{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:02:40Z","timestamp":1758477760236,"version":"3.41.2"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for COVID-19 pandemic, caused catastrophic health and social effects, but little is known about its consequences on mental health. Other viral infections have been associated with psychiatric sequelae: infection-triggered disturbing of the immune system and the stressful intensive unit care can cause psychological and psychiatric complications. Moreover, SARS-CoV-2 can potentially induce neuronal injuries, leading to neurocognitive disabilities. Previous studies during the COVID-19 pandemic reported a high occurrence rate of psychopathological and neurocognitive conditions among COVID-19 survivors, highlighting the need for screening for these impairments in order to implement early interventions and secondary prevention. However, many psychiatric disorders can take several years to develop, and it is still difficult to differentiate between factors linked to the infection itself or to the global context of the pandemic. In this review, we describe the effects of SARS-CoV-2 infection on mental health, the mechanisms involved in psychiatric and neurocognitive sequelae, and the strategies of prevention and management. More studies are needed to investigate the effects of a range of factors including clinical, sociodemographic, and inflammatory predictors. These efforts could be useful to identify high-risk individuals and inform targeted preventive actions.<\/jats:p>","DOI":"10.3389\/fpsyt.2021.738696","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T10:09:13Z","timestamp":1631182153000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["SARS-CoV-2 Psychiatric Sequelae: An Urgent Need of Prevention"],"prefix":"10.3389","volume":"12","author":[{"given":"Hugo","family":"Bottemanne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Delaigue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9dric","family":"Lemogne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.3201\/eid2606.200233","article-title":"Estimating risk for death from coronavirus disease, China, January-February 2020. 26","volume":"26","author":"Mizumoto","year":"2020","journal-title":"Emerg Infect Dis J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1176\/appi.ajp.2020.20040374","article-title":"The mental health effects of COVID-19 on health care providers in China","volume":"177","author":"Lin","year":"2020","journal-title":"Am J Psychiatry."},{"key":"B4","doi-asserted-by":"publisher","first-page":"E13","DOI":"10.1017\/cem.2020.442","article-title":"Emergency physician mental health during the subacute phase of the COVID-19 pandemic","volume":"22","author":"Lim","year":"2020","journal-title":"CJEM."},{"key":"B5","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/da.23073","article-title":"A health care workers mental health crisis line in the age of COVID-19","volume":"37","author":"Feinstein","year":"2020","journal-title":"Depress Anxiety."},{"key":"B6","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1093\/qjmed\/hcaa207","article-title":"The impact of the COVID-19 pandemic on the mental health of healthcare professionals","volume":"113","author":"Braquehais","year":"2020","journal-title":"QJM Mon J Assoc Physicians."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4151","DOI":"10.3390\/ijerph17114151","article-title":"COVID-19 pandemic in the Italian Population: validation of a post-traumatic stress disorder questionnaire and prevalence of PTSD symptomatology","volume":"17","author":"Forte","year":"2020","journal-title":"Int J Environ Res Public Health."},{"key":"B8","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/qjmed\/hcaa201","article-title":"The psychological impact of COVID-19 on the mental health in the general population","volume":"113","author":"Serafini","year":"2020","journal-title":"QJM Int J Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1001\/jamapsychiatry.2020.1730","article-title":"The Coronavirus Disease 2019 (COVID-19) outbreak and mental health: current risks and recommended actions","volume":"78","author":"Amsalem","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/S2215-0366(20)30308-4","article-title":"Mental health before and during the COVID-19 pandemic: a longitudinal probability sample survey of the UK population","volume":"7","author":"Pierce","year":"2020","journal-title":"Lancet Psychiatry."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.3390\/jcm9082527","article-title":"Mental health of medical and non-medical professionals during the peak of the COVID-19 pandemic: a cross-sectional nationwide study","volume":"9","author":"Maciaszek","year":"2020","journal-title":"J Clin Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bbi.2020.04.069","article-title":"Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? 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