{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:27:19Z","timestamp":1787027239212,"version":"build-2736575974"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>For more than a decade, studies have supported the efficacy and safety of placebos without deception\u2014so-called open-label placebos (OLPs)\u2014to harness placebo effects in primary care while aligning with key ethical principles. Since treatment acceptance, feasibility, and successful implementation of novel interventions into clinical practice depend on patients\u2019 attitudes, patients\u2019 perspectives, perceived obstacles, and ideas on OLP use in clinical practice have yet to be elucidated. Therefore, patient and public involvement is increasingly demanded in research and its implementation into clinical practice. Qualitative research offers a unique opportunity to comprehensively understand attitudes, expectations, perceived benefits, and barriers from a patient\u2019s point of view. Thus, we studied patients\u2019 attitudes, concerns, and ideas toward OLP implementation into clinical practice with focus group discussions (FGDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In 2022, three exploratory online FGDs, each including two patients with the same condition, were conducted with adult patients affected by chronic back pain (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f2), chronic migraine (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f2), or chemotherapy-induced emesis\/nausea (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f2). Physicians recruited participants in three outpatient clinics at the University Hospital Basel in Switzerland. The FGDs were held online for 60\u202fmin. Qualitative data was analyzed using\n                      <jats:italic>Reflexive Thematic Analysis,<\/jats:italic>\n                      applying an inductive-deductive hybrid approach within a social constructivist framework.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, five semantic-latent subthemes were identified, entailing: (i)\n                      <jats:italic>Placebos: Promising but risky<\/jats:italic>\n                      ; (ii)\n                      <jats:italic>Acceptance of OLPs depends on a myriad<\/jats:italic>\n                      ; (iii)\n                      <jats:italic>Be trustworthy, but deception may be necessary<\/jats:italic>\n                      ; (iv)\n                      <jats:italic>Harnessing placebo effects without placebos<\/jats:italic>\n                      ; (v)\n                      <jats:italic>From bench to bedside: Clinical transference of OLPs.<\/jats:italic>\n                      The themes reflect an in-depth discussion of the usage of OLPs in the clinical context, accompanied by different ambivalences regarding implementation, prerequisites, and the provider role.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The FGDs provided insights into distinct attitudes, concerns, varying acceptance, and patients\u2019 ideas regarding the clinical implementation of OLP interventions. While some patients displayed high acceptance, several concerns regarding ethical and practical issues have been expressed. OLP acceptance and attitudes toward practical issues of OLP intake differed between groups and within the same clinical condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>ClinicalTrials.gov<\/jats:uri>\n                      , identifier NCT05166213.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2025.1533663","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T14:17:16Z","timestamp":1753971436000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Talking placebo: a qualitative study of patients\u2019 attitudes toward open-label placebo implementation into clinical practice"],"prefix":"10.3389","volume":"16","author":[{"given":"Antje","family":"Frey Nascimento","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berfin","family":"Bakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Gaab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Papadopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte R.","family":"Blease","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosima","family":"Locher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.4135\/9781526441836","volume-title":"Doing focus groups","author":"Barbour","year":"2018"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.jpain.2021.05.001","article-title":"Treating pain with open-label placebos: a qualitative study with post-surgical pain patients","volume":"22","author":"Bernstein","year":"2021","journal-title":"J. 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