{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T23:52:22Z","timestamp":1778975542141,"version":"3.51.4"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"DOI":"10.3389\/fpsyt.2020.00612","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T05:20:11Z","timestamp":1593148811000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Correlation Between Decreased Amygdala Subnuclei Volumes and Impaired Cognitive Functions in Pediatric Bipolar Disorder"],"prefix":"10.3389","volume":"11","author":[{"given":"Dong","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.12.008","article-title":"Comorbidity in pediatric bipolar disorder: prevalence, clinical impact, etiology and treatment","volume":"174","author":"Frias","year":"2015","journal-title":"J Affect Disord"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00069-6","article-title":"Researching the pathophysiology of pediatric bipolar disorder","volume":"53","author":"Leibenluft","year":"2003","journal-title":"Biol Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.01.022","article-title":"Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)","volume":"55","author":"Perlis","year":"2004","journal-title":"Biol Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00324.x","article-title":"Neuropsychological deficits and functional impairment in bipolar depression, hypomania and euthymia","volume":"9","author":"Malhi","year":"2007","journal-title":"Bip Disord"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.01.008","article-title":"Cognitive Impairment in Euthymic Pediatric Bipolar Disorder: A Systematic Review and Meta-Analysis","volume":"56","author":"Elias","year":"2017","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.05.010","article-title":"Prolactin and thyroid hormone levels are associated with suicide attempts in psychiatric patients","volume":"200","author":"Pompili","year":"2012","journal-title":"Psychiatry Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.117145","article-title":"Bereavement after the suicide of a significant other","volume":"55","author":"Pompili","year":"2013","journal-title":"Indian J Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu198","article-title":"Meta-analysis of Cognitive Impairment in First-Episode Bipolar Disorder: Comparison With First-Episode Schizophrenia and Healthy Controls","volume":"41","author":"Bora","year":"2015","journal-title":"Schizophr Bull"},{"key":"B9","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.jad.2014.05.025","article-title":"Neurocognitive impairments among youth with pediatric bipolar disorder: a systematic review of neuropsychological research","volume":"166","author":"Frias","year":"2014","journal-title":"J Affect Disord"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-008-0080-8","article-title":"Limbic changes identified by imaging in bipolar patients","volume":"10","author":"Brambilla","year":"2008","journal-title":"Curr Psychiatry Rep"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.09.028","article-title":"Gating of fear in prelimbic cortex by hippocampal and amygdala inputs","volume":"76","author":"Sotres-Bayon","year":"2012","journal-title":"Neuron."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4324","article-title":"A fast pathway for fear in human amygdala","volume":"19","author":"Mendez-Bertolo","year":"2016","journal-title":"Nat Neurosci"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2008.08.001","article-title":"Amygdalar enlargement associated with unique perception","volume":"46","author":"Asari","year":"2010","journal-title":"Cortex."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.05.011","article-title":"The amygdala, top-down effects, and selective attention to features","volume":"36","author":"Jacobs","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-017-0806-x","article-title":"Reduced amygdala reactivity and impaired working memory during dissociation in borderline personality disorder","volume":"268","author":"Krause-Utz","year":"2018","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12768","article-title":"Neural mechanisms of face emotion processing in youths and adults with bipolar disorder","volume":"21","author":"Kryza-Lacombe","year":"2019","journal-title":"Bip Disord"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e31819f6fbc","article-title":"Relation between amygdala structure and function in adolescents with bipolar disorder","volume":"48","author":"Kalmar","year":"2009","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1111\/bdi.12114","article-title":"Deformations of amygdala morphology in familial pediatric bipolar disorder","volume":"15","author":"Kelley","year":"2013","journal-title":"Bip Disord"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.12.1201","article-title":"Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder","volume":"60","author":"Blumberg","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1046\/j.1399-5618.2003.00087.x","article-title":"Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder","volume":"6","author":"DelBello","year":"2004","journal-title":"Bip Disord"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e318185d299","article-title":"Meta-analysis of amygdala volumes in children and adolescents with bipolar disorder","volume":"47","author":"Pfeifer","year":"2008","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001585","article-title":"The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings","volume":"10","author":"Strakowski","year":"2005","journal-title":"Mol Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810230070011","article-title":"Structural brain abnormalities in bipolar affective disorder. Ventricular enlargement and focal signal hyperintensities","volume":"47","author":"Swayze","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"B24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/WNN.0b013e318192cc67","article-title":"Amygdala volume and verbal memory performance in schizophrenia and bipolar disorder","volume":"22","author":"Killgore","year":"2009","journal-title":"Cognit Behav Neurol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/hbm.24353","article-title":"Amygdala subnuclei and healthy cognitive aging","volume":"40","author":"Aghamohammadi-Sereshki","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pscychresns.2009.09.004","article-title":"Correlation between amygdala volume and age in bipolar disorder - a systematic review and meta-analysis of structural MRI studies","volume":"182","author":"Usher","year":"2010","journal-title":"Psychiatry Res"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.227","article-title":"Subcortical volumetric abnormalities in bipolar disorder","volume":"21","author":"Hibar","year":"2016","journal-title":"Mol Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.660","article-title":"Developmental meta-analyses of the functional neural correlates of bipolar disorder","volume":"71","author":"Wegbreit","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/cne.24130","article-title":"Comprehensive cellular-resolution atlas of the adult human brain","volume":"525","author":"Ding","year":"2017","journal-title":"J Comp Neurol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0292-04.2004","article-title":"The role of the central nucleus of the amygdala in mediating fear and anxiety in the primate","volume":"24","author":"Kalin","year":"2004","journal-title":"J Neurosci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1445-8","article-title":"Collateralization of projections from the paraventricular nucleus of the thalamus to the nucleus accumbens, bed nucleus of the stria terminalis, and central nucleus of the amygdala","volume":"222","author":"Dong","year":"2017","journal-title":"Brain Struct Funct"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.04.046","article-title":"High-resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas","volume":"155","author":"Saygin","year":"2017","journal-title":"Neuroimage"},{"key":"B33","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Psychiatric Disorders","author":"Association","year":"2013"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-56782-2_1605-2","article-title":"Jacobson. Wechsler Intelligence Scale for Children","volume":"19","author":"Traci","year":"2018","journal-title":"Can J Sch Psychol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199707000-00021","article-title":"Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data","volume":"36","author":"Kaufman","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200104000-00014","article-title":"Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections","volume":"40","author":"Geller","year":"2001","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1995.tb01828.x","article-title":"Properties of the mood and feelings questionnaire in adolescent psychiatric outpatients: a research note","volume":"36","author":"Wood","year":"1995","journal-title":"J Child Psychol Psychiatry"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br J Psychiatry"},{"key":"B39","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-79948-3_1597","article-title":"Stroop Color and Word Test, Children\u2019s Version","volume-title":"Encyclopedia of Clinical Neuropsychology","author":"Moran","year":"2011"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1080\/13854049508402057","article-title":"Category test and trail making test as measures of frontal lobe functions","volume":"9","author":"Ralph","year":"1995","journal-title":"Clin Neuropsychol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"0","DOI":"10.1016\/S0010-9452(08)70235-1","article-title":"\u201cWineglass\u201d Confabulations Among Brain- Damaged Alcoholics on the Wechsler Memory Scale-Revised Visual Reproduction Subtest","volume":"33","author":"Welch","year":"1997","journal-title":"Cortex."},{"key":"B42","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.pscychresns.2017.11.015","article-title":"Subcortical volumetric differences between clinical stages of young people with affective and psychotic disorders","volume":"271","author":"Eggins","year":"2018","journal-title":"Psychiatry Res Neuroimag"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1220","article-title":"Neuropathologic alterations in mild cognitive impairment: a review","volume":"19","author":"Markesbery","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5451.248","article-title":"Memory\u2013a century of consolidation","volume":"287","author":"McGaugh","year":"2000","journal-title":"Science"},{"key":"B45","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/01.wno.0000369168.32606.54","article-title":"The Human Brain. An Introduction to Its Functional Anatomy, 6th Edition","volume":"30","author":"Trobe","year":"2010","journal-title":"J Neuro-Ophthalmol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2019.07.010","article-title":"Ultra-High-Resolution Imaging of Amygdala Subnuclei Structural Connectivity in Major Depressive Disorder","volume":"5","author":"Brown","year":"2020","journal-title":"Biol Psychiatry Cognit Neurosci Neuroimaging"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.005","article-title":"The amygdala","volume":"17","author":"LeDoux","year":"2007","journal-title":"Curr Biol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2651","article-title":"Stress, memory and the amygdala","volume":"10","author":"Roozendaal","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"B49","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198505013.001.0001","article-title":"The amygdala: a functional analysis","author":"Aggleton","year":"2000"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.02.030","article-title":"Reprint of: Emotion and cognition and the amygdala: from \u201cwhat is it?\u201d to \u201cwhat\u2019s to be done\u201d","volume":"49","author":"Pessoa","year":"2011","journal-title":"Neuropsychologia"},{"key":"B51","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1089\/cap.2008.064","article-title":"A quantitative and qualitative review of neurocognitive performance in pediatric bipolar disorder","volume":"18","author":"Joseph","year":"2008","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1080\/13546805.2017.1361391","article-title":"Classification of cognitive performance in bipolar disorder","volume":"22","author":"Sparding","year":"2017","journal-title":"Cognit Neuropsychiatry"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1080\/01688639308402595","article-title":"The diagnostic utility of savings scores: differentiating Alzheimer\u2019s and Huntington\u2019s diseases with the logical memory and visual reproduction tests","volume":"15","author":"Troster","year":"1993","journal-title":"J Clin Exp Neuropsychol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617717001059","article-title":"Longitudinal Associations among Posttraumatic Stress Disorder Symptoms, Traumatic Brain Injury, and Neurocognitive Functioning in Army Soldiers Deployed to the Iraq War","volume":"24","author":"Vasterling","year":"2018","journal-title":"J Int Neuropsychol Soc"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1038\/s41598-018-20295-3","article-title":"Cognitive Impairment In Treatment-Naive Bipolar II and Unipolar Depression","volume":"8","author":"Mak","year":"2018","journal-title":"Sci Rep"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1981","article-title":"Weakness of visual working memory in autism","volume":"11","author":"Funabiki","year":"2018","journal-title":"Autism Res"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1155\/1999\/180434","article-title":"Differential contribution of right and left amygdala to affective information processing","volume":"11","author":"Markowitsch","year":"1998","journal-title":"Behav Neurol"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2020.00612\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T13:07:21Z","timestamp":1723122441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2020.00612\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,26]]},"references-count":57,"alternative-id":["10.3389\/fpsyt.2020.00612"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2020.00612","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,26]]},"article-number":"612"}}