{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:54:53Z","timestamp":1793620493950,"version":"4.5.0"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>The characterization of adolescents at high risk for developing depression has traditionally relied on the presence or absence of single risk factors. More recently, the use of composite risk scores combining information from multiple variables has gained attention in prognostic research in the field of mental health. We previously developed a sociodemographic composite score to estimate the individual level probability of depression occurrence in adolescence, the Identifying Depression Early in Adolescence Risk Score (IDEA-RS).<\/jats:p><jats:p><jats:bold>Objectives:<\/jats:bold>In this report, we present the rationale, methods, and baseline characteristics of the Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo), a study designed for in-depth examination of multiple neurobiological, psychological, and environmental measures associated with the risk of developing and with the presence of depression in adolescence, with a focus on immune\/inflammatory and neuroimaging markers.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>Using the IDEA-RS as a tool for risk stratification, we recruited a new sample of adolescents enriched for low (LR) and high (HR) depression risk, as well as a group of adolescents with a currently untreated major depressive episode (MDD). Methods for phenotypic, peripheral biological samples, and neuroimaging assessments are described, as well as baseline clinical characteristics of the IDEA-RiSCo sample.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>A total of 7,720 adolescents aged 14\u201316 years were screened in public state schools in Porto Alegre, Brazil. We were able to identify individuals at low and high risk for developing depression in adolescence: in each group, 50 participants (25 boys, 25 girls) were included and successfully completed the detailed phenotypic assessment with ascertainment of risk\/MDD status, blood and saliva collections, and magnetic resonance imaging (MRI) scans. Across a variety of measures of psychopathology and exposure to negative events, there was a clear pattern in which either the MDD group or both the HR and the MDD groups exhibited worse indicators in comparison to the LR group.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold>The use of an empirically-derived composite score to stratify risk for developing depression represents a promising strategy to establish a risk-enriched cohort that will contribute to the understanding of the neurobiological correlates of risk and onset of depression in adolescence.<\/jats:p>","DOI":"10.3389\/fpsyt.2021.697144","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T05:29:03Z","timestamp":1624253343000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["The Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo): Rationale, Methods, and Baseline Characteristics"],"prefix":"10.3389","volume":"12","author":[{"given":"Christian","family":"Kieling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Buchweitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Caye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Manfro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivka","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Viduani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio","family":"An\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Battel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Benetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Karmacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon A.","family":"Kohrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Petresco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jader","family":"Piccin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Augusto","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Rohrsetzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Velazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leehyun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzanna","family":"Zajkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Zonca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnna R.","family":"Swartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Mondelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1001\/archpsyc.1997.01830160065009","article-title":"Coming to terms with the terms of risk","volume":"54","author":"Kraemer","year":"1997","journal-title":"Arch Gen Psychiatry."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015","volume":"70","author":"Roth","year":"2017","journal-title":"J Am Coll Cardiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"Wilson","year":"1998","journal-title":"Circulation."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e42","DOI":"10.1016\/S0140-6736(18)32408-5","article-title":"Reducing the global burden of depression: a Lancet\u2013World Psychiatric Association Commission","volume":"393","author":"Herrman","year":"2019","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1001\/jamapsychiatry.2019.1200","article-title":"From many to one to many-the search for causes of psychiatric illness","volume":"76","author":"Kendler","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jaac.2014.10.010","article-title":"Major depression in the national comorbidity survey-adolescent supplement: prevalence, correlates, and treatment","volume":"54","author":"Avenevoli","year":"2015","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4758","DOI":"10.3390\/ijerph120504758","article-title":"Where to go from here? An exploratory meta-analysis of the most promising approaches to depression prevention programs for children and adolescents","volume":"12","author":"Hetrick","year":"2015","journal-title":"Int J Environ Res Public Health."},{"key":"B8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S2352-4642(19)30059-8","article-title":"Identifying depression early in adolescence","volume":"3","author":"Kieling","year":"2019","journal-title":"Lancet Child Adolesc Health."},{"key":"B9","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.jaac.2017.09.419","article-title":"Here\/in this issue and there\/abstract thinking: E Pluribus unum","volume":"56","author":"Kieling","year":"2017","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"B10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1001\/jamapsychiatry.2020.3049","article-title":"From basic science to clinical application of polygenic risk scores: a primer","volume":"78","author":"Wray","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.jaac.2019.10.011","article-title":"Meta-analysis: exposure to early life stress and risk for depression in childhood and adolescence","volume":"59","author":"LeMoult","year":"2020","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1001\/jama.2020.2436","article-title":"Addressing social determinants of health: time for a polysocial risk score","volume":"323","author":"Figueroa","year":"2020","journal-title":"JAMA."},{"key":"B13","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jaac.2019.12.004","article-title":"Identifying adolescents at risk for depression: a prediction score performance in cohorts based in three different continents","volume":"60","author":"Rocha","year":"2020","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00787-020-01505-8","article-title":"Predicting the risk of depression among adolescents in Nepal using a model developed in Brazil: the IDEA Project","volume":"30","author":"Brathwaite","year":"2020","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","first-page":"113511","DOI":"10.1016\/j.psychres.2020.113511","article-title":"Predicting the risk of future depression among school-attending adolescents in Nigeria using a model developed in Brazil","volume":"294","author":"Brathwaite","year":"2020","journal-title":"Psychiatry Research."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1093\/ije\/dyx249","article-title":"Cohort profile update: the 1993 Pelotas (Brazil) birth cohort follow-up at 22 years","volume":"47","author":"Gon\u00e7alves","year":"2018","journal-title":"Int J Epidemiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/S1054-139X(01)00333-0","article-title":"The patient health questionnaire for adolescents: validation of an instrument for the assessment of mental disorders among adolescent primary care patients","volume":"30","author":"Johnson","year":"2002","journal-title":"J Adolesc Health."},{"key":"B19","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1590\/1516-4446-2017-2317","article-title":"Schedule for affective disorders and schizophrenia for school-age children - present and lifetime version (K-SADS-PL), DSM-5 update: translation into Brazilian Portuguese","volume":"39","author":"Caye","year":"2017","journal-title":"Braz J Psychiatry."},{"key":"B20","volume-title":"Manual for the Wechsler Abbreviated Intelligence Scale (WASI)","author":"Wechsler","year":"1999"},{"key":"B21","first-page":"227","article-title":"Apresenta\u00e7\u00e3o da escala de intelig\u00eancia Wechsler abreviada (WASI)","volume":"5","author":"Yates","year":"2006","journal-title":"Avalia\u00e7\u00e3o Psicol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/mpr.1459","article-title":"High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results","volume":"24","author":"Salum","year":"2015","journal-title":"Int J Methods Psychiatr Res."},{"key":"B23","volume-title":"Tanner Stages","author":"Emmanuel","year":"2019"},{"key":"B24","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1176\/appi.ajp.2012.12071000","article-title":"DSM-5 field trials in the United States and Canada, Part III: development and reliability testing of a cross-cutting symptom assessment for DSM-5","volume":"170","author":"Narrow","year":"2013","journal-title":"Am J Psychiatry."},{"key":"B25","first-page":"992","volume-title":"DSM-5: Manual Diagn\u00f3stico e estat\u00edstico de Transtornos Mentais","year":"2014"},{"key":"B26","volume-title":"The Development of a Questionnaire for Use in Epidemiological Studies of Depression in Children and Adolescents","author":"Angold","year":"1987"},{"key":"B27","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1590\/2237-6089-2017-0019","article-title":"Translation and cross-cultural adaptation into Brazilian Portuguese of the Mood and Feelings Questionnaire (MFQ) - long version","volume":"40","author":"Rosa","year":"2018","journal-title":"Trends Psychiatry Psychother."},{"key":"B28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1192\/bjp.167.1.99","article-title":"A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale","volume":"167","author":"Snaith","year":"1995","journal-title":"Br J Psychiatry."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1111\/j.1469-7610.2012.02561.x","article-title":"The affective reactivity index: a concise irritability scale for clinical and research settings","volume":"53","author":"Stringaris","year":"2012","journal-title":"J Child Psychol Psychiatry."},{"key":"B30","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1590\/S2237-60892013000300004","article-title":"Cross-cultural adaptation and preliminary psychometric properties of the Affective Reactivity Index in Brazilian Youth: implications for DSM-5 measured irritability","volume":"35","author":"DeSousa","year":"2013","journal-title":"Trends Psychiatry Psychother."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1176\/appi.ajp.2011.10111704","article-title":"The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults","volume":"168","author":"Posner","year":"2011","journal-title":"Am J Psychiatry."},{"key":"B32","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0005-7967(98)00034-5","article-title":"A measure of anxiety symptoms among children","volume":"36","author":"Spence","year":"1998","journal-title":"Behav Res Ther."},{"key":"B33","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.janxdis.2014.03.006","article-title":"Psychometric properties of the Brazilian-Portuguese version of the Spence Children's Anxiety Scale (SCAS): self- and parent-report versions","volume":"28","author":"DeSousa","year":"2014","journal-title":"J Anxiety Disord."},{"key":"B34","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S1389-9457(00)00065-4","article-title":"Validation of the Insomnia Severity Index as an outcome measure for insomnia research","volume":"2","author":"Bastien","year":"2001","journal-title":"Sleep Med."},{"key":"B35","volume-title":"Adaptation and validation of the Insomnia Severity Index (ISI): population characteristics, normative values and associated factors","author":"Castro","year":"2011"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.adolescence.2013.09.008","article-title":"The measurement of reflective function in adolescents with and without borderline traits","volume":"36","author":"Ha","year":"2013","journal-title":"J Adolesc."},{"key":"B37","unstructured":"The reflexive function in adolescents in conflict with the law and school adolescentse28320e FavarettoTC BothLM da Cruz BenettiSP Psico.502019"},{"key":"B38","first-page":"165","article-title":"Development and psychometric evaluation of the Resilience Scale","volume":"1","author":"Wagnild","year":"1993","journal-title":"J Nurs Meas."},{"key":"B39","doi-asserted-by":"publisher","first-page":"8156","DOI":"10.1073\/pnas.1601301113","article-title":"Psychological resilience and the gene regulatory impact of posttraumatic stress in Nepali child soldiers","volume":"113","author":"Kohrt","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1192\/bjp.bp.114.144519","article-title":"Positive attributes in children and reduced risk of future psychopathology","volume":"206","author":"Vidal-Ribas","year":"2015","journal-title":"Br J Psychiatry."},{"key":"B41","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jaac.2015.10.013","article-title":"Positive attributes buffer the negative associations between low intelligence and high psychopathology with educational outcomes","volume":"55","author":"Hoffmann","year":"2016","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.2044-8341.1979.tb02487.x","article-title":"A parental bonding instrument","volume":"52","author":"Parker","year":"1979","journal-title":"Br J Med Psychol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0145-2134(02)00541-0","article-title":"Development and validation of a brief screening version of the Childhood Trauma Questionnaire","volume":"27","author":"Bernstein","year":"2003","journal-title":"Child Abuse Negl."},{"key":"B44","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1590\/S0034-89102006000200010","article-title":"Translation and content validation of the Childhood Trauma Questionnaire into Portuguese language","volume":"40","author":"Grassi-Oliveira","year":"2006","journal-title":"Rev Sa\u00fade P\u00fablica."},{"key":"B45","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1093\/ije\/dyx117","article-title":"Cohort profile: the NSPN 2400 cohort: a developmental sample supporting the Wellcome Trust NeuroScience in Psychiatry Network","volume":"47","author":"Kiddle","year":"2018","journal-title":"Int J Epidemiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1001\/archpedi.155.8.940","article-title":"A multicomponent program for nutrition and physical activity change in primary care: PACE+ for adolescents","volume":"155","author":"Patrick","year":"2001","journal-title":"Arch Pediatr Adolesc Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1590\/S0034-759020160106","article-title":"Socioeconomic stratification criteria and classification tools in Brazil","volume":"56","author":"Kamakura","year":"2016","journal-title":"Rev Adm Empres."},{"key":"B48","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1037\/t55280-000","article-title":"Children's depression rating scale-revised (September 1984)","volume":"21","author":"Poznanski","year":"1985","journal-title":"Psychopharmacol Bull."},{"key":"B49","first-page":"15","article-title":"Escala para avalia\u00e7\u00e3o de depress\u00e3o em crian\u00e7as-revisada (CDRS-R): uma an\u00e1lise explorat\u00f3ria","volume":"5","author":"Barbosa","year":"1997","journal-title":"Rev Neuropsiquiatr Infanc Adolesc."},{"key":"B50","first-page":"28","article-title":"The clinical global impressions scale: applying a research tool in clinical practice","volume":"4","author":"Busner","year":"2007","journal-title":"Psychiatry."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1001\/archpsyc.1983.01790100074010","article-title":"A children's global assessment scale (CGAS)","volume":"40","author":"Shaffer","year":"1983","journal-title":"Arch Gen Psychiatry."},{"key":"B52","first-page":"880","volume-title":"Manual Diagn\u00f3stico e Estat\u00edstico de Transtornos Mentais: Texto Revisado (DSM-IV-TR)","year":"2008"},{"key":"B53","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.neuroimage.2013.05.033","article-title":"Function in the human connectome: task-fMRI and individual differences in behavior","volume":"80","author":"Barch","year":"2013","journal-title":"Neuroimage."},{"key":"B54","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1126\/science.1071829","article-title":"Serotonin transporter genetic variation and the response of the human amygdala","volume":"297","author":"Hariri","year":"2002","journal-title":"Science."},{"key":"B55","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1176\/appi.ajp.2014.14020195","article-title":"Developmental change in amygdala reactivity during adolescence: effects of family history of depression and stressful life events","volume":"172","author":"Swartz","year":"2015","journal-title":"Am J Psychiatry."},{"key":"B56","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1176\/appi.ajp.2008.07081336","article-title":"Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder","volume":"166","author":"Forbes","year":"2009","journal-title":"Am J Psychiatry."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1038\/nn.3257","article-title":"Developmental pathways to amygdala-prefrontal function and internalizing symptoms in adolescence","volume":"15","author":"Burghy","year":"2012","journal-title":"Nat Neurosci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1093\/scan\/nst175","article-title":"Increased neural response to peer rejection associated with adolescent depression and pubertal development","volume":"9","author":"Silk","year":"2014","journal-title":"Soc Cogn Affect Neurosci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/mp.2016.82","article-title":"An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents","volume":"22","author":"Swartz","year":"2017","journal-title":"Mol Psychiatry."},{"key":"B60","doi-asserted-by":"publisher","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inform."},{"key":"B61","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform."},{"key":"B62","unstructured":"Structure estimation for mixed graphical models in high-dimensional data HaslbeckJMB WaldorpLJ arXiv2015"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the Tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"JOSS."},{"key":"B64","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-0-387-98141-3","volume-title":"Elegant Graphics for Data Analysis (ggplot2)","author":"Wickham","year":"2009"},{"key":"B65","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3758\/s13428-017-0862-1","article-title":"Estimating psychological networks and their accuracy: a tutorial paper","volume":"50","author":"Epskamp","year":"2018","journal-title":"Behav Res Methods."},{"key":"B66","unstructured":"Van BorkuloCD EpskampS MillnerA Network Comparison Test: Permutation-Based Test of Differences in Strength of Networks2015"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e034335","DOI":"10.1136\/bmjopen-2019-034335","article-title":"Detection of risk for depression among adolescents in diverse global settings: protocol for the IDEA qualitative study in Brazil, Nepal, Nigeria and the UK","volume":"10","author":"Wahid","year":"2020","journal-title":"BMJ Open."},{"key":"B68","unstructured":"ThomasDR 33238980A General Inductive Approach for Qualitative Data Analysis2003"},{"key":"B69","volume-title":"The Discovery of Grounded Theory: Strategies for Qualitative Research","author":"Glaser","year":"1967"},{"key":"B70","first-page":"218","volume-title":"Using NVIVO in Qualitative Research","author":"Richards","year":"1999"},{"key":"B71","doi-asserted-by":"publisher","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater reliability: the kappa statistic","volume":"22","author":"McHugh","year":"2012","journal-title":"Biochem Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.socnet.2010.03.006","article-title":"Node centrality in weighted networks: generalizing degree and shortest paths","volume":"32","author":"Opsahl","year":"2010","journal-title":"Soc Networks."},{"key":"B73","unstructured":"van BorkuloCD Groningen, NetherlandsUniversity of GroningenSymptom network models in depression research: From methodological exploration to clinical application2018"},{"key":"B74","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1001\/jamapsychiatry.2020.2549","article-title":"Prediction, not association, paves the road to precision medicine","volume":"78","author":"Bzdok","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1001\/jamapsychiatry.2018.2486","article-title":"A case of a college student presenting with mild mental health problems","volume":"75","author":"Fusar-Poli","year":"2018","journal-title":"JAMA Psychiatry."},{"key":"B76","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1093\/schbul\/sbw182","article-title":"What is an attenuated psychotic symptom? On the importance of the context","volume":"43","author":"Fusar-Poli","year":"2017","journal-title":"Schizophr Bull."},{"key":"B77","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.eurpsy.2015.01.010","article-title":"EPA guidance on the early detection of clinical high risk states of psychoses","volume":"30","author":"Schultze-Lutter","year":"2015","journal-title":"Eur Psychiatry."},{"key":"B78","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/wps.20250","article-title":"At risk or not at risk? A meta-analysis of the prognostic accuracy of psychometric interviews for psychosis prediction","volume":"14","author":"Fusar-Poli","year":"2015","journal-title":"World Psychiatry."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1176\/appi.ajp.2016.15101327","article-title":"Offspring of depressed parents: 30 years later","volume":"173","author":"Weissman","year":"2016","journal-title":"Am J Psychiatry."},{"key":"B80","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1001\/jama.2019.21782","article-title":"Predictive accuracy of a polygenic risk score compared with a clinical risk score for incident coronary heart disease","volume":"323","author":"Mosley","year":"2020","journal-title":"JAMA."},{"key":"B81","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1001\/jamapsychiatry.2016.1586","article-title":"A 30-year study of 3 generations at high risk and low risk for depression","volume":"73","author":"Weissman","year":"2016","journal-title":"JAMA Psychiatry."},{"key":"B82","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13073-020-00742-5","article-title":"Polygenic risk scores: from research tools to clinical instruments","volume":"12","author":"Lewis","year":"2020","journal-title":"Genome Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1001\/jamapsychiatry.2020.0431","article-title":"Psychosocial interventions and immune system function: a systematic review and meta-analysis of randomized clinical trials","volume":"77","author":"Shields","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"B84","doi-asserted-by":"publisher","first-page":"e20153075","DOI":"10.1542\/peds.2015-3075","article-title":"State of the art review: poverty and the developing brain","volume":"137","author":"Johnson","year":"2016","journal-title":"Pediatrics."},{"key":"B85","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.brainres.2016.03.021","article-title":"The impact of stress on the structure of the adolescent brain: Implications for adolescent mental health","volume":"1654","author":"Romeo","year":"2017","journal-title":"Brain Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/S0140-6736(11)60827-1","article-title":"Child and adolescent mental health worldwide: evidence for action","volume":"378","author":"Kieling","year":"2011","journal-title":"Lancet."},{"key":"B87","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.jaac.2012.07.002","article-title":"Child and adolescent mental health research across the globe","volume":"51","author":"Kieling","year":"2012","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"B88","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jad.2020.09.098","article-title":"Identifying risk factors and detection strategies for adolescent depression in diverse global settings: a Delphi consensus study","volume":"279","author":"Wahid","year":"2021","journal-title":"J Affect Disord."},{"key":"B89","doi-asserted-by":"publisher","first-page":"117865","DOI":"10.1016\/j.neuroimage.2021.117865","article-title":"Mind the brain gap: the worldwide distribution of neuroimaging research on adolescent depression","volume":"231","author":"Battel","year":"2021","journal-title":"Neuroimage."}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2021.697144\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T04:20:39Z","timestamp":1699158039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2021.697144\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,21]]},"references-count":89,"alternative-id":["10.3389\/fpsyt.2021.697144"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2021.697144","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,21]]},"article-number":"697144"}}