{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:27:42Z","timestamp":1786429662012,"version":"build-2736575974"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Psychotherapy effectively treats depression, but variation exists in response timing and treatment trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from 7,161 adults receiving psychotherapy for depression (baseline PHQ-9 \u226510), we examined how baseline patient characteristics predict time to first response (\u226550% symptom reduction) and first remission (PHQ-9 &amp;lt; 5), and whether patient features predict later outcomes for non-responders after 24 psychotherapy sessions. Baseline predictors were identified using elastic net; time to outcomes used Poisson regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 67.9% achieved first response and 45.6% achieved first remission at median times of 6 and 8 sessions, (respectively); most responses occurred by session 12 (81.9%). Features predicting faster response included adjustment disorder diagnosis and good health; slower response related to comorbid anxiety, chronic pain, and diagnostic complexity. Among non-responders by session 24 (\n                      <jats:italic>n<\/jats:italic>\n                      = 778: first response,\n                      <jats:italic>n<\/jats:italic>\n                      = 1,477 first remission), only early symptom trajectories\u2014not baseline characteristics\u2014predicted later response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Findings support using complexity assessments for initial treatment planning and ongoing symptom monitoring for mid-treatment adjustments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2026.1816893","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:34:39Z","timestamp":1786426479000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient and course of care factors impacting time to response and remission in psychotherapy for depression"],"prefix":"10.3389","volume":"17","author":[{"given":"Nicholas R.","family":"Forand","sequence":"first","affiliation":[{"name":"Two Chairs","place":["San Francisco, CA, United States"]},{"name":"Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell","place":["Hempstead, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Nettiksimmons","sequence":"additional","affiliation":[{"name":"Two Chairs","place":["San Francisco, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Hardy","sequence":"additional","affiliation":[{"name":"JG Research & Evaluation","place":["Bozeman, MT, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Anton","sequence":"additional","affiliation":[{"name":"Two Chairs","place":["San Francisco, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandn","family":"Green","sequence":"additional","affiliation":[{"name":"JG Research & Evaluation","place":["Bozeman, MT, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102430","DOI":"10.1016\/j.cpr.2024.102430","article-title":"The association between quality of therapeutic alliance and treatment outcomes in teletherapy: a systematic review and meta-analysis","volume":"110","author":"Aafjes-van Doorn","year":"2024","journal-title":"Clinic. 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