{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:46:37Z","timestamp":1791348397400,"version":"4.3.1"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depression symptoms are commonly experienced by adults and older people; however, there is uncertainty concerning the associations of lifestyle with the risk of depression. This study systematically reviewed and meta-analyzed observational data to assess the link between instrumented sedentary behavior (i-SB) and physical activity (i-PA) measures and depression risk among adult and older populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review across four databases was performed up to July 27, 2024, targeting studies linking i-SB, i-PA, and depression. The review included a dose\u2013response meta-analysis, presenting results as odds ratios (OR) and 95% confidence intervals (95% CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-one studies, encompassing 1,318,687 participants, fulfilled the inclusion criteria. The comparison between the most and least sedentary groups yielded a pooled OR of 1.09 (95% CI 1.05\u20131.13). The comparison between the least and most active participant groups yielded pooled ORs of 0.96 (95% CI 0.93\u20130.98) for light activity (LPA), 0.91 (95% CI 0.86\u20130.96) for moderate-to-vigorous activity (MVPA), 0.93 (95% CI 0.90\u20130.96) for total physical activity (TPA), and 0.87 (95% CI 0.81\u20130.94) for steps per day. After adjusting i-PA, a lower OR for i-SB did not indicate a significant link to increased depression risk. Meta-regression analyses confirmed a dose\u2013response relationship between SB, MVPA, daily steps, and depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The association between i-SB and the risk of depression was not consistent with the results of previous self-reported studies. MVPA linked to the risk of depression was independent of i-SB, whereas the link between i-SB and the risk of depression was not independent of i-PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.php?RecordID=546666<\/jats:ext-link>\n                      , identifier CRD42024546666.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2025.1542340","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T03:23:48Z","timestamp":1742181828000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Sedentary behavior and physical activity are associated with risk of depression among adult and older populations: a systematic review and dose\u2013response meta-analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Dawei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1249\/MSS.0b013e31821ece12","article-title":"2011 compendium of physical activities: a second update of codes and MET values","volume":"43","author":"Ainsworth","year":"2011","journal-title":"Med. 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