{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:07:13Z","timestamp":1770883633857,"version":"3.50.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Moral decision-making, a core component of social cognition, relies on integrating affective and cognitive processes supported by distributed neural networks. Neurodegenerative diseases disrupt these systems to varying degrees, offering unique models to investigate the neural bases of moral cognition. This review aimed to systematically examine moral decision-making deficits across neurodegenerative diseases, delineate disease-specific patterns of moral cognition impairment, and highlight conceptual and methodological gaps to inform future research and clinical assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Web of Science, and Scopus was conducted for studies published up to January 2025, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventeen studies met inclusion criteria. Convergent evidence indicates that behavioral variant frontotemporal dementia (bvFTD) produces a distinctive utilitarian bias characterized by diminished empathy, emotional blunting, and impaired integration of intention and outcome, reflecting degeneration of the ventromedial prefrontal cortex, anterior insula, and amygdala within the salience and default mode networks. In contrast, Alzheimer\u2019s disease (AD) patients typically preserve affective aversion to harm, suggesting relative sparing of limbic\u2013ventromedial circuits despite conceptual and executive decline. Moral reasoning in Parkinson\u2019s disease (PD) and amyotrophic lateral sclerosis (ALS) remains largely intact unless frontotemporal involvement occurs, while dementia with Lewy bodies (DLB) manifests intermediate profiles marked by reduced cognitive theory of mind and aberrant moral affect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings delineate disease-specific patterns of moral dysfunction linked to network-level degeneration rather than global cognitive decline. Understanding these mechanisms holds translational relevance for early diagnosis, ethical capacity assessment, and the development of ecologically valid tools to monitor socio-emotional deterioration in neurodegenerative disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2026.1745923","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:20:30Z","timestamp":1770880830000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Moral decision-making in patients with neurodegenerative diseases: a systematic review"],"prefix":"10.3389","volume":"17","author":[{"given":"Giorgia","family":"Capitani","sequence":"first","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila","place":["L\u2019Aquila, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Lozzi","sequence":"additional","affiliation":[{"name":"Acquisition, Analysis, Visualization and Imaging Laboratory (A2VI Lab), Department of Life, Health and Environmental Sciences, University of L\u2019Aquila","place":["L\u2019Aquila, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Curcio","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila","place":["L\u2019Aquila, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Migliore","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila","place":["L\u2019Aquila, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1080\/13554794.2024.2404682","article-title":"Socioemotional dysfunction and the greater good: a case study","volume":"30","author":"Antoniou","year":"2024","journal-title":"Neurocase"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1197213","DOI":"10.3389\/FNEUR.2023.1197213","article-title":"Moral reasoning through the eyes of persons with behavioral variant frontotemporal dementia","volume":"14","author":"Antoniou","year":"2023","journal-title":"Front. Neurol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"4283427","DOI":"10.1155\/2018\/4283427","article-title":"Social cognition through the Lens of cognitive and clinical neuroscience","volume":"2018","author":"Arioli","year":"2018","journal-title":"Biomed. Res. 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J. Neurol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1849794","DOI":"10.1155\/2018\/1849794","article-title":"Social cognition dysfunctions in neurodegenerative diseases: neuroanatomical correlates and clinical implications","volume":"2018","author":"Christidi","year":"2018","journal-title":"Behav. Neurol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.3758\/S13415-023-01106-3","article-title":"Decision-making under ambiguity and risk and executive functions in Parkinson\u2019s disease patients: a scoping review of the studies investigating the Iowa gambling task and the game of dice","volume":"23","author":"Colautti","year":"2023","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/bs.pbr.2022.01.012","article-title":"Role of dopamine and clinical heterogeneity in cognitive dysfunction in Parkinson\u2019s disease","volume":"269","author":"Cools","year":"2022","journal-title":"Prog. Brain Res."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"E1370","DOI":"10.1212\/WNL.0000000000006317","article-title":"ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS","volume":"91","author":"Crockford","year":"2018","journal-title":"Neurology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1080\/17470919.2016.1186111","article-title":"Behavioral and autonomic reactivity to moral dilemmas in frontotemporal dementia versus Alzheimer\u2019s disease","volume":"12","author":"Fong","year":"2017","journal-title":"Soc. Neurosci."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/17470919.2010.506751","article-title":"The role of social cognition in moral judgment in frontotemporal dementia","volume":"6","author":"Gleichgerrcht","year":"2011","journal-title":"Soc. Neurosci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.neuron.2004.09.027","article-title":"The neural bases of cognitive conflict and control in moral judgment","volume":"44","author":"Greene","year":"2004","journal-title":"Neuron"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1002\/9781119536604","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins","year":"2019"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/J.JALZ.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3390\/IJMS25010498","article-title":"Pathobiology of cognitive impairment in Parkinson disease: challenges and outlooks","volume":"25","author":"Jellinger","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1684\/PNV.2017.0700","article-title":"Cognitive profile in prodromal disease (dementia) with Lewy bodies","volume":"15","author":"Kemp","year":"2017","journal-title":"Geriatr. Psychol. Neuropsychiatr. Vieil."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3988\/JCN.2019.15.1.27","article-title":"Qualitative comparison of semantic memory impairment in patients with amnestic mild cognitive impairment based on \u03b2-amyloid status","volume":"15","author":"Kim","year":"2019","journal-title":"J. Clin. Neurol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the lancet standing commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/01.WNN.0000191292.17964.BB","article-title":"An investigation of moral judgement in frontotemporal dementia","volume":"18","author":"Mendez","year":"2005","journal-title":"Cogn. Behav. Neurol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1080\/13803395.2024.2357362","article-title":"Multidimensional assessment of social cognition using non-immersive virtual reality in dementia with Lewy bodies and Alzheimer\u2019s disease: an exploratory study","volume":"46","author":"Msika","year":"2024","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1111\/ENE.15388","article-title":"Social cognition deficits in amyotrophic lateral sclerosis: a pilot cross-sectional population-based study","volume":"29","author":"Palumbo","year":"2022","journal-title":"Eur. J. Neurol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(10)70299-4","article-title":"Behavioural-variant frontotemporal dementia: Diagnosis, clinical staging, and management","volume":"10","author":"Piguet","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/S41531-021-00167-W","article-title":"Human moral decision-making through the lens of Parkinson\u2019s disease","volume":"7","author":"Ponsi","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"key":"ref30","article-title":"Guidance on the conduct of narrative synthesis in systematic reviews a product from the ESRC methods Programme","author":"Popay","year":"2006"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1037\/A0033595","article-title":"Moral decision-making and theory of mind in patients with idiopathic Parkinson\u2019s disease","volume":"27","author":"Rosen","year":"2013","journal-title":"Neuropsychology"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.parkreldis.2015.08.016","article-title":"Altered moral decision-making in patients with idiopathic Parkinson\u2019s disease","volume":"21","author":"Rosen","year":"2015","journal-title":"Parkinsonism Relat. 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