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We reported the case of a 61-year-old Japanese woman who presented with intermittent dissociative stupor for several months. Despite her prolonged symptoms, the administration of lorazepam, escitalopram, and aripiprazole, which selectively enhance GABAergic and serotoninergic activity, improved her stupor and prevented relapse. These findings may help with the treatment of persistent dissociative stupor.<\/jats:p>","DOI":"10.3389\/fpsyt.2021.641474","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T04:22:53Z","timestamp":1621398173000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: GABAergic and Serotoninergic Agents for the Treatment and Prevention of Prolonged Dissociative Stupor"],"prefix":"10.3389","volume":"12","author":[{"given":"Daisuke","family":"Yoshioka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S570","DOI":"10.1016\/j.eurpsy.2017.01.840","article-title":"Incidence of dissociative stupor and possession in private psychiatry clinic","volume":"41","author":"Dua","year":"2017","journal-title":"Eur Psychiatry."},{"key":"B2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.4103\/IJPSYM.IJPSYM_237_17","article-title":"Psychological dissection of patients with dissociative disorder: a cross-sectional study","volume":"40","author":"Reddy","year":"2018","journal-title":"Indian J Psychol Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1600-0447.1997.tb09617.x","article-title":"Limited utility of ICD-10 and DSM-IV classification of dissociative and conversion disorders in India","volume":"95","author":"Alexander","year":"1997","journal-title":"Acta Psychiatr Scand"},{"key":"B4","first-page":"1866","article-title":"Dissociative disorders","volume-title":"Kaplan & Sadock's Comprehensive Textbook of Psychiatry.","author":"Loewenstein","year":"2017"},{"key":"B5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4103\/0019-5545.46073","article-title":"Somatoform and dissociative disorders in children and adolescents: a comparative study","volume":"47","author":"Malhotra","year":"2005","journal-title":"Indian J Psychiatry."},{"key":"B6","first-page":"155","volume-title":"The Psychological Consequences of Cerebral Disorder. 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