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Psychiatry"],"abstract":"<jats:p>Mental health problems in the general population have been reported during the SARS-CoV-2 pandemic; however, there were rare data in persons with chronic myeloid leukemia (CML). Therefore, we performed a cross-sectional study on mental health evaluated using the 9-item Patient Health Questionnaire (PHQ-9; depression), the 7-item Generalized Anxiety Disorder (GAD-7; anxiety), and the 22-item Impact of Event Scale\u2014Revised (IES-R; distress), including subscales of avoidance, intrusion, and hyper-arousal in persons with CML, non-cancer persons, and immediate family members of persons with cancer as controls (\u226516 years) by an online survey. Data from 3,197 persons with CML and 7,256 controls were collected. In multivariate analyses, CML was significantly associated with moderate to severe depression (OR = 1.6; 95% Confidence Interval [CI], 1.4, 1.9; <jats:italic>p<\/jats:italic> &amp;lt; 0.001), anxiety (OR = 1.4 [1.1, 1.7]; <jats:italic>p<\/jats:italic> = 0.001), distress (OR = 1.3 [1.1, 1.5]; <jats:italic>p<\/jats:italic> &amp;lt; 0.001), and hyper-arousal (OR = 1.5 [1.3, 1.6]; <jats:italic>p<\/jats:italic> &amp;lt; 0.001). Moreover, delay in regular monitoring was significantly associated with depression (OR 1.3 [1.0, 1.7]; <jats:italic>p<\/jats:italic> = 0.024), anxiety (OR = 1.3 [1.0, 1.8]; <jats:italic>p<\/jats:italic> = 0.044), avoidance (OR = 1.2 [1.0, 1.4]; <jats:italic>p<\/jats:italic> = 0.017), and intrusion (OR = 1.2 [1.0, 1.4]; <jats:italic>p<\/jats:italic> = 0.057); tyrosine kinase-inhibitor dose reduction or discontinuation, depression (OR = 1.9 [1.3, 2.8]; <jats:italic>p<\/jats:italic> = 0.001), distress (OR = 2.0 [1.4, 2.8]; <jats:italic>p<\/jats:italic> &amp;lt; 0.001), avoidance (OR = 1.6 [1.2, 2.1]; <jats:italic>p<\/jats:italic> = 0.004), intrusion (OR = 1.6 [1.1, 2.1]; <jats:italic>p<\/jats:italic> = 0.006), and hyper-arousal (OR = 1.3 [1.0, 1.8]; <jats:italic>p<\/jats:italic> = 0.088). We concluded that persons with CML during the SARS-CoV-2 pandemic have worse mental health including depression, anxiety, and distress symptoms. Decreasing or stopping monitoring or dose resulted in adverse mental health consequences.<\/jats:p>","DOI":"10.3389\/fpsyt.2021.679932","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T04:37:42Z","timestamp":1623127062000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Mental Health in Persons With Chronic Myeloid Leukemia During the SARS-CoV-2 Pandemic: The Need for Increased Access to Health Care Services"],"prefix":"10.3389","volume":"12","author":[{"given":"Mei","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert 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