{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:33:01Z","timestamp":1791952381166,"version":"4.3.4"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"DOI":"10.3389\/fpsyt.2018.00469","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T05:24:47Z","timestamp":1538025887000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Early-Onset Alzheimer Disease (EOAD) With Aphasia: A Case Report"],"prefix":"10.3389","volume":"9","author":[{"given":"Marcus Kiiti","family":"Borges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Nakayama","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Maria","family":"Biella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala\u00edse","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivan","family":"Mauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Aprahamian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF00868807","article-title":"Visual assessment of medial temporal lobe atrophy on magnetic ressonance imaging: interobserver reliability","volume":"242","author":"Scheltens","year":"1995","journal-title":"J Neurol"},{"key":"B2","article-title":"Pathophysiology: a neurochemical perspective","volume-title":"Clinical Diagnosis and Management of Alzheimer's Disease","author":"B\u00e9langer","year":"2007"},{"key":"B3","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1126\/science.1411576","article-title":"Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14","volume":"258","author":"Schellenberg","year":"1992","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1126\/science.3810169","article-title":"Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease","volume":"235","author":"Goldgaber","year":"1987","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/35014735","article-title":"Preselinin-1 mutations on Alzheimer's disease","volume":"405","author":"Russo","year":"2000","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jalz.2018.02.001","article-title":"2018 Alzheimer's disease facts and figures","volume":"14","author":"Alzheimer's","year":"2018","journal-title":"Alzheimers Dement"},{"key":"B7","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning a gene bearing missense mutations in early-onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","article-title":"Role of genes and environments for explaining Alzheimer disease","volume":"63","author":"Gatz","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2147\/CIA.S51571","article-title":"The genetics of Alzheimer's disease","volume":"9","author":"Bagyinszky","year":"2014","journal-title":"Clin Interv Aging"},{"key":"B10","unstructured":"HoraitisO\n            TalbotCCJr\n            PhommarinhM\n            PhillipsKM\n          Data from: Alzheimer Disease & FrontoTemporal Dementia Mutation Database (AD&FTDMD)2007"},{"key":"B11","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1097\/GIM.0b013e31821d69b8","article-title":"Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the american college of medical genetics and the National Society of Genetic Counselors","volume":"13","author":"Goldman","year":"2011","journal-title":"Genet Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.neuropsychologia.2011.11.021","article-title":"Wernicke's aphasia reflects a combination of acoustic-phonological and semantic control deficits: a case-series comparison of Wernicke's aphasia, semantic dementia and semantic aphasia","volume":"50","author":"Robson","year":"2012","journal-title":"Neuropsychologia"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1212\/WNL.0b013e3181c0d427","article-title":"Clinical syndromes associated with posterior atrophy: early age at onset AD spectrum","volume":"73","author":"Migliaccio","year":"2009","journal-title":"Neurology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e62471","DOI":"10.1371\/journal.pone.0062471","article-title":"FDG PET and MRI in logopenic primary progressive aphasia versus dementia of the Alzheimer's type","volume":"8","author":"Madhavan","year":"2013","journal-title":"PLoS ONE"},{"key":"B15","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.jalz.2011.09.225","article-title":"Global gray matter changes in posterior cortical atrophy: a serial imaging study","volume":"8","author":"Lehmann","year":"2012","journal-title":"Alzheimers Dement"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e102995","DOI":"10.1371\/journal.pone.0102995","article-title":"Widespread disruption of functional brain organization in early-onset alzheimer's disease","volume":"9","author":"Adriaanse","year":"2014","journal-title":"PLoS ONE"},{"key":"B17","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1212\/WNL.0b013e31825dce28","article-title":"Early-onset alzheimer disease clinical variants: multivariate analyses of cortical thickness","volume":"79","author":"Ridgway","year":"2012","journal-title":"Neurology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1002\/hbm.22927","article-title":"Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease","volume":"36","author":"Ossenkoppele","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"B19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/brain\/123.3.484","article-title":"Atypical and typical presentations of Alzheimer's disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases","volume":"123","author":"Galton","year":"2000","journal-title":"Brain"},{"key":"B20","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/NEN.0b013e31824b211b","article-title":"Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010","volume":"71","author":"Beach","year":"2012","journal-title":"J Neuropathol Exp Neurol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/S1474-4422(15)00258-6","article-title":"Nursing home replacement in the Donepezil and Memantine to severe Alzheimer's Disease: DOMINO trial: secondary and post-hoc analyses","volume":"14","author":"Howard","year":"2015","journal-title":"Lancet Neurol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1056\/NEJMoa1106668","article-title":"Donepezil and Memantine for moderate-to- severe Alzheimer's disease","volume":"366","author":"Howard","year":"2012","journal-title":"N Engl J Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/gps.4583","article-title":"Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial)","volume":"32","author":"Knapp","year":"2017","journal-title":"Int J Geriatr Psychiatry"},{"key":"B24","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/0269881116680924","article-title":"Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology","volume":"31","author":"O'brien","year":"2017","journal-title":"J Psychopharmacol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/gps.2200","article-title":"Expert opinion on the management of behavioural and psychological symptoms of dementia (BPSD) and investigation into prescribing practice","volume":"24","author":"Bishara","year":"2009","journal-title":"Int J Geriatr Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1176\/appi.ajp.2011.11030347","article-title":"Risk of mortality among individual antipsychotics in patients with dementia","volume":"169","author":"Kales","year":"2012","journal-title":"Am J Psychiatry"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2018.00469\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T05:25:47Z","timestamp":1538025947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2018.00469\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":26,"alternative-id":["10.3389\/fpsyt.2018.00469"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2018.00469","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,27]]},"article-number":"469"}}