{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:23:17Z","timestamp":1787599397264,"version":"build-2736575974"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Emotion regulation is crucial for mental health and adaptive psychological functioning. Despite growing interest in emotion dysregulation (ED) in individuals with intellectual disability (ID), little is known about its association with neuropsychological and psychopathological profiles in children and adolescents with Down syndrome (DS), the most frequent genetic cause of ID. This study aimed to compare the neuropsychological profile, psychopathological symptoms, and sleep disturbances of children with DS with and without ED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrospectively collected from a database. The final sample included 214 participants (6\u201318 years): 69 with co-occurring ED and 145 controls without ED, with groups balanced for age and sex. Emotional\/behavioral difficulties and sleep problems were assessed through parent-report questionnaires and clinical interviews. Language abilities and visual-motor integration skills were evaluated by standardized tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with co-occurring ED exhibited significantly worse visual-integration and motor coordination skills than children without co-occurring ED. Moreover, they displayed more psychopathological symptoms ascribable to both externalizing and internalizing problems. Finally, children with ED exhibited more sleep difficulties associated with insomnia and parasomnias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results emphasize the need to consider ED in assessment and interventions, as it can significantly impact neuropsychological development and overall wellbeing.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyg.2025.1632058","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T05:41:48Z","timestamp":1758692508000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical correlates of emotion dysregulation in Down syndrome: a comparative study"],"prefix":"10.3389","volume":"16","author":[{"given":"Elisa","family":"Fuc\u00e0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina Maria","family":"Mongiov\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Vicari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Costanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"ref1","first-page":"238","volume-title":"Manual for the ASEBA school-age forms & profiles: an integrated system of multi-informant assessment","author":"Achenbach","year":"2001"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s12311-016-0815-8","article-title":"Consensus paper: cerebellum and emotion","volume":"16","author":"Adamaszek","year":"2017","journal-title":"Cerebellum"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"5031","DOI":"10.3390\/jcm11175031","article-title":"Motor coordination and global development in subjects with Down syndrome: the influence of physical activity","volume":"11","author":"Alesi","year":"2022","journal-title":"JCM"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"4078","DOI":"10.3390\/jcm11144078","article-title":"Characterization of cognitive, language and adaptive profiles of children and adolescents with Malan syndrome","volume":"11","author":"Alfieri","year":"2022","journal-title":"JCM"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"103962","DOI":"10.1016\/j.ridd.2021.103962","article-title":"Exploring different aspects of emotion understanding in adults with Down syndrome","volume":"114","author":"Andr\u00e9s-Roqueta","year":"2021","journal-title":"Res. 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