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In this study, 76 patients on MMT from the Wuhan First Health Clinic were selected as the research objects to investigate the effect of COVID-19 on the levels of stress, anxiety, and depression, as well as the withdrawal symptoms and craving and substance use. Our results revealed that, during the outbreak, the Perceived Stress Scale (PSS) score, HAMA score, HAMD score, and craving in the included patients was significantly higher than that at the baseline and post-epidemic (<jats:italic>p<\/jats:italic> &amp;lt; 0.01, <jats:italic>p<\/jats:italic> &amp;lt; 0.01, <jats:italic>p<\/jats:italic> &amp;lt; 0.01, <jats:italic>p<\/jats:italic> &amp;lt; 0.01, respectively); the positive rate of morphine and methamphetamine urine test was significantly lower than that the post-epidemic (<jats:italic>p<\/jats:italic> = 0.01, <jats:italic>p<\/jats:italic> &amp;lt; 0.01, respectively); the amount of tobacco used during the outbreak and the post-epidemic period was significantly higher than that at the baseline (<jats:italic>p<\/jats:italic> &amp;lt; 0.01, <jats:italic>p<\/jats:italic> &amp;lt; 0.01, respectively), while the amount of alcohol consumed at the outbreak was significantly higher than at the baseline and the post-epidemic (<jats:italic>p<\/jats:italic> &amp;lt; 0.01, <jats:italic>p<\/jats:italic> &amp;lt; 0.01, respectively). The negative emotions aroused by the COVID-19 outbreak and the accompanying social isolation to patients on MMT are an important factor of negative reinforcement that adversely affected the patients' craving for drugs and the consumption of legal substances. This finding suggests the need to strengthen the psychological counseling for patients on MMT during severe epidemic, actively alleviating the negative emotions, reducing the risk of substance abuse, and strengthening drug management after the epidemic to prevent the rise of substance (legal or illegal) abuse.<\/jats:p>","DOI":"10.3389\/fpsyt.2021.653662","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T04:49:57Z","timestamp":1617079797000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Coronavirus Disease 2019 on the Psychology and Behavior of Patients on Methadone Maintenance Treatment in Wuhan, China: A Clinical Observational Study"],"prefix":"10.3389","volume":"12","author":[{"given":"Xuebing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.phrs.2019.02.014","article-title":"The paraventricular thalamic nucleus: a key hub of neural circuits underlying drug addiction","volume":"142","author":"Zhou","year":"2019","journal-title":"Pharmacol Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"107532","DOI":"10.1016\/j.drugalcdep.2019.06.034","article-title":"Monitoring consumption of methadone and heroin in major Chinese cities by wastewater-based epidemiology","volume":"205","author":"Du","year":"2019","journal-title":"Drug Alcohol Depend"},{"key":"B3","article-title":"National methadone maintenance treatment working: who uses methadone services in China? 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