{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:15:46Z","timestamp":1788156946856,"version":"build-2803163510"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The nucleus accumbens shell is a key region involved in motivation and reinforcement behavior associated with the consumption of palatable foods. However, it has not been studied whether D4 dopaminergic receptors regulate homeostatic feeding and reward-dependent behaviors. The objective of this study was to evaluate the effects of activation of D4 dopaminergic receptors within nucleus accumbens shell and systemic D4 blockade on motivation for palatable food and homeostatic feeding in male Wistar rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adult male Wistar rats were tested in operant conditioning paradigms using sucrose pellets under fixed-ratio (FR1 and FR5) and progressive-ratio schedules to assess motivation for palatable food. Homeostatic feeding was evaluated by measuring standard chow intake in satiated rats during the first hour of the dark phase. Using stereotaxic surgery, a unilateral guide cannula was implanted into the NAcSh for the microinjection of the selective D4R agonist\n                      <jats:italic>PD-168,077<\/jats:italic>\n                      (0.1 \u03bcg) and the D4R antagonist L-745,870 (0.1 \u03bcg). Additionally, PD-168,077 (1 mg\/kg, i.p.) and L-745,870 (0.1 mg\/kg, i.p.) were administered systemically. Lever presses, reinforcers earned, breakpoint, and chow intake were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intra-nucleus accumbens shell injection of PD-168,077 significantly increased motivation for palatable food, as reflected by greater lever pressing, reinforcers earned, and breakpoint, and increased standard chow intake. These effects were abolished by local pretreatment with L-745,870. Systemic administration of L-745,870 reduced both chow intake and operant responding for palatable food, decreasing lever pressing and breakpoint.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dopamine D4 receptors in the nucleus accumbens shell promote both motivational and consummatory aspects of feeding. In contrast, systemic D4 receptor blockade suppresses homeostatic feeding and motivation for palatable food, supporting an important role for D4 receptors in the regulation of feeding behavior.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2026.1788044","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:40:39Z","timestamp":1788154839000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Activation of dopamine D4 receptors in the nucleus accumbens shell increases motivation for palatable food and homeostatic feeding, whereas systemic blockade reduces feeding behavior in rats"],"prefix":"10.3389","volume":"17","author":[{"given":"Juan Gabriel","family":"Tejas-Ju\u00e1rez","sequence":"first","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica Multidisciplinaria de Comalcalco, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco (UJAT)","place":["Comalcalco, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9 Omar","family":"Su\u00e1rez-Ortiz","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda de la Alimentaci\u00f3n, Grupo de Investigaci\u00f3n en Nutrici\u00f3n, Divisi\u00f3n de Investigaci\u00f3n y Posgrado, FES Iztacala, UNAM, Tlalnepantla","place":["EDOMEX, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Erick","family":"Escart\u00edn-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda de la Alimentaci\u00f3n, Grupo de Investigaci\u00f3n en Nutrici\u00f3n, Divisi\u00f3n de Investigaci\u00f3n y Posgrado, FES Iztacala, UNAM, Tlalnepantla","place":["EDOMEX, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Mancilla-Diaz","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda de la Alimentaci\u00f3n, Grupo de Investigaci\u00f3n en Nutrici\u00f3n, Divisi\u00f3n de Investigaci\u00f3n y Posgrado, FES Iztacala, UNAM, Tlalnepantla","place":["EDOMEX, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9 Vidal","family":"Espinosa-Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Chiapas (UNACH)","place":["Ocozocoautla de Espinosa, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Briones-Aranda","sequence":"additional","affiliation":[{"name":"Pharmacology Laboratory, Faculty of Human Medicine, Autonomous University of Chiapas","place":["Tuxtla Guti\u00e9rrez, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Rodr\u00edguez-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV)","place":["Ciudad de M\u00e9xico, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Mart\u00ednez-Abundis","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica Multidisciplinaria de Comalcalco, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco (UJAT)","place":["Comalcalco, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Patricia","family":"G\u00f3mez-Cris\u00f3stomo","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica Multidisciplinaria de Comalcalco, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco (UJAT)","place":["Comalcalco, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refugio","family":"Cruz-Trujillo","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Chiapas (UNACH)","place":["Ocozocoautla de Espinosa, Mexico"]},{"name":"Departamento de Qu\u00edmicos Farmacobi\u00f3logos, Grupo de Investigaci\u00f3n en Salud y Metabolitos Especializados con Potencial Farmacol\u00f3gico, Universidad Pablo Guardado Ch\u00e1vez (UPGCH)","place":["Tuxtla Guti\u00e9rrez, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"13118","DOI":"10.1073\/pnas.1201011109","article-title":"Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors","volume":"109","author":"Andersson","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B2","doi-asserted-by":"publisher","first-page":"114838","DOI":"10.1016\/j.celrep.2024.114838","article-title":"The flow of reward information through neuronal ensembles in the accumbens","volume":"43","author":"Arroyo","year":"2024","journal-title":"Cell Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/sciadv.1601631","article-title":"Key role of the dopamine D4 receptor in the modulation of corticostriatal glutamatergic neurotransmission","volume":"3","author":"Bonaventura","year":"2017","journal-title":"Sci. Adv."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.3390\/nu12082288","article-title":"Underlying susceptibility to eating disorders and drug abuse: genetic and pharmacological aspects of dopamine D4 receptors","volume":"12","author":"Botticelli","year":"2020","journal-title":"Nutrients"},{"key":"B5","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3389\/fnsys.2015.00090","article-title":"Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry","volume":"9","author":"Castro","year":"2015","journal-title":"Front. Syst. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"4905","DOI":"10.1523\/JNEUROSCI.4404-13.2014","article-title":"Ghrelin acts as an interface between physiological state and phasic dopamine signaling","volume":"34","author":"Cone","year":"2014","journal-title":"J. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.3390\/brainsci14111103","article-title":"Stimulation of dopamine D4 receptors in the nucleus accumbens shell increases palatable food intake in satiated male rats: modulation by NMDA and AMPA receptors","volume":"14","author":"Cruz-Trujillo","year":"2024","journal-title":"Brain Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"22","DOI":"10.31644\/IMASD.22.2020.a02","article-title":"Evaluaci\u00f3n del bloqueo de los receptores dopamin\u00e9rgicos D4 en el n\u00facleo accumbens sobre la motivaci\u00f3n por el alimento palatable","volume":"9","author":"Cruz-Trujillo","year":"2020","journal-title":"Espacio I+ D Innov. Desarro."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0169-328X(96)00235-5","article-title":"Distribution of D4 dopamine receptor in rat brain with sequence-specific antibodies","volume":"45","author":"Defagot","year":"1997","journal-title":"Mol Brain Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.neuropharm.2011.11.001","article-title":"Dopamine D4 receptor stimulation in GABAergic projections of the globus pallidus to the reticular thalamic nucleus and the substantia nigra reticulata of the rat decreases locomotor activity","volume":"62","author":"Erlij","year":"2012","journal-title":"Neuropharmacology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1014678","DOI":"10.3389\/fendo.2022.1014678","article-title":"Functional and pharmacological role of the dopamine D4 receptor and its polymorphic variants","volume":"13","author":"Ferr\u00e9","year":"2022","journal-title":"Front. Endocrinol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1523\/JNEUROSCI.5474-06.2007","article-title":"Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway","volume":"27","author":"Floresco","year":"2007","journal-title":"J. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/s41467-018-03272-2","article-title":"Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum","volume":"9","author":"Gallo","year":"2018","journal-title":"Nat. Commun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/mp.2011.93","article-title":"Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain","volume":"17","author":"Gonz\u00e1lez","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.3390\/ph16101427","article-title":"Modulation of neuron and astrocyte dopamine receptors via receptor-receptor interactions","volume":"16","author":"Guidolin","year":"2023","journal-title":"Pharmaceuticals."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3531","DOI":"10.1038\/s41380-023-02131-x","article-title":"Disentangling the role of NAc D1 and D2 cells in hedonic eating","volume":"28","author":"Guillaumin","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1176\/jnp.9.3.354","article-title":"The accumbens: beyond the core-shell dichotomy","volume":"9","author":"Heimer","year":"1997","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3389\/fpsyt.2018.00410","article-title":"Parallels and overlap: the integration of homeostatic signals by mesolimbic dopamine neurons","volume":"9","author":"Hsu","year":"2018","journal-title":"Front. Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1523\/JNEUROSCI.3800-04.2005","article-title":"Ketamine induces dopamine-dependent depression of evoked hippocampal activity in the nucleus accumbens in freely moving rats","volume":"25","author":"Hunt","year":"2005","journal-title":"J. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"107821","DOI":"10.1016\/j.phrs.2025.107821","article-title":"What's in your plate? AMPA receptors modulation at the crossroads of homeostatic and hedonic eating","volume":"217","author":"Italia","year":"2025","journal-title":"Pharmacol. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.cell.2014.12.026","article-title":"Visualizing hypothalamic network dynamics for appetitive and consummatory behaviors","volume":"160","author":"Jennings","year":"2014","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0166-4328(97)00054-5","article-title":"Feeding induced by blockade of AMPA and kainate receptors within the ventral striatum: a microinfusion mapping study","volume":"89","author":"Kelley","year":"1997","journal-title":"Behav. Brain Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"102068","DOI":"10.1016\/j.molmet.2024.102068","article-title":"FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling","volume":"91","author":"Khan","year":"2025","journal-title":"Mol. Metab."},{"key":"B24","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/(SICI)1096-9861(19981221)402:3andlt;353::AID-CNE5andgt;3.0.CO;2-4","article-title":"Differential regional and cellular distribution of dopamine D2-like receptors: an immunocytochemical study of subtype-specific antibodies in rat and human brain","volume":"402","author":"Khan","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"6066","DOI":"10.1523\/JNEUROSCI.1168-05.2005","article-title":"A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala input","volume":"25","author":"Laviolette","year":"2005","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.pbb.2006.03.021","article-title":"Effects of nicotine withdrawal on performance under a progressive-ratio schedule of sucrose pellet delivery in rats","volume":"83","author":"LeSage","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B27","doi-asserted-by":"publisher","first-page":"923","DOI":"10.3390\/brainsci15090923","article-title":"Dopamine D2 receptors and its downstream signaling in compulsive eating","volume":"15","author":"Leung","year":"2025","journal-title":"Brain Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ibneur.2023.02.001","article-title":"The central blockade of the dopamine DR4 receptor decreases sucrose consumption by modifying the microstructure of drinking behavior in male rats","volume":"14","author":"L\u00f3pez-Alonso","year":"2023","journal-title":"IBRO Neurosci Rep"},{"key":"B29","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0306-4522(97)00327-8","article-title":"Expression of D1 receptor, D2 receptor, substance P and encephalin messenger RNAs in the neurons projecting form the nucleus accumbens","volume":"82","author":"Lu","year":"1998","journal-title":"Neuroscience"},{"key":"B30","doi-asserted-by":"publisher","first-page":"6779","DOI":"10.1523\/JNEUROSCI.15-10-06779.1995","article-title":"Glutamate receptors in the nucleus accumbens shell control feeding behavior via the lateral hypothalamus","volume":"15","author":"Maldonado-Irizarry","year":"1995","journal-title":"J. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1437210","DOI":"10.3389\/fnins.2024.1437210","article-title":"The nucleus accumbens shell: a neural hub at the interface of homeostatic and hedonic feeding","volume":"18","author":"Marinescu","year":"2024","journal-title":"Front. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.biopsych.2022.10.003","article-title":"Nucleus accumbens D1 receptor-expressing spiny projection neurons control food motivation and obesity","volume":"93","author":"Matikainen-Ankney","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.2337\/db24-0207","article-title":"Leptin activation of dorsal raphe neurons inhibits feeding behavior","volume":"73","author":"Maxwell","year":"2024","journal-title":"Diabetes."},{"key":"B34","doi-asserted-by":"publisher","first-page":"18540","DOI":"10.1523\/JNEUROSCI.3323-12.2013","article-title":"Mu-Opioid stimulation in rat prefrontal cortex engages hypothalamic orexin\/hypocretin-containing neurons, and reveals dissociable roles of nucleus accumbens and hypothalamus in cortically driven feeding","volume":"33","author":"Mena","year":"2013","journal-title":"J. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"113152","DOI":"10.1016\/j.physbeh.2020.113152","article-title":"\u2018Liking' and \u2018wanting' in eating and food reward: brain mechanisms and clinical implications","volume":"227","author":"Morales","year":"2020","journal-title":"Physiol Behav."},{"key":"B36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.pneurobio.2005.01.001","article-title":"A review of systems and networks of the limbic forebrain\/limbic midbrain","volume":"75","author":"Morgane","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/381245a0","article-title":"Localization of dopamine D4 receptors in GABAergic neurons of the primate brain","volume":"381","author":"Mrzljak","year":"1996","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"5571","DOI":"10.1038\/s41598-017-15917-1","article-title":"Bidirectional modulation of hippocampal synaptic plasticity by dopaminergic D4-receptors in the CA1 area of hippocampus","volume":"7","author":"Navakkode","year":"2017","journal-title":"Sci. Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0014-2999(00)00562-8","article-title":"The dopamine D4 receptor: one decade of research","volume":"405","author":"Oak","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.neuron.2015.09.038","article-title":"Accumbal D1R neurons projecting to lateral hypothalamus authorize feeding","volume":"88","author":"O'Connor","year":"2015","journal-title":"Neuron"},{"key":"B41","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.neuropharm.2011.06.002","article-title":"Dopaminergic modulation of oscillatory network inhibition in the rat basolateral amygdala depends on initial activity state","volume":"61","author":"Ohshiro","year":"2011","journal-title":"Neuropharmacology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00109-024-02501-0","article-title":"Central dopamine receptors: radiotracers unveiling the role of dopaminergic tone in obesity","volume":"103","author":"Pais","year":"2025","journal-title":"J. Mol. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12889-021-10160-w","article-title":"Dopamine D4 receptor gene polymorphism (DRD4 VNTR) moderates' real-world behavioural response to the food retail environment in children","volume":"21","author":"Paquet","year":"2021","journal-title":"BMC Public Health"},{"key":"B44","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/S0022-3565(24)37092-2","article-title":"Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor","volume":"283","author":"Patel","year":"1997","journal-title":"Pharmacol. Exp. Ther."},{"key":"B45","volume-title":"The Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1152\/jn.1992.67.5.1325","article-title":"Presynaptic dopamine D1 receptors attenuate excitatory and inhibitory limbic inputs to the shell region of the rat nucleus accumbens studied in vitro","volume":"67","author":"Pennartz","year":"1992","journal-title":"J. Neurophysiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"12511","DOI":"10.1523\/JNEUROSCI.1605-16.2016","article-title":"Activation of glutamatergic fibers in the anterior NAc shell modulates reward activity in the aNAcSh, the lateral hypothalamus, and medial prefrontal cortex and transiently stops feeding","volume":"36","author":"Prado","year":"2016","journal-title":"J. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","article-title":"The neural basis of drug craving: an incentive-sensitization theory of addiction","volume":"18","author":"Robinson","year":"1993","journal-title":"Brain Res. Rev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1572374","DOI":"10.3389\/fnbeh.2025.1572374","article-title":"Coadministration antagonist dopamine receptor D4 with CB2 receptor agonist decreases binge-like intake of palatable food in mice","volume":"19","author":"Rodr\u00edguez-Serrano","year":"2025","journal-title":"Front. Behav. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1038\/nn.2219","article-title":"Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli","volume":"11","author":"Roitman","year":"2008","journal-title":"Nat. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1007\/s00018-010-0293-y","article-title":"The dopamine D4 receptor: biochemical and signalling properties","volume":"67","author":"Rondou","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.cmet.2017.09.021","article-title":"Overlapping brain circuits for homeostatic and hedonic feeding","volume":"27","author":"Rossi","year":"2018","journal-title":"Cell Metab."},{"key":"B53","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/0006-8993(90)91146-8","article-title":"In the rat medial nucleus accumbens, hipocampal and catecholaminergic terminals converge on spiny neurons and are in opposition to each other","volume":"527","author":"Sesack","year":"1990","journal-title":"Brain Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0074-7742(08)60573-5","article-title":"Molecular neurobiology of dopaminergic receptors","volume":"35","author":"Sibley","year":"1993","journal-title":"Int. Rev. Neurobiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.appet.2013.10.004","article-title":"Association between the seven-repeat allele of the dopamine-4 receptor gene (DRD4) and spontaneous food intake in pre-school children","volume":"73","author":"Silveira","year":"2014","journal-title":"Appetite"},{"key":"B56","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/0166-2236(90)90106-K","article-title":"The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurons","volume":"13","author":"Smith","year":"1990","journal-title":"Trends Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"106621","DOI":"10.1016\/j.appet.2023.106621","article-title":"Effects of glucose modulation in lateral hypothalamus on motivated behavior to obtain sucrose in an operant task","volume":"189","author":"Stamos","year":"2023","journal-title":"Appetite"},{"key":"B58","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/(SICI)1098-2396(20000601)36:3<222::AID-SYN6>3.0.CO;2-H.","article-title":"Presynaptic dopamine D4 receptor localization in the rat nucleus accumbens shell","volume":"36","author":"Svingos","year":"2000","journal-title":"Synapse"},{"key":"B59","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.physbeh.2014.04.040","article-title":"Stimulation of dopamine D4 receptors in the paraventricular nucleus of the hypothalamus of male rats induces hyperphagia: involvement of glutamate","volume":"133","author":"Tejas-Ju\u00e1rez","year":"2014","journal-title":"Physiol. Behav."},{"key":"B60","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.bbr.2009.10.020","article-title":"Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine","volume":"207","author":"Thanos","year":"2010","journal-title":"Behav. Brain Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/npp.2008.74","article-title":"Decreased dopamine D4 receptor expression increases extracellular glutamate and alters its regulation in mouse striatum","volume":"34","author":"Thomas","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.jneumeth.2007.03.009","article-title":"Dopamine D4 receptor knockout mice exhibit neuro chemical changes consistent with decreased dopamine release","volume":"166","author":"Thomas","year":"2007","journal-title":"J. Neurosci. Meth."},{"key":"B63","year":"2024","journal-title":"Obesidad 2024"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1420028","DOI":"10.3389\/fnbeh.2024.1420028","article-title":"The nucleus accumbens in reward and aversion processing: insights and implications","volume":"18","author":"Xu","year":"2024","journal-title":"Front. Behav. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.1523\/JNEUROSCI.06-08-02470.1986","article-title":"Dopamine enhances terminal excitability of hippocampal-accumbens neurons via D2 receptor: role of dopamine in presynaptic inhibition","volume":"6","author":"Yan","year":"1986","journal-title":"J. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/npp.2011.245","article-title":"Blockade of dopamine d4 receptors attenuate reinstatement of extinguished nicotine-seeking behavior in rats","volume":"37","author":"Yan","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0006-8993(86)90548-2","article-title":"Mesolimbic dopamine projection modulates amygdala-evoked EPSP in nucleus accumbens neurons: an in vivo study","volume":"369","author":"Yim","year":"1986","journal-title":"Brain Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"6581","DOI":"10.1523\/JNEUROSCI.0838-22.2022","article-title":"Contingent amygdala inputs trigger heterosynaptic LTP at hippocampus-to-accumbens synapses","volume":"42","author":"Yu","year":"2022","journal-title":"J. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1037\/0735-7044.117.2.202","article-title":"Nucleus accumbens opioid, GABAergic, and dopaminergic modulation of palatable food motivation: constrasting effects revealed by a progressive ratio study in the rat","volume":"117","author":"Zhang","year":"2003","journal-title":"Behav. Neurosci."}],"container-title":["Frontiers in Psychology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2026.1788044\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:40:40Z","timestamp":1788154840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2026.1788044\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":69,"alternative-id":["10.3389\/fpsyg.2026.1788044"],"URL":"https:\/\/doi.org\/10.3389\/fpsyg.2026.1788044","relation":{},"ISSN":["1664-1078"],"issn-type":[{"value":"1664-1078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"article-number":"1788044"}}