{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:33:46Z","timestamp":1791923626592,"version":"4.3.4"},"reference-count":120,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Psychiatry"],"DOI":"10.3389\/fpsyt.2014.00048","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T07:57:45Z","timestamp":1400140665000},"source":"Crossref","is-referenced-by-count":211,"title":["Gene\u00e2\u20ac\u201cEnvironment Interactions in Severe Mental Illness"],"prefix":"10.3389","volume":"5","author":[{"given":"Rudolf","family":"Uher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"issue":"9","key":"B1","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/ng.2711","article-title":"Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs","volume":"45","year":"2013","journal-title":"Nat Genet"},{"issue":"8","key":"B2","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1001\/archgenpsychiatry.2010.86","article-title":"Full spectrum of psychiatric outcomes among offspring with parental history of mental disorder","volume":"67","author":"Dean","year":"2010","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"B3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/schbul\/sbt114","article-title":"Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder and major depressive disorder: a meta-analysis of family high-risk studies","volume":"40","author":"Rasic","year":"2014","journal-title":"Schizophr Bull"},{"issue":"10","key":"B4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/gm501","article-title":"Genomics and the classification of mental illness: focus on broader categories","volume":"5","author":"Uher","year":"2013","journal-title":"Genome Med"},{"issue":"3","key":"B5","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1001\/archgenpsychiatry.2010.1","article-title":"Severe mental disorders in offspring with 2 psychiatrically ill parents","volume":"67","author":"Gottesman","year":"2010","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"B6","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1080\/09540260400014401","article-title":"A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders","volume":"16","author":"Shih","year":"2004","journal-title":"Int Rev Psychiatry"},{"issue":"2","key":"B7","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1001\/archpsyc.56.2.162","article-title":"Heritability estimates for psychotic disorders: the Maudsley twin psychosis series","volume":"56","author":"Cardno","year":"1999","journal-title":"Arch Gen Psychiatry"},{"issue":"9659","key":"B8","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/S0140-6736(09)60072-6","article-title":"Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study","volume":"373","author":"Lichtenstein","year":"2009","journal-title":"Lancet"},{"issue":"5","key":"B9","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1001\/archpsyc.60.5.497","article-title":"The heritability of bipolar affective disorder and the genetic relationship to unipolar depression","volume":"60","author":"McGuffin","year":"2003","journal-title":"Arch Gen Psychiatry"},{"issue":"10","key":"B10","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1176\/appi.ajp.157.10.1552","article-title":"Genetic epidemiology of major depression: review and meta-analysis","volume":"157","author":"Sullivan","year":"2000","journal-title":"Am J Psychiatry"},{"issue":"2","key":"B11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1001\/archpsyc.1996.01830020047006","article-title":"A hospital-based twin register of the heritability of DSM-IV unipolar depression","volume":"53","author":"McGuffin","year":"1996","journal-title":"Arch Gen Psychiatry"},{"issue":"9875","key":"B12","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/S0140-6736(12)62129-1","article-title":"Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis","volume":"381","year":"2013","journal-title":"Lancet"},{"issue":"12","key":"B13","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/mp.2012.142","article-title":"Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample","volume":"18","author":"Green","year":"2013","journal-title":"Mol Psychiatry"},{"issue":"10","key":"B14","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1038\/ng.2742","article-title":"Genome-wide association analysis identifies 13 new risk loci for schizophrenia","volume":"45","author":"Ripke","year":"2013","journal-title":"Nat Genet"},{"issue":"9","key":"B15","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1001\/archgenpsychiatry.2010.110","article-title":"Neonatal vitamin D status and risk of schizophrenia: a population-based case-control study","volume":"67","author":"McGrath","year":"2010","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"B16","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1093\/schbul\/sbs050","article-title":"Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies","volume":"38","author":"Varese","year":"2012","journal-title":"Schizophr Bull"},{"issue":"8","key":"B17","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1056\/NEJM199902253400803","article-title":"Effects of family history and place and season of birth on the risk of schizophrenia","volume":"340","author":"Mortensen","year":"1999","journal-title":"N Engl J Med"},{"issue":"9584","key":"B18","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0140-6736(07)61162-3","article-title":"Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review","volume":"370","author":"Moore","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0920-9964(97)00092-3","article-title":"Seasonality of births in schizophrenia and bipolar disorder: a review of the literature","volume":"28","author":"Torrey","year":"1997","journal-title":"Schizophr Res"},{"issue":"12","key":"B20","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1001\/archpsyc.1992.01820120071010","article-title":"Schizophrenia after prenatal exposure to the Dutch hunger winter of 1944-1945","volume":"49","author":"Susser","year":"1992","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"B21","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1176\/appi.ajp.157.2.190","article-title":"Further evidence of relation between prenatal famine and major affective disorder","volume":"157","author":"Brown","year":"2000","journal-title":"Am J Psychiatry"},{"issue":"11","key":"B22","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1289\/ehp.10464","article-title":"Prenatal exposure to lead, delta-aminolevulinic acid, and schizophrenia: further evidence","volume":"116","author":"Opler","year":"2008","journal-title":"Environ Health Perspect"},{"issue":"8","key":"B23","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.biopsych.2007.09.022","article-title":"Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring","volume":"63","author":"Buka","year":"2008","journal-title":"Biol Psychiatry"},{"issue":"6","key":"B24","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0006-3223(01)01068-X","article-title":"Prenatal rubella, premorbid abnormalities, and adult schizophrenia","volume":"49","author":"Brown","year":"2001","journal-title":"Biol Psychiatry"},{"issue":"7","key":"B25","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.jpsychires.2010.12.005","article-title":"Risk of affective disorders following prenatal exposure to severe life events: a Danish population-based cohort study","volume":"45","author":"Khashan","year":"2011","journal-title":"J Psychiatr Res"},{"issue":"6","key":"B26","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1001\/archgenpsychiatry.2011.1374","article-title":"Preterm birth and psychiatric disorders in young adult life","volume":"69","author":"Nosarti","year":"2012","journal-title":"Arch Gen Psychiatry"},{"issue":"7","key":"B27","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1176\/appi.ajp.159.7.1080","article-title":"Obstetric complications and schizophrenia: historical and meta-analytic review","volume":"159","author":"Cannon","year":"2002","journal-title":"Am J Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1192\/bjp.bp.105.010579","article-title":"Exposure to obstetric complications and subsequent development of bipolar disorder: systematic review","volume":"189","author":"Scott","year":"2006","journal-title":"Br J Psychiatry"},{"issue":"1","key":"B29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1176\/appi.ajp.2007.07050740","article-title":"Infections in the CNS during childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects","volume":"165","author":"Dalman","year":"2008","journal-title":"Am J Psychiatry"},{"issue":"8","key":"B30","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1017\/S0033291713002316","article-title":"Additive effects of childhood abuse and cannabis abuse on clinical expressions of bipolar disorders","volume":"44","author":"Aas","year":"2014","journal-title":"Psychol Med"},{"issue":"2","key":"B31","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1034\/j.1399-5618.2000.020206.x","article-title":"Relationship of childhood physical and sexual abuse to adult bipolar disorder","volume":"2","author":"Hyun","year":"2000","journal-title":"Bipolar Disord"},{"issue":"1\u00e2\u20ac\u201c3","key":"B32","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jad.2011.04.023","article-title":"Reactivity of affect and self-esteem during remission in bipolar affective disorder: an experimental investigation","volume":"134","author":"Pavlova","year":"2011","journal-title":"J Affect Disord"},{"issue":"2","key":"B33","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s00038-013-0519-5","article-title":"Sexual and physical abuse in childhood is associated with depression and anxiety over the life course: systematic review and meta-analysis","volume":"59","author":"Lindert","year":"2014","journal-title":"Int J Public Health"},{"issue":"2","key":"B34","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1176\/appi.ajp.2011.11020335","article-title":"Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta- analysis","volume":"169","author":"Nanni","year":"2012","journal-title":"Am J Psychiatry"},{"issue":"10","key":"B35","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1177\/070674379103601002","article-title":"The loss of a parent during childhood as a risk factor for depression","volume":"36","author":"Patten","year":"1991","journal-title":"Can J Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/epirev\/mxh001","article-title":"Socioeconomic position and major mental disorders","volume":"26","author":"Muntaner","year":"2004","journal-title":"Epidemiol Rev"},{"issue":"6","key":"B37","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1093\/schbul\/sbs112","article-title":"Social disadvantage: cause or consequence of impending psychosis?","volume":"39","author":"Stilo","year":"2013","journal-title":"Schizophr Bull"},{"issue":"12","key":"B38","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1136\/jech-2013-202768","article-title":"Social determinants of mental health: a Finnish nationwide follow-up study on mental disorders","volume":"67","author":"Paananen","year":"2013","journal-title":"J Epidemiol Community Health"},{"issue":"1","key":"B39","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.schres.2013.07.001","article-title":"Prevalence of bullying victimisation amongst first-episode psychosis patients and unaffected controls","volume":"150","author":"Trotta","year":"2013","journal-title":"Schizophr Res"},{"issue":"1\u00e2\u20ac\u201c2","key":"B40","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jad.2007.12.226","article-title":"Childhood bullying as a risk for later depression and suicidal ideation among Finnish males","volume":"109","author":"Klomek","year":"2008","journal-title":"J Affect Disord"},{"issue":"11","key":"B41","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1017\/S0033291706008774","article-title":"Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC AESOP study","volume":"36","author":"Fearon","year":"2006","journal-title":"Psychol Med"},{"issue":"1","key":"B42","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00127-010-0321-0","article-title":"Depressive symptoms among immigrants and ethnic minorities: a population based study in 23 European countries","volume":"47","author":"Missinne","year":"2012","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"issue":"4","key":"B43","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1093\/schbul\/sbt065","article-title":"Life events and psychosis: a review and meta-analysis","volume":"39","author":"Beards","year":"2013","journal-title":"Schizophr Bull"},{"issue":"4B","key":"B44","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1176\/ajp.1979.136.4b.508","article-title":"Life events at the onset of bipolar affective illness","volume":"136","author":"Dunner","year":"1979","journal-title":"Am J Psychiatry"},{"key":"B45","volume-title":"Social Origins of Depression: A Study of Psychiatric Disorder in Women","author":"Brown","year":"1978"},{"issue":"2","key":"B46","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/bdi.12123","article-title":"Antibodies to Toxoplasma gondii in individuals with mania","volume":"16","author":"Dickerson","year":"2014","journal-title":"Bipolar Disord"},{"key":"B47","volume-title":"Modern Epidemiology","author":"Rothman","year":"2008"},{"key":"B48","first-page":"310","article-title":"Modern epidemiology approaches to interaction: application to the study of genetic interactions","volume-title":"Genes, Behavior, and the Social Environment: Moving Beyond the Nature\/Nurture Debate","author":"Schwartz","year":"2006"},{"issue":"Suppl 1","key":"B49","doi-asserted-by":"publisher","first-page":"S144","DOI":"10.2105\/AJPH.2004.059204","article-title":"Causation and causal inference in epidemiology","volume":"95","author":"Rothman","year":"2005","journal-title":"Am J Public Health"},{"key":"B50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/9780470696781.ch2","article-title":"Gene-environment interaction: overcoming methodological challenges","volume":"293","author":"Uher","year":"2008","journal-title":"Novartis Found Symp"},{"issue":"7","key":"B51","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nrn1925","article-title":"Gene-environment interactions in psychiatry: joining forces with neuroscience","volume":"7","author":"Caspi","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"B52","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.chiabu.2007.02.004","article-title":"Resilience to adult psychopathology following childhood maltreatment: evidence from a community sample","volume":"31","author":"Collishaw","year":"2007","journal-title":"Child Abuse Negl"},{"issue":"2 Suppl","key":"B53","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1016\/j.jadohealth.2012.04.004","article-title":"Risk and developmental heterogeneity in previously institutionalized children","volume":"51","author":"Tottenham","year":"2012","journal-title":"J Adolesc Health"},{"issue":"4","key":"B54","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/YCO.0b013e328306a7b9","article-title":"Forum: the case for gene-environment interactions in psychiatry","volume":"21","author":"Uher","year":"2008","journal-title":"Curr Opin Psychiatry"},{"issue":"12","key":"B55","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/mp.2009.85","article-title":"The role of genetic variation in the causation of mental illness: an evolution-informed framework","volume":"14","author":"Uher","year":"2009","journal-title":"Mol Psychiatry"},{"key":"B56","doi-asserted-by":"crossref","DOI":"10.1093\/acprof:oso\/9780195101812.001.0001","volume-title":"Psychiatric Epidemiology","author":"Susser","year":"2006"},{"key":"B57","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1162\/biot.2006.1.2.150","article-title":"Heritability and heterogeneity: on the limited relevance of heritability in investigating genetic and environmental factors","volume":"1","author":"Taylor","year":"2006","journal-title":"Biol Theory"},{"issue":"3","key":"B58","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/070674370104600302","article-title":"Why are children in the same family so different? Nonshared environment a decade later","volume":"46","author":"Plomin","year":"2001","journal-title":"Can J Psychiatry"},{"key":"B59","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1162\/biot.2007.2.4.387","article-title":"The unreliability of high human heritability estimates and small shared effects of growing up in the same family","volume":"2","author":"Taylor","year":"2008","journal-title":"Biol Theory"},{"issue":"1","key":"B60","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1037\/0033-2909.126.1.78","article-title":"Nonshared environment: a theoretical, methodological, and quantitative review","volume":"126","author":"Turkheimer","year":"2000","journal-title":"Psychol Bull"},{"issue":"5","key":"B61","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1093\/schbul\/sbs098","article-title":"Genetic risk for schizophrenia, obstetric complications, and adolescent school outcome: evidence for gene-environment interaction","volume":"39","author":"Forsyth","year":"2013","journal-title":"Schizophr Bull"},{"issue":"1","key":"B62","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1176\/appi.ajp.2008.08030343","article-title":"Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis","volume":"166","author":"Koenen","year":"2009","journal-title":"Am J Psychiatry"},{"issue":"3","key":"B63","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/MCO.0b013e328351f543","article-title":"Genetic origins of low birth weight","volume":"15","author":"Yaghootkar","year":"2012","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"B64","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1192\/bjp.184.3.216","article-title":"Genotype-environment interaction in schizophrenia-spectrum disorder. Long-term follow-up study of Finnish adoptees","volume":"184","author":"Tienari","year":"2004","journal-title":"Br J Psychiatry"},{"issue":"4","key":"B65","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1093\/aje\/kwp398","article-title":"A comparison of sample size and power in case-only association studies of gene-environment interaction","volume":"171","author":"Clarke","year":"2010","journal-title":"Am J Epidemiol"},{"issue":"10","key":"B66","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1176\/appi.ajp.2010.09010114","article-title":"Social risk or genetic liability for psychosis? A study of children born in Sweden and reared by adoptive parents","volume":"167","author":"Wicks","year":"2010","journal-title":"Am J Psychiatry"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt201","article-title":"Interplay between childhood physical abuse and familial risk in the onset of psychotic disorders","author":"Fisher","year":"2014","journal-title":"Schizophr Bull"},{"issue":"6","key":"B68","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1176\/ajp.152.6.833","article-title":"Stressful life events, genetic liability, and onset of an episode of major depression in women","volume":"152","author":"Kendler","year":"1995","journal-title":"Am J Psychiatry"},{"issue":"1","key":"B69","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00127-013-0801-0","article-title":"Gene-environment interactions in common mental disorders: an update and strategy for a genome-wide search","volume":"49","author":"Uher","year":"2014","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"issue":"5","key":"B70","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.biopsych.2006.11.020","article-title":"Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders","volume":"62","author":"Kim","year":"2007","journal-title":"Biol Psychiatry"},{"issue":"4","key":"B71","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/da.22221","article-title":"Functional polymorphism in the brain-derived neurotrophic factor gene interacts with stressful life events but not childhood maltreatment in the etiology of depression","volume":"31","author":"Brown","year":"2014","journal-title":"Depress Anxiety"},{"issue":"2","key":"B72","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1001\/archgenpsychiatry.2007.26","article-title":"Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene","volume":"65","author":"Bradley","year":"2008","journal-title":"Arch Gen Psychiatry"},{"issue":"9","key":"B73","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1001\/archgenpsychiatry.2009.114","article-title":"Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension","volume":"66","author":"Polanczyk","year":"2009","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"B74","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1001\/archpsyc.64.3.356","article-title":"Serotonin receptor 2A gene and the influence of childhood maternal nurturance on adulthood depressive symptoms","volume":"64","author":"Jokela","year":"2007","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"B75","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1017\/S0954579407000600","article-title":"Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: depressive symptomatology among adolescents from low socioeconomic status backgrounds","volume":"19","author":"Cicchetti","year":"2007","journal-title":"Dev Psychopathol"},{"issue":"7","key":"B76","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1017\/S1461145713000102","article-title":"Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities","volume":"16","author":"Melas","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"issue":"5","key":"B77","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1002\/ajmg.b.30886","article-title":"Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: new evidence for a gene-environment interaction","volume":"150B","author":"Bet","year":"2009","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"5631","key":"B78","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1126\/science.1083968","article-title":"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene","volume":"301","author":"Caspi","year":"2003","journal-title":"Science"},{"issue":"5","key":"B79","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1001\/archgenpsychiatry.2010.189","article-title":"The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation","volume":"68","author":"Karg","year":"2011","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"B80","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/da.21982","article-title":"Serotonin transporter length polymorphism, childhood maltreatment, and chronic depression: a specific gene-environment interaction","volume":"30","author":"Brown","year":"2013","journal-title":"Depress Anxiety"},{"issue":"1\u00e2\u20ac\u201c3","key":"B81","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.jad.2010.01.071","article-title":"Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder","volume":"125","author":"Hosang","year":"2010","journal-title":"J Affect Disord"},{"issue":"10","key":"B82","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.biopsych.2005.01.026","article-title":"Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction","volume":"57","author":"Caspi","year":"2005","journal-title":"Biol Psychiatry"},{"key":"B83","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1192\/bjp.bp.107.036129","article-title":"Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use","volume":"191","author":"Zammit","year":"2007","journal-title":"Br J Psychiatry"},{"issue":"1","key":"B84","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/acps.12108","article-title":"Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes","volume":"129","author":"Alemany","year":"2014","journal-title":"Acta Psychiatr Scand"},{"issue":"1","key":"B85","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.schres.2013.07.020","article-title":"The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val(1)(5)(8)Met polymorphism","volume":"150","author":"Vinkers","year":"2013","journal-title":"Schizophr Res"},{"issue":"2","key":"B86","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1001\/archgenpsychiatry.2010.152","article-title":"Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up","volume":"68","author":"van Winkel","year":"2011","journal-title":"Arch Gen Psychiatry"},{"issue":"10","key":"B87","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.biopsych.2012.06.020","article-title":"Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users","volume":"72","author":"Di Forti","year":"2012","journal-title":"Biol Psychiatry"},{"issue":"1","key":"B88","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1192\/bjp.bp.110.083808","article-title":"Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences","volume":"199","author":"Alemany","year":"2011","journal-title":"Br J Psychiatry"},{"issue":"11","key":"B89","doi-asserted-by":"publisher","first-page":"e79741","DOI":"10.1371\/journal.pone.0079741","article-title":"Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample","volume":"8","author":"Ramsay","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"B90","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1192\/bjp.bp.112.115972","article-title":"FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma","volume":"202","author":"Collip","year":"2013","journal-title":"Br J Psychiatry"},{"issue":"1","key":"B91","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/schbul\/sbr113","article-title":"Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders","volume":"38","author":"Aas","year":"2012","journal-title":"Schizophr Bull"},{"issue":"8","key":"B92","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/ajmg.b.31234","article-title":"Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk","volume":"156B","author":"Demontis","year":"2011","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"3","key":"B93","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/mp.2013.2","article-title":"Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci","volume":"19","author":"Borglum","year":"2013","journal-title":"Mol Psychiatry"},{"issue":"12","key":"B94","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1038\/sj.npp.1301197","article-title":"An experimental study of catechol-O-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition","volume":"31","author":"Henquet","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"1\u00e2\u20ac\u201c3","key":"B95","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.schres.2013.10.037","article-title":"Age at onset of schizophrenia: cannabis, COMT gene, and their interactions","volume":"151","author":"De Sousa","year":"2013","journal-title":"Schizophr Res"},{"issue":"4","key":"B96","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s11126-009-9108-4","article-title":"Adolescent cannabis use, psychosis and catechol-O-methyltransferase genotype in African Americans and Caucasians","volume":"80","author":"Kantrowitz","year":"2009","journal-title":"Psychiatr Q"},{"issue":"5","key":"B97","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1192\/bjp.bp.111.091421","article-title":"Cannabis, COMT and psychotic experiences","volume":"199","author":"Zammit","year":"2011","journal-title":"Br J Psychiatry"},{"issue":"1\u00e2\u20ac\u201c3","key":"B98","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.schres.2011.01.014","article-title":"Interaction between COMT haplotypes and cannabis in schizophrenia: a case-only study in two samples from Spain","volume":"127","author":"Costas","year":"2011","journal-title":"Schizophr Res"},{"key":"B99","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3389\/fpsyt.2013.00130","article-title":"Does cannabidiol protect against adverse psychological effects of THC?","volume":"4","author":"Niesink","year":"2013","journal-title":"Front Psychiatry"},{"issue":"1\u00e2\u20ac\u201c3","key":"B100","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.schres.2011.04.017","article-title":"Cannabis with high cannabidiol content is associated with fewer psychotic experiences","volume":"130","author":"Schubart","year":"2011","journal-title":"Schizophr Res"},{"key":"B101","article-title":"Confirmation that the AKT1 (RS 2494732) genotype influences the risk of psychosis in cannabis users","author":"Murray","year":"2013"},{"issue":"1","key":"B102","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pneurobio.2010.09.003","article-title":"The environment and susceptibility to schizophrenia","volume":"93","author":"Brown","year":"2011","journal-title":"Prog Neurobiol"},{"issue":"11","key":"B103","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1001\/archpsyc.58.11.1032","article-title":"Maternal infections and subsequent psychosis among offspring","volume":"58","author":"Buka","year":"2001","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"B104","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1017\/S0033291712000736","article-title":"Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies","volume":"43","author":"Khandaker","year":"2013","journal-title":"Psychol Med"},{"issue":"11","key":"B105","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1001\/jama.299.11.1291","article-title":"Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults","volume":"299","author":"Binder","year":"2008","journal-title":"JAMA"},{"issue":"1\u00e2\u20ac\u201c3","key":"B106","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jad.2011.03.010","article-title":"Serotonin transporter gene moderates childhood maltreatment\u00e2\u20ac\u2122s effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results","volume":"135","author":"Uher","year":"2011","journal-title":"J Affect Disord"},{"issue":"1\u00e2\u20ac\u201c2","key":"B107","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jad.2011.02.001","article-title":"Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis","volume":"132","author":"Carver","year":"2011","journal-title":"J Affect Disord"},{"key":"B108","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1741-7015-12-7","article-title":"Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis","volume":"12","author":"Hosang","year":"2014","journal-title":"BMC Med"},{"issue":"3","key":"B109","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1017\/S0033291711001607","article-title":"Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results","volume":"42","author":"Collins","year":"2012","journal-title":"Psychol Med"},{"issue":"4","key":"B110","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1176\/appi.ajp.2007.07101573","article-title":"No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics","volume":"165","author":"Sanders","year":"2008","journal-title":"Am J Psychiatry"},{"issue":"2","key":"B111","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1093\/aje\/kwn353","article-title":"Gene-environment interaction in genome-wide association studies","volume":"169","author":"Murcray","year":"2009","journal-title":"Am J Epidemiol"},{"issue":"5","key":"B112","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1176\/appi.ajp.2010.09101452","article-title":"Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits","volume":"167","author":"Caspi","year":"2010","journal-title":"Am J Psychiatry"},{"issue":"2","key":"B113","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1037\/0033-2909.114.2.376","article-title":"Statistical difficulties of detecting interactions and moderator effects","volume":"114","author":"McClelland","year":"1993","journal-title":"Psychol Bull"},{"issue":"1","key":"B114","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/mp.2009.123","article-title":"The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update","volume":"15","author":"Uher","year":"2010","journal-title":"Mol Psychiatry"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt181","article-title":"Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users","author":"Di Forti","year":"2014","journal-title":"Schizophr Bull"},{"issue":"10","key":"B116","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1111\/j.1467-9280.2008.02181.x","article-title":"Gene-environment interactions in depression research: genetic polymorphisms and life-stress polyprocedures","volume":"19","author":"Monroe","year":"2008","journal-title":"Psychol Sci"},{"issue":"2","key":"B117","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/sj.mp.4002067","article-title":"The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis","volume":"13","author":"Uher","year":"2008","journal-title":"Mol Psychiatry"},{"issue":"2","key":"B118","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1017\/thg.2013.6","article-title":"Genes, environments, and developmental research: methods for a multi-site study of early substance abuse","volume":"16","author":"Costello","year":"2013","journal-title":"Twin Res Hum Genet"},{"issue":"3","key":"B119","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/mpr.1352","article-title":"Genetic Risk and Outcome of Psychosis (GROUP), a multi site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods","volume":"21","author":"Korver","year":"2012","journal-title":"Int J Methods Psychiatr Res"},{"issue":"12","key":"B120","doi-asserted-by":"publisher","first-page":"e004035","DOI":"10.1136\/bmjopen-2013-004035","article-title":"Epidemiology and genetics of common mental disorders in the general population: the PEGASUS-Murcia project","volume":"3","author":"Navarro-Mateu","year":"2013","journal-title":"BMJ Open"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T08:58:34Z","timestamp":1597827514000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fpsyt.2014.00048\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,15]]},"references-count":120,"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2014.00048","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727614575.793539079","asserted-by":"object"}]},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,15]]}}}