{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:04:37Z","timestamp":1789452277665,"version":"build-2803163510"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, substantially affecting quality of life among young adults. Although regular physical activity (RPA) benefits both mental and gastrointestinal health, its potential psychological mechanisms in IBS-related symptom severity remain unclear. This study was designed to examine the association between RPA and IBS-related symptom severity among Chinese college students and to clarify the mediating roles of depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional survey was conducted among 872 students from three universities in Shandong Province, China. Data on demographics, RPA, anxiety and depression assessed by the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS), and IBS-related symptom severity evaluated using the Irritable Bowel Syndrome Severity Scoring System (IBS-SSS) and the Gastrointestinal Symptom Rating Scale (GSRS) were collected. Group comparisons, multiple regression, and mediation analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Comparisons between students engaging in RPA and their sedentary peers revealed significantly lower IBS-SSS and GSRS scores in the RPA group. Consistent with these observations, multiple linear regression indicated that RPA was inversely associated with IBS-SSS [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u221228.665, 95%\n                      <jats:italic>CI<\/jats:italic>\n                      : (\u221240.129, \u221217.201),\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01] and GSRS [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22123.538, 95%\n                      <jats:italic>CI<\/jats:italic>\n                      : (\u22125.740, \u22121.335),\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01] scores. In addition, higher SAS and SDS scores were positively associated with IBS-SSS and GSRS scores (all\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.001). Mediation analysis showed an estimated indirect association between RPA and IBS-SSS scores through depressive symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), with a mediation proportion of 19.43%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate that RPA is associated with reduced IBS-related symptom severity, and that depressive symptoms statistically account for part of this association, highlighting the importance of lifestyle strategies integrating physical and psychological interventions for managing IBS-related symptom in young adults.<\/jats:p>\n                  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