{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:44:37Z","timestamp":1789753477725,"version":"4.0.1"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:p>\n                    Cognitive reserve (CR) may help explain why older adults differ in cognitive functioning despite comparable age- or pathology-related changes. However, the electrophysiological expression of CR across stages of cognitive decline remains unclear. This study examined whether CR predicts P300 event-related potential, and whether working memory (WM) capacity modulated the CR-P300 link across cognitive status groups. Seventy-one older adults [healthy controls (HC),\n                    <jats:italic>n<\/jats:italic>\n                    \u202f=\u202f31,\n                    <jats:italic>\n                      M\n                      <jats:sub>age<\/jats:sub>\n                    <\/jats:italic>\n                    \u202f=\u202f67.3,\n                    <jats:italic>\n                      SD\n                      <jats:sub>age<\/jats:sub>\n                    <\/jats:italic>\n                    \u202f=\u202f7.19; mild cognitive impairment (MCI),\n                    <jats:italic>n<\/jats:italic>\n                    \u202f=\u202f28,\n                    <jats:italic>\n                      M\n                      <jats:sub>age<\/jats:sub>\n                    <\/jats:italic>\n                    \u202f=\u202f70.8,\n                    <jats:italic>\n                      SD\n                      <jats:sub>age<\/jats:sub>\n                    <\/jats:italic>\n                    \u202f=\u202f7.06; moderate cognitive impairment (MoCI),\n                    <jats:italic>n<\/jats:italic>\n                    \u202f=\u202f12,\n                    <jats:italic>\n                      M\n                      <jats:sub>age<\/jats:sub>\n                    <\/jats:italic>\n                    \u202f=\u202f70.6,\n                    <jats:italic>\n                      SD\n                      <jats:sub>age<\/jats:sub>\n                    <\/jats:italic>\n                    \u202f=\u202f6.50] completed a visuospatial WM task (Corsi block-tapping test). Using 32-channel EEG, P300 ERP responses were recorded during an auditory oddball task. CR was quantified using the Cognitive Reserve Index questionnaire, including education, working activity, and leisure activity domains, and global cognition was assessed using the Montreal Cognitive Assessment. Group-stratified hierarchical regression models tested (1) CR prediction of P300 amplitude and latency after adjusting for age and global cognition, and (2) CR\u202f\u00d7\u202fWM interaction. A whole-sample hierarchical regression model was used to test whether the CR-P300 amplitude association differed across cognitive status groups. In HC, CR positively predicted larger P300 amplitude. In MCI, the CR coefficient at mean WM was negative, whereas CR\u202f\u00d7\u202fWM interaction was positive, suggesting that CR-related amplitude patterns may depend on preserved WM capacity. The whole-sample model provided evidence that the CR-P300 amplitude association differed between HC and MCI. In MoCI, amplitude estimates were unstable and showed wide confidence intervals, supporting only exploratory interpretation. CR and CR\u202f\u00d7\u202fWM showed no reliable associations with P300 latency in HC or MCI. However, in MoCI, domain-level latency analyses, occupational and educational reserve showed comparatively larger negative coefficients, suggesting possible associations with shorter P300 latency. However, confidence intervals crossed zero. Thus, latency findings were treated as exploratory and less stable than amplitude effects. These findings suggest that the electrophysiological expression of CR may differ across cognitive status, with P300 amplitude showing preliminary evidence of CR-related variation in healthy aging and WM-dependent modulation in MCI. P300 latency appeared less sensitive to CR-related variation in the present sample.\n                  <\/jats:p>","DOI":"10.3389\/fpsyg.2026.1795165","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:48:25Z","timestamp":1782276505000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The P300 event-related potential as a physiological signature of cognitive reserve: links to working memory in aging"],"prefix":"10.3389","volume":"17","author":[{"given":"Agnese","family":"U\u0161acka","sequence":"first","affiliation":[{"name":"Department of Health Psychology and Paedagogy, Riga Stradi\u0146\u0161 University","place":["Riga, Latvia"]},{"name":"Institute of Public Health, Riga Stradi\u0146\u0161 University","place":["Riga, Latvia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Skrule","sequence":"additional","affiliation":[{"name":"Department of Health Psychology and Paedagogy, Riga Stradi\u0146\u0161 University","place":["Riga, Latvia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u012bne","family":"\u0160neidere","sequence":"additional","affiliation":[{"name":"Department of Health Psychology and Paedagogy, Riga Stradi\u0146\u0161 University","place":["Riga, Latvia"]},{"name":"Institute of Public Health, Riga Stradi\u0146\u0161 University","place":["Riga, Latvia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zigmunds","family":"Freibergs","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Riga Stradi\u0146\u0161 University","place":["Riga, Latvia"]},{"name":"Institute of Psychology, University of Tartu","place":["Tartu, Estonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aivars","family":"Kaupu\u017es","sequence":"additional","affiliation":[{"name":"Riga Technical University Rezekne Academy","place":["R\u0113zekne, Latvia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ain\u0101rs","family":"Stepens","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Riga Stradi\u0146\u0161 University","place":["Riga, Latvia"]},{"name":"Department of Education and Science, Riga East University Hospital","place":["Riga, Latvia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1093\/arclin\/acx125","article-title":"A systematic review for functional neuroimaging studies of cognitive reserve across the cognitive aging spectrum","volume":"33","author":"Anthony","year":"2017","journal-title":"Arch. Clin. Neuropsychol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1080\/13803395.2022.2047160","article-title":"Cognitive reserve, cognition, and real-world functioning in MCI: a systematic review and meta-analysis","volume":"43","author":"Berezuk","year":"2021","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41583-018-0068-2","article-title":"Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing","volume":"19","author":"Cabeza","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref4","author":"Canty","year":"2023"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3389\/fnhum.2018.00445","article-title":"Event-related potentials reveal altered executive control activity in healthy elderly with subjective memory complaints","volume":"12","author":"Cesp\u00f3n","year":"2018","journal-title":"Front. Hum. Neurosci."},{"key":"ref6","volume-title":"Human memory and the medial temporal region of the brain","author":"Corsi","year":"1972"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/s13195-024-01607-4","article-title":"Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer\u2019s disease progression: a systematic review","volume":"16","author":"Costanzo","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","article-title":"EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis","volume":"134","author":"Delorme","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"15956","DOI":"10.1038\/s41598-023-43132-8","article-title":"Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairment","volume":"13","author":"Demirayak","year":"2023","journal-title":"Sci. Rep."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1017\/S0140525X00058027","article-title":"Is the P300 component a manifestation of context updating?","volume":"11","author":"Donchin","year":"1988","journal-title":"Behav. Brain Sci."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1017\/S1041610213002391","article-title":"Working memory span in mild cognitive impairment. Influence of processing speed and cognitive reserve","volume":"26","author":"Facal","year":"2014","journal-title":"Int. Psychogeriatr."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3389\/fnagi.2017.00145","article-title":"The effect of apolipoprotein E \u03b54 (APOE \u03b54) on visuospatial working memory in healthy elderly and amnestic mild cognitive impairment patients: an event-related potentials study","volume":"9","author":"Gu","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.clinph.2017.10.030","article-title":"Cognitive reserve modulates attention processes in healthy elderly and amnestic mild cognitive impairment: an event-related potential study","volume":"129","author":"Gu","year":"2018","journal-title":"Clin. Neurophysiol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neurobiolaging.2025.07.016","article-title":"The moderating effect of cognitive reserve on the association between neuroimaging biomarkers and cognition: a systematic review","volume":"156","author":"Guo","year":"2025","journal-title":"Neurobiol. Aging"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.cger.2013.07.002","article-title":"Normal cognitive aging","volume":"29","author":"Harada","year":"2013","journal-title":"Clin. Geriatr. Med."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1177\/1550059414550567","article-title":"P300 amplitude in Alzheimer\u2019s disease: a meta-analysis and meta-regression","volume":"47","author":"Hedges","year":"2016","journal-title":"Clin. EEG Neurosci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1249\/MSS.0000000000002926","article-title":"Acute exercise effects on neurocognitive function: a systematic review and meta-analysis on P3 amplitude and latency","volume":"54","author":"Kao","year":"2022","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"690856","DOI":"10.3389\/fnhum.2021.690856","article-title":"Electrophysiological proxy of cognitive reserve index","volume":"15","author":"Khachatryan","year":"2021","journal-title":"Front. Hum. Neurosci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1017\/S0048577201990559","article-title":"On the utility of P3 amplitude as a measure of processing capacity","volume":"38","author":"Kok","year":"2001","journal-title":"Psychophysiology"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the lancet standing commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3389\/fnagi.2018.00189","article-title":"Effects of cognitive reserve on cognitive performance in a follow-up study in older adults with subjective cognitive complaints. The role of working memory","volume":"10","author":"Lojo-Seoane","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"ref22","volume-title":"An Introduction to the Event-Related Potential Technique","author":"Luck","year":"2014"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/ana.27055","article-title":"Factors affecting resilience and prevention of Alzheimer\u2019s disease and related dementias","volume":"96","author":"Masurkar","year":"2024","journal-title":"Ann. Neurol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.neubiorev.2021.11.002","article-title":"Modulation of the cognitive event-related potential P3 by transcranial direct current stimulation: a systematic review and meta-analysis","volume":"132","author":"Mendes","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/1874609812666190819125542","article-title":"The impact of working memory training on cognitive abilities in older adults: the role of cognitive reserve","volume":"13","author":"Mi\u010di\u010d","year":"2020","journal-title":"Curr. Aging Sci."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/BF03654795","article-title":"Cognitive reserve index questionnaire (CRIq): a new instrument for measuring cognitive reserve","volume":"24","author":"Nucci","year":"2012","journal-title":"Aging Clin. Exp. 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Otorhinolaryngol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/j.clinph.2007.04.019","article-title":"Updating P300: an integrative theory of P3a and P3b","volume":"118","author":"Polich","year":"2007","journal-title":"Clin. Neurophysiol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"515","DOI":"10.2174\/156720505774932214","article-title":"Alzheimer's disease and P300: review and evaluation of task and modality","volume":"2","author":"Polich","year":"2005","journal-title":"Curr. Alzheimer Res."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0168-5597(90)90036-D","article-title":"P300 assessment of early Alzheimer's disease","volume":"77","author":"Polich","year":"1990","journal-title":"Electroencephal. Clin. Neurophysiol."},{"key":"ref34","volume-title":"RStudio: Integrated Development Environment for R (Version 2024.Xx.x)","year":"2024"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1001\/archneurol.2010.166","article-title":"Alzheimer disease and cognitive reserve: variation of education effect with carbon 11\u2013labeled Pittsburgh compound B uptake","volume":"67","author":"Roe","year":"2010","journal-title":"Arch. Neurol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1136\/jnnp.2005.072306","article-title":"Education and rates of cognitive decline in incident Alzheimer\u2019s disease","volume":"77","author":"Scarmeas","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1212\/WNL.57.12.2236","article-title":"Influence of leisure activity on the incidence of Alzheimer\u2019s disease","volume":"57","author":"Scarmeas","year":"2001","journal-title":"Neurology"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3389\/fnagi.2020.00249","article-title":"Role of EEG in measuring cognitive reserve: a rapid review","volume":"12","author":"\u0160neidere","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/j.neurobiolaging.2014.12.025","article-title":"Cognitive reserve modulates ERPs associated with verbal working memory in healthy younger and older adults","volume":"36","author":"Speer","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.bbadis.2011.09.012","article-title":"Exploring the neural basis of cognitive reserve in aging","volume":"1822","author":"Steffener","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1017\/S1355617702813248","article-title":"What is cognitive reserve? Theory and research application of the reserve concept","volume":"8","author":"Stern","year":"2002","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1016\/j.neuropsychologia.2009.03.004","article-title":"Cognitive reserve","volume":"47","author":"Stern","year":"2009","journal-title":"Neuropsychologia"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/S1474-4422(12)70191-6","article-title":"Cognitive reserve in ageing and Alzheimer\u2019s disease","volume":"11","author":"Stern","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neurobiolaging.2022.10.015","article-title":"A framework for concepts of reserve and resilience in aging","volume":"124","author":"Stern","year":"2023","journal-title":"Neurobiol. Aging"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.jalz.2018.07.219","article-title":"Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance","volume":"16","author":"Stern","year":"2020","journal-title":"Alzheimers Dement."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.neurobiolaging.2019.03.022","article-title":"Brain reserve, cognitive reserve, compensation, and maintenance: operationalization, validity, and mechanisms of cognitive resilience","volume":"83","author":"Stern","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"ref47","volume-title":"MATLAB (Version R2022b) [Computer Software]","year":"2022"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3233\/JAD-161099","article-title":"Dissociating normal aging from Alzheimer\u2019s disease","volume":"57","author":"Toepper","year":"2017","journal-title":"J. Alzheimer's Dis"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"e87347","DOI":"10.1371\/journal.pone.0087347","article-title":"P300 development across the lifespan: a systematic review and meta-analysis","volume":"9","author":"van Dinteren","year":"2014","journal-title":"PLoS One"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e334","DOI":"10.1212\/wnl.0000000000007821","article-title":"Cognitive reserve and clinical progression in Alzheimer disease: a paradoxical relationship","volume":"93","author":"van Loenhoud","year":"2019","journal-title":"Neurology"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1469-8986.1997.tb02125.x","article-title":"On the utility of P3 latency as an index of mental chronometry","volume":"34","author":"Verleger","year":"1997","journal-title":"Psychophysiology"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J. Open Source Software"},{"key":"ref53","year":"2019"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"699","DOI":"10.3233\/jad-201196","article-title":"The characteristics of social network structure in later life in relation to incidence of mild cognitive impairment and conversion to probable dementia","volume":"81","author":"Zhang","year":"2021","journal-title":"J. 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