{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:49:49Z","timestamp":1791355789284,"version":"4.3.1"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence linking Big Five personality traits to clinical biomarker-based PhenoAge acceleration remains limited, and the behavioral pathways underlying these associations are not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examined the associations between Big Five personality traits and PhenoAge acceleration (PhenoAA), tested health-related coping behavior as a statistical mediator, and explored differences across genetic risk strata.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional analysis of 119,250 European-ancestry participants from the UK Biobank. PhenoAA was derived from clinical biomarker-based PhenoAge after adjusting for chronological age. Multivariable linear regression, mediation analysis, inverse-probability-weighted sensitivity analysis, and exploratory analyses stratified by a genetic risk score (GRS) based on 29 single-nucleotide polymorphisms were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Neuroticism was positively associated with PhenoAA (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f0.038,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Extraversion (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.301,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), conscientiousness (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.314,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), and agreeableness (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.037,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01) were inversely associated with PhenoAA, while openness was not significant (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.023,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). Coping behavior statistically mediated the associations for neuroticism, extraversion, conscientiousness, and agreeableness, accounting for 15.4, 19.5, 12.3, and 28.2% of the total associations, respectively. Weighted sensitivity analyses showed similar patterns. In GRS-stratified analyses, neuroticism, extraversion, and conscientiousness showed broadly consistent associations across low- and high-GRS groups. Agreeableness was inversely associated with PhenoAA only in the high-GRS group. Interaction tests did not provide evidence of genetic effect modification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Big Five personality traits were associated with PhenoAA, and coping behavior partly accounted for several of these associations. These findings support a biopsychosocial view of biological aging, but they should be interpreted as associations rather than causal relationships.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2026.1876764","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:53:47Z","timestamp":1791352427000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Personality traits and biological aging: the mediating role of coping behavior"],"prefix":"10.3389","volume":"17","author":[{"given":"Shirui","family":"Peng","sequence":"first","affiliation":[{"name":"School of Public Administration and Policy, Renmin University of China","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Prevention and Control","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Biostatistics, School of Public Health, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailun","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Population and Health, Renmin University of China","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e54870","DOI":"10.7554\/eLife.54870","article-title":"Quantification of the pace of biological aging in humans through a blood test: the DunedinPoAm DNA methylation algorithm","volume":"9","author":"Belsky","year":"2020","journal-title":"eLife"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1177\/1359105319891650","article-title":"Perceived sleep quality, coping behavior, and associations with major depression among older adults","volume":"26","author":"Bergmans","year":"2021","journal-title":"J. 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