the Mexican mushroom Psilicybe mexicana Heim","volume":"14","author":"Hofmann","year":"1958","journal-title":"Experientia"},{"key":"ref71","volume-title":"Flashback-Ph\u00e4nomene als Nachwirkung von Halluzinogeneinnahme: eine kritische Untersuchung zu klinischen und \u00e4tiologischen Aspekten","author":"Holland","year":"2011"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jad.2024.01.197","article-title":"Longitudinal associations between psychedelic use and psychotic symptoms in the United States and the United Kingdom","volume":"351","author":"Honk","year":"2024","journal-title":"J. Affect. Disord."},{"key":"ref73","first-page":"289","volume-title":"The rational treatment of multiple personality disorder","author":"Horevitz","year":"1994"},{"key":"ref74","volume-title":"Medical muses: Hysteria in nineteenth-century Paris","author":"Hustvedt","year":"2012"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1093\/scan\/nst161","article-title":"MDMA enhances emotional empathy and prosocial behavior","volume":"9","author":"Hysek","year":"2014","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref76","volume-title":"L\u2019automatisme psychologique: essai de psychologie exp\u00e9rimentale sur les formes inf\u00e9rieures de l\u2019activit\u00e9 humaine","author":"Janet","year":"1889"},{"key":"ref77","first-page":"121","article-title":"Histoire d\u2019une id\u00e9e fixe","volume":"37","author":"Janet","year":"1894","journal-title":"Revue Philosophique de la France et de l\u2019Etranger"},{"key":"ref78","volume-title":"\u00c9tat mental des hyst\u00e9riques: les stigmates mentaux","author":"Janet","year":"1911"},{"key":"ref79","volume-title":"Les m\u00e9dications psychologiques: \u00e9tudes historiques, psychologiques et cliniques sur les m\u00e9thodes de la psychoth\u00e9rapie","author":"Janet","year":"1919"},{"key":"ref80","volume-title":"De l\u2019angoisse \u00e0 l\u2019extase: \u00e9tudes sur les croyances et les sentiments","author":"Janet","year":"1928"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/BF01067310","article-title":"The role of stress on the language-independence and code-switching phenomena","volume":"18","author":"Javier","year":"1989","journal-title":"J. Psycholinguist. Res."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1177\/0269881114548296","article-title":"Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction","volume":"28","author":"Johnson","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1177\/0269881108093587","article-title":"Human hallucinogen research: guidelines for safety","volume":"22","author":"Johnson","year":"2008","journal-title":"J. Psychopharmacol."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1556\/2054.2021.00155","article-title":"Day trip to hell: a mixed methods study of challenging psychedelic experiences","volume":"5","author":"Johnstad","year":"2021","journal-title":"J. Psych. Stud."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1177\/008124630603600304","article-title":"Healing processes in trauma narratives: a review","volume":"36","author":"Kaminer","year":"2006","journal-title":"S. Afr. J. Psychol."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1126\/science.220.4598.671","article-title":"Optimization by simulated annealing","volume":"220","author":"Kirkpatrick","year":"1983","journal-title":"Science"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s44184-024-00068-9","article-title":"A rapid narrative review of the clinical evolution of psychedelic treatment in clinical trials","volume":"3","author":"Kishon","year":"2024","journal-title":"NPJ Mental Health Res."},{"key":"ref88","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9798894550183","volume-title":"Clinical perspectives on multiple personality disorder","author":"Kluft","year":"1993"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jad.2022.09.168","article-title":"Psychedelic therapy for depressive symptoms: a systematic review and meta-analysis","volume":"322","author":"Ko","year":"2023","journal-title":"J. Affect. Disord."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"661233","DOI":"10.3389\/fpsyt.2021.661233","article-title":"Does psychedelic therapy have a transdiagnostic action and prophylactic potential?","volume":"12","author":"Ko\u010d\u00e1rov\u00e1","year":"2021","journal-title":"Front. Psych."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1177\/02698811231158245","article-title":"Investigation of self-treatment with lysergic acid diethylamide and psilocybin mushrooms: findings from the global drug survey 2020","volume":"37","author":"Kopra","year":"2023","journal-title":"J. Psychopharmacol."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1177\/02698811221084063","article-title":"Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms","volume":"36","author":"Kopra","year":"2022","journal-title":"J. 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J. Psychiatry"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/02698811241232548","article-title":"Psychiatric risks for worsened mental health after psychedelic use","volume":"38","author":"Marrocu","year":"2024","journal-title":"J. Psychopharmacol."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"106620","DOI":"10.1016\/j.phrs.2022.106620","article-title":"IUPHAR\u2013invited review-Ibogaine\u2013a legacy within the current renaissance of psychedelic therapy","volume":"190","author":"Mash","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref103","volume-title":"Try to remember: Psychiatry\u2019s clash over meaning, memory, and mind","author":"McHugh","year":"2008"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-078084","article-title":"Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis","volume":"385","author":"Metaxa","year":"2024","journal-title":"BMJ"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1176\/appi.focus.23021011","article-title":"MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study","volume":"21","author":"Mitchell","year":"","journal-title":"Focus"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1038\/s41591-023-02565-4","article-title":"MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial","volume":"29","author":"Mitchell","year":"","journal-title":"Nat. Med."},{"key":"ref107","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1007\/s00213-019-05249-5","article-title":"MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials","volume":"236","author":"Mithoefer","year":"2019","journal-title":"Psychopharmacology"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1038\/s41380-022-01661-0","article-title":"The serotonin theory of depression: a systematic umbrella review of the evidence","volume":"28","author":"Moncrieff","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cobeha.2016.10.009","article-title":"Tripping up addiction: the use of psychedelic drugs in the treatment of problematic drug and alcohol use","volume":"13","author":"Morgan","year":"2017","journal-title":"Curr. Opin. Behav. Sci."},{"key":"ref110","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1007\/s00213-022-06066-z","article-title":"Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants","volume":"239","author":"M\u00fcller","year":"2022","journal-title":"Psychopharmacology"},{"key":"ref111","volume-title":"Shell shock in France 1914\u201318: Based on a war diary","author":"Myers","year":"1940"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41586-019-1075-9","article-title":"Oxytocin-dependent reopening of a social reward learning critical period with MDMA","volume":"569","author":"Nardou","year":"2019","journal-title":"Nature"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"2031592","DOI":"10.1080\/20008198.2022.2031592","article-title":"An examination of the relations between emotion dysregulation, dissociation, and self-injury among dissociative disorder patients","volume":"13","author":"Nester","year":"2022","journal-title":"Eur. J. Psychotraumatol."},{"key":"ref114","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/02791072.1986.10472362","article-title":"Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens","volume":"18","author":"Nichols","year":"1986","journal-title":"J. Psychoactive Drugs"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1124\/pr.115.011478","article-title":"Psychedelics","volume":"68","author":"Nichols","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"ref116","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41429-020-0311-8","article-title":"Psilocybin: from ancient magic to modern medicine","volume":"73","author":"Nichols","year":"2020","journal-title":"J. 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Trauma Dissociation"},{"key":"ref9002","volume-title":"Somatoform Dissociation: Phenomena, Measurement, and Theoretical Issues","author":"Nijenhuis","year":"2004"},{"key":"ref119","first-page":"337","article-title":"Psychobiology of traumatization and trauma-related structural dissociation of the personality","volume-title":"Dissociation and the dissociative disorders: DSM-V and beyond","author":"Nijenhuis","year":"2009"},{"key":"ref120","first-page":"39","article-title":"Forgetting and reexperiencing trauma: From anesthesia to pain","volume-title":"Splintered reflections: Images of the body in trauma","author":"Nijenhuis","year":"1999"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF03379560","article-title":"Trauma-related structural dissociation of the personality","volume":"52","author":"Nijenhuis","year":"2010","journal-title":"Act. Nerv. 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Psych."},{"key":"ref128","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-3-030-55688-4_6","article-title":"Ayahuasca and childhood trauma: potential therapeutic applications","author":"Perkins","year":"2021","journal-title":"Ayahuasca Healing and Science"},{"key":"ref129","year":"2024"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"e35082","DOI":"10.7554\/eLife.35082","article-title":"Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor","volume":"7","author":"Preller","year":"2018","journal-title":"eLife"},{"key":"ref131","first-page":"145","article-title":"Dissociative phenomena","volume-title":"American psychiatric press review of psychiatry","author":"Putnam","year":"1991"},{"key":"ref132","volume-title":"Dissociation in children and adolescents: A developmental perspective","author":"Putnam","year":"1997"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"1051542","DOI":"10.3389\/fpsyt.2023.1051542","article-title":"Cannabis-assisted psychotherapy for complex dissociative posttraumatic stress disorder: a case report","volume":"14","author":"Ragnhildstveit","year":"2023","journal-title":"Front. 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Sci."},{"key":"ref137","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0145-2134(96)00147-0","article-title":"Social support and coping strategies as mediators of adult adjustment following childhood maltreatment","volume":"21","author":"Runtz","year":"1997","journal-title":"Child Abuse Negl."},{"key":"ref138","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12888-019-2417-8","article-title":"Improving the psychometric properties of the dissociative experiences scale (DES-II): a Rasch validation study","volume":"20","author":"Saggino","year":"2020","journal-title":"BMC Psychiatry"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1093\/bjc\/azv032","article-title":"Stories of violence: a narrative criminological study of ambiguity","volume":"55","author":"Sandberg","year":"2015","journal-title":"Br. J. Criminol."},{"key":"ref140","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1177\/02698811211069100","article-title":"Adverse effects of psychedelics: from anecdotes and misinformation to systematic science","volume":"36","author":"Schlag","year":"2022","journal-title":"J. Psychopharmacol."},{"key":"ref141","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1037\/0022-006X.67.1.54","article-title":"Frightening maternal behavior linking unresolved loss and disorganized infant attachment","volume":"67","author":"Schuengel","year":"1999","journal-title":"J. Consult. Clin. Psychol."},{"key":"ref142","volume-title":"1995","author":"Schwartz","year":"1995"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00213-017-4713-7","article-title":"The 21st century psychedelic renaissance: heroic steps forward on the back of an elephant","volume":"235","author":"Sessa","year":"2018","journal-title":"Psychopharmacology"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1176\/ajp.153.2.219","article-title":"Predictors of PTSD in injured trauma survivors: a prospective study","volume":"153","author":"Shalev","year":"1996","journal-title":"Am. J. Psychiatry"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1001\/archpsyc.55.6.553","article-title":"A prospective study of heart rate response following trauma and the subsequent development of posttraumatic stress disorder","volume":"55","author":"Shalev","year":"1998","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1016\/j.neuron.2021.06.008","article-title":"Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo","volume":"109","author":"Shao","year":"2021","journal-title":"Neuron"},{"key":"ref147","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jad.2023.01.073","article-title":"Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics","volume":"326","author":"Simonsson","year":"2023","journal-title":"J. Affect. Disord."},{"key":"ref148","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S2215-0366(19)30533-4","article-title":"Approval of esketamine for treatment-resistant depression","volume":"7","author":"Singh","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"947622","DOI":"10.3389\/fpsyt.2022.947622","article-title":"Altered brain activity and functional connectivity after MDMA-assisted therapy for post-traumatic stress disorder","volume":"13","author":"Singleton","year":"2023","journal-title":"Front. Psych."},{"key":"ref150","doi-asserted-by":"crossref","first-page":"1128589","DOI":"10.3389\/fpsyg.2023.1128589","article-title":"On the need for metaphysics in psychedelic therapy and research","volume":"14","author":"Sj\u00f6stedt-Hughes","year":"2023","journal-title":"Front. Psychol."},{"key":"ref151","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1177\/02698811231154852","article-title":"Psilocybin-assisted therapy for major depressive disorder: an exploratory placebo-controlled, fixed-order trial","volume":"37","author":"Sloshower","year":"2023","journal-title":"J. Psychopharmacol."},{"key":"ref152","doi-asserted-by":"publisher","first-page":"406","DOI":"10.15288\/qjsa.1958.19.406","article-title":"A new adjunct to the treatment of alcoholism: the hallucinogenic drugs","volume":"19","author":"Smith","year":"1958","journal-title":"Q. J. Stud. Alcohol"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/jcph.1995","article-title":"MDMA-assisted psychotherapy for treatment of posttraumatic stress disorder: a systematic review with meta-analysis","volume":"62","author":"Smith","year":"2022","journal-title":"J. Clin. Pharmacol."},{"key":"ref154","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/S2215-0366(22)00317-0","article-title":"Maintenance ketamine treatment for depression: a systematic review of efficacy, safety, and tolerability","volume":"9","author":"Smith-Apeldoorn","year":"2022","journal-title":"Lancet Psychiatry"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"105688","DOI":"10.1016\/j.jas.2022.105688","article-title":"Use of psychoactive and stimulant plants on the south coast of Peru from the early intermediate to late intermediate period","volume":"148","author":"Socha","year":"2022","journal-title":"J. Archaeol. Sci."},{"key":"ref156","doi-asserted-by":"publisher","first-page":"E17","DOI":"10.1002\/da.20923","article-title":"Dissociative disorders in DSM-5","volume":"28","author":"Spiegel","year":"2011","journal-title":"Depress. 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Psychopharma."},{"key":"ref165","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/1467-8721.ep10770899","article-title":"What is episodic memory?","volume":"2","author":"Tulving","year":"1993","journal-title":"Curr. Dir. Psychol. Sci."},{"key":"ref166","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.psych.53.100901.135114","article-title":"Episodic memory: from mind to brain","volume":"53","author":"Tulving","year":"2002","journal-title":"Annu. Rev. Psychol."},{"key":"ref167","first-page":"3","article-title":"A reader's guide to Pierre Janet on dissociation: A neglected intellectual heritage","volume-title":"Dissociation: Progress in the Dissociative Disorders","author":"Van der Hart","year":"1989"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1080\/0004867010060506","article-title":"Generalized dissociative amnesia: episodic, semantic and procedural memories lost and found","volume":"35","author":"Van Der Hart","year":"2001","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref169","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/0004867010060506","article-title":"Loss and recovery of different memory types in generalized dissociative amnesia","volume":"35","author":"Van der Hart","year":"2001","journal-title":"Aust. N. Z. J. 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Psychiatry"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ejtd.2019.06.003","article-title":"Vehement emotions and trauma-generated dissociation: a Janetian perspective on integrative failure","volume":"3","author":"Van der Hart","year":"2019","journal-title":"Europ. J. Trauma Dissoc."},{"key":"ref174","first-page":"91","article-title":"Time distortions in dissociative identity disorder: Janetian concepts and treatment","volume-title":"Dissociation: Progress in the Dissociative Disorders. 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Imago"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"1400878","DOI":"10.1080\/20008198.2017.1400878","article-title":"Affect dysregulation, psychoform dissociation, and adult relational fears mediate the relationship between childhood trauma and complex posttraumatic stress disorder independent of the symptoms of borderline personality disorder","volume":"9","author":"van Dijke","year":"2018","journal-title":"Eur. J. Psychotraumatol."},{"key":"ref182","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1001\/archpsyc.58.5.475","article-title":"Psychiatric disorders among tortured Bhutanese refugees in Nepal","volume":"58","author":"Van Ommeren","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1176\/ajp.2006.163.4.630","article-title":"Hippocampal and amygdalar volumes in dissociative identity disorder","volume":"163","author":"Vermetten","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"675768","DOI":"10.3389\/fnins.2021.675768","article-title":"On perception and consciousness in HPPD: a systematic review","volume":"15","author":"Vis","year":"2021","journal-title":"Front. 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Psychopharmacol."},{"key":"ref189","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1037\/1082-989X.1.3.300","article-title":"Types of dissociation and dissociative types: a taxometric analysis of dissociative experiences","volume":"1","author":"Waller","year":"1996","journal-title":"Psychol. Methods"},{"key":"ref190","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000359993","article-title":"The girls of La Salp\u00eatri\u00e8re","volume":"35","author":"Walusinski","year":"2014","journal-title":"Hysteria"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jcbs.2019.12.004","article-title":"The use of the psychological flexibility model to support psychedelic assisted therapy","volume":"15","author":"Watts","year":"2020","journal-title":"J. Contextual Behav. Sci."},{"key":"ref192","doi-asserted-by":"publisher","first-page":"108071","DOI":"10.1016\/j.drugalcdep.2020.108071","article-title":"Trends in LSD use among US adults: 2015\u20132018","volume":"212","author":"Yockey","year":"2020","journal-title":"Drug Alcohol Depend."},{"key":"ref193","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1521\/pedi.2023.37.1.16","article-title":"A systematic review of the association between early childhood trauma and borderline personality disorder","volume":"37","author":"Yuan","year":"2023","journal-title":"J. Personal. 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