{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:28:32Z","timestamp":1784294912344,"version":"3.55.0"},"reference-count":137,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:p>Spinal cord stimulation (SCS) represents an established treatment for refractory chronic pain, yet significant outcome variability persists despite technological advances. This narrative review examines why psychological factors assume central importance in neuromodulation outcomes by establishing pathophysiological contrasts between SCS and pharmacological pain management. Unlike passive pharmaceutical approaches operating through systemic biochemical modulation, SCS requires active patient engagement in device operation, expectancy management, and behavioral adaptation, creating distinct neurobiological requirements for success. Multiple psychological domains predict outcomes. Cognitive factors include pain catastrophizing (the strongest predictor), patient expectations, and cognitive control capacity. Emotional determinants encompass pre-implantation depression, anxiety, and alexithymia. Behavioral patterns such as fear-avoidance, locus of control, and coping strategies significantly influence treatment success. Neuroimaging evidence suggests that these psychological factors modulate response through alterations in prefrontal\u2013limbic circuits, reward processing networks, and cortical reorganization. Maladaptive profiles are associated with reduced prefrontal top-down control, heightened limbic reactivity, impaired mesolimbic reward valuation, and persistent central sensitization. As a narrative synthesis prioritizing conceptual integration over quantitative aggregation, this review: (1) establishes psychological readiness as a neurobiological prerequisite rather than an administrative requirement, (2) delineates mechanisms through which catastrophizing, depression, and fear-avoidance disrupt SCS efficacy via limbic hyperactivity and impaired descending modulation, and (3) presents evidence-based optimization strategies including pre-implantation cognitive-behavioral therapy, acceptance and commitment therapy, behavioral activation, graded exposure, and digital health technologies. Future directions require standardized multidomain assessment protocols, multimodal predictive models integrating psychological phenotypes with objective biomarkers, and expanded digital therapeutics maintaining evidence-based rigor.<\/jats:p>","DOI":"10.3389\/fpsyg.2026.1783577","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:53:00Z","timestamp":1778651580000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Beyond device parameters: psychological predictors of spinal cord stimulation success and their neurobiological mechanisms\u2014a narrative review"],"prefix":"10.3389","volume":"17","author":[{"given":"Anna B.","family":"Marcinkowska","sequence":"first","affiliation":[{"name":"Applied Cognitive Neuroscience Lab, Department of Neurophysiology, Neuropsychology and Neuroinformatics, Medical University of Gda\u0144sk","place":["Gda\u0144sk, Poland"]},{"name":"2nd Department of Radiology, Medical University of Gda\u0144sk","place":["Gda\u0144sk, Poland"]},{"name":"Department of Neurosurgery, Copernicus Hospital in Gdansk","place":["Gda\u0144sk, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Wi\u015bniewski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Copernicus Hospital in Gdansk","place":["Gda\u0144sk, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Sobstyl","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Psychiatry and Neurology","place":["Warsaw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Kiero\u0144ska-Siwak","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun","place":["Bydgoszcz, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142 J.","family":"Winklewski","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, Medical University of Gda\u0144sk","place":["Gda\u0144sk, Poland"]},{"name":"Department of Neurophysiology, Neuropsychology and Neuroinformatics, Medical University of Gda\u0144sk","place":["Gda\u0144sk, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"101197","DOI":"10.1016\/J.BJPT.2025.101197","article-title":"Unraveling the role of fear and avoidance behavior in chronic musculoskeletal pain: from theory to physical therapy clinical practice","volume":"29","author":"Alaiti","year":"2025","journal-title":"Braz. 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Opin."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1002\/DA.20600","article-title":"Understanding the co-occurrence of anxiety disorders and chronic pain: state-of-the-art","volume":"26","author":"Asmundson","year":"2009","journal-title":"Depress. Anxiety"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-2377-7-21","article-title":"Use of the novel contact heat evoked potential stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts","volume":"7","author":"Atherton","year":"2007","journal-title":"BMC Neurol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/j.jocn.2011.02.025","article-title":"Recommendations for patient selection in spinal cord stimulation","volume":"18","author":"Atkinson","year":"2011","journal-title":"J. Clin. 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Med."},{"key":"ref10","first-page":"261","article-title":"Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles","volume-title":"Pain","author":"Baron","year":"2017"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1093\/PM\/PNAE126","article-title":"The efficacy of an interdisciplinary pain management program for complex regional pain syndrome compared to low back pain and chronic widespread pain: an observational study","volume":"26","author":"Bean","year":"2025","journal-title":"Pain Med."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/ner.12321","article-title":"Psychological factors as outcome predictors for spinal cord stimulation","volume":"18","author":"Bendinger","year":"2015","journal-title":"Neuromodulation"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"7880611","DOI":"10.1155\/PRM\/7880611","article-title":"Multidisciplinary approach to spinal cord stimulation for persistent spinal pain syndromes: a 65-month integrated data collection from the Belgian neuro-pain\u00ae real-world data register","volume":"2025","author":"Bernaerts","year":"2025","journal-title":"Pain Res. Manag."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.jpain.2025.105493","article-title":"Neurophysiological effects of high-frequency spinal cord stimulation on cortico-sensory areas in large ovine animal model","volume":"34","author":"Bharmauria","year":"2025","journal-title":"J. Pain"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/S41467-024-50103-8","article-title":"Placebo treatment affects brain systems related to affective and cognitive processes, but not nociceptive pain","volume":"15","author":"Botvinik-Nezer","year":"2024","journal-title":"Nat. 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Pain Headache Rep."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1109\/TNSRE.2003.822763","article-title":"Epidural spinal-cord stimulation facilitates recovery of functional walking following incomplete spinal-cord injury","volume":"12","author":"Carhart","year":"2004","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3791\/57614","article-title":"Home-based transcranial direct current stimulation device development: an updated protocol used at home in healthy subjects and fibromyalgia patients","volume":"2018","author":"Carvalho","year":"2018","journal-title":"J. Vis. Exp."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jphysparis.2014.04.003","article-title":"Frontal midline theta reflects anxiety and cognitive control: Meta-analytic evidence","volume":"109","author":"Cavanagh","year":"2015","journal-title":"J. Physiol. Paris"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1111\/J.1526-4637.2009.00632.X","article-title":"Pretreatment psychosocial variables as predictors of outcomes following lumbar surgery and spinal cord stimulation: a systematic review and literature synthesis","volume":"10","author":"Celestin","year":"2009","journal-title":"Pain Med."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1073537","DOI":"10.3389\/FNCIR.2023.1073537\/FULL","article-title":"Hierarchical predictive coding in distributed pain circuits","volume":"17","author":"Chen","year":"2023","journal-title":"Front. 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Neurophysiol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.wneu.2013.01.040","article-title":"Burst spinal cord stimulation for limb and back pain","volume":"80","author":"De Ridder","year":"2013","journal-title":"World Neurosurg."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1016\/J.PAIN.2014.08.031","article-title":"Spinal cord stimulation in patients with painful diabetic neuropathy: a multicentre randomized clinical trial","volume":"155","author":"De Vos","year":"2014","journal-title":"Pain"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/ner.12208","article-title":"The appropriate use of neurostimulation of the spinal cord and peripheral nervous system for the treatment of chronic pain and ischemic diseases: the neuromodulation appropriateness consensus committee","volume":"17","author":"Deer","year":"2014","journal-title":"Neuromodulation"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/FOC.2006.21.6.4","article-title":"Psychological factors in spinal cord stimulation therapy: brief review and discussion","volume":"21","author":"Doleys","year":"2006","journal-title":"Neurosurg. Focus."},{"key":"ref35","volume-title":"Spinal cord stimulator implant(archived)","author":"Dydyk","year":"2023"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/14651858.CD010152.PUB2","article-title":"Psychological therapies (internet-delivered) for the management of chronic pain in adults","volume":"2014","author":"Eccleston","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"T70","DOI":"10.1016\/j.jpain.2016.01.001","article-title":"The role of psychosocial processes in the development and maintenance of chronic pain","volume":"17","author":"Edwards","year":"","journal-title":"J. Pain"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1097\/J.PAIN.0000000000000602","article-title":"Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations","volume":"157","author":"Edwards","year":"","journal-title":"Pain"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1037\/A0035747","article-title":"Cognitive-behavioral therapy for individuals with chronic pain: efficacy, innovations, and directions for research","volume":"69","author":"Ehde","year":"2014","journal-title":"Am. Psychol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/00002508-199706000-00006","article-title":"Chronic pain-associated depression: antecedent or consequence of chronic pain? A review","volume":"13","author":"Fishbain","year":"1997","journal-title":"Clin. J. Pain"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.neurom.2024.09.001","article-title":"A proposed psychologic clearance algorithm for spinal cord stimulation implantation supported by a scoping review","volume":"27","author":"Fisher","year":"2024","journal-title":"Neuromodulation"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1152\/jn.00205.2022","article-title":"Spinal electrical stimulation to improve sympathetic autonomic functions needed for movement and exercise after spinal cord injury: a scoping clinical review","volume":"128","author":"Flett","year":"2022","journal-title":"J. Neurophysiol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0304-3940(97)13441-3","article-title":"Extensive reorganization of primary somatosensory cortex in chronic back pain patients","volume":"224","author":"Flor","year":"1997","journal-title":"Neurosci. Lett."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1093\/ijnp\/pyaa051","article-title":"Evidence-based guidelines and secondary Meta-analysis for the use of transcranial direct current stimulation in neurological and psychiatric disorders","volume":"24","author":"Fregni","year":"2021","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1503\/cjs.015417","article-title":"Can pain catastrophizing be changed in surgical patients? A scoping review","volume":"61","author":"Gibson","year":"2018","journal-title":"Can. J. Surg."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"160","DOI":"10.2196\/60160","article-title":"Following up patients with chronic pain using a mobile app with a support center: Unicenter prospective study","volume":"12","author":"G\u00f3mez-Gonz\u00e1lez","year":"2025","journal-title":"JMIR Hum. Factors"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"9279","DOI":"10.1038\/s41598-025-92111-8","article-title":"Machine learning predicts spinal cord stimulation surgery outcomes and reveals novel neural markers for chronic pain","volume":"15","author":"Gopal","year":"2025","journal-title":"Sci. Rep."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.2147\/JPR.S250455","article-title":"Patient selection for spinal cord stimulation in treatment of pain: sequential decision-making model - a narrative review","volume":"15","author":"Goudman","year":"2022","journal-title":"J. Pain Res."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1093\/brain\/awh098","article-title":"Pain catastrophizing and neural responses to pain among persons with fibromyalgia","volume":"127","author":"Gracely","year":"2004","journal-title":"Brain"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1097\/J.PAIN.0000000000000495","article-title":"Normative data for A\u03b4 contact heat evoked potentials in adult population: a multicenter study","volume":"157","author":"Granovsky","year":"2016","journal-title":"Pain"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"E33","DOI":"10.36076\/ppj\/2016.19.e33","article-title":"Effectiveness of spinal cord stimulation in chronic spinal pain: a systematic review","volume":"19","author":"Grider","year":"2016","journal-title":"Pain Physician"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1227\/NEU.0000000000001855","article-title":"Development of machine learning-based models to predict treatment response to spinal cord stimulation","volume":"90","author":"Hadanny","year":"2022","journal-title":"Neurosurgery"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jpain.2016.10.014","article-title":"Telehealth versus in-person acceptance and commitment therapy for chronic pain: a randomized noninferiority trial","volume":"18","author":"Herbert","year":"2017","journal-title":"J. Pain"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"8688","DOI":"10.1038\/s41598-018-26602-2","article-title":"Lumbosacral spinal cord epidural stimulation improves voiding function after human spinal cord injury","volume":"8","author":"Herrity","year":"2018","journal-title":"Sci. Rep."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0005-7967(90)90079-X","article-title":"The influence of family support on chronic pain","volume":"28","author":"Jamison","year":"1990","journal-title":"Behav. Res. Ther."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and central sensitization in chronic and widespread pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"S104","DOI":"10.1097\/J.PAIN.0000000000001854","article-title":"Spinal cord stimulation in chronic neuropathic pain: mechanisms of action, new locations, new paradigms","volume":"161","author":"Joosten","year":"2020","journal-title":"Pain"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.biopsych.2024.06.016","article-title":"Stress and inflammation target dorsolateral prefrontal cortex function: neural mechanisms underlying weakened cognitive control","volume":"97","author":"Joyce","year":"2025","journal-title":"Biol. Psychiatry"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3389\/fnins.2020.00718","article-title":"Functional electrical stimulation therapy for retraining reaching and grasping after spinal cord injury and stroke","volume":"14","author":"Kapadia","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1227\/NEU.0000000000001418","article-title":"Comparison of 10-kHz high-frequency and traditional low-frequency spinal cord stimulation for the treatment of chronic Back and leg pain: 24-month results from a multicenter, randomized","volume":"79","author":"Kapural","year":"2016","journal-title":"Control. Pivot. Trial. Neurosurg."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e0303775","DOI":"10.1371\/JOURNAL.PONE.0303775","article-title":"The role of pain self-efficacy and pain catastrophising in the relationship between chronic pain and depression: a moderated mediation model","volume":"19","author":"Kardash","year":"2024","journal-title":"PLoS One"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1136\/RAPM-2024-105523","article-title":"Emotional and psychosocial function after dorsal column spinal cord stimulator implantation: a systematic review and meta-analysis","volume":"50","author":"Klasova","year":"2025","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.neurom.2022.06.009","article-title":"Allodynia, hyperalgesia, (quantitative) sensory testing and conditioned pain modulation in patients with complex regional pain syndrome before and after spinal cord stimulation therapy","volume":"26","author":"Kriek","year":"2023","journal-title":"Neuromodulation"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1227\/01.NEU.0000192162.99567.96","article-title":"Spinal cord stimulation in treatment of chronic benign pain: challenges in treatment planning and present status, a 22-year experience","volume":"58","author":"Kumar","year":"2006","journal-title":"Neurosurgery"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/J.PAIN.2007.07.028","article-title":"Spinal cord stimulation versus conventional medical management for neuropathic pain: a multicentre randomised controlled trial in patients with failed back surgery syndrome","volume":"132","author":"Kumar","year":"2007","journal-title":"Pain"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J. Pain"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.neuroscience.2019.12.031","article-title":"Low-intensity, kilohertz frequency spinal cord stimulation differently affects excitatory and inhibitory neurons in the rodent superficial dorsal horn","volume":"428","author":"Lee","year":"2020","journal-title":"Neuroscience"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"134","DOI":"10.2196\/35134","article-title":"User engagement and assessment of treatment effectiveness in patients using a novel digital mHealth app during spinal cord stimulation screening trials","volume":"9","author":"Lee","year":"2022","journal-title":"JMIR Hum. 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Neurosci."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.3390\/DIAGNOSTICS15243149","article-title":"Spinal cord stimulation real-world outcomes: a 24-month longitudinal cohort study","volume":"15","author":"Lo Bianco","year":"2025","journal-title":"Diagnostics"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/J.PAIN.2008.04.025","article-title":"The Kyoto protocol of IASP basic pain terminology","volume":"137","author":"Loeser","year":"2008","journal-title":"Pain"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1002\/JCLP.20816","article-title":"Pain and emotion: a biopsychosocial review of recent research","volume":"67","author":"Lumley","year":"2011","journal-title":"J. Clin. 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Psychol."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/ner.12287","article-title":"Increased pain catastrophizing associated with lower pain relief during spinal cord stimulation: results from a large post-market study","volume":"18","author":"Rosenberg","year":"2015","journal-title":"Neuromodulation"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"E1092","DOI":"10.1097\/PR9.0000000000001092","article-title":"Changes in pain catastrophizing, fear-avoidance beliefs, and pain self-efficacy mediate changes in pain intensity on disability in the treatment of chronic low back pain","volume":"8","author":"Ryum","year":"2023","journal-title":"Pain Rep."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1002\/EJP.4713","article-title":"Central sensitization inventory is associated with psychological functioning but not with psychophysical assessment of pain amplification","volume":"29","author":"Salbego","year":"2025","journal-title":"Eur. J. Pain"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/978-3-031-46217-7_49","volume-title":"Essentials of Interventional Techniques in Managing Chronic Pain","author":"Sanapati","year":"2024"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.pain.2005.11.008","article-title":"Cortical responses to pain in healthy individuals depends on pain catastrophizing","volume":"120","author":"Seminowicz","year":"2006","journal-title":"Pain"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.jpain.2017.03.008","article-title":"The dorsolateral prefrontal cortex in acute and chronic pain","volume":"18","author":"Seminowicz","year":"2017","journal-title":"J. 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Comput. Neurosci."},{"key":"ref118","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1177\/1742395311433132","article-title":"Qualitative exploration of psychological factors associated with spinal cord stimulation outcome","volume":"8","author":"Sparkes","year":"2012","journal-title":"Chronic Illn."},{"key":"ref119","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/J.PAIN.2010.05.001","article-title":"A systematic literature review of psychological characteristics as determinants of outcome for spinal cord stimulation therapy","volume":"150","author":"Sparkes","year":"2010","journal-title":"Pain"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.neuroimage.2005.12.042","article-title":"Persistent EEG overactivation in the cortical pain matrix of neurogenic pain patients","volume":"31","author":"Stern","year":"2006","journal-title":"NeuroImage"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1097\/j.pain.0000000000001666","article-title":"Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography","volume":"160","author":"Ta Dinh","year":"2019","journal-title":"Pain"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3390\/LIFE14050612","article-title":"The association of central sensitisation with depression, anxiety, and somatic symptoms: a cross-sectional study of a mental health outpatient clinic in Japan","volume":"14","author":"Takeuchi","year":"2024","journal-title":"Life"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/PAPR.12095","article-title":"Predictors of pain relief following spinal cord stimulation in chronic Back and leg pain and failed Back surgery syndrome: a systematic review and Meta-regression analysis","volume":"14","author":"Taylor","year":"2014","journal-title":"Pain Pract."},{"key":"ref124","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.neucli.2003.10.009","article-title":"Clinical usefulness of laser-evoked potentials","volume":"33","author":"Treede","year":"2003","journal-title":"Neurophysiol. 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