{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:40:32Z","timestamp":1793320832539,"version":"4.5.0"},"reference-count":109,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"DOI":"10.3389\/fpsyt.2019.00337","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T04:27:15Z","timestamp":1557894435000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":109,"title":["Is There a Role of Autophagy in Depression and Antidepressant Action?"],"prefix":"10.3389","volume":"10","author":[{"given":"Nils C.","family":"Gassen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Rein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1056\/NEJMra073096","article-title":"Major depressive disorder","volume":"358","author":"Belmaker","year":"2008","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2147\/NDT.S19617","article-title":"The increasing burden of depression","volume":"7","author":"Lepine","year":"2011","journal-title":"Neuropsychiatr Dis Treat"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0159-x","article-title":"Depression as a risk factor for the onset of type 2 diabetes mellitus","volume":"49","author":"Knol","year":"2006","journal-title":"Diabetologia"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl338","article-title":"Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies","volume":"27","author":"Nicholson","year":"2006","journal-title":"Eur Heart J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3389\/fpsyt.2018.00334","article-title":"Genetics factors in major depression disease","volume":"9","author":"Shadrina","year":"2018","journal-title":"Front Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0090-3","article-title":"Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression","volume":"50","author":"Wray","year":"2018","journal-title":"Nat Genet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/a0038550","article-title":"A brief history of the development of antidepressant drugs: from monoamines to glutamate","volume":"23","author":"Hillhouse","year":"2015","journal-title":"Exp Clin Psychopharmacol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3389\/fncel.2017.00305","article-title":"From serotonin to neuroplasticity: evolvement of theories for major depressive disorder","volume":"11","author":"Liu","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0893-133X(00)00159-7","article-title":"The corticosteroid receptor hypothesis of depression","volume":"23","author":"Holsboer","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"De Kloet","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-015-1548-2","article-title":"Molecular network of neuronal autophagy in the pathophysiology and treatment of depression","volume":"31","author":"Jia","year":"2015","journal-title":"Neurosci Bull"},{"key":"B12","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1016\/j.cub.2011.11.034","article-title":"Mechanisms of autophagosome biogenesis","volume":"22","author":"Rubinsztein","year":"2012","journal-title":"Curr Biol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol Cell"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biophys-060414-034248","article-title":"Mechanisms of autophagy","volume":"44","author":"Noda","year":"2015","journal-title":"Annu Rev Biophys"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201796697","article-title":"Molecular definitions of autophagy and related processes 3687","volume":"36","author":"Galluzzi","year":"2017","journal-title":"EMBO J"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1042\/BST20170128","article-title":"Autophagy in the context of the cellular membrane-trafficking system: the enigma of Atg9 vesicles","volume":"45","author":"Noda","year":"2017","journal-title":"Biochem Soc Trans"},{"key":"B17","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nrd.2017.22","article-title":"Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles","volume":"16","author":"Galluzzi","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"B18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1172\/JCI73938","article-title":"Development of autophagy inducers in clinical medicine","volume":"125","author":"Levine","year":"2015","journal-title":"J Clin Invest"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3802","article-title":"Autophagy modulation as a potential therapeutic target for diverse diseases","volume":"11","author":"Rubinsztein","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150956","article-title":"Therapeutic targeting of autophagy in neurodegenerative and infectious diseases","volume":"212","author":"Rubinsztein","year":"2015","journal-title":"J Exp Med"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.08.004","article-title":"The effect of fasting or calorie restriction on autophagy induction: a review of the literature","volume":"47","author":"Bagherniya","year":"2018","journal-title":"Ageing Res Rev"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: crosstalk between autophagy and apoptosis","volume":"8","author":"Maiuri","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"135908","DOI":"10.1155\/2014\/135908","article-title":"Lithium improves survival of PC12 pheochromocytoma cells in high-density cultures and after exposure to toxic compounds","volume":"2014","author":"Fabrizi","year":"2014","journal-title":"Int J Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.11.028","article-title":"The role of cell signalling in the crosstalk between autophagy and apoptosis","volume":"26","author":"Booth","year":"2014","journal-title":"Cell Signal"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.04.011","article-title":"Apoptosis, autophagy, and more","volume":"36","author":"Lockshin","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2647","article-title":"Animal models of neuropsychiatric disorders","volume":"13","author":"Nestler","year":"2010","journal-title":"Nat Neurosci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4552-6","article-title":"Modelling depression in animals: at the interface of reward and stress pathways","volume":"234","author":"Slattery","year":"2017","journal-title":"Psychopharmacology (Berl)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13041-018-0381-8","article-title":"Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling","volume":"11","author":"Woo","year":"2018","journal-title":"Mol Brain"},{"key":"B30","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neuint.2018.01.004","article-title":"Nicotine alleviates chronic stress-induced anxiety and depressive-like behavior and hippocampal neuropathology via regulating autophagy signaling","volume":"114","author":"Xiao","year":"2018","journal-title":"Neurochem Int"},{"key":"B31","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.expneurol.2017.09.001","article-title":"Prenatal stress-induced impairments of cognitive flexibility and bidirectional synaptic plasticity are possibly associated with autophagy in adolescent male-offspring","volume":"298","author":"Zhang","year":"2017","journal-title":"Exp Neurol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.02.026","article-title":"Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats","volume":"142","author":"Shih","year":"2019","journal-title":"Pharmacol Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12755","article-title":"Psychological status in depressive patients correlates with metabolic gene expression","volume":"23","author":"Alcocer-G\u00f3mez","year":"2017","journal-title":"CNS Neurosci Ther"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.02.002","article-title":"Decreased AKT1\/mTOR pathway mRNA expression in short-term bipolar disorder","volume":"25","author":"Machado-Vieira","year":"2015","journal-title":"Eur Neuropsychopharmacol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.05.010","article-title":"The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder","volume":"35","author":"Jernigan","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001755","article-title":"Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans","volume":"11","author":"Gassen","year":"2014","journal-title":"PLoS Med"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666150326003852","article-title":"The effects of calorie restriction in depression and potential mechanisms","volume":"13","author":"Zhang","year":"2015","journal-title":"Curr Neuropharmacol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nature10758","article-title":"Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis","volume":"481","author":"He","year":"2012","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200232120-00001","article-title":"Exercise and the treatment of clinical depression in adults: recent findings and future directions 1","volume":"32","author":"Brosse","year":"2002","journal-title":"Sports Med"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145703003729","article-title":"Desipramine treatment reduces the long-term behavioural and neurochemical sequelae of early-life maternal separation","volume":"6","author":"MacQueen","year":"2003","journal-title":"Int J Neuropsychopharmacol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.01.043","article-title":"Maternal separation induces different autophagic responses in the hippocampus and prefrontal cortex of adult rats","volume":"374","author":"Liu","year":"2018","journal-title":"Neuroscience"},{"key":"B42","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.neuropharm.2017.12.003","article-title":"Corticosterone impairs gap junctions in the prefrontal cortical and hippocampal astrocytes via different mechanisms","volume":"131","author":"Xia","year":"2018","journal-title":"Neuropharmacology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3389\/fnins.2017.00428","article-title":"miR-16 and fluoxetine both reverse autophagic and apoptotic change in chronic unpredictable mild stress model rats","volume":"11","author":"Yang","year":"2017","journal-title":"Front Neurosci"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2018.05.020","article-title":"The antidepressant effects of a-tocopherol are related to activation of autophagy via the AMPK\/mTOR pathway","volume":"833","author":"Huang","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3389\/fnmol.2017.00293","article-title":"Rosiglitazone exerts an anti-depressive effect in unpredictable chronic mild-stress-induced depressive mice by maintaining essential neuron autophagy and inhibiting excessive astrocytic apoptosis","volume":"10","author":"Zhao","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"B46","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/s12974-017-1013-4","article-title":"Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome","volume":"14","author":"Jiang","year":"2017","journal-title":"J Neuroinflammation"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.05.004","article-title":"Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology","volume":"25","author":"Levine","year":"2015","journal-title":"Trends Cell Biol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0090-9","article-title":"Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide","volume":"23","author":"Gulbins","year":"2018","journal-title":"Mol Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.01.028","article-title":"Chlorimipramine: a novel anticancer agent with a mitochondrial target","volume":"328","author":"Daley","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.048181","article-title":"Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux","volume":"122","author":"Rossi","year":"2009","journal-title":"J Cell Sci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.57","article-title":"Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons\u2014dissociation from cholesterol homeostasis","volume":"36","author":"Zschocke","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.10.16520","article-title":"Antidepressants encounter autophagy in neural cells","volume":"7","author":"Zschocke","year":"2011","journal-title":"Autophagy"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000334","article-title":"Mood-stabilizing effects of rapamycin and its analog temsirolimus: relevance to autophagy","volume":"29","author":"Kara","year":"2018","journal-title":"Behav Pharmacol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2008.03.005","article-title":"Antidepressive-like effects of rapamycin in animal models: implications for mTOR inhibition as a new target for treatment of affective disorders","volume":"76","author":"Cleary","year":"2008","journal-title":"Brain Res Bull"},{"key":"B56","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/ijms19082226","article-title":"mTOR-related brain dysfunctions in neuropsychiatric disorders","author":"Ryskalin","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1021\/cn500056q","article-title":"Lithium and autophagy","volume":"5","author":"Motoi","year":"2014","journal-title":"ACS Chem Neurosci"},{"key":"B58","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/00124509-200403000-00004","article-title":"Efficacy of ECT in depression: a meta-analytic review","volume":"20","author":"Pagnin","year":"2004","journal-title":"J ECT"},{"key":"B59","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.pnpbp.2013.11.012","article-title":"Electroconvulsive seizures enhance autophagy signaling in rat hippocampus","volume":"50","author":"Otabe","year":"2014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.2174\/1871520611313020011","article-title":"Antidepressant desipramine leads to C6 glioma cell autophagy: implication for the adjuvant therapy of cancer","volume":"13","author":"Ma","year":"2013","journal-title":"Anticancer Agents Med Chem"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10901","article-title":"Desipramine-induced lysosomal vacuolization is independent of autophagy","volume":"42","author":"Sawai","year":"2018","journal-title":"Cell Biol Int"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.01.008","article-title":"Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing","volume":"13","author":"Sundaramurthy","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.08.012","article-title":"Dual targeting of the autophagic regulatory circuitry in gliomas with repurposed drugs elicits cell-lethal autophagy and therapeutic benefit","volume":"28","author":"Shchors","year":"2015","journal-title":"Cancer Cell"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.04.028","article-title":"Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder","volume":"121","author":"Alcocer-G\u00f3mez","year":"2017","journal-title":"Pharmacol Res"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.08.093","article-title":"The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells","volume":"413","author":"Jeon","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25477","article-title":"The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt\u2019s lymphoma","volume":"128","author":"Cloonan","year":"2011","journal-title":"Int J Cancer"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12402","article-title":"Fluoxetine induces autophagic cell death via eEF2K-AMPK-mTOR-ULK complex axis in triple negative breast cancer","volume":"51","author":"Sun","year":"2018","journal-title":"Cell Prolif"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160716655","article-title":"Fluoxetine decreases the proliferation and adipogenic differentiation of human adipose-derived stem cells","volume":"16","author":"Sun","year":"2015","journal-title":"Int J Mol Sci"},{"key":"B69","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s12974-017-0959-6","article-title":"Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats","volume":"14","author":"Li","year":"2017","journal-title":"J Neuroinflammation"},{"key":"B70","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1172\/jci.insight.98921","article-title":"Repurposing sertraline sensitizes non-small cell lung cancer cells to erlotinib by inducing autophagy","author":"Jiang","year":"2018","journal-title":"JCI Insight"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10428194.2017.1287358","article-title":"Sertraline exerts its antitumor functions through both apoptosis and autophagy pathways in acute myeloid leukemia cells","volume":"58","author":"Xia","year":"2017","journal-title":"Leuk Lymphoma"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708022105","article-title":"Lithium delays progression of amyotrophic lateral sclerosis","volume":"105","author":"Fornai","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B73","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1471-4159.2009.05906.x","article-title":"Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy","volume":"109","author":"Heiseke","year":"2009","journal-title":"J Neurochem"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nop005","article-title":"Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines","volume":"12","author":"Fu","year":"2010","journal-title":"Neuro Oncol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27094","article-title":"Ketamine induces reactive oxygen species and enhances autophagy in SV-HUC-1 human uroepithelial cells","volume":"234","author":"Shan","year":"2018","journal-title":"J Cell Physiol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3119-4","article-title":"Trehalose induced antidepressant-like effects and autophagy enhancement in mice","volume":"229","author":"Kara","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609532200","article-title":"Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein","volume":"282","author":"Sarkar","year":"2007","journal-title":"J Biol Chem"},{"key":"B78","doi-asserted-by":"publisher","first-page":"e2527","DOI":"10.1038\/cddis.2016.433","article-title":"Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB","volume":"7","author":"Li","year":"2016","journal-title":"Cell Death Dis"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13022","article-title":"Molecular events leading to death of Leishmania donovani under spermidine starvation after hypericin treatment","volume":"90","author":"Singh","year":"2017","journal-title":"Chem Biol Drug Des"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.07.023","article-title":"Silibinin ameliorates anxiety\/depression-like behaviors in amyloid beta-treated rats by upregulating BDNF\/TrkB pathway and attenuating autophagy in hippocampus","volume":"179","author":"Song","year":"2017","journal-title":"Physiol Behav"},{"key":"B81","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.neulet.2017.04.019","article-title":"Protective effect of dapsone on cognitive impairment induced by propofol involves hippocampal autophagy","volume":"649","author":"Yang","year":"2017","journal-title":"Neurosci Lett"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-015-0619-1","article-title":"Geldanamycin reduces Abeta-associated anxiety and depression, concurrent with autophagy provocation","volume":"57","author":"Zare","year":"2015","journal-title":"J Mol Neurosci"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1731","article-title":"Extract of Euryale ferox Salisb exerts antidepressant effects and regulates autophagy through the adenosine monophosphate-activated protein kinase-UNC-51-like kinase 1 pathway","volume":"70","author":"Huang","year":"2018","journal-title":"IUBMB Life"},{"key":"B84","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/ijms18122614","article-title":"The FKBP51 Glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease","author":"Fries","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407498200","article-title":"FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells","volume":"280","author":"Wochnik","year":"2005","journal-title":"J Biol Chem"},{"key":"B86","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1002\/bies.201600050","article-title":"FK506 binding protein 51 integrates pathways of adaptation: FKBP51 shapes the reactivity to environmental change","volume":"38","author":"Rein","year":"2016","journal-title":"Bioessays"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1017224","article-title":"FKBP5\/FKBP51 enhances autophagy to synergize with antidepressant action","volume":"11","author":"Gassen","year":"2015","journal-title":"Autophagy"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3214","article-title":"Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs","volume":"19","author":"Gulbins","year":"2013","journal-title":"Nat Med"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1021\/jm070524a","article-title":"Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model","volume":"51","author":"Kornhuber","year":"2008","journal-title":"J Med Chem"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32833da5da","article-title":"Intracellular pathways underlying the effects of lithium","volume":"21","author":"Pasquali","year":"2010","journal-title":"Behav Pharmacol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200504035","article-title":"Lithium induces autophagy by inhibiting inositol monophosphatase","volume":"170","author":"Sarkar","year":"2005","journal-title":"J Cell Biol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148608","article-title":"Azidobupramine, an antidepressant-derived bifunctional neurotransmitter transporter ligand allowing covalent labeling and attachment of fluorophores","volume":"11","author":"Kirmeier","year":"2016","journal-title":"PLoS One"},{"key":"B93","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.bcp.2017.08.005","article-title":"Adult hippocampal neurogenesis: is it the alpha and omega of antidepressant action","volume":"141","author":"Eliwa","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"10533","DOI":"10.1038\/ncomms10533","article-title":"Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis 1","volume":"7","author":"Wu","year":"2016","journal-title":"Nat Commun"},{"key":"B95","doi-asserted-by":"publisher","first-page":"e1403","DOI":"10.1038\/cddis.2014.358","article-title":"The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone","volume":"5","author":"Yazdankhah","year":"2014","journal-title":"Cell Death Dis"},{"key":"B96","doi-asserted-by":"publisher","first-page":"670756","DOI":"10.1155\/2014\/670756","article-title":"Plastic changes in the spinal cord in motor neuron disease","volume":"2014","author":"Fornai","year":"2014","journal-title":"Biomed. Res Int"},{"key":"B97","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/cells8010044","article-title":"Is autophagy involved in the diverse effects of antidepressants","author":"Rein","year":"2019","journal-title":"Cells"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.255","article-title":"Mechanisms of ketamine action as an antidepressant","volume":"23","author":"Zanos","year":"2018","journal-title":"Mol Psychiatry"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1007\/BF00470582","article-title":"Brain concentrations of tricyclic antidepressants: single-dose kinetics and relationship to plasma concentrations in chronically dosed rats","volume":"78","author":"Glotzbach","year":"1982","journal-title":"Psychopharmacology (Berl)"},{"key":"B100","article-title":"Pharmacokinetics and antidepressant activity of fluoxetine in transgenic mice with elevated serum alpha-1-acid glycoprotein levels","volume":"26","author":"Holladay","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"B101","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1055\/s-0031-1286287","article-title":"AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011","volume":"44","author":"Hiemke","year":"2011","journal-title":"Pharmacopsychiatry"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4533-11.2012","article-title":"Neuronal stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical long-term depression","volume":"32","author":"Shehata","year":"2012","journal-title":"J Neurosci"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.02.020","article-title":"Regulation of presynaptic neurotransmission by macroautophagy","volume":"74","author":"Hernandez","year":"2012","journal-title":"Neuron"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.10.012","article-title":"Hsc70-4 deforms membranes to promote synaptic protein turnover by endosomal microautophagy","volume":"88","author":"Uytterhoeven","year":"2015","journal-title":"Neuron"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.008","article-title":"Eating locally: microautophagy and protein turnover at the synapse","volume":"88","author":"McPherson","year":"2015","journal-title":"Neuron"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.02.068","article-title":"Changes of TSPO-mediated mitophagy signaling pathway in learned helplessness mice","volume":"245","author":"Li","year":"2016","journal-title":"Psychiatry Res"},{"key":"B107","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3389\/fnmol.2018.00299","article-title":"Interdependency between autophagy and synaptic vesicle trafficking: implications for dopamine release","volume":"11","author":"Limanaqi","year":"2018","journal-title":"Front Mol Neurosci"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1338556","article-title":"NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells","volume":"14","author":"Mu","year":"2018","journal-title":"Autophagy"},{"key":"B109","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.neulet.2016.05.015","article-title":"Increased expression of endocytosis-related proteins in rat hippocampus following 10-day electroconvulsive seizure treatment","volume":"624","author":"Enomoto","year":"2016","journal-title":"Neurosci Lett"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2019.00337\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T04:27:18Z","timestamp":1557894438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2019.00337\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,15]]},"references-count":109,"alternative-id":["10.3389\/fpsyt.2019.00337"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2019.00337","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,15]]},"article-number":"337"}}