{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:34:32Z","timestamp":1777354472979,"version":"3.51.4"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"American Psychoanalytic Association (APsaA) International Psychoanalytic Association (IPA) Deutsche Gesellschaft"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:p>Chronic depression associated with early trauma remains one of the most treatment-resistant conditions in mental healthcare. Clinical and empirical findings have increasingly suggested that patients with histories of early trauma may benefit differentially from intensive psychoanalytic treatments compared to symptom-focused or short-term psychotherapies. Our conceptual article aims to elucidate the mechanisms underlying sustained therapeutic change in psychoanalysis with chronically depressed, early traumatized patients by integrating clinical psychoanalytic theory, contemporary dream research, and interdisciplinary models of memory reconsolidation. Taking a longitudinal case from the LAC Depression Study as an illustration, this study examines a patient who underwent high-frequency psychoanalysis and demonstrated enduring structural change, which remained accessible for more than a decade after treatment termination. Clinical material from the original analysis and from a later crisis intervention illustrates how embodied memories of early traumatic experiences can be discovered and understood within the transference relationship and gradually transformed through repeated analytic working-through. Particular emphasis is placed on changes in dream processes as indicators of deep psychic reorganization. Using psychoanalytically informed dream research, including the Zurich Dream Process Coding System (ZDPCS), the analysis demonstrates a shift from early trauma-dominated nightmares characterized by helplessness and an absence of a helping object to a later dream reflecting increased affect regulation, symbolic capacity, involvement, and self-agency. These transformations are conceptualized as markers of structural change rather than mere symptom reduction. This article further argues that psychoanalytic processes resonate with contemporary neurobiological models of memory reconsolidation. When embodied memories of trauma are revived within a safe and emotionally attuned analytic relationship, they may enter a labile state that allows for enduring modification and reintegration. From this interdisciplinary perspective, psychoanalysis is uniquely positioned to foster sustained change in patients with chronic depression and early trauma by enabling the re-transcription and reconsolidation of traumatic embodied memories within the analytic relationship. This conceptual integration contributes to a more profound understanding of why psychoanalysis can produce lasting therapeutic effects in a patient population traditionally considered difficult to treat.<\/jats:p>","DOI":"10.3389\/fpsyg.2026.1778793","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:34:15Z","timestamp":1777350855000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sustaining transformations in psychoanalysis: an interdisciplinary case study on trauma, dreams, and memory reconsolidation"],"prefix":"10.3389","volume":"17","author":[{"given":"Gilles","family":"Ambresin","sequence":"first","affiliation":[{"name":"Centre Hospitalier Universitaire Vaudois","place":["Lausanne, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Fischmann","sequence":"additional","affiliation":[{"name":"International Psychoanalytic University Berlin","place":["Berlin, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Leuzinger-Bohleber","sequence":"additional","affiliation":[{"name":"Universitatsmedizin der Johannes Gutenberg-Universitat Mainz","place":["Mainz, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref1","first-page":"25","volume-title":"Psychoanalytic Therapy: Principles and Application","author":"Alexander","year":"1946"},{"key":"ref2","article-title":"How to understand sustaining transformations of chronically depressed, early traumatized patients in psychoanalyses. 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