{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:01:55Z","timestamp":1792598515950,"version":"4.5.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Major depression is a highly prevalent and heterogenous mental disorder. Although therapeutic advances for major depressive disorder over the past quarter-century have been incremental rather than transformative, booster sessions have been proposed as a means of solidifying acute treatment gains and lowering relapse risk. However, evidence for the effectiveness of these treatment booster sessions remains inconclusive. This study therefore evaluated the long-term effectiveness of relapse prevention treatment booster sessions for major depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In a two-arm, parallel-group, maintenance-phase randomized controlled trial (RCT) with repeated longitudinal measures, the sample consisted of participants in Sweden who had received acute treatment for depression (internet-based behavioral activation or physical activity) and were then randomly assigned to either an 8-week relapse prevention program (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f119) or control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f143). Participants were followed-up for 24-months with both monthly self-report questionnaires (Patient Health Questionnaire 9-item &amp;amp; Generalized Anxiety Disorder 7-item) and quarterly diagnostic interviews (Mini-International Neuropsychiatric Interview; MINI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both the relapse prevention group and control group exhibited similar depression-free trends over the course of the study period, with over 95% of participants in each group maintaining remission at the 24-month follow-up. Furthermore, all pre-hypothesized predictors of relapse were non-significant in differentiating the two groups at 24-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings raise the question of whether treatment booster sessions are uniformly advisable for all mild\u2013moderate cases of depression. For instance, preferentially recommending treatment boosters for psychotherapy-na\u00efve individuals with depression may yield greater effects compared to individuals with difficult-to-treat depression. Our findings indicate that the efficacy of behavioral activation and physical activity may be even greater than previously reported, a testament to the lasting effects of internet-based psychotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trail registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>ClinicalTrials.gov<\/jats:uri>\n                      , identifier NCT01619930.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2025.1568141","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:19:31Z","timestamp":1750771171000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating the necessity of booster sessions in relapse prevention for depression: a longitudinal study"],"prefix":"10.3389","volume":"16","author":[{"given":"J\u00f3n Ingi","family":"Hlynsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00f3mas","family":"Kristj\u00e1nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Carlbring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ACTUA research group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e41643","DOI":"10.2196\/41643","article-title":"Internet-based behavioral activation for depression: systematic review and Meta-analysis","volume":"25","author":"Alber","year":"2023","journal-title":"J. Med. Internet Res."},{"key":"ref2","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2022"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/d41586-019-00857-9","article-title":"Scientists rise up against statistical significance","volume":"567","author":"Amrhein","year":"2019","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1080\/14737175.2018.1400381","article-title":"Long-term effects of internet-supported cognitive behaviour therapy","volume":"18","author":"Andersson","year":"2018","journal-title":"Expert. Rev. Neurother."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e0272200","DOI":"10.1371\/journal.pone.0272200","article-title":"Psychological interventions to prevent relapse in anxiety and depression: a systematic review and meta-analysis","volume":"17","author":"Bruin","year":"2022","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s00127-011-0389-1","article-title":"Factors associated with differential response to online cognitive behavioural therapy","volume":"47","author":"Button","year":"2012","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1745-6215-14-35","article-title":"The effects on depression of internet-administered behavioural activation and physical exercise with treatment rationale and relapse prevention: study protocol for a randomised controlled trial","volume":"14","author":"Carlbring","year":"2013","journal-title":"Trials"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.cpr.2015.04.002","article-title":"Can non-pharmacological interventions prevent relapse in adults who have recovered from depression? A systematic review and meta-analysis of randomised controlled trials","volume":"39","author":"Clarke","year":"2015","journal-title":"Clin. Psychol. Rev."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41392-024-01738-y","article-title":"Major depressive disorder: hypothesis, mechanism, prevention and treatment","volume":"9","author":"Cui","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jad.2024.05.019","article-title":"The outcomes of mental health care for depression over time: a meta-regression analysis of response rates in usual care","volume":"358","author":"Cuijpers","year":"2024","journal-title":"J. Affect. Disord."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e46419","DOI":"10.2196\/46419","article-title":"The role of daily steps in the treatment of major depressive disorder: secondary analysis of a randomized controlled trial of a 6-month internet-based, mindfulness-based cognitive behavioral therapy intervention for youth","volume":"12","author":"Dang","year":"2023","journal-title":"Interact. J. Med. Res."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-clinpsy-032210-104535","article-title":"The origins and current status of behavioral activation treatments for depression","volume":"7","author":"Dimidjian","year":"2011","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"ref13","first-page":"339","article-title":"Behavioral activation for depression","volume-title":"Clinical handbook of psychological disorders: A step-by-step treatment manual","author":"Dimidjian","year":"2021"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.jad.2013.06.020","article-title":"Predictors and moderators of response to internet-delivered interpersonal psychotherapy and cognitive behavior therapy for depression","volume":"151","author":"Donker","year":"2013","journal-title":"J. Affect. Disord."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1017\/S0033291716001562","article-title":"Does internet-based guided-self-help for depression cause harm? An individual participant data meta-analysis on deterioration rates and its moderators in randomized controlled trials","volume":"46","author":"Ebert","year":"2016","journal-title":"Psychol. Med."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S2215-0366(20)30169-3","article-title":"The 341 737 ways of qualifying for the melancholic specifier","volume":"7","author":"Fried","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/s44159-022-00050-2","article-title":"Revisiting the theoretical and methodological foundations of depression measurement","volume":"1","author":"Fried","year":"2022","journal-title":"Nat. Rev. Psychol."},{"key":"ref18","first-page":"729","article-title":"The interpolation of time series by related series","volume-title":"J. Am. Stat. Assoc.","author":"Friedman","year":"1962"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1037\/1040-3590.4.1.92","article-title":"Clinical validation of the quality of life inventory: a measure of life satisfaction for use in treatment planning and outcome assessment","volume":"4","author":"Frisch","year":"1992","journal-title":"Psychol. Assess."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e5467","DOI":"10.32872\/cpe.5467","article-title":"Explaining the efficacy of an internet-based behavioral activation intervention for major depression: a mechanistic study of a randomized-controlled trial","volume":"3","author":"Fu","year":"2021","journal-title":"Clinic. Psychol. Europe"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","article-title":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: a systematic analysis for the global burden of disease study 2019","volume":"9","year":"2022","journal-title":"Lancet Psychiatry"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"274","DOI":"10.4103\/0974-7788.76794","article-title":"Understanding survival analysis: Kaplan-Meier estimate","volume":"1","author":"Goel","year":"2010","journal-title":"Int. J. Ayurveda Res."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/j.2051-5545.2011.tb00061.x","article-title":"The heterogeneity of \u201cmajor depression\u201d","volume":"10","author":"Goldberg","year":"2011","journal-title":"World Psychiatry"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s40273-021-01019-4","article-title":"The economic burden of adults with major depressive disorder in the United States (2010 and 2018)","volume":"39","author":"Greenberg","year":"2021","journal-title":"PharmacoEconomics"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"100499","DOI":"10.1016\/j.invent.2022.100499","article-title":"A randomized factorial trial of internet-delivered cognitive behavioural therapy: an 8-week program with or without extended support and booster lesson","volume":"27","author":"Hadjistavropoulos","year":"2022","journal-title":"Internet Interv."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"100635","DOI":"10.1016\/j.invent.2023.100635","article-title":"Who benefits from guided internet-based interventions? A systematic review of predictors and moderators of treatment outcome","volume":"33","author":"Haller","year":"2023","journal-title":"Internet Interv."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/wps.21088","article-title":"Therapist-supported internet-based cognitive behaviour therapy yields similar effects as face-to-face therapy for psychiatric and somatic disorders: an updated systematic review and meta-analysis","volume":"22","author":"Hedman-Lagerl\u00f6f","year":"2023","journal-title":"World Psychiatry"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1136\/bjsports-2022-106282","article-title":"Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regression","volume":"57","author":"Heissel","year":"2023","journal-title":"Br. J. Sports Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ypmed.2017.08.008","article-title":"Long-term effects of exercise at different intensity levels on depression: a randomized controlled trial","volume":"105","author":"Helgad\u00f3ttir","year":"2017","journal-title":"Prev. Med."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-024-02922-y","article-title":"From movement to motivation: a proposed framework to understand the antidepressant effect of exercise","volume":"14","author":"Hird","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1259997","DOI":"10.3389\/fpsyg.2024.1259997","article-title":"Diagnostic accuracy and clinical utility of the PHQ-2 and GAD-2: a comparison with long-format measures for depression and anxiety","volume":"15","author":"Hlynsson","year":"2024","journal-title":"Front. Psychol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1600-0447.2011.01698.x","article-title":"Randomized trial of internet-based relapse prevention for partially remitted depression","volume":"124","author":"Holl\u00e4ndare","year":"2011","journal-title":"Acta Psychiatr. Scand."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1080\/03610928008827941","article-title":"Goodness of fit tests for the multiple logistic regression model","volume":"9","author":"Hosmer","year":"1980","journal-title":"Commun. Statist."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jad.2018.02.073","article-title":"A systematic review and meta-analysis on the efficacy of internet-delivered behavioral activation","volume":"235","author":"Huguet","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.jad.2020.07.052","article-title":"Aerobic exercise or stretching as add-on to inpatient treatment of depression: similar antidepressant effects on depressive symptoms and larger effects on working memory for aerobic exercise alone","volume":"276","author":"Imboden","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.7717\/peerj.98","article-title":"Depression, anxiety and their comorbidity in the Swedish general population: point prevalence and the effect on health-related quality of life","volume":"1","author":"Johansson","year":"2013","journal-title":"PeerJ"},{"key":"ref37","author":"Kassambara","year":"2021"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e10437","DOI":"10.2196\/10437","article-title":"Economic evaluation of an internet-based preventive cognitive therapy with minimal therapist support for recurrent depression: randomized controlled trial","volume":"20","author":"Klein","year":"2018","journal-title":"J. Med. Internet Res."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J. Gen. Intern. Med."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.genhosppsych.2010.03.006","article-title":"The patient health questionnaire somatic, anxiety, and depressive symptom scales: a systematic review","volume":"32","author":"Kroenke","year":"2010","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jad.2016.03.063","article-title":"Exercise as a treatment for depression: a meta-analysis","volume":"202","author":"Kvam","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S0924-9338(97)83296-8","article-title":"The mini international neuropsychiatric interview (MINI). A short diagnostic structured interview: reliability and validity according to the CIDI","volume":"12","author":"Lecrubier","year":"1997","journal-title":"Eur. Psychiatry"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/16506073.2013.806584","article-title":"Validation of the internet-administered quality of life inventory (QOLI) in different psychiatric conditions","volume":"42","author":"Lindner","year":"2013","journal-title":"Cogn. Behav. Ther."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1080\/16506073.2016.1143526","article-title":"The Brunnsviken brief quality of life scale (BBQ): development and psychometric evaluation","volume":"45","author":"Lindner","year":"2016","journal-title":"Cogn. Behav. Ther."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.genhosppsych.2019.07.008","article-title":"Adaptation of the two-item generalized anxiety disorder scale (GAD-2) to Chinese rural population: a validation study and meta-analysis","volume":"60","author":"Luo","year":"2019","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"e003440","DOI":"10.1136\/bmjopen-2013-003440","article-title":"Behavioural activation versus mindfulness-based guided self-help treatment administered through a smartphone application: a randomised controlled trial","volume":"4","author":"Ly","year":"2014","journal-title":"BMJ Open"},{"key":"ref47","volume-title":"Behavioral","author":"Martell","year":"2021"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e32824","DOI":"10.2196\/32824","article-title":"The current state and validity of digital assessment tools for psychiatry: systematic review","volume":"9","author":"Martin-Key","year":"2022","journal-title":"JMIR Mental Health"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.jad.2020.02.023","article-title":"The identification, assessment and management of difficult-to-treat depression: an international consensus statement","volume":"267","author":"McAllister-Williams","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/acps.13242","article-title":"Mindfulness-based cognitive therapy for prevention and time to depressive relapse: systematic review and network meta-analysis","volume":"143","author":"McCartney","year":"2021","journal-title":"Acta Psychiatr. Scand."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/da.22842","article-title":"Aerobic exercise for adult patients with major depressive disorder in mental health services: a systematic review and meta-analysis","volume":"36","author":"Morres","year":"2019","journal-title":"Depress. Anxiety"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/00019442-200401000-00003","article-title":"The course of depression in elderly patients","volume":"12","author":"Mueller","year":"2004","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.tree.2021.10.009","article-title":"Rewriting results sections in the language of evidence","volume":"37","author":"Muff","year":"2022","journal-title":"Trends Ecol. Evol."},{"key":"ref54","year":"2022"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"177","DOI":"10.2147\/IJGM.S243150","article-title":"Correspondence between the neuropsychiatric interview M.I.N.I. And the BDI-II and MADRS-S self-rating instruments as diagnostic tools in primary care patients with depression","volume":"13","author":"Nejati","year":"2020","journal-title":"Int. J. General Med."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1080\/16506073.2015.1015440","article-title":"Treating major depression with physical activity: a systematic overview with recommendations","volume":"44","author":"Nystr\u00f6m","year":"2015","journal-title":"Cogn. Behav. Ther."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jad.2017.03.018","article-title":"Behavioral activation versus physical activity via the internet: a randomized controlled trial","volume":"215","author":"Nystr\u00f6m","year":"2017","journal-title":"J. Affect. Disord."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1017\/S1754470X22000265","article-title":"Transdiagnostic internet-delivered therapy among post-secondary students: exploring student use and preferences for booster lessons post-treatment","volume":"15","author":"Patterson","year":"2022","journal-title":"Cogn. Behav. Ther."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e40637","DOI":"10.2196\/40637","article-title":"Internet-delivered cognitive behavioral therapy for postsecondary students: randomized factorial trial for examining motivational interviewing and booster lessons","volume":"24","author":"Peynenburg","year":"2022","journal-title":"J. Med. Internet Res."},{"key":"ref60","volume-title":"R: a language and environment for statistical computing","year":"2021"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1080\/17437199.2015.1022901","article-title":"A meta-meta-analysis of the effect of physical activity on depression and anxiety in non-clinical adult populations","volume":"9","author":"Rebar","year":"2015","journal-title":"Health Psychol. Rev."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1037\/ccp0000158","article-title":"For better or worse: an individual patient data meta-analysis of deterioration among participants receiving internet-based cognitive behavior therapy","volume":"85","author":"Rozental","year":"2017","journal-title":"J. Consult. Clin. Psychol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1017\/S0033291721004943","article-title":"Clinical research challenges posed by difficult-to-treat depression","volume":"52","author":"Rush","year":"2022","journal-title":"Psychol. Med."},{"key":"ref64","first-page":"11980","article-title":"The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S0924-9338(97)83297-X","article-title":"The validity of the mini international neuropsychiatric interview (MINI) according to the SCID-P and its reliability","volume":"12","author":"Sheehan","year":"1997","journal-title":"Eur. Psychiatry"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1742-9536.2012.00054.x","article-title":"The psychometric properties of the quality of life inventory in an Australian community sample","volume":"64","author":"Thomas","year":"2012","journal-title":"Aust. J. Psychol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.chb.2008.05.006","article-title":"Web-based measurement: effect of completing single or multiple items per webpage","volume":"25","author":"Thorndike","year":"2009","journal-title":"Comput. Hum. Behav."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"e16802","DOI":"10.2196\/16802","article-title":"24-month outcomes of primary care web-based depression prevention intervention in adolescents: randomized clinical trial","volume":"22","author":"Voorhees","year":"2020","journal-title":"J. Med. Internet Res."},{"key":"ref70","article-title":"Uncomplicated depression as normal sadness: rethinking the boundary between normal and disordered depression","volume-title":"The Oxford handbook of mood disorders","author":"Wakefield","year":"2017"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/HRP.0000000000000139","article-title":"Internet-based cognitive behavioral therapy for depression: Current Progress & Future Directions","volume":"25","author":"Webb","year":"2017","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1017\/S0033291712001717","article-title":"Estimating remission from untreated major depression: a systematic review and meta-analysis","volume":"43","author":"Whiteford","year":"2013","journal-title":"Psychol. Med."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S2215-0366(24)00069-5","article-title":"A transdiagnostic group exercise intervention for mental health outpatients in Germany (ImPuls): results of a pragmatic, multisite, block-randomised, phase 3 controlled trial","volume":"11","author":"Wolf","year":"2024","journal-title":"Lancet Psychiatry"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000509283","article-title":"Probability of major depression classification based on the SCID, CIDI, and MINI diagnostic interviews: a synthesis of three individual participant data Meta-analyses","volume":"90","author":"Wu","year":"2020","journal-title":"Psychother. Psychosom."}],"container-title":["Frontiers in Psychology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2025.1568141\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:19:33Z","timestamp":1750771173000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2025.1568141\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":74,"alternative-id":["10.3389\/fpsyg.2025.1568141"],"URL":"https:\/\/doi.org\/10.3389\/fpsyg.2025.1568141","relation":{},"ISSN":["1664-1078"],"issn-type":[{"value":"1664-1078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]},"article-number":"1568141"}}