{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:31:47Z","timestamp":1790721107295,"version":"4.1.0"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"DOI":"10.3389\/fpsyt.2020.00664","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:32:41Z","timestamp":1594373561000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":146,"title":["Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome \u2013 An Update"],"prefix":"10.3389","volume":"11","author":[{"given":"Will","family":"Takakura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel Disorders","volume":"150","author":"Lacy","year":"2016","journal-title":"Gastroenterology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095","article-title":"AGA technical review on irritable bowel syndrome","volume":"123","author":"Drossman","year":"2002","journal-title":"Gastroenterology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41395-018-0222-5","article-title":"Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis","volume":"114","author":"Ford","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.46","article-title":"Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus","volume":"112","author":"Rezaie","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000501","article-title":"ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth","volume":"115","author":"Pimentel","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197106242842502","article-title":"Volume and composition of human intestinal gas determined by means of an intestinal washout technic","volume":"284","author":"Levitt","year":"1971","journal-title":"N Engl J Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.133.3.572","article-title":"Factors influencing pulmonary methane excretion in man. An indirect method of studying the in situ metabolism of the methane-producing colonic bacteria","volume":"133","author":"Bond","year":"1971","journal-title":"J Exp Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90765-Q","article-title":"Production, metabolism, and excretion of hydrogen in the large intestine","volume":"102","author":"Christl","year":"1992","journal-title":"Gastroenterology"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05664.x","article-title":"Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretation","volume":"97","author":"Romagnuolo","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1476-9","article-title":"Prevalence and predictors of small intestinal bacterial overgrowth in irritable bowel syndrome: a systematic review and meta-analysis","volume":"53","author":"Chen","year":"2018","journal-title":"J Gastroenterol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s10620-009-0778-4","article-title":"Evaluating breath methane as a diagnostic test for constipation-predominant IBS","volume":"55","author":"Hwang","year":"2010","journal-title":"Dig Dis Sci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15588","article-title":"Irritable Bowel Syndrome, Particularly the Constipation-Predominant Form, Involves an Increase in Methanobrevibacter smithii, Which Is Associated with Higher Methane Production","volume":"10","author":"Ghoshal","year":"2016","journal-title":"Gut Liver"},{"key":"B13","doi-asserted-by":"publisher","first-page":"S","DOI":"10.1016\/S0016-5085(19)39870-1","article-title":"Patients with Appendectomy Have Significantly Less Methane in Their Exhaled Breath: is the Appendix a Vestigial Organ Or an Important Reservoir for Methanogens","volume":"156","author":"Takakura","year":"2019","journal-title":"Gastroenterology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1136\/gut.27.6.698","article-title":"Incidence of methanogenic bacteria in a sigmoidoscopy population: an association of methanogenic bacteria and diverticulosis","volume":"27","author":"Weaver","year":"1986","journal-title":"Gut"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"key":"B16","doi-asserted-by":"publisher","first-page":"190","DOI":"10.14309\/ajg.0000000000000504","article-title":"Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies","volume":"115","author":"Shah","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00365521.2019.1694067","article-title":"Small intestinal bacterial overgrowth is associated with Diarrhea-predominant irritable bowel syndrome by increasing mainly Prevotella abundance","volume":"54","author":"Wu","year":"2019","journal-title":"Scand J Gastroenterol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181a099a5","article-title":"Positive glucose breath testing is more prevalent in patients with IBS-like symptoms compared with controls of similar age and gender distribution","volume":"43","author":"Parodi","year":"2009","journal-title":"J Clin Gastroenterol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2010.56.4.242","article-title":"[Usefulness of lactulose breath test for the prediction of small intestinal bacterial overgrowth in irritable bowel syndrome]","volume":"56","author":"Park","year":"2010","journal-title":"Korean J Gastroenterol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06654.x","article-title":"Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: frequency and predictors","author":"Sachdeva","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"S132","DOI":"10.1016\/S1590-8658(12)60365-X","article-title":"P.07.16 Bacterial Overgrowth In Irritable Bowel Syndrome: A Cohort Study","volume":"44","author":"Bertel\u00e8","year":"2012","journal-title":"Digest Liver Dis"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12664-013-0417-z","article-title":"SI-11 Prevalence of small intestinal bacterial overgrowth in patients with irritable bowel syndrome using lactulose hydrogen breath test","volume":"32","author":"Philip","year":"2013","journal-title":"Indian J Gastroenterol"},{"key":"B23","first-page":"23","article-title":"Relationship betweeen the irritable bowel syndrome and small intestinal bacterial","volume":"28","author":"Qing","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"B24","first-page":"11","article-title":"Measurement of methane and hydrogen on lactulose breath test detects small intestinal bacterial overgrowth in patients with irritable bowel syndrome","volume":"26","author":"Li","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"B25","article-title":"Small intestinal bacterial overgrowth is associated to symptoms in irritable bowel syndrome. Evidence from a multicentre study in Romania","volume":"52","author":"Moraru","year":"2014","journal-title":"Rom J Intern Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.12.022","article-title":"Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy","volume":"8","author":"Lombardo","year":"2010","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302514d.50","article-title":"PWE-050\u2005Does small intestine bacterial overgrowth cause neurodysmotility in IBS and coeliac disease","volume":"61","author":"Evans","year":"2012","journal-title":"Gut"},{"key":"B28","first-page":"36","article-title":"Small bowel bacterial overgrowth in patients with irritable bowel syndrome: the first study in iran","volume":"7","author":"Abbasi","year":"2015","journal-title":"Middle East J Dig Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3230859","DOI":"10.1155\/2016\/3230859","article-title":"Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: Clinical Characteristics, Psychological Factors, and Peripheral Cytokines","volume":"2016","author":"Chu","year":"2016","journal-title":"Gastroenterol Res Pract"},{"key":"B30","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1023\/A:1021738515885","article-title":"Methane production during lactulose breath test is associated with gastrointestinal disease presentation","volume":"48","author":"Pimentel","year":"2003","journal-title":"Dig Dis Sci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01072.x","article-title":"The degree of breath methane production in IBS correlates with the severity of constipation","volume":"102","author":"Chatterjee","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e10554","DOI":"10.1097\/MD.0000000000010554","article-title":"Elevated methane levels in small intestinal bacterial overgrowth suggests delayed small bowel and colonic transit","volume":"97","author":"Suri","year":"2018","journal-title":"Med (Baltimore)"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00574.2004","article-title":"Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity","volume":"290","author":"Pimentel","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e13077","DOI":"10.1111\/nmo.13077","article-title":"The effects and mechanism of action of methane on ileal motor function","volume":"29","author":"Park","year":"2017","journal-title":"Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.655","article-title":"Methanogenic flora is associated with altered colonic transit but not stool characteristics in constipation without IBS","volume":"105","author":"Attaluri","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/BF00423270","article-title":"Methanosphaera stadtmaniae gen. nov., sp. nov.: a species that forms methane by reducing methanol with hydrogen","volume":"141","author":"Miller","year":"1985","journal-title":"Arch Microbiol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.43.1.227-232.1982","article-title":"Isolation of Methanobrevibacter smithii from human feces","volume":"43","author":"Miller","year":"1982","journal-title":"Appl Environ Microbiol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2197-1","article-title":"Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath","volume":"57","author":"Kim","year":"2012","journal-title":"Dig Dis Sci"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.3.418","article-title":"Inhibition of methanogenesis by human bile","volume":"37","author":"Florin","year":"1995","journal-title":"Gut"},{"key":"B40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0234906","article-title":"The microbiome in small intestinal bacterial overgrowth: the REIMAGINE study","author":"Leite","year":"2020","journal-title":"PloS One"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000122","article-title":"Breath tests in the diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome in comparison with quantitative upper gut aspirate culture","volume":"26","author":"Ghoshal","year":"2014","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.108712","article-title":"Small intestinal bacterial overgrowth in patients with irritable bowel syndrome","volume":"56","author":"Posserud","year":"2007","journal-title":"Gut"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2033-7","article-title":"The prevalence of overgrowth by aerobic bacteria in the small intestine by small bowel culture: relationship with irritable bowel syndrome","volume":"57","author":"Pyleris","year":"2012","journal-title":"Dig Dis Sci"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.8","article-title":"Autoimmunity as a Potential Cause of Post-Infectious Gut Dysmotility: A Longitudinal Observation","volume":"112","author":"Rezaie","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03399.x","article-title":"Systematic review and meta-analysis: The incidence and prognosis of post-infectious irritable bowel syndrome","volume":"26","author":"Thabane","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.007","article-title":"Increased risk for irritable bowel syndrome after acute diverticulitis","volume":"11","author":"Cohen","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.039","article-title":"Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-analysis","volume":"152","author":"Klem","year":"2017","journal-title":"Gastroenterology"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029","article-title":"Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis","volume":"10","author":"Lovell","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3201\/eid1701.P11101","article-title":"Foodborne illness acquired in the United States\u2013major pathogens","volume":"17","author":"Scallan","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.2.200","article-title":"Estimating the contribution of acute gastroenteritis to the overall prevalence of irritable bowel syndrome","volume":"18","author":"Shah","year":"2012","journal-title":"J\u00a0Neurogastroenterol Motil"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/BF01303174","article-title":"Intestinal permeability to [51Cr]EDTA in infectious diarrhea","volume":"38","author":"Zuckerman","year":"1993","journal-title":"Dig Dis Sci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.6.804","article-title":"Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome","volume":"47","author":"Spiller","year":"2000","journal-title":"Gut"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00672.x","article-title":"Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes","volume":"101","author":"Dunlop","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.micpath.2009.10.002","article-title":"Enteropathogenic Escherichia coli changes distribution of occludin and ZO-1 in tight junction membrane microdomains in vivo","volume":"48","author":"Zhang","year":"2010","journal-title":"Microb Pathog"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: the role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000053","article-title":"Diet, the gut microbiome, and epigenetics","volume":"20","author":"Hullar","year":"2014","journal-title":"Cancer J"},{"key":"B57","doi-asserted-by":"publisher","first-page":"12693","DOI":"10.1038\/srep12693","article-title":"Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome","volume":"5","author":"Pozuelo","year":"2015","journal-title":"Sci Rep"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12675","article-title":"Early-life stress-induced visceral hypersensitivity and anxiety behavior is reversed by histone deacetylase inhibition","volume":"27","author":"Moloney","year":"2015","journal-title":"Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322010000600012","article-title":"Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine","volume":"65","author":"Rapin","year":"2010","journal-title":"Clinics (Sao Paulo)"},{"key":"B60","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1136\/gutjnl-2017-315136","article-title":"Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome","volume":"68","author":"Zhou","year":"2019","journal-title":"Gut"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.04.002","article-title":"Does glutamine-enriched parenteral nutrition really affect intestinal morphology and gut permeability","volume":"23","author":"Hulsewe","year":"2004","journal-title":"Clin Nutr"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.028","article-title":"Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS","volume":"125","author":"Dunlop","year":"2003","journal-title":"Gastroenterology"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33579","article-title":"Activation of the mucosal immune system in irritable bowel syndrome","volume":"122","author":"Chadwick","year":"2002","journal-title":"Gastroenterology"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.006","article-title":"Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction","volume":"127","author":"Bercik","year":"2004","journal-title":"Gastroenterology"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1342141","article-title":"Reduced interstitial cells of Cajal and increased intraepithelial lymphocytes are associated with development of small intestinal bacterial overgrowth in post-infectious IBS mouse model","volume":"52","author":"Chen","year":"2017","journal-title":"Scand J Gastroenterol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9977-z","article-title":"A new rat model links two contemporary theories in irritable bowel syndrome","volume":"53","author":"Pimentel","year":"2008","journal-title":"Dig Dis Sci"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.4.434","article-title":"Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome","volume":"18","author":"Pokkunuri","year":"2012","journal-title":"J Neurogastroenterol Motil"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3435-5","article-title":"Autoimmunity Links Vinculin to the Pathophysiology of Chronic Functional Bowel Changes Following Campylobacter jejuni Infection in a Rat Model","volume":"60","author":"Pimentel","year":"2015","journal-title":"Dig Dis Sci"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1007\/s00018-017-2511-3","article-title":"Vinculin in cell-cell and cell-matrix adhesions","volume":"74","author":"Bays","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmxen.2016.07.002","article-title":"Clinical experience with the use of anti-CdtB and anti-vinculin antibodies in patients with diarrhea in Mexico","volume":"81","author":"Schmulson","year":"2016","journal-title":"Rev Gastroenterol Mex"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4585-z","article-title":"Assessment of Anti-vinculin and Anti-cytolethal Distending Toxin B Antibodies in Subtypes of Irritable Bowel Syndrome","volume":"62","author":"Rezaie","year":"2017","journal-title":"Dig Dis Sci"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05684-6","article-title":"Second-Generation Biomarker Testing for Irritable Bowel Syndrome Using Plasma Anti-CdtB and Anti-Vinculin Levels","volume":"64","author":"Morales","year":"2019","journal-title":"Dig Dis Sci"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1111\/jtm.12218","article-title":"Immunological Biomarkers in Postinfectious Irritable Bowel Syndrome","volume":"22","author":"Pike","year":"2015","journal-title":"J Travel Med"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e00064","DOI":"10.14309\/ctg.0000000000000064","article-title":"Circulating Anti-cytolethal Distending Toxin B and Anti-vinculin Antibodies as Biomarkers in Community and Healthcare Populations With Functional Dyspepsia and Irritable Bowel Syndrome","volume":"10","author":"Talley","year":"2019","journal-title":"Clin Transl Gastroenterol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1159\/000103892","article-title":"Small intestinal bacterial overgrowth: diagnosis and treatment","volume":"25","author":"Gasbarrini","year":"2007","journal-title":"Dig Dis"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21041","article-title":"Malabsorption syndrome with and without small intestinal bacterial overgrowth: a study on upper-gut aspirate using 1H NMR spectroscopy","volume":"56","author":"Bala","year":"2006","journal-title":"Magn Reson Med"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12479","article-title":"Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth","volume":"38","author":"Shah","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"B78","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1056\/NEJMoa1004409","article-title":"Rifaximin therapy for patients with irritable bowel syndrome without constipation","volume":"364","author":"Pimentel","year":"2011","journal-title":"N Engl J Med"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.08.003","article-title":"Repeat Treatment With Rifaximin Is Safe and Effective in Patients With Diarrhea-Predominant Irritable Bowel Syndrome","volume":"151","author":"Lembo","year":"2016","journal-title":"Gastroenterology"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4598-7","article-title":"Repeat Rifaximin for Irritable Bowel Syndrome: No Clinically Significant Changes in Stool Microbial Antibiotic Sensitivity","volume":"62","author":"Pimentel","year":"2017","journal-title":"Dig Dis Sci"},{"key":"B81","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1080\/19490976.2018.1460013","article-title":"Rifaximin is associated with modest, transient decreases in multiple taxa in the gut microbiota of patients with diarrhoea-predominant irritable bowel syndrome","volume":"10","author":"Fodor","year":"2019","journal-title":"Gut Microbes"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181c64c90","article-title":"A combination of rifaximin and neomycin is most effective in treating irritable bowel syndrome patients with methane on lactulose breath test","volume":"44","author":"Low","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9104-6","article-title":"Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled study","volume":"51","author":"Pimentel","year":"2006","journal-title":"Dig Dis Sci"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3157-8","article-title":"Antibiotic treatment of constipation-predominant irritable bowel syndrome","volume":"59","author":"Pimentel","year":"2014","journal-title":"Dig Dis Sci"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000444","article-title":"Lactulose Breath Testing as a Predictor of Response to Rifaximin in Patients With Irritable Bowel Syndrome With Diarrhea","volume":"114","author":"Rezaie","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.32","article-title":"Breath Testing for Small Intestinal Bacterial Overgrowth: A Means to Enrich Rifaximin Responders in IBS Patients","volume":"111","author":"Gupta","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15001","article-title":"Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome","volume":"48","author":"Ford","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008970312068","article-title":"Health-related quality of life and associated psychosocial factors in irritable bowel syndrome: a review","volume":"9","author":"Luscombe","year":"2000","journal-title":"Qual Life Res"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1053\/bega.1999.0038","article-title":"The role of psychosocial factors in irritable bowel syndrome","volume":"13","author":"Gaynes","year":"1999","journal-title":"Baillieres Best Pract Res Clin Gastroenterol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(88)80017-9","article-title":"Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome","volume":"95","author":"Drossman","year":"1988","journal-title":"Gastroenterology"},{"key":"B91","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/s41424-018-0030-7","article-title":"Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis","volume":"9","author":"Rao","year":"2018","journal-title":"Clin Transl Gastroenterol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1067\/j.cpsurg.2011.10.002","article-title":"Current management of short bowel syndrome","volume":"49","author":"Thompson","year":"2012","journal-title":"Curr Probl Surg"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.slsci.2015.10.001","article-title":"Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study","volume":"8","author":"Jackson","year":"2015","journal-title":"Sleep Sci"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B95","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/s12866-019-1617-1","article-title":"Optimizing microbiome sequencing for small intestinal aspirates: validation of novel techniques through the REIMAGINE study","volume":"19","author":"Leite","year":"2019","journal-title":"BMC Microbiol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1038\/s41467-019-09964-7","article-title":"Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders","volume":"10","author":"Saffouri","year":"2019","journal-title":"Nat Commun"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5312","article-title":"Hydrogen sulfide signaling in the gastrointestinal tract","volume":"20","author":"Linden","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"B98","doi-asserted-by":"publisher","first-page":"S","DOI":"10.1016\/S0016-5085(18)30625-5","article-title":"182 - Competitive Hydrogen Gas Utilization by Methane- and Hydrogen Sulfide-Producing Microorganisms and Associated Symptoms: Results of a Novel 4-Gas Breath Test Machine","volume":"154","author":"Singer-Englar","year":"2018","journal-title":"Gastroenterology"}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2020.00664\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:32:44Z","timestamp":1594373564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fpsyt.2020.00664\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,10]]},"references-count":98,"alternative-id":["10.3389\/fpsyt.2020.00664"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2020.00664","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,10]]},"article-number":"664"}}