{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:01:38Z","timestamp":1785391298280,"version":"3.55.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Allostatic load (AL) reflects the cumulative physiological burden on the body, quantified using biomarkers across multiple systems. The current study identified latent AL profiles in young adults and examined whether resilience moderates associations between AL and depressive symptoms, social functioning, and role functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 165 nonclinical young adults (84 women; aged 19\u201330 years) provided data on 15 biomarkers spanning the hypothalamic-pituitary-adrenal axis, oxidative stress, inflammatory-immune, lipid\/glucose-metabolic, and renal systems, which were z-standardized. Latent profile analysis was conducted using the\n                      <jats:italic>mclust<\/jats:italic>\n                      package in R. Moderated regression models examined depressive symptoms, social functioning, and role functioning as outcomes of AL profile, resilience, and their interaction, adjusting for age, sex, and cognitive ability. Percentile bootstrap confidence intervals were estimated (\n                      <jats:italic>R<\/jats:italic>\n                      = 5,000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A two-profile solution was retained based on classification quality and interpretability, yielding control and higher-dysregulation profiles (\n                      <jats:italic>n<\/jats:italic>\n                      = 132 and\n                      <jats:italic>n<\/jats:italic>\n                      = 33, respectively; entropy = 0.965; average posterior probability = 0.993). The higher-dysregulation profile showed relatively elevated dysregulation, particularly in inflammatory-immune and lipid\/glucose-metabolic markers. Resilience was inversely associated with depressive symptoms [\n                      <jats:italic>b<\/jats:italic>\n                      = \u22120.138,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001, 95% CI (\u22120.199, \u22120.079)], and a significant AL profile \u00d7 resilience interaction [\n                      <jats:italic>b<\/jats:italic>\n                      = \u22120.335,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001, 95% CI (\u22120.645, \u22120.055)] indicated that this association was stronger in the higher-dysregulation group. A similar interaction was observed for social functioning (\n                      <jats:italic>b<\/jats:italic>\n                      = 0.038,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001, 95% CI [0.003, 0.063]), whereas the interaction for role functioning was not significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings suggest that person-centered AL profiles capture heterogeneous physiological risk patterns. Resilience showed stronger associations with lower depressive symptoms and better social functioning among individuals with relatively greater physiological dysregulation, highlighting profile-dependent links between psychological resilience and psychosocial adaptation in young adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2026.1860265","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:40:19Z","timestamp":1785390019000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Allostatic load profiles, resilience, and psychosocial adaptation in young adults"],"prefix":"10.3389","volume":"17","author":[{"given":"Se Jun","family":"Koo","sequence":"first","affiliation":[{"name":"Section of Self, Affect and Neuroscience, Institute of Behavioural Science in Medicine, Yonsei University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Section of Self, Affect and Neuroscience, Institute of Behavioural Science in Medicine, Yonsei University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Eun","family":"Min","sequence":"additional","affiliation":[{"name":"Section of Self, Affect and Neuroscience, Institute of Behavioural Science in Medicine, Yonsei University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Section of Self, Affect and Neuroscience, Institute of Behavioural Science in Medicine, Yonsei University College of Medicine","place":["Seoul, Republic of Korea"]},{"name":"Department of Psychiatry, Yonsei University College of Medicine, Severance Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Kyoon","family":"An","sequence":"additional","affiliation":[{"name":"Section of Self, Affect and Neuroscience, Institute of Behavioural Science in Medicine, Yonsei University College of Medicine","place":["Seoul, Republic of Korea"]},{"name":"Department of Psychiatry, Yonsei University College of Medicine, Severance Hospital","place":["Seoul, Republic of Korea"]},{"name":"Graduate Program in Cognitive Science, Yonsei University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/s2215-0366(14)00080-7","article-title":"The new life stage of emerging adulthood at ages 18\u201329 years: Implications for mental health.","volume":"1","author":"Arnett","year":"2014","journal-title":"Lancet Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1017\/s0033291721003019","article-title":"Social engagement and allostatic load mediate between adverse childhood experiences and multimorbidity in mid to late adulthood: The Canadian longitudinal study on aging.","volume":"53","author":"Atkinson","year":"2023","journal-title":"Psychol. 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