{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:05:05Z","timestamp":1792184705365,"version":"4.4.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Not a few patients with obsessive-compulsive disorder (OCD) have experienced events that affected the onset. The onset of OCD is not limited to the original meaning of trauma; rather, traumatic experiences such as unexpected exposure to contaminants or various stressful life events often cause the onset of OCD. It would be useful to understand the experiences surrounding the onset, including stressful life events and traumatic experiences, for comprehension of the pathophysiology of OCD. In the present study, we investigated the onset conditions of 281 patients with OCD and compared clinical characteristics among groups with or without stressful life events including traumatic experiences. As a result, 172 (61.2%) participants had experienced various stressful life events, and 98 (34%) participants had had traumatic experiences before the onset. Furthermore, the participants who had had stressful life events showed more contamination\/fear symptoms compared with those without such life events. Meanwhile, the patients who had had specific traumatic experiences showed a tendency toward hoarding obsessions. To comprehend the pathophysiology of OCD, it is important to understand the stressful life events that precede its onset.<\/jats:p>","DOI":"10.3389\/fpsyt.2020.561266","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T01:06:35Z","timestamp":1606957595000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["Impacts of Stressful Life Events and Traumatic Experiences on Onset of Obsessive-Compulsive Disorder"],"prefix":"10.3389","volume":"11","author":[{"given":"Keitaro","family":"Murayama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikana","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae","family":"Tsuruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Tomiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Hasuzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Mizobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenobu","family":"Kanba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"B1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: Fifth Edition (DSM-5)","year":"2013"},{"key":"B2","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1037\/h0054288","article-title":"A stimulus-response analysis of anxiety and its role as a reinforcing agent","volume":"46","author":"Mowrer","year":"1939","journal-title":"Psychol Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.comppsych.2004.02.010","article-title":"Life events and personality factors in children and adolescents with obsessive-compulsive disorder and other anxiety disorders","volume":"45","author":"Gothelf","year":"2004","journal-title":"Compr Psychiatry."},{"key":"B4","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1192\/bjp.144.2.185","article-title":"Life events and personality traits in obsessive-compulsive neurosis","volume":"144","author":"McKeon","year":"1984","journal-title":"Br J Psychiatry."},{"key":"B5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.eurpsy.2014.11.008","article-title":"Are stressful life events causally related to the severity of obsessive-compulsive symptoms? a monozygotic twin difference study","volume":"30","author":"Vidal-Ribas","year":"2015","journal-title":"Eur Psychiatry."},{"key":"B6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.psychres.2011.10.005","article-title":"Stressful life events and obsessive-compulsive disorder: clinical features and symptom dimensions","volume":"197","author":"Rosso","year":"2012","journal-title":"Psychiatry Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/j.brat.2006.08.018","article-title":"An investigation of traumatic life events and obsessive-compulsive disorder","volume":"45","author":"Cromer","year":"2007","journal-title":"Behav Res Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S0924-9338(99)00224-2","article-title":"Gender-related clinical differences in obsessive-compulsive disorder","volume":"14","author":"Bogetto","year":"1999","journal-title":"Eur Psychiatry."},{"key":"B9","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jpsychires.2020.07.027","article-title":"Social losses predict a faster onset and greater severity of obsessive-compulsive disorder","volume":"130","author":"Destree","year":"2020","journal-title":"J Psychiatr Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.11477\/mf.1405101120","article-title":"A research of onset situation and treatment response in obsessive-compulsive disorder: effect of life event and influential experience","volume":"49","author":"Tomita","year":"2007","journal-title":"Seishinigaku."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"the yale-brown obsessive-compulsive scale. 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