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Rumination and executive dysfunction characterize adult-onset MDD, but sex differences in these domains and in the related brain mechanisms are still largely unexplored. The present pilot study aimed to explore any interactions between adult-onset MDD and sex on brain morphology and brain function during a Go\/No-Go paradigm. We hypothesized to detect diagnosis by sex effects on brain regions involved in self-referential processes and cognitive control. Twenty-four subjects, 12 healthy (HC) (mean age 68.7 y, 7 females and 5 males) and 12 affected by adult-onset MDD (mean age 66.5 y, 5 females and 7 males), underwent clinical evaluations and a 3T magnetic resonance imaging (MRI) session. Diagnosis and diagnosis by sex effects were assessed on regional gray matter (GM) volumes and task-related functional MRI (fMRI) activations. The GM volume analyses showed diagnosis effects in left mid frontal cortex (<jats:italic>p<\/jats:italic> &amp;lt; 0.01), and diagnosis by sex effects in orbitofrontal, olfactory, and calcarine regions (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). The Go\/No-Go fMRI analyses showed MDD effects on fMRI activations in left precuneus and right lingual gyrus, and diagnosis by sex effects on fMRI activations in right parahippocampal gyrus and right calcarine cortex (<jats:italic>p<\/jats:italic> &amp;lt; 0.001, \u2265 40 voxels). Our exploratory results suggest the presence of sex-specific brain correlates of adult-onset MDD\u2013especially in regions involved in attention processing and in the brain default mode\u2013potentially supporting cognitive and symptom differences between sexes.<\/jats:p>","DOI":"10.3389\/fpsyt.2021.683912","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T07:22:57Z","timestamp":1641367377000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Sexual Dimorphism in the Brain Correlates of Adult-Onset Depression: A Pilot Structural and Functional 3T MRI Study"],"prefix":"10.3389","volume":"12","author":[{"given":"Maria 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