{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:08:51Z","timestamp":1784182131224,"version":"3.55.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Before the loss of a loved one to cancer, many relatives experience feelings of pre-loss grief. While pre-loss grief seems to have adverse health impacts, its longitudinal associations are still unclear. Therefore, this study aims to investigate the change of pre-loss grief over time, predictors of change and its relationship with psychological health over a time period of 1.5\u202fyears.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty-two relatives of people with cancer who were at least 18 years old and spoke German were included. Multiple linear regression analysis and paired\n                      <jats:italic>t<\/jats:italic>\n                      -tests were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total pre-loss grief score significantly decreased over time (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.009), while at the subscale level only emotional pain showed a significant decrease. Attendance of a psychotherapist (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.452,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.041) more than once per month compared to never, less than or once per month was associated with a greater reduction in pre-loss grief. While psychological health did not predict later pre-loss grief (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05), pre-loss grief was found to predict higher levels of anxiety (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f0.335,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.046) 1.5\u202fyears later.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Findings suggest that emotional pain may lessen over time, whereas other dimensions of pre-loss grief may remain stable. At the same time, because pre-loss grief is associated with some adverse health outcomes 1.5\u202fyears later, relatives with high levels of pre-loss grief may need additional support. Furthermore, this study provides preliminary insights into helpful intervention approaches for pre-loss grief. To understand underlying mechanisms, further dismantling studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyg.2026.1880352","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:37:04Z","timestamp":1784180224000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Change of pre-loss grief in relatives of cancer patients: a longitudinal study"],"prefix":"10.3389","volume":"17","author":[{"given":"Viktoria","family":"Schmidt","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Leipzig","place":["Leipzig, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Treml","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Leipzig","place":["Leipzig, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Leipzig","place":["Leipzig, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Kersting","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Leipzig","place":["Leipzig, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. 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