{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:25:32Z","timestamp":1753892732871,"version":"3.41.2"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Major depressive disorders are strongly correlated with alterations in sleep pattern and architecture, including changes in the Rapid Eye Movement (REM) phase. However, it is still unknown whether sleep alterations precede other depression-related symptoms, particularly in patients with recurrent depressive episodes at relapse risk.<\/jats:p><jats:p><jats:bold>Case Presentation:<\/jats:bold> We initiated a study aimed at examining the value of ambulatory sleep monitoring using a WatchPAT device, in predicting recurrence of Major depression. Depression was assessed monthly with the Beck Depression Inventory version II (BDI-II). Here we present the case of a 63 years old woman, with a history of recurrent depressive episodes. AT the time of recruitment, she was asymptomatic, she experienced recurrence of Major depression 3 months into the study. We observed a significant reduction of the Rem Latency parameters 5 weeks prior to BDI-II score increase, reflecting major depressive episode recurrence.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Though our results are preliminary, they suggest that ambulatory sleep monitoring can be used as a simple and accessible tool, predicting recurrence of Major Depressive episodes in patients at high risk, thus enabling early treatment intervention.<\/jats:p>","DOI":"10.3389\/fpsyt.2021.572660","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T07:35:11Z","timestamp":1624606511000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Sleep Monitoring Using WatchPAT Device to Predict Recurrence of Major Depression in Patients at High Risk for Major Depression Disorder Recurrence: A Case Report"],"prefix":"10.3389","volume":"12","author":[{"given":"Daniel","family":"Harlev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramit","family":"Ravona-Springer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonatan","family":"Nuriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Fruchter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","first-page":"269e75","DOI":"10.3109\/15622970802503086","article-title":"Sleep disturbances: core symptoms of major depressive disorder rather than associated or comorbid disorders","volume":"10","author":"Mendlewicz","year":"2009","journal-title":"World J Biol Psychiatry"},{"journal-title":"Kaplan & Sadock's Synopsis of Psychiatry: Behavioral Sciences","year":"2015","author":"Sadock","key":"B3"},{"key":"B4","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1001\/archpsyc.1989.01810090013002","article-title":"The advantage of early treatment intervention in recurrent depression","volume":"46","author":"Kupfer","year":"1989","journal-title":"Arch Gen Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","first-page":"67e103","DOI":"10.1016\/S0301-0511(01)00090-4","article-title":"Sleep and depression e results from psychobiological studies: an overview","volume":"57","author":"Riemann","year":"2001","journal-title":"Biol Psychol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"329e35","DOI":"10.31887\/DCNS.2008.10.3\/dnutt","article-title":"Sleep disorders as core symptoms of depression","volume":"10","author":"Nutt","year":"2008","journal-title":"Dialogues Clin Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1254e69","DOI":"10.4088\/JCP.v66n1008","article-title":"Sleep and depression","volume":"66","author":"Tsuno","year":"2005","journal-title":"J Clin Psychiatry."},{"key":"B8","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0165-1781(00)00178-5","article-title":"Slow-wave activity in NREM sleep: sex and age effects in depressed outpatients and healthy controls","volume":"95","author":"Armitage","year":"2000","journal-title":"Psychiatry Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.biopsych.2011.07.016","article-title":"A meta-analysis of electroencephalographic sleep in depression: evidence for genetic biomarkers","volume":"70","author":"Pillai","year":"2011","journal-title":"Biol Psychiatry."},{"key":"B10","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.smrv.2012.11.001","article-title":"REM sleep dysregulation in depression: state of the art","volume":"17","author":"Palagini","year":"2013","journal-title":"Sleep Med Rev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/0006-3223(95)00188-3","article-title":"Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults","volume":"39","author":"Breslau","year":"1996","journal-title":"Biol Psychiatry"},{"key":"B12","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/0006-3223(87)90090-4","article-title":"REM latency concordance in depressed family members","volume":"22","author":"Giles","year":"1987","journal-title":"Biol Psychiatry."},{"key":"B13","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0165-0327(88)90071-7","article-title":"Risk factors in families of unipolar depression. 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