{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:46:53Z","timestamp":1776840413836,"version":"3.51.2"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:p>Alcohol misuse is a major global risk factor for morbidity and mortality among adolescents and young adults. During adolescence and young adulthood, alcohol can disrupt brain maturation, alter brain connectivity, and persistently weaken self-regulation. The limited effectiveness of current evidence-based treatments underscores the need for adjunctive interventions. Neuroscientific models suggest that an imbalance between the appetitive system and executive control processes contributes to alcohol misuse. Alcohol-specific inhibition training (Alc-IT) addresses this imbalance and has shown first indications of beneficial effects in inpatient settings. However, app-based delivery and its use in adolescents and young adults are novel and have not yet been systematically investigated for feasibility, preliminary effectiveness, and neurophysiological effects. This multicenter, double-blind, randomized controlled feasibility trial aims to assess the implementation of app-based Alc-IT as an add-on to outpatient treatment for alcohol use disorder (AUD). Up to 210 participants (14\u201327\u202fyears) will be randomized to Alc-IT or an active control condition. Both groups complete six training sessions over a two-week period and six booster sessions one month later. Feasibility outcomes include recruitment and completion rates. Changes in drinking behavior will be assessed at one-month and three-month follow-up using the Timeline Follow-Back method. In a sub-study with up to 60 participants, neurophysiological correlates of inhibitory control (N2 and P3 event-related potentials) will be measured. EEG will be recorded during a modified Go\/NoGo task before and after training. This study will inform the feasibility, preliminary effectiveness, and potential neurophysiological mechanisms of app-based Alc-IT for young people with AUD. The findings will guide the design of a subsequent fully powered randomized controlled trial.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>\n                      , ID: NCT07071779; SNCPT, ID: SNCTP000006292.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2026.1684231","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:49:05Z","timestamp":1776836945000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mobile alcohol-specific inhibition training in adolescents and young adults with alcohol use disorder: study protocol for a randomized controlled feasibility trial"],"prefix":"10.3389","volume":"17","author":[{"given":"Kirstin","family":"Schuerch","sequence":"first","affiliation":[{"name":"University Hospital of Psychiatry and Psychotherapy, Translational Research Center, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Koenig","sequence":"additional","affiliation":[{"name":"University Hospital of Psychiatry and Psychotherapy, Translational Research Center, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Guarriello","sequence":"additional","affiliation":[{"name":"University Hospital of Psychiatry and Psychotherapy, Translational Research Center, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Soravia","sequence":"additional","affiliation":[{"name":"University Hospital of Psychiatry and Psychotherapy, Translational Research Center, University of Bern","place":["Bern, Switzerland"]},{"name":"Clinic Suedhang, Center for Treatment of Addictive Disorders","place":["Kirchlindach, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapy, Institute of Psychology, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Adorjan","sequence":"additional","affiliation":[{"name":"University Hospital of Psychiatry and Psychotherapy, Translational Research Center, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Moggi","sequence":"additional","affiliation":[{"name":"University Hospital of Psychiatry and Psychotherapy, Translational Research Center, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Stein","sequence":"additional","affiliation":[{"name":"University Hospital of Psychiatry and Psychotherapy, Translational Research Center, University of Bern","place":["Bern, Switzerland"]},{"name":"Department of Clinical Psychology and Psychotherapy, Institute of Psychology, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"ref1","volume-title":"WHOQOL-100 und WHOQOL-BREF. 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