{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:49:28Z","timestamp":1781153368533,"version":"3.54.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701776"],"award-info":[{"award-number":["81701776"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901383"],"award-info":[{"award-number":["81901383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventional frequency band (0.01\u20130.08 Hz) in TS. No published studies have reported abnormalities of local synchronization across different frequency bands. We estimated the alterations of local synchronization across five bands ranging from 0 to 0.25 Hz. Seventy-nine children with TS and 63 age-, sex-, and handedness-matched healthy children were recruited. Frequency-specific regional homogeneity (ReHo) and independent component analysis were used to identify functional alterations between TS and healthy children. TS patients showed significantly increased ReHo in the left precentral gyrus and decreased ReHo in the right operculum. Abnormal ReHo alterations of the superior frontal gyrus, superior parietal gyrus, anterior cingulate gyrus, putamen, superior temporal gyrus, and operculum were observed in different frequency bands. TS patients showed increased connectivity of the right superior frontal gyrus within the left executive control network. In addition, a significantly negative correlation was found between Yale Global Tic Severity Scale (YGTSS) vocal score and ReHo values of the right operculum in the highest frequency bands (0.198\u20130.25 Hz), while a significant positive correlation was found between YGTSS motor score and altered connectivity of the right superior frontal gyrus. The present study revealed frequency-specific abnormal alterations of ReHo in the whole brain and altered connectivity within the executive control network of TS children. Its neural importance and clinical practicability require further investigation.<\/jats:p>","DOI":"10.3389\/fpsyt.2020.543049","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T15:53:02Z","timestamp":1610034782000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome"],"prefix":"10.3389","volume":"11","author":[{"given":"Yu-Ting","family":"Lou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Long","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong-Jun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Feng","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Hua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1097\/chi.0b013e318068fbcc","article-title":"Tourette syndrome and tic disorders: a decade of progress","volume":"46","author":"Swain","year":"2007","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e4354","DOI":"10.1097\/MD.0000000000004354","article-title":"The prevalence of tic disorders for children in China: a systematic review and meta-analysis","volume":"95","author":"Yang","year":"2016","journal-title":"Medicine."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1177\/0883073808316370","article-title":"Validation of the presence of comorbidities in a Danish clinical cohort of children with tourette syndrome","volume":"23","author":"Mol Debes","year":"2008","journal-title":"J Child Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s00787-016-0823-8","article-title":"The effects of gilles de la tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review","volume":"25","author":"Evans","year":"2016","journal-title":"Eur Child Adolesc Psychiatry."},{"key":"B5","first-page":"2695","article-title":"[Tourette syndrome. 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