{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:16:08Z","timestamp":1778134568678,"version":"3.51.4"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"\n Background<\/jats:title>\n Depressive disorder is affecting significantly more women than men. It is often accompanied by interpersonal difficulties, which severely impair patients\u2019 social functioning. Individual interpersonal therapy can help improve interpersonal problems, but the implementation of individual therapy is more difficult than that of group therapy. This study aims to evaluate the efficacy of Yalom group therapy in reducing depressive symptoms and interpersonal difficulties among Chinese women with depressive disorders.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 90 participants will be allocated to either the intervention group or the control group. Inclusion criteria: \u2460 Diagnosis of depressive disorder or recurrent depressive disorder according to the International Classification of Diseases, 10th Revision (ICD-10), confirmed by two attending physicians or above; \u2461 Female sex; \u2462 Age \u226518\u202fyears and &lt;60\u202fyears; \u2463 Ability to communicate verbally; \u2464 Hamilton Depression Scale-17 (HAMD-17) score \u226518; \u2465 No psychological treatment received within 6\u202fmonths; \u2466 Voluntary participation with informed consent. Exclusion criteria: \u2460 Current or planned physical therapy (e.g., electroconvulsive therapy, deep transcranial magnetic stimulation); \u2461 Participation in other group or individual psychological therapy; \u2462 Comorbidity with severe conditions (e.g., severe personality disorders, substance abuse, neurological diseases); \u2463 Intellectual disability. The control group will receive 5\u202fweeks of routine care and standard treatment. The intervention group will receive 5\u202fweeks of stepwise Yalom group therapy plus routine care and standard treatment. Primary outcomes include improvements in depressive symptoms and interpersonal difficulties. Secondary outcomes include reductions in anxiety symptoms and enhancements in social functioning. Statistical analyses will be performed using SPSS 27.0. Data will be analyzed in accordance with statistical principles, and missing data will be handled using multiple imputation.\n p<\/jats:italic>\n \u202f&lt;\u202f0.05 will be considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n This study will enhance understanding of the application of Yalom group therapy in female patients with depressive disorders. As the first study in China to implement a full-course intervention for female inpatients with depressive disorders, it will provide insights into the utility of Yalom group therapy for mitigating disease severity and improving interpersonal outcomes in this population.<\/jats:p>\n <\/jats:sec>\n \n Clinical trial registration<\/jats:title>\n \n https:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n , identifier ChiCTR2600116067\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fpsyg.2026.1831835","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:44:29Z","timestamp":1778132669000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A prospective, single-center, quasi-experimental study protocol for evaluating the efficacy of stepwise Yalom group therapy in reducing depressive symptoms and interpersonal problems in Chinese female patients with depressive disorders"],"prefix":"10.3389","volume":"17","author":[{"given":"Yue","family":"Zhou","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyi","family":"Du","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixuan","family":"Hou","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runing","family":"Hou","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Yang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Guo","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Yu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhong","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Nursing, Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yan","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]},{"name":"Henan Collaborative Innovation Centre of Prevention and Treatment of Mental Disorder","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuansheng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Henan Medical University (Henan Mental Hospital)","place":["Xinxiang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1037\/0278-6133.23.5.443","article-title":"Enhancing treatment fidelity in health behavior change studies: best practices and recommendations from the NIH behavior change consortium","volume":"23","author":"Bellg","year":"2004","journal-title":"Health Psychol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/wps.20860","article-title":"Psychotherapies for depression: a network meta-analysis covering efficacy, acceptability and long-term outcomes of all main treatment types","volume":"20","author":"Cuijpers","year":"2021","journal-title":"World Psychiatry"},{"key":"ref3","first-page":"260","article-title":"Real-life functioning domains in patients with affective disorders","volume":"37","author":"Fisenko","year":"2025","journal-title":"Psychiatr. Danub."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref5","volume-title":"Awakening and Transcendence: Group Psychotherapy for Hospitalised Patients","author":"Irvin","year":""},{"key":"ref6","volume-title":"Existential Psychotherapy","author":"Irvin","year":""},{"key":"ref7","first-page":"138","article-title":"The application and implications of Yalom's group psychotherapy in the college system model of higher education institutions: a case study of Shantou University","volume":"17","author":"Jiang","year":"2024","journal-title":"Univ. Educ."},{"key":"ref8","first-page":"63","article-title":"A cross-sectional survey on rehabilitation therapists in grade III public psychiatric hospitals","volume":"38","author":"Kang","year":"2024","journal-title":"Chin. Ment. Health J."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.5080\/u27482","article-title":"Examining the role of type D personality traits in predicting depression and anxiety symptoms in postpartum women","volume":"36","author":"K\u00f6kta\u015f","year":"2025","journal-title":"Turk Psikiyatri Derg."},{"key":"ref10","author":"Li","year":"2009"},{"key":"ref11","first-page":"91","article-title":"Effect of Yalom dynamic group psychotherapy on patients receiving surgery for tongue carcinoma","volume":"33","author":"Li","year":"2018","journal-title":"J. Nurs. Sci."},{"key":"ref12","first-page":"3083","article-title":"Mechanism of depression with insomnia mediated by the locus coeruleus-norepinephrine system: an assessment based on resting-state functional magnetic resonance imaging","volume":"30","author":"Li","year":"2026","journal-title":"Chin. J. Tissue Eng. Res."},{"key":"ref13","first-page":"450","article-title":"Research on current situation and countermeasure of Chinese primary care physicians' community rehabilitation service ability","volume":"28","author":"Lian","year":"2025","journal-title":"Chin. Gen. Pract."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1630601","DOI":"10.3389\/fpsyt.2025.1630601","article-title":"Burden and trends of major depressive disorders among women of childbearing age and the impact of the COVID-19 pandemic: insights from the global burden of disease study 2021","volume":"16","author":"Liao","year":"2025","journal-title":"Front. Psych."},{"key":"ref15","first-page":"1","article-title":"The impact of workplace anxiety on work-family conflict: the role of work behavior and regulatory focus","volume":"34","author":"Ling","year":"2025","journal-title":"China J. Health Psychol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jclinepi.2022.07.013","article-title":"The RIPI-f (reporting integrity of psychological interventions delivered face-to-face) checklist was developed to guide reporting of treatment integrity in face-to-face psychological interventions","volume":"151","author":"Lopez-Alcalde","year":"2022","journal-title":"J. Clin. Epidemiol."},{"key":"ref17","first-page":"84","article-title":"Chinese expert consensus on interpersonal psychotherapy for depressive disorders","volume":"8","author":"Luo","year":"2025","journal-title":"Psychol. Commun."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1146\/annurev-clinpsy-072220-021440","article-title":"Major depression and its recurrences: life course matters","volume":"18","author":"Monroe","year":"2022","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1111\/inm.13281","article-title":"\u201cIt was a reflection of myself, that i was weak\u201d: the impact of depression on the sense of self - an interpretive phenomenological analysis","volume":"33","author":"O'Mahony","year":"2024","journal-title":"Int. J. Ment. Health Nurs."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/j.1468-2850.2011.01246.x","article-title":"On the topic of treatment integrity","volume":"18","author":"Perepletchikova","year":"2011","journal-title":"Clin. Psychol. (New York)"},{"key":"ref21","author":"Qiu","year":"2017"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1192\/bjp.2025.10358","article-title":"Global, regional and national burden of depressive disorders and attributable risk factors, from 1990 to 2021: results from the 2021 global burden of disease study: commentary, Shen et al","volume":"227","author":"Shen","year":"2025","journal-title":"Br. J. Psychiatry"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jad.2023.01.063","article-title":"Women's reproductive traits and major depressive disorder: a two-sample Mendelian randomization study","volume":"326","author":"Wang","year":"2023","journal-title":"J. Affect. Disord."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"7242","DOI":"10.1017\/S0033291723000788","article-title":"Efficacy of dynamic interpersonal therapy for major depressive disorder in China: results of a multicentered, three-arm, randomized, controlled trial","volume":"53","author":"Wang","year":"2023","journal-title":"Psychol. Med."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1696199","DOI":"10.3389\/fpubh.2025.1696199","article-title":"Chronic diseases and depressive symptoms in China: a psychosocial mechanism perspective","volume":"13","author":"Xu","year":"2025","journal-title":"Front. Public Health"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.15912\/j.cnki.gocm.2023.05.040","article-title":"Influence of short-term focus group therapy on interpersonal problems of patients with depression","volume":"21","author":"Zhao","year":"2023","journal-title":"Guide China Med."},{"key":"ref27","first-page":"236","article-title":"Application of the Beck depression inventory (BDI) in patients with depression","volume":"4","author":"Zheng","year":"1987","journal-title":"Chin. J. Nerv. Ment. Dis."},{"key":"ref28","first-page":"144","article-title":"A self-designed scale for social function in in-patients with psychosis (SSFPI):preliminary test of reliability and validity","volume":"3","author":"Zhou","year":"2004","journal-title":"Sichuan Ment. 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