{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:43:36Z","timestamp":1790142216385,"version":"4.0.1"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"DOI":"10.3389\/fpsyt.2021.764776","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T05:34:31Z","timestamp":1644989671000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Deep Brain Stimulation Neuromodulation for the Treatment of Mood Disorders: Obsessive Compulsive Disorder and Treatment Resistant Depression"],"prefix":"10.3389","volume":"12","author":[{"given":"Rene","family":"Marquez-Franco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Damian","family":"Carrillo-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luisa","family":"Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat Rev Dis Prim."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-019-0102-3","article-title":"Obsessive\u2013compulsive disorder","volume":"5","author":"Stein","year":"2019","journal-title":"Nat Rev Dis Prim."},{"key":"B3","doi-asserted-by":"publisher","first-page":"101111","DOI":"10.1016\/j.eclinm.2021.101111","article-title":"Mental and neurological disorders and risk of COVID-19 susceptibility, illness severity and mortality: a systematic review, meta-analysis and call for action","volume":"40","author":"Liu","year":"2021","journal-title":"EClin Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.janxdis.2017.09.008","article-title":"A network perspective on comorbid depression in adolescents with obsessive-compulsive disorder","volume":"53","author":"Jones","year":"2018","journal-title":"J Anxiety Dis."},{"key":"B5","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-020-01007-8","article-title":"Toward a neurocircuit-based taxonomy to guide treatment of obsessive\u2013compulsive disorder","volume-title":"Mol Psychiatry.","author":"Shephard","year":"2021"},{"key":"B6","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.nicl.2018.08.020","article-title":"Tractography-assisted deep brain stimulation of the superolateral branch of the medial forebrain bundle (slMFB DBS) in major depression","volume":"20","author":"Coenen","year":"2018","journal-title":"Neuro Image Clin."},{"key":"B7","first-page":"288","article-title":"Cerebral cortex: architecture, intracortical connections, motor projections","volume-title":"Fulton JF, editor. Physiology of the Nervous System","author":"Lorente","year":"1938"},{"key":"B8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1152\/ajplegacy.1941.135.2.293","article-title":"The production of rhythmically recurrent cortical potentials after localized thalamic stimulation","volume":"135","author":"Dempsey","year":"1941","journal-title":"Am J Physiol Legacy Cont."},{"key":"B9","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/0013-4694(49)90219-9","article-title":"Brain stem reticular formation and activation of the EEElectroencephalography G","volume":"1","author":"Moruzzi","year":"1949","journal-title":"Clin Neurophysiol."},{"key":"B10","first-page":"305","article-title":"Das schlafsyndrom als folge dienzephaler reizung","volume":"2","author":"Hess","year":"1944","journal-title":"Helv Physiol Acta."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1126\/science.149.3690.1375","article-title":"Role of orbital cortex in regulation of thalamocortical electrical activity","volume":"149","author":"Velasco","year":"1965","journal-title":"Science."},{"key":"B12","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-564340-5.50016-0","article-title":"The nonspecific mediothalamic-frontocortical system: its influence on electrocortical activity and behavior","volume-title":"Psychophysiol Front Lobes","author":"Skinner","year":"1973"},{"key":"B13","first-page":"327","article-title":"Effect of orbital cortex ablations on thalamocortical potentials and behavior","volume":"16","author":"Velasco","year":"1966","journal-title":"Neurology."},{"key":"B14","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1176\/ajp.117.6.525","article-title":"Late results of orbital undercutting: report of 76 patients undergoing quantitative selective lobotoimies","volume":"117","author":"Scoville","year":"1960","journal-title":"Am J Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/bjs.1800510207","article-title":"The orbital cortex as an objective in the surgical treatment of mental illness. The results of 450 cases of open operation and the development of the stereotactic approach","volume":"51","author":"Knight","year":"1964","journal-title":"Brit J Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S0013-4694(96)95203-0","article-title":"Electrocortical and behavioral responses produced by acute electrical stimulation of the human centromedian thalamic nucleus","volume":"102","author":"Velasco","year":"1997","journal-title":"Electroencephal Clin Neurophysiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.clinph.2005.10.023","article-title":"Electrocortical and behavioral responses elicited by acute electrical stimulation of inferior thalamic peduncle and nucleus reticularis thalami in a patient with major depression disorder","volume":"117","author":"Velasco","year":"2006","journal-title":"Clin Neurophysiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/0006-8993(67)90183-7","article-title":"Structural organization of nonspecific thalamic nuclei and their projection toward cortex","volume":"6","author":"Scheibel","year":"1967","journal-title":"Brain Res."},{"key":"B19","article-title":"The neuroanatomy of depression","volume-title":"J Clin Psychiatry","author":"Cummings","year":"1993"},{"key":"B20","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/cne.903630408","article-title":"Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys","volume":"363","author":"Carmichael","year":"1995","journal-title":"J Comp Neurol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0022-3999(02)00428-2","article-title":"Frontal\u2013subcortical neuronal circuits and clinical neuropsychiatry: an update","volume":"53","author":"Tekin","year":"2002","journal-title":"J Psychos Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1017\/S1092852916000286","article-title":"The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder","volume":"22","author":"Coenen","year":"2017","journal-title":"CNS spectrums."},{"key":"B23","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00429-016-1201-5","article-title":"Anatomic characterization of prelemniscal radiations by probabilistic tractography: implications in Parkinson's disease","volume":"222","author":"Garc\u00eda-Gomar","year":"2017","journal-title":"Brain Struct Fun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1227\/00006123-197901000-00006","article-title":"A reticulothalamic system mediating proprioceptive attention and tremor in man","volume":"4","author":"Velasco","year":"1979","journal-title":"Neurosurgery."},{"key":"B25","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1097\/00006123-198611000-00005","article-title":"Neglect induced by thalamotomy in humans: a quantitative appraisal of the sensory and motor deficits","volume":"19","author":"Velasco","year":"1986","journal-title":"Neurosurgery."},{"key":"B26","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0896-6273(00)00113-6","article-title":"Toward a neurobiology of obsessive-compulsive disorder","volume":"28","author":"Graybiel","year":"2000","journal-title":"Neuron."},{"key":"B27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0166-4328(90)90144-4","article-title":"Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli","volume":"41","author":"Damasio","year":"1990","journal-title":"Behav Brain Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/19525","article-title":"Relative reward preference in primate orbitofrontal cortex","volume":"398","author":"Tremblay","year":"1999","journal-title":"Nature."},{"key":"B29","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0028-3932(98)00107-9","article-title":"Ventromedial prefrontal cortex mediates guessing","volume":"37","author":"Elliott","year":"1999","journal-title":"Neuropsychologia."},{"key":"B30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.neuroscience.2004.08.037","article-title":"Role of the orbital cortex and of the serotonergic system in a rat model of obsessive compulsive disorder","volume":"130","author":"Joel","year":"2005","journal-title":"Neuroscience."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1152\/jn.1997.77.4.2197","article-title":"Activation on the medial wall during remembered sequences of reaching movements in monkeys","volume":"77","author":"Picard","year":"1997","journal-title":"J Neurophysiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/BF01253612","article-title":"Increased\u03b1 2;-adrenoceptor density in the frontal cortex of depressed suicide victims","volume":"70","author":"Meana","year":"1987","journal-title":"J Neural Transm."},{"key":"B33","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1176\/ajp.122.5.509","article-title":"The catecholamine hypothesis of affective disorders: a review of supporting evidence","volume":"122","author":"Schildkraut","year":"1965","journal-title":"Am J Psychiatry."},{"key":"B34","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/0006-3223(92)90259-3","volume":"31","author":"Meana","year":"1992","journal-title":"Biol Psychiatry"},{"key":"B35","first-page":"153","article-title":"Neural circuitry and signaling in depression","volume-title":"Brain Circ Sign Psychiatry.","author":"Marek","year":"2002"},{"key":"B36","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1176\/appi.ajp.160.1.76","article-title":"Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders","volume":"160","author":"Kegeles","year":"2003","journal-title":"Am J Psychiatry."},{"key":"B37","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S0006-3223(00)01020-9","article-title":"Neuroimaging studies of mood disorders","volume":"48","author":"Drevets","year":"2000","journal-title":"Biol Psychiatry."},{"key":"B38","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/S0893-133X(99)00082-2","article-title":"Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder","volume":"21","author":"Saxena","year":"1999","journal-title":"Neuropsychopharmacology."},{"key":"B39","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1001\/archpsyc.1994.03950010062008","article-title":"Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15\u2014labeled carbon dioxide and positron emission tomography","volume":"51","author":"Rauch","year":"1994","journal-title":"Arch Gen Psychiatry."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1016\/S0140-6736(99)02376-4","article-title":"Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder","volume":"354","author":"Nuttin","year":"1999","journal-title":"Lancet."},{"key":"B41","volume-title":"Book of Stereotactic and Functional Neurosurgery","author":"ILozano","year":"2019"},{"key":"B42","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1093\/bmb\/65.1.193","article-title":"Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment","volume":"65","author":"Mayberg","year":"2003","journal-title":"Brit Med Bull."},{"key":"B43","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1227\/01.NEU.0000170434.44335.19","article-title":"A patient with a resistant major depression disorder treated with deep brain stimulation in the inferior thalamic peduncle","volume":"57","author":"Jim\u00e9nez","year":"2005","journal-title":"Neurosurgery."},{"key":"B44","article-title":"Preliminary study in patients with obsessive-compulsive disorder treated with electrical stimulation in the inferior thalamic peduncle","volume-title":"Operative Neurosurgery.","author":"Jim\u00e9nez-Ponce","year":"2009"},{"key":"B45","doi-asserted-by":"publisher","first-page":"S30","DOI":"10.1016\/j.wneu.2012.07.010","article-title":"Electrical stimulation of the inferior thalamic peduncle in the treatment of major depression and obsessive compulsive disorders","volume":"80","author":"Jim\u00e9nez","year":"2013","journal-title":"World Neurosurgery."},{"key":"B46","doi-asserted-by":"publisher","first-page":"S30","DOI":"10.1016\/j.wneu.2012.12.029","article-title":"Targeting bed nucleus of the stria terminalis for severe obsessive-compulsive disorder: more unexpected lead placement in obsessive-compulsive disorder than in surgery for movement disorders","volume":"80","author":"Nuttin","year":"2013","journal-title":"World Neurosurgery."},{"key":"B47","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1093\/ons\/opaa186","article-title":"Long-term improvement of parkinson disease motor symptoms derived from lesions of prelemniscal fiber tract components","volume":"19","author":"Garc\u00eda-Gomar","year":"2020","journal-title":"Operative Neurosurg."},{"key":"B48","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1159\/000438997","article-title":"Metabolic changes induced by electrical stimulation of prelemniscal radiations for the treatment of Parkinson disease","volume":"93","author":"Velasco","year":"2015","journal-title":"Stereo Function Neurosurgery."},{"key":"B49","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.nurt.2007.10.067","article-title":"Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency","volume":"5","author":"Birdno","year":"2008","journal-title":"Neurotherapeutics."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1097\/01.wnr.0000187629.38010.12","article-title":"Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease","volume":"16","author":"Mazzone","year":"2005","journal-title":"Neuroreport."},{"key":"B51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.pain.2009.08.024","article-title":"Motor cortex electrical stimulation applied to patients with complex regional pain syndrome","volume":"147","author":"Velasco","year":"2009","journal-title":"PAIN."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1525-1403.2009.00242.x","article-title":"Effects of thalamic reticular nucleus electrical stimulation in rats in a T-maze perseverative behavior model induced by 8-OH-DPAT","volume":"13","author":"Andrade","year":"2010","journal-title":"Neuromod Technol Neural Interface."},{"key":"B53","doi-asserted-by":"publisher","first-page":"803","DOI":"10.4172\/Neuropsychiatry.1000283","article-title":"Deep brain stimulation of the medial forebrain bundle in a patient with treatment-resistant bipolar depression and comorbid OCD: acute and 12-month follow-up results","volume":"7","author":"Oldani","year":"2017","journal-title":"Neuropsychiatry."},{"key":"B54","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3171\/jns.1963.20.10.0871","article-title":"Campotomy in various extrapyramidal disorders","volume":"20","author":"Spiegel","year":"1963","journal-title":"J Neurosurgery."}],"updated-by":[{"DOI":"10.3389\/fpsyt.2023.1310446","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000}}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2021.764776\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T10:45:01Z","timestamp":1701427501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2021.764776\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,16]]},"references-count":54,"alternative-id":["10.3389\/fpsyt.2021.764776"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2021.764776","relation":{"corrigendum":[{"id-type":"doi","id":"10.3389\/fpsyt.2023.1310446","asserted-by":"object"}]},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,16]]},"article-number":"764776"}}