{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:08:56Z","timestamp":1792588136256,"version":"4.5.0"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"DOI":"10.3389\/fpsyt.2020.00500","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T01:11:31Z","timestamp":1591837891000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":71,"title":["Depression Preceding Diagnosis of Bipolar Disorder"],"prefix":"10.3389","volume":"11","author":[{"given":"Claire","family":"O'Donovan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Alda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.10.1754","article-title":"Familiality of polarity at illness onset in bipolar affective disorder","volume":"163","author":"Kassem","year":"2006","journal-title":"Am J Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00421.x","article-title":"The early manifestations of bipolar disorder: a longitudinal prospective study of the offspring of bipolar parents","volume":"9","author":"Duffy","year":"2007","journal-title":"Bipolar Disord"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12030401","article-title":"The Dutch bipolar offspring study: 12-year follow-up","volume":"170","author":"Mesman","year":"2013","journal-title":"Am J Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14010035","article-title":"Diagnostic Precursors to Bipolar Disorder in Offspring of Parents With Bipolar Disorder: A Longitudinal Study","volume":"172","author":"Axelson","year":"2015","journal-title":"Am J Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01048.x","article-title":"Mental disorders in offspring of parents with bipolar and major depressive disorders","volume":"14","author":"Vandeleur","year":"2012","journal-title":"Bipolar Disord"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17090972","article-title":"Early Intervention in Bipolar Disorder","volume":"175","author":"Vieta","year":"2018","journal-title":"Am J Psychiatry"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12508","article-title":"Characteristics of depression among offspring at high and low familial risk of bipolar disorder","volume":"19","author":"Diler","year":"2017","journal-title":"Bipolar Disord"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.01.027","article-title":"History of illness prior to a diagnosis of bipolar disorder or schizoaffective disorder","volume":"103","author":"Berk","year":"2007","journal-title":"J Affect Disord"},{"key":"B9","doi-asserted-by":"publisher","first-page":"96","DOI":"10.4306\/pi.2009.6.2.96","article-title":"Polarity of the first episode and time to diagnosis of bipolar I disorder","volume":"6","author":"Cha","year":"2009","journal-title":"Psychiatry Investig"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.09.009","article-title":"The role of comorbidities in duration of untreated illness for bipolar spectrum disorders","volume":"188","author":"Murru","year":"2015","journal-title":"J Affect Disord"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(03)00195-2","article-title":"Diagnostic conversion from depression to bipolar disorders: results of a long-term prospective study of hospital admissions","volume":"84","author":"Angst","year":"2005","journal-title":"J Affect Disord"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.3.385","article-title":"Long-term stability of polarity distinctions in the affective disorders","author":"Coryell","year":"1995","journal-title":"Am J Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10030328","article-title":"Subthreshold hypomanic symptoms in progression from unipolar major depression to bipolar disorder","volume":"168","author":"Fiedorowicz","year":"2011","journal-title":"Am J Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00738.x","article-title":"Mood episodes and mood disorders: patterns of incidence and conversion in the first three decades of life","volume":"11","author":"Beesdo","year":"2009","journal-title":"Bipolar Disord"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12869","article-title":"Patterns and predictors of conversion to bipolar disorder in 91 587 individuals diagnosed with unipolar depression","volume":"137","author":"Musliner","year":"2018","journal-title":"Acta Psychiatr Scand"},{"key":"B16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/ajmg.1320480405","article-title":"Unipolar relatives in bipolar pedigrees: are they bipolar","volume":"3","author":"Blacker","year":"1993","journal-title":"Psychiatr Genet"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01009.x","article-title":"Depression in bipolar disorder versus major depressive disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"14","author":"Moreno","year":"2012","journal-title":"Bipolar Disord"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(03)00195-2","article-title":"Diagnostic conversion from depression to bipolar disorders: results of a long-term prospective study of hospital admissions","volume":"84","author":"Angst","year":"2005","journal-title":"J Affect Disord"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.225","article-title":"Clinical features of bipolar depression versus major depressive disorder in large multicenter trials","volume":"163","author":"Perlis","year":"2006","journal-title":"Am J Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00556.x","article-title":"Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report","volume":"10","author":"Ghaemi","year":"2008","journal-title":"Bipolar Disord"},{"key":"B21","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/schbul\/sbt114","article-title":"Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies","volume":"40","author":"Rasic","year":"2014","journal-title":"Schizophr Bull"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.03.001","article-title":"Risk factors of treatment resistance in major depression: association with bipolarity","volume":"126","author":"Dudek","year":"2010","journal-title":"J Affect Disord"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.5.628","article-title":"The family history in clinical psychiatric practice","volume":"144","author":"Swift","year":"1987","journal-title":"Am J Psychiatry"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.5.630","article-title":"Family diagnoses missed on a clinical inpatient service","volume":"144","author":"Baker","year":"1987","journal-title":"Am J Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0608","article-title":"Is bipolar disorder overdiagnosed","volume":"69","author":"Zimmerman","year":"2008","journal-title":"J Clin Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1977.01770220111013","article-title":"The family history method using diagnostic criteria. Reliability and validity","volume":"34","author":"Andreasen","year":"1977","journal-title":"Arch Gen Psychiatry"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.7.675","article-title":"Brief screening for family psychiatric history: the family history screen","volume":"57","author":"Weissman","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12727","article-title":"Testing a clinical staging model for bipolar disorder using longitudinal life chart data","volume":"21","author":"van der Markt","year":"2019","journal-title":"Bipolar Disord"},{"key":"B29","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/acps.12140","article-title":"DSM-5 criteria for depression with mixed features: a farewell to mixed depression","volume":"129","author":"Koukopoulos","year":"2014","journal-title":"Acta Psychiatr Scand"},{"key":"B30","volume-title":"American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders: Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"B31","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jad.2013.03.007","article-title":"Mixed states in DSM-5: implications for clinical care, education, and research","volume":"148","author":"Vieta","year":"2013","journal-title":"J Affect Disord"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08050746","article-title":"Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD","volume":"166","author":"Goldberg","year":"2009","journal-title":"Am J Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852917000165","article-title":"Guidelines for the recognition and management of mixed depression","volume":"22","author":"Stahl","year":"2017","journal-title":"CNS Spectr."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.07.021","article-title":"A clinically useful self-report measure of the DSM-5 mixed features specifier of major depressive disorder","volume":"168","author":"Zimmerman","year":"2014","journal-title":"J Affect Disord"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15060770","article-title":"Lurasidone for the Treatment of Major Depressive Disorder With Mixed Features: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"173","author":"Suppes","year":"2016","journal-title":"Am J Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000323","article-title":"A 13-week, randomized double-blind, placebo-controlled, cross-over trial of ziprasidone in bipolar spectrum disorder","volume":"35","author":"Patkar","year":"2015","journal-title":"J Clin Psychopharmacol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1176\/appi.ajp.2012.12030301","article-title":"Bipolar mixed states: an international society for bipolar disorders task force report of symptom structure, course of illness, and diagnosis","volume":"170","author":"Swann","year":"2013","journal-title":"Am J Psychiatry"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00536.x","article-title":"The Bipolar Depression Rating Scale (BDRS): its development, validation and utility","volume":"9","author":"Berk","year":"2007","journal-title":"Bipolar Disord"},{"key":"B39","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1017\/S1092852916000857","article-title":"Measures of the DSM-5 mixed-features specifier of major depressive disorder","volume":"22","author":"Zimmerman","year":"2017","journal-title":"CNS Spectr."},{"key":"B40","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jad.2018.01.025","article-title":"The Koukopoulos Mixed Depression Rating Scale (KMDRS): An International Mood Network (IMN) validation study of a new mixed mood rating scale","volume":"232","author":"Sani","year":"2018","journal-title":"J Affect Disord"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00548-3","article-title":"The Altman Self-Rating Mania Scale","volume":"42","author":"Altman","year":"1997","journal-title":"Biol Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2000.020409.x","article-title":"The Internal State Scale: replication of its discriminating abilities in a multisite, public sector sample","volume":"2","author":"Bauer","year":"2000","journal-title":"Bipolar Disord"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.05.011","article-title":"The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients","volume":"88","author":"Angst","year":"2005","journal-title":"J Affect Disord"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2002.01195.x","article-title":"A clinical monitoring form for mood disorders","volume":"4","author":"Sachs","year":"2002","journal-title":"Bipolar Disord"},{"key":"B45","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1600-0447.2004.00409.x","article-title":"Strategies for improving treatment of bipolar disorder: integration of measurement and management","author":"Sachs","year":"2004","journal-title":"Acta Psychiatr Scand"},{"key":"B46","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jad.2015.02.004","article-title":"The Bipolarity Index: a clinician-rated measure of diagnostic confidence","volume":"177","author":"Aiken","year":"2015","journal-title":"J Affect Disord"},{"key":"B47","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/bdi.12609","article-title":"Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder","volume":"20","author":"Yatham","year":"2018","journal-title":"Bipolar Disord"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00659","article-title":"Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders: major depression summary","volume":"208","author":"Malhi","year":"2018","journal-title":"Med J Aust"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2013.804195","article-title":"World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders, part 1: update 2013 on the acute and continuation treatment of unipolar depressive disorders","volume":"14","author":"Bauer","year":"2013","journal-title":"World J Biol Psychiatry"},{"key":"B50","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1177\/0269881115581093","article-title":"Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines","volume":"29","author":"Cleare","year":"2015","journal-title":"J Psychopharmacol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1177\/0706743716659417","article-title":"Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 3. Pharmacological Treatments","volume":"61","author":"Kennedy","year":"2016","journal-title":"Can J Psychiatry"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415617657","article-title":"Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders","volume":"49","author":"Malhi","year":"2015","journal-title":"Aust N. Z. J Psychiatry"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-4081","article-title":"Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management","volume":"141","author":"Zuckerbrot","year":"2018","journal-title":"Pediatrics"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1097\/chi.0b013e318145ae1c","article-title":"Practice parameter for the assessment and treatment of children and adolescents with depressive disorders","volume":"46","author":"Birmaher","year":"2007","journal-title":"J Am Acad Child Adolesc. Psychiatry"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.10.033","article-title":"Antidepressant-associated mood-switching and transition from unipolar major depression to bipolar disorder: a review","volume":"148","author":"Baldessarini","year":"2013","journal-title":"J Affect Disord"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12788","article-title":"Clinical Conundrum: How do you treat youth with depression and a family history of bipolar disorder","volume":"21","author":"Angal","year":"2019","journal-title":"Bipolar Disord"},{"key":"B57","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1177\/0706743716659276","article-title":"Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 6. Special Populations: Youth, Women, and the Elderly","volume":"61","author":"MacQueen","year":"2016","journal-title":"Can J Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.cppeds.2017.12.001","article-title":"Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management","volume":"48","author":"Luft","year":"2018","journal-title":"Curr Probl Pediatr Adolesc. Health Care"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2018.07.871","article-title":"A Risk Calculator for Bipolar Disorder in Youth: Improving the Odds for Personalized Prevention and Early Intervention","volume":"57","author":"Delbello","year":"2018","journal-title":"J Am Acad Child Adolesc. Psychiatry"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.08.003","article-title":"Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk","volume":"107","author":"O'Donovan","year":"2008","journal-title":"J Affect. Disord"},{"key":"B61","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.mehy.2005.02.010","article-title":"Are treatment emergent suicidality and decreased response to antidepressants in younger patients due to bipolar disorder being misdiagnosed as unipolar depression","volume":"65","author":"Berk","year":"2005","journal-title":"Med Hypotheses"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318299d2d5","article-title":"Antidepressant response and subthreshold bipolarity in \u201cunipolar\u201d major depressive disorder: implications for practice and drug research","volume":"33","author":"Rihmer","year":"2013","journal-title":"J Clin Psychopharmacol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1159\/000358808","article-title":"Mixed depression: clinical features and predictors of its onset associated with antidepressant use","volume":"83","author":"Sani","year":"2014","journal-title":"Psychother Psychosom"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1159\/000288880","article-title":"Do antidepressant and antianxiety drugs increase chronicity in affective disorders","volume":"61","author":"Fava","year":"1994","journal-title":"Psychother. Psychosom."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666160621113432","article-title":"Athanasios Koukopoulos' Psychiatry: The Primacy of Mania and the Limits of Antidepressants","volume":"15","author":"Ghaemi","year":"2017","journal-title":"Curr Neuropharmacol."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.06.001","article-title":"Patterns of response to antidepressants in major depressive disorder: Drug resistance or worsening of depression are associated with a bipolar diathesis","volume":"29","author":"Perugi","year":"2019","journal-title":"Eur Neuropsychopharmacol"},{"key":"B67","first-page":"312","article-title":"Antidepressants in bipolar depression: when less is more","volume":"27","author":"Ruzickova","year":"2002","journal-title":"J Psychiatry Neurosci"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.05122032","article-title":"Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD","volume":"164","author":"Goldberg","year":"2007","journal-title":"Am J Psychiatry"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0204","article-title":"Can long-term treatment with antidepressant drugs worsen the course of depression","volume":"64","author":"Fava","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.03.025","article-title":"Antidepressant-associated chronic irritable dysphoria (ACID) in STEP-BD patients","volume":"111","author":"El-Mallakh","year":"2008","journal-title":"J Affect Disord"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.04.054","article-title":"Antidepressants worsen rapid-cycling course in bipolar depression: A STEP-BD randomized clinical trial","volume":"184","author":"El-Mallakh","year":"2015","journal-title":"J Affect Disord"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/15622975.2017.1384850","article-title":"The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Acute and long-term treatment of mixed states in bipolar disorder","volume":"19","author":"Grunze","year":"2018","journal-title":"World J Biol Psychiatry"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13020185","article-title":"The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders","volume":"170","author":"Pacchiarotti","year":"2013","journal-title":"Am J Psychiatry"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852916000493","article-title":"What is the role of conventional antidepressants in the treatment of major depressive episodes with Mixed Features Specifier","volume":"22","author":"Faedda","year":"2017","journal-title":"CNS Spectr."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2018.16.4.376","article-title":"Pharmacological Treatment of Major Depressive Episodes with Mixed Features: A Systematic Review","volume":"16","author":"Shim","year":"2018","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852917000256","article-title":"Mixed features in major depressive disorder: diagnoses and treatments","volume":"22","author":"Suppes","year":"2017","journal-title":"CNS Spectr."},{"key":"B77","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/acps.12896","article-title":"Mixed states in bipolar and major depressive disorders: systematic review and quality appraisal of guidelines","volume":"138","author":"Verdolini","year":"2018","journal-title":"Acta Psychiatr Scand"},{"key":"B78","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/PRA.0000000000000213","article-title":"Repetitive Transcranial Magnetic Stimulation (5 and 10 Hz) With Modified Parameters in the Treatment of Resistant Unipolar and Bipolar Depression in a Private Practice Setting","volume":"23","author":"Rachid","year":"2017","journal-title":"J Psychiatr Pract"},{"key":"B79","doi-asserted-by":"crossref","DOI":"10.1017\/S1092852919001184","article-title":"The use of lithium in mixed states","volume-title":"CNS Spectr","author":"Sani","year":""},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13122","article-title":"Prediction of lithium response using clinical data","volume":"141","author":"Nunes","year":"2020","journal-title":"Acta Psychiatr Scand"},{"key":"B81","doi-asserted-by":"crossref","DOI":"10.1017\/S003329172000015X","article-title":"Discriminating bipolar depression from major depressive disorder with polygenic risk scores","volume-title":"Psychol Med.","author":"Liebers","year":""},{"key":"B82","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2019.10.015","article-title":"The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls","volume-title":"Biol Psychiatry.","author":"Coleman","year":""}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2020.00500\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T01:11:36Z","timestamp":1591837896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2020.00500\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,11]]},"references-count":82,"alternative-id":["10.3389\/fpsyt.2020.00500"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2020.00500","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,11]]},"article-number":"500"}}