{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:26:32Z","timestamp":1773300392208,"version":"3.50.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671057"],"award-info":[{"award-number":["81671057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371485"],"award-info":[{"award-number":["81371485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"DOI":"10.3389\/fpsyt.2018.00399","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T04:30:28Z","timestamp":1535689828000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Hydrogen Sulfide Antagonizes Chronic Restraint Stress-Induced Depressive-Like Behaviors via Upregulation of Adiponectin"],"prefix":"10.3389","volume":"9","author":[{"given":"Qing","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Qing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/nm0205-116","article-title":"Stressed and depressed","volume":"11","author":"Akil","year":"2005","journal-title":"Nat Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1146\/annurev.psych.48.1.191","article-title":"The effects of stressful life events on depression","volume":"48","author":"Kessler","year":"1997","journal-title":"Ann Rev Psychol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pnpbp.2012.05.018","article-title":"Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex","volume":"39","author":"Chiba","year":"2012","journal-title":"Prog Neuro Psychopharmacol Biol Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","first-page":"S112","DOI":"10.1590\/1516-4446-2013-1098","article-title":"Animal models as tools to study the pathophysiology of depression","volume":"35","author":"Abelaira","year":"2013","journal-title":"Rev Bras Psiquiatr."},{"key":"B5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0149-7634(94)90027-2","article-title":"Restraint stress in biomedical research: an update","volume":"18","author":"Glavin","year":"1994","journal-title":"Neurosci Biobehav Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.pbb.2006.06.005","article-title":"Animal models of depression in drug discovery: a historical perspective","volume":"84","author":"McArthur","year":"2006","journal-title":"Pharmacol Biochem Behav."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.neuint.2009.08.008","article-title":"Hydrogen sulfide: a novel signaling molecule in the central nervous system","volume":"56","author":"Tan","year":"2010","journal-title":"Neurochem Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1097\/fbp.0000000000000143","article-title":"Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in streptozotocin-induced diabetic rats through inhibition of hippocampal oxidative stress","volume":"26","author":"Tang","year":"2015","journal-title":"Behav Pharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1038\/nm.2886","article-title":"Decreased expression of synapse-related genes and loss of synapses in major depressive disorder","volume":"18","author":"Kang","year":"2012","journal-title":"Nat Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s12264-015-1548-2","article-title":"Molecular network of neuronal autophagy in the pathophysiology and treatment of depression","volume":"31","author":"Jia","year":"2015","journal-title":"Neurosci Bull."},{"key":"B11","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"B12","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.biopsych.2010.12.015","article-title":"Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure","volume":"69","author":"Li","year":"2011","journal-title":"Biol Psychiatry"},{"key":"B13","doi-asserted-by":"crossref","first-page":"10697","DOI":"10.1074\/jbc.271.18.10697","article-title":"AdipoQ is a novel adipose-specific gene dysregulated in obesity","volume":"271","author":"Hu","year":"1996","journal-title":"J Biol Chem."},{"key":"B14","doi-asserted-by":"crossref","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","article-title":"A novel serum protein similar to C1q, produced exclusively in adipocytes","volume":"270","author":"Scherer","year":"1995","journal-title":"J Biol Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1210\/jc.2006-1841","article-title":"Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus","volume":"92","author":"Kos","year":"2007","journal-title":"J Clin Endocrinol Metabol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"15810","DOI":"10.1073\/pnas.1415219111","article-title":"Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin","volume":"111","author":"Yau","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B17","doi-asserted-by":"publisher","first-page":"44913","DOI":"10.1074\/jbc.M111.310052","article-title":"Adiponectin stimulates proliferation of adult hippocampal neural stem\/progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)\/glycogen synthase kinase 3beta (GSK-3beta)\/beta-catenin signaling cascade","volume":"286","author":"Zhang","year":"2011","journal-title":"J Biol Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1476-5381.2011.01560.x","article-title":"Adiponectin receptor signalling in the brain","volume":"165","author":"Thundyil","year":"2012","journal-title":"Br J Pharmacol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"12248","DOI":"10.1073\/pnas.1202835109","article-title":"Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity","volume":"109","author":"Liu","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/mp.2016.225","article-title":"Role of the adipose PPARgamma-adiponectin axis in susceptibility to stress and depression\/anxiety-related behaviors","volume":"22","author":"Guo","year":"2017","journal-title":"Mol Psychiatry"},{"key":"B21","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/ijo.2016.5","article-title":"Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity","volume":"40","author":"Slutsky","year":"2016","journal-title":"Int J Obes."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e21964","DOI":"10.1002\/syn.21964","article-title":"The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus","volume":"71","author":"Weisz","year":"2017","journal-title":"Synapse"},{"key":"B23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"B24","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/BF00181937","article-title":"The effects of chronic antidepressant treatment in an animal model of anxiety","volume":"95","author":"Bodnoff","year":"1988","journal-title":"Psychopharmacology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.euroneuro.2010.06.019","article-title":"Chronic all-trans retinoic acid administration induced hyperactivity of HPA axis and behavioral changes in young rats","volume":"20","author":"Cai","year":"2010","journal-title":"Eur Neuropsychopharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2015.04.004","article-title":"Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice","volume":"288","author":"Huang","year":"2015","journal-title":"Behav Brain Res."},{"key":"B27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1515\/REVNEURO.2008.19.6.395","article-title":"Chronic stress-induced hippocampal vulnerability: the glucocorticoid vulnerability hypothesis","volume":"19","author":"Conrad","year":"2008","journal-title":"Rev Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.neuint.2007.05.016","article-title":"Hydrogen sulfide: neurochemistry and neurobiology","volume":"52","author":"Qu","year":"2008","journal-title":"Neurochem Int."},{"key":"B29","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1089\/ars.2010.3517","article-title":"Hydrogen sulfide: neurophysiology and neuropathology","volume":"15","author":"Hu","year":"2011","journal-title":"Antioxi Redox Signal."},{"key":"B30","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/jnr.10443","article-title":"Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine","volume":"70","author":"Ando","year":"2002","journal-title":"J Neurosci Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1161\/circulationaha.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"B32","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/aps.2013.197","article-title":"Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway","volume":"35","author":"Wei","year":"2014","journal-title":"Acta Pharmacol Sin."},{"key":"B33","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1083\/jcb.96.5.1337","article-title":"Synapsin I (protein I) a nerve terminal-specific phosphoprotein","volume":"96","author":"De Camilli","year":"1983","journal-title":"J Cell Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1038\/sj.npp.1301386","article-title":"Mifepristone repairs region-dependent alteration of synapsin I in hippocampus in rat model of depression","volume":"32","author":"Wu","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.neuroscience.2006.04.060","article-title":"Hippocampal synapsin I, growth-associated protein-43, and microtubule-associated protein-2 immunoreactivity in learned helplessness rats and antidepressant-treated rats","volume":"141","author":"Iwata","year":"2006","journal-title":"Neuroscience"},{"key":"B36","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.bbr.2016.06.057","article-title":"The antidepressant-like effect of alarin is related to TrkB-mTOR signaling and synaptic plasticity","volume":"313","author":"Zhuang","year":"2016","journal-title":"Behav Brain Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.biopsych.2015.12.025","article-title":"Sex differences in effects of ketamine on behavior, spine density, and synaptic proteins in socially isolated rats","volume":"80","author":"Sarkar","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"B38","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/nature05293","article-title":"Cell death in the nervous system","volume":"443","author":"Bredesen","year":"2006","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00403-014-1521-3","article-title":"Oxidative stress and substance P mediate psychological stress-induced autophagy and delay of hair growth in mice","volume":"307","author":"Wang","year":"2015","journal-title":"Arch Dermatol Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1176\/appi.ajp.2011.11010128","article-title":"Monitoring ketamine treatment response in a depressed patient via peripheral mammalian target of rapamycin activation","volume":"168","author":"Denk","year":"2011","journal-title":"Am J Psychiatry"},{"key":"B41","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.febslet.2007.11.070","article-title":"The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS","volume":"582","author":"Kadowaki","year":"2008","journal-title":"FEBS Lett."},{"key":"B42","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.neulet.2006.08.043","article-title":"Decreased plasma adiponectin concentration in major depression","volume":"407","author":"Leo","year":"2006","journal-title":"Neuroscience Lett."},{"key":"B43","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/mp.2016.36","article-title":"The role of adipokines in the rapid antidepressant effects of ketamine","volume":"22","author":"Machado-Vieira","year":"2017","journal-title":"Mol Psychiatry"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2018.00399\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T04:30:30Z","timestamp":1535689830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2018.00399\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,31]]},"references-count":43,"alternative-id":["10.3389\/fpsyt.2018.00399"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2018.00399","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,31]]},"article-number":"399"}}