{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T11:23:30Z","timestamp":1768217010837,"version":"3.49.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Evaluation of the Trajectory of Negative Emotional Changes and the Effectiveness of Narrative Nursing Intervention in Inflammatory Bowel Disease Patients from the Perspective of Brain-Gut Interaction","award":["2026HLKY02"],"award-info":[{"award-number":["2026HLKY02"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Crohn\u2019s disease (CD) is a chronic inflammatory disorder marked by unpredictable disease activity and complex interactions between biological and psychosocial factors. Although social support and illness acceptance are known to influence patient outcomes, their combined impact on disease activity has not been systematically investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to elucidate the interrelationships between social support, illness acceptance, and disease activity in patients with Crohn\u2019s disease using network analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a cross-sectional design, 276 CD patients completed standardized assessments, including the Multidimensional Scale of Perceived Social Support (MSPSS), the Acceptance of Illness Scale (AIS), and the Crohn\u2019s Disease Activity Index (CDAI). A regularized partial correlation network was estimated using the graphical LASSO algorithm, with centrality and bridge strength metrics computed to identify influential variables. Subgroup analyses by marital status were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The network revealed key nodes with high centrality, including lack of self-worth (AIS7), feeling unneeded (AIS3), and lack of self-sufficiency (AIS6), along with perceived support from significant others. Bridge centrality analysis identified AIS7, family support, and overall disease activity as key bridging nodes connecting psychosocial and clinical domains. Subgroup analysis revealed distinct patterns: in single patients, family support and self-worth were directly linked to disease activity; in married patients, friend support and autonomy emerged as central, with no direct psychosocial-clinical links. Network structures did not significantly differ in global strength, but key node positions varied by marital status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight self-worth, autonomy, and perceived social support as central psychosocial factors influencing disease activity in CD. These pathways differ by relationship status, underscoring the need for personalized psychosocial care strategies tailored to marital context. Longitudinal research is warranted to validate these dynamic relationships.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2025.1700857","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:12:00Z","timestamp":1768205520000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Network modeling of the impact of social support and illness acceptance on disease activity in Crohn\u2019s disease patients: a cross-sectional study"],"prefix":"10.3389","volume":"16","author":[{"given":"Jinli","family":"Bu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S2468-1253(21)00014-5","article-title":"Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis","volume":"6","author":"Barberio","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0163-8343(82)90029-9","article-title":"Behavioral--physiological factors in the development and management of cancer","volume":"4","author":"Borysenko","year":"1982","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"131","DOI":"10.7334\/psicothema2020.263","article-title":"Multidimensional scale of perceived social support (MSPSS) in cancer patients: psychometric properties and measurement invariance","volume":"33","author":"Calder\u00f3n","year":"2021","journal-title":"Psicothema"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.21037\/jtd.2017.08.70","article-title":"The acceptance of illness, the intensity of pain and the quality of life in patients with lung cancer","volume":"9","author":"Chabowski","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1001\/jama.2013.4466","article-title":"Management of active Crohn disease","volume":"309","author":"Cheifetz","year":"2013","journal-title":"JAMA"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.11124\/JBISRIR-2016-003180","article-title":"Self-management for patients with inflammatory bowel disease in a gastroenterology ward in China: a best practice implementation project","volume":"14","author":"Chen","year":"2016","journal-title":"JBI Database System Rev. Implement. Rep."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1093\/biomet\/asn034","article-title":"Extended Bayesian information criteria for model selection with large model spaces","volume":"95","author":"Chen","year":"2008","journal-title":"Biometrika"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"17562848221127474","DOI":"10.1177\/17562848221127474","article-title":"Associations between inflammatory bowel disease, social isolation, and mortality: evidence from a longitudinal cohort study","volume":"15","author":"Chen","year":"2022","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1093\/eurjcn\/zvac034","article-title":"Determinants of adherence to diet and exercise behaviours among individuals with metabolic syndrome based on the capability, opportunity, motivation, and behaviour model: a cross-sectional study","volume":"22","author":"Chen","year":"2023","journal-title":"Eur. J. Cardiovasc. Nurs."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.15585\/mmwr.mm6542a3","article-title":"Prevalence of inflammatory bowel disease among adults aged \u226518 years - United States, 2015","volume":"65","author":"Dahlhamer","year":"2016","journal-title":"MMWR Morb. Mortal Wkly. Rep."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.3390\/jcm13113086","article-title":"Impact of psychosocial factors on the activity of Crohn's disease: a cross-sectional analysis of social support, stress, and flare-up incidence","volume":"13","author":"de Dios-Duarte","year":"2024","journal-title":"J. Clin. Med."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1007\/s11547-022-01535-z","article-title":"Contrast-enhanced ultrasound in the assessment of Crohn's disease activity: comparison with computed tomography enterography","volume":"127","author":"Ding","year":"2022","journal-title":"Radiol. Med."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3758\/s13428-017-0862-1","article-title":"Estimating psychological networks and their accuracy: a tutorial paper","volume":"50","author":"Epskamp","year":"2018","journal-title":"Behav. Res. Methods"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1037\/0022-006X.52.3.343","article-title":"Coping with chronic illness: a study of illness controllability and the influence of coping strategies on psychological adjustment","volume":"52","author":"Felton","year":"1984","journal-title":"J. Consult. Clin. Psychol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/spe.4380211102","article-title":"Graph drawing by force-directed placement","volume":"21","author":"Fruchterman","year":"1991","journal-title":"Softw. Pract. Experience"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/jan.17102","article-title":"Health-promoting lifestyle and associated factors among head and neck Cancer patients in Northeast China: a cross-sectional study","author":"Gao","year":"2025","journal-title":"J. Adv. Nurs."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e2281","DOI":"10.1053\/j.gastro.2009.02.069","article-title":"Reactivation of inflammatory bowel disease in a mouse model of depression","volume":"136","author":"Ghia","year":"2009","journal-title":"Gastroenterology"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"otad006","DOI":"10.1093\/crocol\/otad006","article-title":"The real-world global use of patient-reported outcomes for the Care of Patients with Inflammatory Bowel Disease","volume":"5","author":"Horrigan","year":"2023","journal-title":"Crohns Colitis 360"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12912-024-02671-9","article-title":"Mediating effect of social support on the relationships between caregiver burden and quality of life in family caregivers of people with dementia: a cross-sectional study in rural China","volume":"24","author":"Hu","year":"2025","journal-title":"BMC Nurs."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"730845","DOI":"10.3389\/fpubh.2021.730845","article-title":"Medication adherence and associated factors in patients with type 2 diabetes: a structural equation model","volume":"9","author":"Huang","year":"2021","journal-title":"Front. Public Health"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e076219","DOI":"10.1136\/bmjopen-2023-076219","article-title":"Is disease activity associated with social support and psychological distress in Crohn's disease patients? Results of a cross-sectional study in a Chinese hospital population","volume":"13","author":"Huang","year":"2023","journal-title":"BMJ Open"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2196\/65892","article-title":"Schema-informed digital mental health intervention for maladaptive cognitive-emotional patterns: a randomized controlled trial","author":"Jeong","year":"2025","journal-title":"J. Med. Internet Res."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/jnu.12487","article-title":"Systematic review of social support on psychological symptoms and self-management Behaviors among adults with inflammatory bowel disease","volume":"51","author":"Kamp","year":"2019","journal-title":"J. Nurs. Scholarsh."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jad.2023.10.132","article-title":"Negative parenting style and depression in adolescents: a moderated mediation of self-esteem and perceived social support","volume":"345","author":"Kang","year":"2024","journal-title":"J. Affect. Disord."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/ibd.21314","article-title":"The role of self-efficacy in inflammatory bowel disease management: preliminary validation of a disease-specific measure","volume":"17","author":"Keefer","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.jcjd.2023.07.004","article-title":"The Association of Children and Their Educational Attainment with Diabetes-related Complications and mortality among older adults with type 2 diabetes: a Nationwide cohort study","volume":"47","author":"Larsen","year":"2023","journal-title":"Can. J. Diabetes"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.asjsur.2022.08.083","article-title":"Preoperative and postoperative clinical signatures of postgastrectomy venous thromboembolism in patients with gastric cancer: a retrospective cohort study","volume":"46","author":"Li","year":"2023","journal-title":"Asian J. Surg."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1186\/s12903-025-05789-7","article-title":"Oral frailty and its influencing factors in patients with cancer undergoing chemotherapy: a cross-sectional study","volume":"25","author":"Li","year":"","journal-title":"BMC Oral Health"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"100715","DOI":"10.1016\/j.apjon.2025.100715","article-title":"Acceptance of illness and its relationship with benefit finding among patients with colorectal cancer undergoing chemotherapy: a latent profile analysis","volume":"12","author":"Li","year":"","journal-title":"Asia Pac. J. Oncol. Nurs."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1186\/s12967-018-1723-0","article-title":"Clinical significance of soluble immunoglobulins A and G and their coated bacteria in feces of patients with inflammatory bowel disease","volume":"16","author":"Lin","year":"2018","journal-title":"J. Transl. Med."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1578836","DOI":"10.3389\/fnut.2025.1578836","article-title":"Factors influencing nutritional literacy among rural older adults: a cross-sectional survey based on the theory of planned behavior","volume":"12","author":"Liu","year":"2025","journal-title":"Front. Nutr."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"12248","DOI":"10.1073\/pnas.1202835109","article-title":"Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity","volume":"109","author":"Liu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"112196","DOI":"10.1016\/j.diabres.2025.112196","article-title":"Associations between disease acceptance and dietary adherence in patients with type 2 diabetes mellitus in China: a cross-sectional study","volume":"224","author":"Liu","year":"2025","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"108821","DOI":"10.1016\/j.pec.2025.108821","article-title":"Associations between acceptance of illness, psychological resilience, and patient activation among young and middle-aged patients with lung cancer","volume":"137","author":"Ma","year":"2025","journal-title":"Patient Educ. Couns."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1007\/s11136-020-02467-9","article-title":"Self-esteem in patients with inflammatory bowel disease","volume":"29","author":"Opheim","year":"2020","journal-title":"Qual. Life Res."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1037\/abn0000181","article-title":"Identifying highly influential nodes in the complicated grief network","volume":"125","author":"Robinaugh","year":"2016","journal-title":"J. Abnorm. Psychol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"980614","DOI":"10.3389\/fpsyt.2022.980614","article-title":"Relationship between social support and schizophrenia relapse among patients with schizophrenia on follow-up at Amanuel mental specialized hospital, Addis Ababa, Ethiopia: a case-control study","volume":"13","author":"Samuel","year":"2022","journal-title":"Front. Psychol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1093\/ibd\/izz258","article-title":"Poor sleep quality in Crohn's disease is associated with disease activity and risk for hospitalization or surgery","volume":"26","author":"Sofia","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2025.1013","article-title":"Disease burden and unmet medical need in patients with Crohn\u2019s disease in Greece: a cross-sectional patient survey","author":"Tzanetakos","year":"2025","journal-title":"Ann. Gastroenterol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/apt.14832","article-title":"Clinical disease activity is associated with anxiety and depressive symptoms in adolescents and young adults with inflammatory bowel disease","volume":"48","author":"van den Brink","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"114653","DOI":"10.1016\/j.bbr.2023.114653","article-title":"Effects of cognitive behavioral therapy on mental health and quality of life in inflammatory bowel disease patients: a meta-analysis of randomized controlled trials","volume":"454","author":"Wang","year":"2023","journal-title":"Behav. Brain Res."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"6057","DOI":"10.3748\/wjg.v26.i39.6057","article-title":"Dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging in the activity staging of terminal ileum Crohn's disease","volume":"26","author":"Wu","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1007318","DOI":"10.3389\/fpsyt.2022.1007318","article-title":"The impact of family function on mental health status in patient with inflammatory bowel disease: the mediating role of self-esteem","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Psychol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"110983","DOI":"10.1016\/j.jpsychores.2022.110983","article-title":"Association of inflammatory bowel disease with suicidal ideation, suicide attempts, and suicide: a systematic review and meta-analysis","volume":"160","author":"Xiong","year":"2022","journal-title":"J. Psychosom. Res."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jad.2022.04.034","article-title":"Mediation effect of perceived social support and resilience between physical disability and depression in acute stroke patients in China: a cross-sectional survey","volume":"308","author":"Zhao","year":"2022","journal-title":"J. Affect. Disord."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1111\/jan.16044","article-title":"Pre-hospital symptom clusters and symptom network analysis in decompensated cirrhotic patients: a cross-sectional study","volume":"80","author":"Zhou","year":"2024","journal-title":"J. Adv. Nurs."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1080\/00223891.1990.9674095","article-title":"Psychometric characteristics of the multidimensional scale of perceived social support","volume":"55","author":"Zimet","year":"1990","journal-title":"J. Pers. Assess."}],"container-title":["Frontiers in Psychology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2025.1700857\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:12:02Z","timestamp":1768205522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2025.1700857\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":47,"alternative-id":["10.3389\/fpsyg.2025.1700857"],"URL":"https:\/\/doi.org\/10.3389\/fpsyg.2025.1700857","relation":{},"ISSN":["1664-1078"],"issn-type":[{"value":"1664-1078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"article-number":"1700857"}}