{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:12:11Z","timestamp":1785535931113,"version":"3.56.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Numerous studies suggest that hypnosis has significant potential in mental health and cognitive disorder treatments. However, the mechanisms by which hypnosis influences brain activity and functional network connectivity remain unclear. This study employed functional near-infrared spectroscopy (fNIRS) to investigate resting-state functional connectivity (rsFC) under hypnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty-six healthy college students participated in the study. Resting-state oxygenated hemoglobin (HbO) data were collected from the prefrontal cortex (PFC) during both control aware and hypnotic states. Functional connectivity strengths between these states were analyzed to assess changes in brain activity associated with deep hypnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 55 paired samples <jats:italic>t<\/jats:italic>-tests were conducted across 11 regions of interest (ROIs), revealing statistically significant differences (<jats:italic>p<\/jats:italic>\u202f&amp;lt;\u202f0.05) in functional connectivity strength between the control state and hypnotic state in 10 paired comparisons. Increased connectivity during hypnosis (6 pairs): LBA9-RBA10 (<jats:italic>t<\/jats:italic>\u202f=\u202f\u22122.672, <jats:italic>p<\/jats:italic>\u202f=\u202f0.013), LBA6-RBA46 (<jats:italic>t<\/jats:italic>\u202f=\u202f\u22122.948, <jats:italic>p<\/jats:italic>\u202f=\u202f0.007), LBA46-RBA46 (<jats:italic>t<\/jats:italic>\u202f=\u202f\u22122.516, <jats:italic>p<\/jats:italic>\u202f=\u202f0.019), RBA8-RBA46 (<jats:italic>t<\/jats:italic>\u202f=\u202f\u22122.689, <jats:italic>p<\/jats:italic>\u202f=\u202f0.013), RBA9-RBA46 (<jats:italic>t<\/jats:italic>\u202f=\u202f\u22122.090, <jats:italic>p<\/jats:italic>\u202f=\u202f0.047), LBA10-RBA10 (<jats:italic>t<\/jats:italic>\u202f=\u202f\u22122.315, <jats:italic>p<\/jats:italic>\u202f=\u202f0.029); Decreased connectivity during hypnosis (4 pairs): LBA9-LBA45 (<jats:italic>t<\/jats:italic>\u202f=\u202f2.064, <jats:italic>p<\/jats:italic>\u202f=\u202f0.049), LBA6-LBA45 (<jats:italic>t<\/jats:italic>\u202f=\u202f3.151, <jats:italic>p<\/jats:italic>\u202f=\u202f0.004), LBA8-LBA45 (<jats:italic>t<\/jats:italic>\u202f=\u202f2.438, <jats:italic>p<\/jats:italic>\u202f=\u202f0.022), LBA8-RBA9 (<jats:italic>t<\/jats:italic> =\u202f2.085, <jats:italic>p<\/jats:italic>\u202f=\u202f0.047). No significant differences were observed in connectivity strength between other ROI pairs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypnosis appears to modulate the function of the DLPFC, PFC, and related regions, enhancing specific brain network functional connectivity. This preliminary study demonstrates that resting-state functional connectivity analysis using fNIRS is a valuable approach for studying brain activity during hypnosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyg.2025.1567526","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T11:27:42Z","timestamp":1749122862000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Study on resting-state functional connectivity characteristics under hypnosis using functional near-infrared spectroscopy"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhisong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqiu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger C.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"ref1","first-page":"969","article-title":"Imaging of hypnosis with functional magnetic resonance","volume":"40","author":"Aleksandrowicz","year":"2006","journal-title":"Psychiatr. Pol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.5664\/jcsm.6952","article-title":"Hypnosis intervention effects on sleep outcomes: a systematic review","volume":"14","author":"Chamine","year":"2018","journal-title":"J. Clin. Sleep Med."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.neuroimage.2008.08.036","article-title":"NIRS-SPM: statistical parametric mapping for near-infrared spectroscopy","volume":"44","author":"Chul","year":"2009","journal-title":"NeuroImage"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202312.0382.v1","article-title":"EEG oscillations and neural functional connectivity underpinning hypnosis and hypnotizability","author":"De Pascalis","year":"2023","journal-title":"Preprints"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3390\/brainsci14020115","article-title":"Brain functional correlates of resting hypnosis and Hypnotizability: a review","volume":"14","author":"De Pascalis","year":"2024","journal-title":"Brain Sci."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/B978-0-444-53839-0.00020-X","article-title":"Hypnotic modulation of resting state fMRI default mode and extrinsic network connectivity","volume-title":"Slow brain oscillations of sleep, resting state and vigilance","author":"Demertzi","year":"2011"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.neuroimage.2005.05.002","article-title":"Hypnosis decouples cognitive control from conflict monitoring processes of the frontal lobe","volume":"27","author":"Egner","year":"2005","journal-title":"NeuroImage"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1080\/00029157.2020.1865129","article-title":"Towards a multi-brain framework for hypnosis: a review of quantitative methods","volume":"63","author":"Farahzadi","year":"2021","journal-title":"Am. J. Clin. Hypn."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1080\/00207140701338696","article-title":"The efficacy of hypnotherapy in the treatment of psychosomatic disorders: Meta-analytical evidence","volume":"55","author":"Flammer","year":"2007","journal-title":"Int. J. Clin. Exp. Hypn."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"101776","DOI":"10.1016\/j.ctcp.2023.101776","article-title":"Demystifying hypnosis: unravelling facts, exploring the historical roots of myths, and discerning what is hypnosis","volume":"52","author":"Geagea","year":"2023","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1080\/00207144.2019.1650551","article-title":"Functional changes in brain activity after hypnosis: neurobiological mechanisms and application to patients with a specific phobia\u2014limitations and future directions","volume":"67","author":"Halsband","year":"2019","journal-title":"Int. J. Clin. Exp. Hypn."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"010802","DOI":"10.1117\/1.NPh.8.1.010802","article-title":"NIRS-KIT: a MATLAB toolbox for both resting-state and task fNIRS data analysis","volume":"8","author":"Hou","year":"2021","journal-title":"Neurophotonics"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"4083","DOI":"10.1093\/cercor\/bhw220","article-title":"Brain activity and functional connectivity associated with hypnosis","volume":"27","author":"Jiang","year":"2016","journal-title":"Cereb. Cortex"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"N91","DOI":"10.1088\/0031-9155\/51\/5\/N02","article-title":"The modified beer\u2013Lambert law revisited","volume":"51","author":"Kocsis","year":"2006","journal-title":"Phys. Med. Biol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neubiorev.2017.02.020","article-title":"Brain correlates of hypnosis: a systematic review and meta-analytic exploration","volume":"81","author":"Landry","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.jneumeth.2009.11.010","article-title":"Use of fNIRS to assess resting state functional connectivity","volume":"186","author":"Lu","year":"2010","journal-title":"J. Neurosci. Methods"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.concog.2009.09.001","article-title":"Hypnotic induction decreases anterior default mode activity","volume":"18","author":"McGeown","year":"2009","journal-title":"Conscious. Cogn."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1109\/taffc.2024.3407380","article-title":"FEAD: introduction to the fNIRS-EEG affective database","volume":"16","author":"Nia","year":"2025","journal-title":"J IEEE Trans. Affect. Comput."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cortex.2024.05.008","article-title":"An interhemispheric frontoparietal network supports hypnotic states","volume":"177","author":"Niedernhuber","year":"2024","journal-title":"Cortex"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1377900","DOI":"10.3389\/fpsyg.2024.1377900","article-title":"Hypnosis in psychotherapy, psychosomatics and medicine. A brief overview","volume":"15","author":"Peter","year":"2024","journal-title":"Front. Psychol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1016\/j.neuroimage.2011.03.078","article-title":"Brain correlates of hypnotic paralysis-a resting-state fMRI study","volume":"56","author":"Pyka","year":"2011","journal-title":"NeuroImage"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1080\/00207144.2019.1650578","article-title":"HYPNOTIC AUTOMATICITY IN THE BRAIN AT REST: an arterial spin labelling study","volume":"67","author":"Rainville","year":"2019","journal-title":"Int. J. Clin. Exp. Hypn."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1330238","DOI":"10.3389\/fpsyg.2023.1330238","article-title":"Meta-analytic evidence on the efficacy of hypnosis for mental and somatic health issues: a 20-year perspective","volume":"14","author":"Rosendahl","year":"2023","journal-title":"Front. Psychol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.neuroimage.2013.05.004","article-title":"A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology","volume":"85","author":"Scholkmann","year":"2014","journal-title":"NeuroImage"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.neurad.2023.11.002","article-title":"Neural correlates of mindfulness meditation and hypnosis on magnetic resonance imaging: similarities and differences. A scoping review","volume":"51","author":"Sim","year":"2024","journal-title":"J. Neuroradiol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.neuroimage.2005.05.019","article-title":"Spatial registration of multichannel multi-subject fNIRS data to MNI space without MRI","volume":"27","author":"Singh","year":"2005","journal-title":"NeuroImage"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neures.2014.05.009","article-title":"Hypnotic suggestion alters the state of the motor cortex","volume":"85","author":"Takarada","year":"2014","journal-title":"Neurosci. Res."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/15622975.2023.2265997","article-title":"Brain functional connectivity of hypnosis without target suggestion. An intrinsic hypnosis rs-fMRI study","volume":"25","author":"Vazquez","year":"2024","journal-title":"World J. Biol. Psychiatry"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/brainsci12010108","article-title":"Functional changes in brain activity using hypnosis: a systematic review","volume":"12","author":"Wolf","year":"2022","journal-title":"Brain Sci."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.1364\/boe.491610","article-title":"Test-retest reliability of fNIRS in resting-state cortical activity and brain network assessment in stroke patients","volume":"14","author":"Xu","year":"2023","journal-title":"Biomed. Opt. Express"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"29187","DOI":"10.1038\/s41598-024-79820-2","article-title":"Resting-state fNIRS reveals changes in prefrontal cortex functional connectivity during TENS in patients with chronic pain","volume":"14","author":"Yijing Luo","year":"2024","journal-title":"J. Sci. Rep."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"8366","DOI":"10.3390\/ijerph17228366","article-title":"Brief relaxation practice induces significantly more prefrontal cortex activation during arithmetic tasks comparing to viewing greenery images as revealed by functional near-infrared spectroscopy (fNIRS)","volume":"17","author":"Zhang","year":"2020","journal-title":"Int. J. Environ. Res. 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