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Psychiatry"],"abstract":"<jats:p>Attempts to increase early identification of individuals in the early stages of bipolar disorders (i.e., individuals at high risk of bipolar disorders and\/or experiencing a subthreshold syndrome with bipolar symptoms) have highlighted the need to develop high benefit-low risk interventions. We suggest that any new psychological therapy should (i) be acceptable to young people seeking help for the first time, (ii) be applicable to \u201cat risk\u201d conditions and sub-syndromal states and (iii) consider pluripotent factors that may be linked to illness progression not only for bipolar disorders specifically but also for other potential disease trajectories. However, evidence indicates that current interventions for youth with emerging mood disorders mainly represent approaches abbreviated from \u201cdisorder-specific\u201d therapies used with older adults and are primarily offered to first episode cases of bipolar disorders who are also receiving psychotropic medication. This brief report discusses empirical findings used to construct core targets for therapeutic interventions that might reduce or delay transition to full-threshold bipolar disorders. We describe an intervention that includes strategies for problem-solving, reducing sleep-wake cycle disturbances, self-management of rumination and that addresses the needs of individuals with \u201csub-threshold\u201d presentations who are probably at risk of developing a bipolar or other major mental disorders. Outcome data from a case series of 14 youth indicates that the intervention appears to demonstrate a relatively high benefit-to-risk ratio, promising levels of engagement with the therapy modules, and the therapy appears to be acceptable to a wide range of help-seeking youth with early expressions of bipolar psychopathology.<\/jats:p>","DOI":"10.3389\/fpsyt.2020.616829","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T05:13:11Z","timestamp":1611292391000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Brief Research Report: A Pilot Study of Cognitive Behavioral Regulation Therapy (CBT-REG) for Young People at High Risk of Early Transition to Bipolar Disorders"],"prefix":"10.3389","volume":"11","author":[{"given":"Jan","family":"Scott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1016\/S0140-6736(11)60512-6","article-title":"Global burden of disease in young people aged 10-24 years: a systematic analysis","volume":"377","author":"Gore","year":"2011","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1146\/annurev.clinpsy.2.022305.095213","article-title":"Reinterpreting comorbidity: a model-based approach to understanding and classifying psychopathology","volume":"2","author":"Krueger","year":"2006","journal-title":"Ann Rev Clin Psychol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1001\/jamapsychiatry.2018.3658","article-title":"Exploring comorbidity within mental disorders among a Danish national population","volume":"76","author":"Plana-Ripoll","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1017\/S2045796020000633","article-title":"Comorbidity within mental disorders: a comprehensive analysis based on 145 990 survey respondents from 27 countries","volume":"29","author":"McGrath","year":"2020","journal-title":"Epidemiol Psychiatr Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1176\/appi.ajp.160.8.1385","article-title":"Examining the effects of prevention programs on the incidence of new cases of mental disorders: the lack of statistical power","volume":"160","author":"Cuijpers","year":"2003","journal-title":"Am J Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/wps.20745","article-title":"Trans-diagnostic clinical staging in youth mental health: a first international consensus statement","volume":"19","author":"Shah","year":"2020","journal-title":"World Psychiatry"},{"key":"B7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/wps.20514","article-title":"Beyond the \u201cat risk mental state\u201d concept: transitioning to transdiagnostic psychiatry","volume":"17","author":"McGorry","year":"2018","journal-title":"World Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/S2215-0366(15)00156-X","article-title":"An evidence map of psychosocial interventions for the earliest stages of bipolar disorder","volume":"2","author":"Vallarino","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/eip.12082","article-title":"Psychotherapeutic interventions in individuals at risk of developing bipolar disorder: a systematic review","volume":"8","author":"Pfennig","year":"2014","journal-title":"Early Interv Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/bdi.12273","article-title":"Randomized, controlled trial of interpersonal and social rhythm therapy for young people with bipolar disorder","volume":"17","author":"Inder","year":"2015","journal-title":"Bipolar Disord"},{"key":"B11","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/bdi.12894","article-title":"Efficacy of cognitive-behavioral group therapy in patients at risk for serious mental illness presenting with subthreshold bipolar symptoms: results from a prespecified interim analysis of a multicenter, randomized, controlled study","volume":"22","author":"Leopold","year":"2020","journal-title":"Bipolar Disord"},{"key":"B12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/med\/9780198820833.003.0012","article-title":"From principles to practice: translating the philosophy of early intervention to individuals with emerging bipolar disorders. 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