{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:38:35Z","timestamp":1792460315420,"version":"4.5.0"},"reference-count":178,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"DOI":"10.3389\/fpsyt.2015.00121","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T10:04:16Z","timestamp":1441793056000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":109,"title":["The Impact of Neuroimmune Alterations in Autism Spectrum Disorder"],"prefix":"10.3389","volume":"6","author":[{"given":"Carmem","family":"Gottfried","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victorio","family":"Bambini-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudimar","family":"Riesgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Savino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4103\/0019-5545.94660","article-title":"Paul Eugen Bleuler and the origin of the term schizophrenia","volume":"54","author":"Ashok","year":"2012","journal-title":"Indian J Psychiatry"},{"key":"B2","first-page":"217","article-title":"Autistic disturbances of affective contact","volume":"2","author":"Kanner","year":"1943","journal-title":"Nervous Child"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511526770.001","volume-title":"Asperger and His Syndrome","author":"Frith","year":"1991"},{"issue":"7560","key":"B4","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0022-510X(98)00021-5","article-title":"Elevated cerebrospinal fluid and serum nitrate and nitrite levels in patients with central nervous system complications of HIV-1 infection: a correlation with blood-brain-barrier dysfunction","volume":"156","author":"Giovannoni","year":"1998","journal-title":"J Neurol Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ntt.2012.07.006","article-title":"Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment","volume":"36","author":"Goines","year":"2013","journal-title":"Neurotoxicol Teratol"},{"key":"B7","volume-title":"Autism Spectrum Disorder","author":"DSM-5","year":"2013"},{"key":"B8","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/mi.2008.27","article-title":"Immune privilege or privileged immunity?","volume":"1","author":"Forrester","year":"2008","journal-title":"Mucosal Immunol"},{"key":"B9","volume-title":"Clinical Approach in Autism: Management and Treatment, In Recent Advances in Autism Spectrum Disorders","author":"Riesgo","year":"2013"},{"key":"B10","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00441-014-1814-z","article-title":"Neuroglia in ageing and disease","volume":"357","author":"Verkhratsky","year":"2014","journal-title":"Cell Tissue Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1586\/erm.09.59","article-title":"Autism genetics: emerging data from genome-wide copy-number and single nucleotide polymorphism scans","volume":"9","author":"Weiss","year":"2009","journal-title":"Expert Rev Mol Diagn"},{"key":"B12","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ygeno.2008.09.015","article-title":"Comparative analysis of neurological disorders focuses genome-wide search for autism genes","volume":"93","author":"Wall","year":"2009","journal-title":"Genomics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/1471-2350-10-102","article-title":"Autism genetic database (AGD): a comprehensive database including autism susceptibility gene-CNVs integrated with known noncoding RNAs and fragile sites","volume":"10","author":"Matuszek","year":"2009","journal-title":"BMC Med Genet"},{"key":"B14","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1097\/GIM.0b013e3181ff67ba","article-title":"Autism spectrum disorders \u2013 a genetics review","volume":"13","author":"Miles","year":"2011","journal-title":"Genet Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.neuron.2012.11.002","article-title":"Using whole-exome sequencing to identify inherited causes of autism","volume":"77","author":"Yu","year":"2013","journal-title":"Neuron"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/mp.2012.138","article-title":"Using large clinical data sets to infer pathogenicity for rare copy number variants in autism cohorts","volume":"18","author":"Moreno-De-Luca","year":"2012","journal-title":"Mol Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1097\/HRP.0000000000000029","article-title":"Gastrointestinal issues in autism spectrum disorder","volume":"22","author":"Hsiao","year":"2014","journal-title":"Harv Rev Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.ajhg.2013.06.012","article-title":"Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing","volume":"93","author":"Jiang","year":"2013","journal-title":"Am J Hum Genet"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e472","DOI":"10.1542\/peds.113.5.e472","article-title":"The genetics of autism","volume":"113","author":"Muhle","year":"2004","journal-title":"Pediatrics"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1542\/peds.2008-0819","article-title":"Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions","volume":"123","author":"Campbell","year":"2009","journal-title":"Pediatrics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.1038\/tp.2011.48","article-title":"Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression","volume":"1","author":"Heuer","year":"2011","journal-title":"Transl Psychiatry"},{"key":"B22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/ana.21180","article-title":"Disruption of cerebral cortex MET signaling in autism spectrum disorder","volume":"62","author":"Campbell","year":"2007","journal-title":"Ann Neurol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/aur.30","article-title":"A large-scale screen for coding variants in SERT\/SLC6A4 in autism spectrum disorders","volume":"1","author":"Sakurai","year":"2008","journal-title":"Autism Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00439-006-0301-3","article-title":"Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels","volume":"121","author":"Coutinho","year":"2007","journal-title":"Hum Genet"},{"key":"B25","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1039\/c3ib40022k","article-title":"Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS","volume":"5","author":"Kunze","year":"2013","journal-title":"Integr Biol (Camb)"},{"key":"B26","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.biopsych.2014.11.001","article-title":"Genetic epidemiology and insights into interactive genetic and environmental effects in autism spectrum disorders","volume":"77","author":"Kim","year":"2014","journal-title":"Biol Psychiatry"},{"issue":"21","key":"B27","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1002\/ajmg.a.31465","article-title":"Head circumference and height in autism: a study by the collaborative program of excellence in autism","volume":"140","author":"Lainhart","year":"2006","journal-title":"Am J Med Genet A"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1001\/jama.2011.1638","article-title":"Neuron number and size in prefrontal cortex of children with autism","volume":"306","author":"Courchesne","year":"2011","journal-title":"JAMA"},{"issue":"4","key":"B29","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/ana.20032","article-title":"Localization of white matter volume increase in autism and developmental language disorder","volume":"55","author":"Herbert","year":"2004","journal-title":"Ann Neurol"},{"issue":"7","key":"B30","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1176\/ajp.2006.163.7.1290","article-title":"An MRI study of increased cortical thickness in autism","volume":"163","author":"Hardan","year":"2006","journal-title":"Am J Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3389\/fnhum.2013.00609","article-title":"Altered neural connectivity in excitatory and inhibitory cortical circuits in autism","volume":"7","author":"Zikopoulos","year":"2013","journal-title":"Front Hum Neurosci"},{"issue":"3","key":"B32","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1212\/WNL.58.3.428","article-title":"Minicolumnar pathology in autism","volume":"58","author":"Casanova","year":"2002","journal-title":"Neurology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s00401-010-0655-4","article-title":"The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes","volume":"119","author":"Wegiel","year":"2010","journal-title":"Acta Neuropathol"},{"issue":"5","key":"B34","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00401-009-0568-2","article-title":"The anterior cingulate cortex in autism: heterogeneity of qualitative and quantitative cytoarchitectonic features suggests possible subgroups","volume":"118","author":"Simms","year":"2009","journal-title":"Acta Neuropathol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/aur.188","article-title":"Altered posterior cingulate cortical cyctoarchitecture, but normal density of neurons and interneurons in the posterior cingulate cortex and fusiform gyrus in autism","volume":"4","author":"Oblak","year":"2011","journal-title":"Autism Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.brainres.2009.09.120","article-title":"Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders","volume":"1309","author":"Hutsler","year":"2009","journal-title":"Brain Res"},{"key":"B37","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.brainres.2010.08.091","article-title":"Abnormal cell patterning at the cortical gray-white matter boundary in autism spectrum disorders","volume":"1360","author":"Avino","year":"2010","journal-title":"Brain Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"14595","DOI":"10.1523\/JNEUROSCI.2257-10.2010","article-title":"Changes in prefrontal axons may disrupt the network in autism","volume":"30","author":"Zikopoulos","year":"2010","journal-title":"J Neurosci"},{"issue":"10","key":"B39","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.biopsych.2009.07.022","article-title":"A meta-analysis of the corpus callosum in autism","volume":"66","author":"Frazier","year":"2009","journal-title":"Biol Psychiatry"},{"key":"B40","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1177\/1362361310386506","article-title":"Quantitative analysis of the shape of the corpus callosum in patients with autism and comparison individuals","volume":"15","author":"Casanova","year":"2011","journal-title":"Autism"},{"key":"B41","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1176\/appi.ajp.2011.11091447","article-title":"Differences in white matter fiber tract development present from 6 to 24 months in infants with autism","volume":"169","author":"Wolff","year":"2012","journal-title":"Am J Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13229-015-0001-8","article-title":"Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation","volume":"6","author":"Travers","year":"2015","journal-title":"Mol Autism"},{"key":"B43","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.neuroimage.2006.08.032","article-title":"Diffusion tensor imaging of the corpus callosum in autism","volume":"34","author":"Alexander","year":"2007","journal-title":"Neuroimage"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1093\/brain\/awn099","article-title":"Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD)","volume":"131","author":"Thakkar","year":"2008","journal-title":"Brain"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1001\/archgenpsychiatry.2010.123","article-title":"Similar white matter aberrations in children with autism and their unaffected siblings: a diffusion tensor imaging study using tract-based spatial statistics","volume":"67","author":"Barnea-Goraly","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.brainres.2010.09.051","article-title":"Altered white matter fractional anisotropy and social impairment in children with autism spectrum disorder","volume":"1362","author":"Noriuchi","year":"2010","journal-title":"Brain Res"},{"key":"B47","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/17470910802198510","article-title":"Atypical frontal-posterior synchronization of theory of mind regions in autism during mental state attribution","volume":"4","author":"Kana","year":"2009","journal-title":"Soc Neurosci"},{"issue":"4","key":"B48","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3109\/15622975.2011.591824","article-title":"Fronto-temporal disconnectivity and symptom severity in children with autism spectrum disorder","volume":"13","author":"Poustka","year":"2012","journal-title":"World J Biol Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1093\/cercor\/bhm054","article-title":"fMRI investigation of working memory for faces in autism: visual coding and underconnectivity with frontal areas","volume":"18","author":"Koshino","year":"2008","journal-title":"Cereb Cortex"},{"key":"B50","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1093\/cercor\/bhl006","article-title":"Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry","volume":"17","author":"Just","year":"2007","journal-title":"Cereb Cortex"},{"key":"B51","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1093\/scan\/nsn011","article-title":"Functional abnormalities of the default network during self- and other-reflection in autism","volume":"3","author":"Kennedy","year":"2008","journal-title":"Soc Cogn Affect Neurosci"},{"key":"B52","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.brainres.2009.11.057","article-title":"Alterations of resting state functional connectivity in the default network in adolescents with autism spectrum disorders","volume":"1313","author":"Weng","year":"2013","journal-title":"Brain Res"},{"key":"B53","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.neuroimage.2009.04.069","article-title":"Abnormalities of intrinsic functional connectivity in autism spectrum disorders","volume":"47","author":"Monk","year":"2009","journal-title":"Neuroimage"},{"key":"B54","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.brainres.2008.12.076","article-title":"Aberrant functional connectivity in autism: evidence from low-frequency BOLD signal fluctuations","volume":"1262","author":"Noonan","year":"2009","journal-title":"Brain Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1093\/brain\/awm334","article-title":"Abnormal functional connectivity in autism spectrum disorders during face processing","volume":"131","author":"Kleinhans","year":"2008","journal-title":"Brain"},{"key":"B56","article-title":"Neuronal migration defects","author":"Stouffer","year":"in press","journal-title":"Neurobiol Dis"},{"key":"B57","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3389\/fncel.2014.00030","article-title":"Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models","volume":"8","author":"Doll","year":"2012","journal-title":"Front Cell Neurosci"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s10571-005-8357-5","article-title":"Altered expression of the prion gene in rat astrocyte and neuron cultures treated with prion peptide 106-126","volume":"25","author":"Ning","year":"2005","journal-title":"Cell Mol Neurobiol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nrn3978","article-title":"Immune mediators in the brain and peripheral tissues in autism spectrum disorder","volume":"16","author":"Estes","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1001\/archgenpsychiatry.2011.39","article-title":"Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years","volume":"68","author":"Hazlett","year":"2011","journal-title":"Arch Gen Psychiatry"},{"key":"B61","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1080\/87565640701729821","article-title":"Regional callosal morphology in autism and macrocephaly","volume":"33","author":"Kilian","year":"2008","journal-title":"Dev Neuropsychol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1227\/NEU.0000000000000452","article-title":"Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming","volume":"75","author":"Potts","year":"2014","journal-title":"Neurosurgery"},{"key":"B63","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1111\/j.1749-6632.1987.tb23698.x","article-title":"Are neuronotrophic neuron-astrocyte interactions regionally specified?","volume":"495","author":"Chamak","year":"1987","journal-title":"Ann N Y Acad Sci"},{"key":"B64","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.conb.2007.01.009","article-title":"Autism spectrum disorders: developmental disconnection syndromes","volume":"17","author":"Geschwind","year":"2007","journal-title":"Curr Opin Neurobiol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.neuro.2011.07.002","article-title":"Assessment of neurotoxicity of monocrotaline, an alkaloid extracted from Crotalaria retusa in astrocyte\/neuron co-culture system","volume":"32","author":"Pitanga","year":"2011","journal-title":"Neurotoxicology"},{"key":"B66","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1177\/1073858406290375","article-title":"Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy","volume":"12","author":"Casanova","year":"2006","journal-title":"Neuroscientist"},{"key":"B67","doi-asserted-by":"publisher","first-page":"748","DOI":"10.3109\/15563650.2013.820831","article-title":"Assessment of serum S100B and neuron specific enolase levels to evaluate the neurotoxic effects of organic solvent exposure","volume":"51","author":"Zungun","year":"2013","journal-title":"Clin Toxicol (Phila)"},{"key":"B68","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.mcn.2004.07.003","article-title":"Astrocyte activation and dysfunction and neuron death by HIV-1 Tat expression in astrocytes","volume":"27","author":"Zhou","year":"2004","journal-title":"Mol Cell Neurosci"},{"key":"B69","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1471-4159.2004.02984.x","article-title":"Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis","volume":"93","author":"Cassina","year":"2005","journal-title":"J Neurochem"},{"key":"B70","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1385\/0-89603-612-X:133","article-title":"Astrocyte and neuron coculturing method","volume":"22","author":"Aschner","year":"1999","journal-title":"Methods Mol Med"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1007\/s11064-008-9758-x","article-title":"Astrocyte and neuron intone through glutamate","volume":"33","author":"Yang","year":"2008","journal-title":"Neurochem Res"},{"key":"B72","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnsys.2011.00010","article-title":"Inter-regional brain communication and its disturbance in autism","volume":"5","author":"Schipul","year":"2011","journal-title":"Front Syst Neurosci"},{"key":"B73","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/aur.1243","article-title":"Diffusion tensor imaging in autism spectrum disorder: a review","volume":"5","author":"Travers","year":"2012","journal-title":"Autism Res"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1016\/j.neuroimage.2008.03.041","article-title":"Altered cerebellar feedback projections in Asperger syndrome","volume":"41","author":"Catani","year":"2008","journal-title":"Neuroimage"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e81255","DOI":"10.1371\/journal.pone.0081255","article-title":"Regional alterations in purkinje cell density in patients with autism","volume":"9","author":"Skefos","year":"2014","journal-title":"PLoS One"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1111\/j.1471-4159.2006.03674.x","article-title":"Astrocyte control of fetal cortical neuron glutathione homeostasis: up-regulation by ethanol","volume":"96","author":"Rathinam","year":"2006","journal-title":"J Neurochem"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1002\/glia.20848","article-title":"Astrocyte function and role in motor neuron disease: a future therapeutic target?","volume":"57","author":"Blackburn","year":"2009","journal-title":"Glia"},{"key":"B78","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s10827-012-0432-6","article-title":"Astrocyte-neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments","volume":"34","author":"Amiri","year":"2013","journal-title":"J Comput Neurosci"},{"key":"B79","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0165-0270(98)00146-0","article-title":"Astrocyte-conditioned saline supports embryonic rat hippocampal neuron differentiation in short-term cultures","volume":"86","author":"Liu","year":"1998","journal-title":"J Neurosci Methods"},{"key":"B80","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.neuron.2014.07.005","article-title":"Astrocyte morphology is controlled by neuron-derived FGF","volume":"83","author":"Agarwal","year":"2014","journal-title":"Neuron"},{"key":"B81","doi-asserted-by":"publisher","first-page":"934","DOI":"10.3389\/fnhum.2013.00934","article-title":"A new methodology of viewing extra-axial fluid and cortical abnormalities in children with autism via transcranial ultrasonography","volume":"7","author":"Bradstreet","year":"2014","journal-title":"Front Hum Neurosci"},{"key":"B82","doi-asserted-by":"crossref","first-page":"d88","DOI":"10.2741\/A177","article-title":"Cross-talk signals in the CNS: role of neurotrophic and hormonal factors, adhesion molecules and intercellular signaling agents in luteinizing hormone-releasing hormone (LHRH)-astroglial interactive network","volume":"2","author":"Marchetti","year":"1997","journal-title":"Front Biosci"},{"key":"B83","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/400_2009_6","article-title":"Neuro-immune crosstalk in CNS diseases","volume":"51","author":"Kerschensteiner","year":"2009","journal-title":"Results Probl Cell Differ"},{"key":"B84","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1210\/edrv-17-1-64","article-title":"Immune-neuro-endocrine interactions: facts and hypotheses","volume":"17","author":"Besedovsky","year":"1996","journal-title":"Endocr Rev"},{"key":"B85","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.bbi.2011.08.007","article-title":"The role of immune dysfunction in the pathophysiology of autism","volume":"26","author":"Onore","year":"2011","journal-title":"Brain Behav Immun"},{"key":"B86","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/sj.mp.4000813","article-title":"Cytokine signals propagate through the brain","volume":"5","author":"Vitkovic","year":"2000","journal-title":"Mol Psychiatry"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.03.086","article-title":"Mast cells, brain inflammation and autism","author":"Theoharides","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/BF01531114","article-title":"Depressed lymphocyte responsiveness in autistic children","volume":"7","author":"Stubbs","year":"1977","journal-title":"J Autism Child Schizophr"},{"key":"B89","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1196\/annals.1381.009","article-title":"Autoantibodies in autism spectrum disorders (ASD)","volume":"1107","author":"Wills","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"B90","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.bbi.2006.08.005","article-title":"Maternal antibrain antibodies in autism","volume":"21","author":"Zimmerman","year":"2007","journal-title":"Brain Behav Immun"},{"key":"B91","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1001\/archneurol.2011.2506","article-title":"Maternal autoantibodies in autism","volume":"69","author":"Braunschweig","year":"2012","journal-title":"Arch Neurol"},{"issue":"Suppl 1","key":"B92","doi-asserted-by":"publisher","first-page":"S90","DOI":"10.1007\/s10875-010-9402-9","article-title":"Adaptive and innate immune responses in autism: rationale for therapeutic use of intravenous immunoglobulin","volume":"30","author":"Gupta","year":"2010","journal-title":"J Clin Immunol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jneuroim.2014.04.011","article-title":"Systemic auto-antibodies in children with autism","volume":"272","author":"Mostafa","year":"2014","journal-title":"J Neuroimmunol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.bbi.2010.08.003","article-title":"Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome","volume":"25","author":"Ashwood","year":"2011","journal-title":"Brain Behav Immun"},{"key":"B95","doi-asserted-by":"publisher","first-page":"e20470","DOI":"10.1371\/journal.pone.0020470","article-title":"Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders","volume":"6","author":"Suzuki","year":"2011","journal-title":"PLoS One"},{"key":"B96","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.neulet.2010.01.033","article-title":"Low-grade endotoxemia in patients with severe autism","volume":"471","author":"Emanuele","year":"2010","journal-title":"Neurosci Lett"},{"key":"B97","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S0165-5728(01)00421-0","article-title":"Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression","volume":"120","author":"Jyonouchi","year":"2001","journal-title":"J Neuroimmunol"},{"issue":"1","key":"B98","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bbi.2009.08.001","article-title":"Differential monocyte responses to TLR ligands in children with autism spectrum disorders","volume":"24","author":"Enstrom","year":"2009","journal-title":"Brain Behav Immun"},{"key":"B99","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.imbio.2010.03.001","article-title":"Expression of inflammatory cytokines, Bcl2 and cathepsin D are altered in lymphoblasts of autistic subjects","volume":"216","author":"Malik","year":"2011","journal-title":"Immunobiology"},{"key":"B100","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1742-2094-8-52","article-title":"IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation","volume":"8","author":"Wei","year":"2011","journal-title":"J Neuroinflammation"},{"key":"B101","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann Neurol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"531518","DOI":"10.1155\/2015\/531518","article-title":"Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders","volume":"2015","author":"Xu","year":"2015","journal-title":"Mediators Inflamm"},{"issue":"1\u20132","key":"B103","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jneuroim.2008.12.002","article-title":"Elevated immune response in the brain of autistic patients","volume":"207","author":"Li","year":"2009","journal-title":"J Neuroimmunol"},{"issue":"1","key":"B104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000048665","article-title":"Activation of the inflammatory response system in autism","volume":"45","author":"Croonenberghs","year":"2002","journal-title":"Neuropsychobiology"},{"key":"B105","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jneuroim.2008.07.006","article-title":"Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes","volume":"204","author":"Ashwood","year":"2008","journal-title":"J Neuroimmunol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.pnpbp.2006.08.020","article-title":"Decreased serum levels of transforming growth factor-beta1 in patients with autism","volume":"31","author":"Okada","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1038\/mp.2013.101","article-title":"Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder","volume":"18","author":"Brimberg","year":"2013","journal-title":"Mol Psychiatry"},{"key":"B108","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000319828","article-title":"Maternal immune activation and autism spectrum disorder: interleukin-6 signaling as a key mechanistic pathway","volume":"18","author":"Parker-Athill","year":"2010","journal-title":"Neurosignals"},{"key":"B109","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.braindev.2013.04.015","article-title":"Autoantibodies against neuronal progenitors in sera from children with autism","volume":"36","author":"Mazur-Kolecka","year":"2014","journal-title":"Brain Dev"},{"key":"B110","doi-asserted-by":"publisher","first-page":"12776","DOI":"10.1073\/pnas.1202556109","article-title":"Modeling an autism risk factor in mice leads to permanent immune dysregulation","volume":"109","author":"Hsiao","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B111","doi-asserted-by":"publisher","first-page":"e240","DOI":"10.1038\/tp.2013.16","article-title":"Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice","volume":"3","author":"Schwartzer","year":"2013","journal-title":"Transl Psychiatry"},{"key":"B112","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/aur.1338","article-title":"Altered peripheral and central inflammatory responses in a mouse model of autism","volume":"7","author":"Lucchina","year":"2014","journal-title":"Autism Res"},{"key":"B113","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.bbi.2008.08.001","article-title":"Altered gene expression and function of peripheral blood natural killer cells in children with autism","volume":"23","author":"Enstrom","year":"2009","journal-title":"Brain Behav Immun"},{"key":"B114","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.molmed.2011.03.001","article-title":"Maternal infection and immune involvement in autism","volume":"17","author":"Patterson","year":"2011","journal-title":"Trends Mol Med"},{"key":"B115","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1542\/peds.2008-2445","article-title":"Association of family history of autoimmune diseases and autism spectrum disorders","volume":"124","author":"Atladottir","year":"2009","journal-title":"Pediatrics"},{"key":"B116","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/jnen\/63.5.461","article-title":"Neuron-binding human monoclonal antibodies support central nervous system neurite extension","volume":"63","author":"Warrington","year":"2004","journal-title":"J Neuropathol Exp Neurol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1385\/JMN:26:1:001","article-title":"2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia","volume":"26","author":"Baslow","year":"2005","journal-title":"J Mol Neurosci"},{"key":"B118","first-page":"463","article-title":"Autoimmunity in autism","volume":"10","author":"Enstrom","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1007\/s10803-013-2017-2","article-title":"Maternal immune-mediated conditions, autism spectrum disorders, and developmental delay","volume":"44","author":"Lyall","year":"2013","journal-title":"J Autism Dev Disord"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1176\/appi.ajp.160.9.1691","article-title":"High blood monocyte counts and neopterin levels in children with autistic disorder","volume":"160","author":"Sweeten","year":"2003","journal-title":"Am J Psychiatry"},{"key":"B121","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bbi.2009.08.001","article-title":"Differential monocyte responses to TLR ligands in children with autism spectrum disorders","volume":"24","author":"Enstrom","year":"2009","journal-title":"Brain Behav Immun"},{"key":"B122","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.pediatrneurol.2007.01.012","article-title":"Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children","volume":"36","author":"Chez","year":"2007","journal-title":"Pediatr Neurol"},{"key":"B123","doi-asserted-by":"publisher","first-page":"4446","DOI":"10.1182\/blood-2002-06-1778","article-title":"Specific involvement of caspases in the differentiation of monocytes into macrophages","volume":"100","author":"Sordet","year":"2002","journal-title":"Blood"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1007\/s10803-011-1373-z","article-title":"The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients","volume":"42","author":"Siniscalco","year":"2012","journal-title":"J Autism Dev Disord"},{"key":"B125","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fendo.2013.00026","article-title":"Stress responsiveness of the hypothalamic-pituitary-adrenal axis: age-related features of the vasopressinergic regulation","volume":"4","author":"Goncharova","year":"2013","journal-title":"Front Endocrinol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1055\/s-0032-1301914","article-title":"Altered neurotrophin, neuropeptide, cytokines and nitric oxide levels in autism","volume":"45","author":"Tostes","year":"2012","journal-title":"Pharmacopsychiatry"},{"key":"B127","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.biopsych.2003.09.001","article-title":"High nitric oxide production in autistic disorder: a possible role for interferon-gamma","volume":"55","author":"Sweeten","year":"2004","journal-title":"Biol Psychiatry"},{"key":"B128","doi-asserted-by":"publisher","first-page":"4000","DOI":"10.2174\/092986712802002572","article-title":"Glutathione-related factors and oxidative stress in autism, a review","volume":"19","author":"Ghanizadeh","year":"2012","journal-title":"Curr Med Chem"},{"key":"B129","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/j.freeradbiomed.2012.03.011","article-title":"Oxidative stress-related biomarkers in autism: systematic review and meta-analyses","volume":"52","author":"Frustaci","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"B130","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s12011-010-8840-9","article-title":"Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation","volume":"143","author":"Meguid","year":"2010","journal-title":"Biol Trace Elem Res"},{"key":"B131","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/sj.npp.1300518","article-title":"Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism","volume":"30","author":"Schneider","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1002\/glia.20564","article-title":"Acute treatment with 17beta-estradiol attenuates astrocyte-astrocyte and astrocyte-neuron communication","volume":"55","author":"Rao","year":"2007","journal-title":"Glia"},{"key":"B133","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.yfrne.2012.08.006","article-title":"The immune system and developmental programming of brain and behavior","volume":"33","author":"Bilbo","year":"2012","journal-title":"Front Neuroendocrinol"},{"key":"B134","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3389\/fncel.2014.00240","article-title":"Never-resting microglia: physiological roles in the healthy brain and pathological implications","volume":"8","author":"Sierra","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"B135","doi-asserted-by":"publisher","first-page":"610343","DOI":"10.1155\/2014\/610343","article-title":"Surveillance, phagocytosis, and inflammation: how never-resting microglia influence adult hippocampal neurogenesis","volume":"2014","author":"Sierra","year":"2014","journal-title":"Neural Plast"},{"key":"B136","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.biopsych.2010.05.024","article-title":"Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism","volume":"68","author":"Morgan","year":"2010","journal-title":"Biol Psychiatry"},{"key":"B137","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1007\/s10803-012-1513-0","article-title":"Microglia in the cerebral cortex in autism","volume":"42","author":"Tetreault","year":"2012","journal-title":"J Autism Dev Disord"},{"key":"B138","doi-asserted-by":"publisher","first-page":"175","DOI":"10.9734\/INDJ\/2014\/7284","article-title":"Interleukin-2 treatment induces an acquired behavioral response pattern (repetitive stereotyped movements) mediated by dopamine D1 and D2 receptors","volume":"2","author":"Patel","year":"2014","journal-title":"Int Neuropsychiatr Dis J"},{"key":"B139","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1517\/13543784.9.3.497","article-title":"Soluble cytokine receptors: novel immunotherapeutic agents","volume":"9","author":"Fernandez-Botran","year":"2000","journal-title":"Expert Opin Investig Drugs"},{"key":"B140","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1096\/fasebj.5.11.1868981","article-title":"Soluble cytokine receptors: their role in immunoregulation","volume":"5","author":"Fernandez-Botran","year":"1991","journal-title":"FASEB J"},{"key":"B141","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1182\/blood.V87.3.847.bloodjournal873847","article-title":"Soluble cytokine receptors","volume":"87","author":"Heaney","year":"1996","journal-title":"Blood"},{"key":"B142","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s10555-009-9198-3","article-title":"Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer","volume":"28","author":"Knowles","year":"2009","journal-title":"Cancer Metastasis Rev"},{"key":"B143","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3978\/j.issn.2305-5839.2015.01.26","article-title":"MicroRNA and MET in lung cancer","volume":"3","author":"Brighenti","year":"2015","journal-title":"Ann Transl Med"},{"key":"B144","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.molimm.2014.02.004","article-title":"Regulation of T lymphocyte activation by microRNA-21","volume":"59","author":"Wang","year":"2014","journal-title":"Mol Immunol"},{"key":"B145","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fpsyt.2012.00039","article-title":"The emerging role of microRNAs in schizophrenia and autism spectrum disorders","volume":"3","author":"Mellios","year":"2012","journal-title":"Front Psychiatry"},{"key":"B146","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/2040-2392-5-40","article-title":"Serum microRNA profiles in children with autism","volume":"5","author":"Mundalil Vasu","year":"2014","journal-title":"Mol Autism"},{"key":"B147","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.nbd.2015.05.006","article-title":"Elevated microRNA-181c and microRNA-30d levels in the enlarged amygdala of the valproic acid rat model of autism","volume":"80","author":"Olde Loohuis","year":"2015","journal-title":"Neurobiol Dis"},{"key":"B148","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jneuroim.2005.12.007","article-title":"Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms","volume":"173","author":"Ashwood","year":"2006","journal-title":"J Neuroimmunol"},{"key":"B149","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s10875-004-6241-6","article-title":"Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10","volume":"24","author":"Ashwood","year":"2004","journal-title":"J Clin Immunol"},{"key":"B150","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.bbadis.2010.12.017","article-title":"Mast cell activation and autism","volume":"1822","author":"Theoharides","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"B151","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.bbi.2008.12.005","article-title":"Increased IgG4 levels in children with autism disorder","volume":"23","author":"Enstrom","year":"2009","journal-title":"Brain Behav Immun"},{"key":"B152","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/labinvest.3700281","article-title":"Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium","volume":"85","author":"Coisne","year":"2005","journal-title":"Lab Invest"},{"key":"B153","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/ni1551","article-title":"Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system","volume":"9","author":"Cayrol","year":"2008","journal-title":"Nat Immunol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.neulet.2014.09.039","article-title":"Resveratrol prevents social deficits in animal model of autism induced by valproic acid","volume":"583","author":"Bambini-Junior","year":"2014","journal-title":"Neurosci Lett"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.4161\/cc.7.8.5740","article-title":"Resveratrol: a multitargeted agent for age-associated chronic diseases","volume":"7","author":"Harikumar","year":"2008","journal-title":"Cell Cycle"},{"issue":"3","key":"B156","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jvs.2008.04.007","article-title":"Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors","volume":"48","author":"Dong","year":"2008","journal-title":"J Vasc Surg"},{"issue":"6","key":"B157","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0024-3205(02)01691-0","article-title":"Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats","volume":"71","author":"Sinha","year":"2002","journal-title":"Life Sci"},{"key":"B158","doi-asserted-by":"publisher","first-page":"e19881","DOI":"10.1371\/journal.pone.0019881","article-title":"What is new for an old molecule? Systematic review and recommendations on the use of resveratrol","volume":"6","author":"Vang","year":"2011","journal-title":"PLoS One"},{"key":"B159","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.psyneuen.2008.02.011","article-title":"Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid","volume":"33","author":"Schneider","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"B160","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1126\/science.1255679","article-title":"Comment on \u201coxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring\u201d","volume":"346","author":"Bambini-Junior","year":"2014","journal-title":"Science"},{"key":"B161","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.brainres.2011.06.015","article-title":"Animal model of autism induced by prenatal exposure to valproate: behavioral changes and liver parameters","volume":"1408","author":"Bambini-Junior","year":"2011","journal-title":"Brain Res"},{"key":"B162","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.intimp.2010.07.011","article-title":"Regulatory role of resveratrol on Th17 in autoimmune disease","volume":"11","author":"Petro","year":"2011","journal-title":"Int Immunopharmacol"},{"key":"B163","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1124\/mol.107.038984","article-title":"Resveratrol (trans-3,5,4\u2019-trihydroxystilbene) ameliorates experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptor","volume":"72","author":"Singh","year":"2007","journal-title":"Mol Pharmacol"},{"key":"B164","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0149-7634(96)00018-8","article-title":"Neurobehavioral alterations in autoimmune mice","volume":"21","author":"Sakic","year":"1997","journal-title":"Neurosci Biobehav Rev"},{"key":"B165","doi-asserted-by":"publisher","first-page":"12102","DOI":"10.1073\/pnas.96.21.12102","article-title":"An infection-based model of neurodevelopmental damage","volume":"96","author":"Hornig","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B166","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1523\/JNEUROSCI.23-01-00297.2003","article-title":"Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring","volume":"23","author":"Shi","year":"2003","journal-title":"J Neurosci"},{"key":"B167","doi-asserted-by":"publisher","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J Neurosci"},{"key":"B168","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jneuroim.2009.03.011","article-title":"Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: a pregnant dam mouse model","volume":"211","author":"Singer","year":"2009","journal-title":"J Neuroimmunol"},{"key":"B169","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.bbr.2010.12.023","article-title":"Brain enlargement and increased behavioral and cytokine reactivity in infant monkeys following acute prenatal endotoxemia","volume":"219","author":"Willette","year":"2011","journal-title":"Behav Brain Res"},{"key":"B170","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.bbi.2012.01.011","article-title":"Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism","volume":"26","author":"Malkova","year":"2012","journal-title":"Brain Behav Immun"},{"key":"B171","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.biopsych.2013.06.025","article-title":"Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring","volume":"75","author":"Bauman","year":"2014","journal-title":"Biol Psychiatry"},{"key":"B172","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.bbr.2014.02.045","article-title":"Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice","volume":"266","author":"Camacho","year":"2014","journal-title":"Behav Brain Res"},{"key":"B173","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.bbi.2014.02.007","article-title":"Maternal immune activation leads to activated inflammatory macrophages in offspring","volume":"38","author":"Onore","year":"2014","journal-title":"Brain Behav Immun"},{"key":"B174","doi-asserted-by":"publisher","first-page":"e104433","DOI":"10.1371\/journal.pone.0104433","article-title":"Gender-dependent effects of maternal immune activation on the behavior of mouse offspring","volume":"9","author":"Xuan","year":"2014","journal-title":"PLoS One"},{"key":"B175","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1080\/15287394.2015.1010466","article-title":"Altered expression levels of neurodevelopmental proteins in fetal brains of BTBR T+tf\/J mice with autism-like behavioral characteristics","volume":"78","author":"Hwang","year":"2015","journal-title":"J Toxicol Environ Health A"},{"key":"B176","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/1547691X.2015.1014581","article-title":"Aberrant IgG isotype generation in mice with abnormal behaviors","author":"Kim","year":"2015","journal-title":"J Immunotoxicol"},{"key":"B177","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/aji.12364","article-title":"Maternal lipopolysaccharide exposure promotes immunological functional changes in adult offspring CD4 T cells","volume":"73","author":"Luan","year":"2015","journal-title":"Am J Reprod Immunol"},{"key":"B178","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.bbi.2010.12.017","article-title":"Activation of the maternal immune system induces endocrine changes in the placenta via IL-6","volume":"25","author":"Hsiao","year":"2011","journal-title":"Brain Behav Immun"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T03:57:20Z","timestamp":1599537440000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fpsyt.2015.00121\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,9]]},"references-count":178,"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2015.00121","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,9]]}}}