{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:23:53Z","timestamp":1759940633383,"version":"3.41.2"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> During the coronavirus disease 2019 (COVID-19) pandemic, quarantine as an effective public health measure has been widely used in China and elsewhere to slow down the spread, while high-risk psychological response populations remain under-reported.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> The aim of the study is to investigate the depressive and anxiety symptoms among the high-risk individuals quarantined during the COVID-19 pandemic in China.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> An online survey was conducted from February 29 to April 10, 2020, among individuals quarantined for at least 2 weeks due to the high-risk exposure. Chinese versions of the nine-item Patient Health Questionnaire (PHQ-9) with a seven-item Generalized Anxiety Disorder (GAD-7) were applied to assess depressive and anxiety symptoms, respectively. Compliance with quarantine and knowledge of COVID-19 was also assessed. An unconditional logistic regression model was performed to identify the correlators.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Of the 1,260 participants completing the full survey, 14.0% (95% CI: 12.2\u201316.1%), 7.1% (95% CI: 5.9\u20138.7%), and 6.3% (95% CI: 5.1\u20137.8%) had at least moderate symptoms of depression, anxiety, and a combination of depression and anxiety (CDA), respectively; 14.8% (95% CI: 13.0\u201316.9%) had at least one condition. Multivariate analysis showed that participants with an undergraduate or above degree were more likely to report depressive (OR = 2.98, 95% CI: 1.56\u20135.72) and anxiety symptoms (OR = 2.95, 95% CI: 1.14\u20137.63) than those with middle school education. Those who were unemployed (OR = 0.37, 95% CI: 0.21\u20130.65 for depression; OR = 0.31, 95% CI: 0.14\u20130.73 for anxiety), students (OR = 0.14, 95% CI: 0.04\u20130.48 for depression; OR = 0.11, 95% CI: 0.01\u20130.85 for anxiety), and more knowledgeable of COVID-19 (OR = 0.84, 95% CI: 0.73\u20130.96 for depression, OR = 0.82, 95% CI: 0.68\u20130.98 for anxiety) were less likely to report depressive and anxiety symptoms. Higher quarantine compliance correlated with lower risks of depressive (OR = 0.94, 95% CI: 0.91\u20130.96) and anxiety symptoms (OR = 0.95, 95% CI: 0.91\u20130.98).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Individuals under quarantine during the COVID-19 pandemic suffered prevalent depressive and anxiety symptoms. Consequently, comprehensive interventional measures, including knowledge dissemination, timely virus tests, and strengthened communication, may minimize quarantine's adverse effects.<\/jats:p>","DOI":"10.3389\/fpsyt.2021.566241","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T05:55:43Z","timestamp":1613368543000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Depressive and Anxiety Symptoms Among People Under Quarantine During the COVID-19 Epidemic in China: A Cross-Sectional 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