{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:05Z","timestamp":1790107985624,"version":"4.0.1"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"DOI":"10.3389\/fpsyt.2018.00501","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T07:00:16Z","timestamp":1539673216000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Hydrogen Sulfide Affects Radical Formation in the Hippocampus of LPS Treated Rats and the Effect of Antipsychotics on Hydrogen Sulfide Forming Enzymes in Human Cell Lines"],"prefix":"10.3389","volume":"9","author":[{"given":"Olaf","family":"Sommer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana L.","family":"Aug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas J.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Heiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Vedder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Willi","family":"Clement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00406-008-2012-3","article-title":"A psychoneuroimmunological perspective to Emil Kraepelins dichotomy: schizophrenia and major depression as inflammatory CNS disorders","volume":"258","author":"M\u00fcller","year":"2008","journal-title":"Eur Arch Psychiatry Clin Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1055\/s-0033-1335253","article-title":"Schizophrenia\u2013a mild encephalitis?","volume":"81","author":"Bechter","year":"2013","journal-title":"Fortschr Neurol Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00406-014-0562-0","article-title":"Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses?","volume":"265","author":"Busse","year":"2015","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/S2215-0366(16)30262-0","article-title":"The association between first-episode psychosis and abnormal glycaemic control: systematic review and meta-analysis","volume":"3","author":"Perry","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.4088\/JCP.15m10467","article-title":"Effect of aripiprazole lauroxil on metabolic and endocrine profiles and related safety considerations among patients with acute schizophrenia","volume":"77","author":"Nasrallah","year":"2016","journal-title":"J Clin Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.psyneuen.2016.07.209","article-title":"\u03b2-hydroxybutyrate, pyruvate and metabolic profiles in patients with schizophrenia: a case control study","volume":"73","author":"Huang","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2202-12-13","article-title":"Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls","volume":"12","author":"Reale","year":"2011","journal-title":"BMC Neurosci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.biopsych.2008.03.004","article-title":"N-acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial","volume":"64","author":"Berk","year":"2008","journal-title":"Biol Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.biopsych.2008.04.022","article-title":"N-acetyl cysteine for depressive symptoms in bipolar disorder-a double-blind randomized placebo-controlled trial","volume":"64","author":"Berk","year":"2008","journal-title":"Biol Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1042\/BST0351119","article-title":"Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase","volume":"35","author":"Brown","year":"2007","journal-title":"Biochem Soc Trans."},{"key":"B11","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/pcn.12040","article-title":"Is T-helper type 2 shift schizophrenia-specific? Primary results from a comparison of related psychiatric disorders and healthy controls","volume":"67","author":"Chiang","year":"2013","journal-title":"Psychiatry Clin Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1475-2891-7-29","article-title":"The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk\/benefit profile","volume":"7","author":"Brambilla","year":"2008","journal-title":"Nutr J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jpsychires.2016.09.017","article-title":"Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs","volume":"84","author":"da","year":"2016","journal-title":"J Psychiatr Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/schbul\/sbw129","article-title":"Redox dysregulation in schizophrenia revealed by in vivo NAD+\/NADH measurement","volume":"43","author":"Kim","year":"2016","journal-title":"Schizophr Bull"},{"key":"B15","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/npp.2016.211","article-title":"Towards an immunophenotype of schizophrenia: progress, potential mechanisms, and future directions","volume":"42","author":"Miller","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cytogfr.2016.08.004","article-title":"Growth factors as clinical biomarkers of prognosis and diagnosis in psychiatric disorders","volume":"32","author":"Galvez-Contreras","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"B17","first-page":"162","article-title":"Evaluation of the cortisol concentrations in patients with schizophrenia","volume":"28","author":"Tobolska","year":"2016","journal-title":"Psychiatr Danub"},{"key":"B18","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.psyneuen.2012.06.002","article-title":"Blunted cortisol awakening response in men with first episode psychosis: relationship to parental bonding","volume":"38","author":"Pruessner","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.neuroscience.2012.12.017","article-title":"Stress and neurodevelopmental processes in the emergence of psychosis","volume":"249","author":"Holtzman","year":"2013","journal-title":"Neuroscience"},{"key":"B20","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s002130000381","article-title":"Selective impairments in the stress response in schizophrenic patients","volume":"149","author":"Jansen","year":"2000","journal-title":"Psychopharmacology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.psyneuen.2012.12.025","article-title":"A systematic review of the activity of the hypothalamic-pituitary-adrenal axis in first episode psychosis","volume":"38","author":"Borges","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jchemneu.2016.07.010","article-title":"Crosstalk between insulin and dopamine signaling: a basis for the metabolic effects of antipsychotic drugs","volume":"4","author":"Nash","year":"2016","journal-title":"J Chem Neuroanat"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s10802-015-0103-y","article-title":"Stressful life events prior to depression onset and the cortisol response to stress in youth with first onset versus recurrent depression","volume":"44","author":"Mazurka","year":"2016","journal-title":"J Abnorm Child Psychol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"266","DOI":"10.2174\/1871527315666161122144659","article-title":"How immune-inflammatory processes link CNS and psychiatric disorders: classification and treatment implications","volume":"16","author":"Anderson","year":"2017","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"B25","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.psc.2005.01.005","article-title":"Hypothalamic-pituitary-adrenal axis and bipolar disorder","volume":"28","author":"Daban","year":"2005","journal-title":"Psychiatr Clin North Am"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-018-0908-0","article-title":"Chronic low-grade peripheral inflammation is associated with ultra resistant schizophrenia","author":"Fond","year":"2018","journal-title":"Eur Arch Psychiatry Clin Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1093\/oxfordjournals.jbchem.a133393","article-title":"The mechanism of the L-cystine cleavage reaction cat- alyzed by rat liver gamma-cystathionase","volume":"89","author":"Yamanishi","year":"1981","journal-title":"J Biochem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"7606","DOI":"10.1073\/pnas.1321232111","article-title":"Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling","volume":"111","author":"Ida","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B29","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1089\/ars.2013.5339","article-title":"Enzymology of H2S biogenesis, decay and signaling","volume":"20","author":"Kabil","year":"2014","journal-title":"Anti-oxid Redox Signal."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1089\/ars.2012.5031","article-title":"Regulation of mercaptopyruvate sulfurtransferase activity via intrasubunit and intersubunit redox-sensing switches","volume":"19","author":"Nagahara","year":"2013","journal-title":"Antioxid Redox Signal."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/bs.mie.2014.11.036","article-title":"Mechanistic chemical perspective of hydrogen sulfide signaling","volume":"554","author":"Nagy","year":"2015","journal-title":"Methods Enzymol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J Neurosci"},{"key":"B33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-3-319-18144-8_3","article-title":"Physiological roles of hydrogen sulfide and polysulfides","volume":"230","author":"Kimura","year":"2015","journal-title":"Handb Exp Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.abb.2016.09.018","article-title":"Biological chemistry of hydrogen sulfide and persulfides","volume":"617","author":"Cuevasanta","year":"2016","journal-title":"Arch Biochem Biophys"},{"key":"B35","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.pharep.2015.01.005","article-title":"Hydrogen sulfide in pharmacology and medicine\u2013an update","volume":"67","author":"Be\u0142towski","year":"2015","journal-title":"Pharmacol Rep"},{"key":"B36","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1515\/revneuro-2014-0051","article-title":"Neuroprotective effects of hydrogen sulfide and the underlying signaling pathways","volume":"26","author":"Chen","year":"2015","journal-title":"Rev Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.niox.2014.05.014","article-title":"Hydrogen sulfide and nitric oxide interactions in inflammation","volume":"41","author":"Lo","year":"2014","journal-title":"Nitric Oxide"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","article-title":"Hydrogen sulfide protects neurons from oxidative stress","volume":"18","author":"Kimura","year":"2004","journal-title":"FASEB J"},{"key":"B39","doi-asserted-by":"publisher","first-page":"8360738","DOI":"10.1155\/2016\/8360738","article-title":"AP39, a mitochondria-targeted hydrogen sulfide donor, supports cellular bioenergetics and protects against Alzheimer's disease by preserving mitochondrial function in APP\/PS1 mice and neurons","volume":"2016","author":"Zhao","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1038\/ncomms2623","article-title":"Sulfhydration mediates neuroprotective actions of parkin","volume":"4","author":"Vandiver","year":"2013","journal-title":"Nat Commun"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coph.2015.08.005","article-title":"Gaseous mediator-based anti-inflammatory drugs","volume":"25","author":"Sulaieva","year":"2015","journal-title":"Curr Opin Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.phrs.2016.10.019","article-title":"ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo","volume":"114","author":"De","year":"2016","journal-title":"Pharmacol Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/sj.bjp.0706367","article-title":"Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia","volume":"146","author":"Collin","year":"2005","journal-title":"Br J Pharmacol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J"},{"key":"B45","doi-asserted-by":"publisher","first-page":"L960","DOI":"10.1152\/ajplung.00388.2006","article-title":"Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB","volume":"292","author":"Zhang","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.4049\/jimmunol.181.6.4320","article-title":"Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis","volume":"181","author":"Zhang","year":"2008","journal-title":"J Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.rvsc.2012.10.009","article-title":"Endogenous hydrogen sulfide formation mediates the liver damage in endotoxemic rats","volume":"94","author":"Yan","year":"2013","journal-title":"Res Vet Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.3892\/ijmm.2016.2771","article-title":"Effect of endotoxemia in mice genetically deficient in cystathionine-\u03b3-lyase, cystathionine-\u03b2-synthase or 3-mercaptopyruvate sulfurtransferase","volume":"38","author":"Ahmad","year":"2016","journal-title":"Int J Mol Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1089\/ars.2013.5354","article-title":"Cystathionine \u03b3-lyase deficiency protects mice from galactosamine\/lipopolysaccharide-induced acute liver failure","volume":"20","author":"Shirozu","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"B50","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s12038-016-9598-9","article-title":"Cystathionine-\u03b3-lyase gene silencing with siRNA in monocytes\/ macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse","volume":"41","author":"Badiei","year":"2016","journal-title":"J Biosci"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1007\/s00213-018-4923-7","article-title":"Decreased plasma levels of gasotransmitter hydrogen sulfide in patients with schizophrenia: correlation with psychopathology and cognition","volume":"235","author":"Xiong","year":"2018","journal-title":"Psychopharmacology"},{"key":"B52","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1982"},{"key":"B53","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0074-7742(05)71011-4","article-title":"Effects of secretin on extracellular GABA and other amino acid concentrations in the rat hippocampus","volume":"71","author":"Clement","year":"2005","journal-title":"Int Rev Neurobiol"},{"key":"B54","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/bbrc.1998.8936","article-title":"Detection of superoxide radicals and peroxynitrite by 1-hydroxy-4-phosphonooxy-2,2,6,6-tetramethylpiperidine: quantification of extracellular superoxide radicals formation","volume":"248","author":"Dikalov","year":"1998","journal-title":"Biochem Biophys Res Commun."},{"key":"B55","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/j.bcp.2006.12.012","article-title":"Production of extracellular superoxide by human lymphoblast cell lines: comparison of electron spin resonance techniques and cytochrome C reduction assay","volume":"73","author":"Dikalov","year":"2007","journal-title":"Biochem Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00702-009-0327-5","article-title":"Lipopolysaccharide-induced radical formation in the striatum is abolished in Nox2 gp91phox-deficient mice","volume":"117","author":"Clement","year":"2010","journal-title":"J Neural Transm."},{"key":"B57","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1111\/j.1471-4159.2007.05191.x","article-title":"Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: and in vivo microdialysis study","volume":"105","author":"Vazquez","year":"2008","journal-title":"J Neurochem."},{"key":"B58","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.jpsychires.2008.11.005","article-title":"Impact of haloperidol and quetiapine on the expression of genes encoding antioxidant enzymes in human neuroblastoma SH-SY5Y cells","volume":"43","author":"Schmidt","year":"2009","journal-title":"J Psychiatr Res"},{"key":"B59","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/15287399009531436","article-title":"Exposure to low levels of hydrogen sulfide elevates circulating glucose in maternal rats","volume":"31","author":"Hayden","year":"1990","journal-title":"J Toxicol Environ Health"},{"key":"B60","doi-asserted-by":"publisher","first-page":"3285074","DOI":"10.1155\/2016\/3285074","article-title":"Implications of hydrogen sulfide in glucose regulation: how H2S can alter glucose homeostasis through metabolic hormones","volume":"2016","author":"Pichette","year":"2016","journal-title":"Oxid Med Cell Longev."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3892\/ijmm.2017.3330","article-title":"Exogenous hydrogen sulfide protects human umbilical vein endothelial cells against high glucose-induced injury by inhibiting the necroptosis pathway","volume":"41","author":"Lin","year":"2017","journal-title":"Int J Mol Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0306-4492(82)90034-X","article-title":"Physiological and biochemical effects of acute exposure of fish to hydrogen sulfide","volume":"71","author":"Torrans","year":"1982","journal-title":"Comp Biochem Physiol C"},{"key":"B63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1152\/jn.1993.70.1.81","article-title":"The actions of hydrogen sulfide on dorsal raphe serotonergic neurons in vitro","volume":"70","author":"Kombian","year":"1993","journal-title":"J Neurophysiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e64495","DOI":"10.1371\/journal.pone.0064495","article-title":"Depolarizing actions of hydrogen sulfide on hypothalamic paraventricular nucleus neurons","volume":"8","author":"Khademullah","year":"2013","journal-title":"PLoS ONE"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e105772","DOI":"10.1371\/journal.pone.0105772","article-title":"Hydrogen Sulfide regulates cardiovascular function by influencing the excitability of subfornical organ neurons","volume":"9","author":"Kuksis","year":"2014","journal-title":"PLoS ONE"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e46917","DOI":"10.1371\/journal.pone.0046917","article-title":"TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide","volume":"7","author":"Andersson","year":"2012","journal-title":"PLoS ONE"},{"key":"B67","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jpsychires.2014.01.017","article-title":"Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders","volume":"52","author":"Steen","year":"2014","journal-title":"J Psychiatr Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.psyneuen.2016.03.010","article-title":"Perceived stress and hair cortisol: differences in bipolar disorder and schizophrenia","volume":"69","author":"Streit","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/S0006-3223(00)01052-0","article-title":"Cognitive functioning, cortisol release, and symptom severity in patients with schizophrenia","volume":"48","author":"Walder","year":"2000","journal-title":"Biol Psychiatry"},{"key":"B70","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.biopsych.2013.02.016","article-title":"Cortisol levels and risk for psychosis: initial findings from the North American prodrome longitudinal study","volume":"74","author":"Walker","year":"2013","journal-title":"Biol Psychiatry"},{"key":"B71","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00213-005-0279-x","article-title":"The atypical antipsychotics olanzapine and quetiapine, but not haloperidol, reduce ACTH and cortisol secretion in healthy subjects","volume":"185","author":"Cohrs","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1038\/sj.npp.1300756","article-title":"Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: association with psychopathology and response to antipsychotics","volume":"30","author":"Zhang","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/sj.npp.1300884","article-title":"Clinical and biological effects of mifepristone treatment for psychotic depression","volume":"31","author":"Flores","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"B74","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1089\/ars.2013.5682","article-title":"CBS and CSE are critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex","volume":"21","author":"Wang","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"B75","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1749-6632.2000.tb05429.x","article-title":"Gaseous neuromodulators in the control of neuroendocrine stress axis","volume":"917","author":"Navarra","year":"2000","journal-title":"Ann NY Acad Sci USA."},{"key":"B76","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.phrs.2016.07.026","article-title":"H2S-induced thiol-based redox switches: biochemistry and functional relevance for inflammatory diseases","volume":"111","author":"Longen","year":"2016","journal-title":"Pharmacol Res"},{"key":"B77","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11010-015-2364-8","article-title":"Hydrogen sulfide decreases the plasma lipid peroxidation induced by homocysteine and its thiolactone","volume":"404","author":"Olas","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/ars.2008.2282","article-title":"Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria","volume":"12","author":"Kimura","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"B79","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1042\/BJ20131434","article-title":"The cystathionine Y-lyase\/hydrogen sulfide system maintains cellular glutathione status","volume":"3","author":"Lee","year":"2014","journal-title":"Biochem J"},{"key":"B80","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen sulfide-linked sulfhydration of NF-\u03baB mediates its antiapoptotic actions","volume":"45","author":"Sen","year":"2012","journal-title":"Mol Cell"},{"key":"B81","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1097\/FBP.0000000000000143","article-title":"Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in streptozotocin-induced diabetic rats through inhibition of hippocampal oxidative stress","volume":"26","author":"Tang","year":"2015","journal-title":"Behav Pharmacol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1089\/ars.2006.8.661","article-title":"Hydrogen sulfide protects HT22 neuronal cells from oxidative stress","volume":"8","author":"Kimura","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"B83","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-18144-8_1","article-title":"H2S synthesizing enzymes: biochemistry and molecular aspects","volume-title":"Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide","author":"Huang","year":"2015"},{"key":"B84","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3409\/fb60_3-4.243-247","article-title":"Vitamin D3 (cholecalciferol) boosts hydrogen sulfide tissue concentrations in heart and other mouse organs","volume":"60","author":"Wilinski","year":"2012","journal-title":"Folia Biol (Krakow)"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.joca.2014.04.031","article-title":"Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1\u00df-stimulated human articular chondrocytes","volume":"22","author":"Burguera","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"B86","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.bbagen.2016.10.026","article-title":"Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures","volume":"1861","author":"Di","year":"2016","journal-title":"Biochim Biophys Acta."},{"key":"B87","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fpsyt.2017.00024","article-title":"IL1R2, CCR2, and CYCR4 may form heteroreceptor comlexes with NMDAR and D2R: relevance for schizophrenia","volume":"8","author":"Borroto-Escuela","year":"2017","journal-title":"Front Psychiatry"},{"key":"B88","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/npp.2008.139","article-title":"Olfactory receptor neuron dysfunction in schizophrenia","volume":"34","author":"Turetsky","year":"2009","journal-title":"Neuropsychopharmacology"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2018.00501\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T07:00:18Z","timestamp":1539673218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2018.00501\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":88,"alternative-id":["10.3389\/fpsyt.2018.00501"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2018.00501","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,16]]},"article-number":"501"}}