{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:25:48Z","timestamp":1777573548270,"version":"3.51.4"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>In behavioral medicine, sleep disorders, insomnia in particular, may be considered comorbidities and precipitating factors to intellectual or developmental disabilities (IDD). Nevertheless, sleep alterations have often been neglected in favor of daytime features and symptoms, albeit simple behavioral nighttime observations may disclose hypermotor features that characterize restless sleep. The root of most hypermotor restlessness is linked to central iron deficiency. The latter is often exacerbated by vitamin D deficiency (VDD), which interferes with both dopaminergic and serotonergic mechanisms. In this way, an imbalance affecting daytime behavior and mood is created. Several sleep-related motor disorders such as bruxism, periodic and aperiodic leg movements, Restless Legs Syndrome (RLS), and Restless Sleep Disorder (RSD) are commonly seen in Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorders (ASD). However, they are rarely diagnosed and often overlooked in affected children and adolescents. As a result, not only are these disorders not adequately addressed therapeutically, but their symptoms may be worsened by the side-effects of drugs used to contain disruptive daytime behavior, such as antipsychotics and antidepressants. In children with IDDs, obesity, inactivity and metabolic effects of antipsychotics often lead to Sleep Disordered Breathing (SDB), which is currently understood as an inflammatory state leading to \u201chyperactive\u201d lethargy and further alterations of the hypoxic chain and vitamin D levels. Endorsing simple routine blood tests, including inflammatory markers such as C-reactive protein, ferritin, transferrin, and vitamin D levels, may favorably complement caregiver observations and ambulatory sleep recordings, leading to a sleep disorder diagnosis and consequent therapy. In fact, the treatment of SDB, RLS, and RSD has been copiously demonstrated to favorably impact vigilance, behavior, social competence, and academic skills in healthy and, to a greater extent, in IDD children. Thus, consulting and deliberating the root causes of functional and categorical diagnoses within a clinical framework may engender a more precise diagnosis and further benefit pediatric daytime and nighttime management of hyperactive behaviors.<\/jats:p>","DOI":"10.3389\/fpsyt.2022.1003019","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T06:07:17Z","timestamp":1664172437000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Behavioral sleep medicine\u2014The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental disabilities and restless sleep"],"prefix":"10.3389","volume":"13","author":[{"given":"Rosalia","family":"Silvestri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman S.","family":"Ipsiroglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1542\/peds.2007-3308","article-title":"Sleep hygiene for children with neurodevelopmental disabilities","volume":"122","author":"Jan","year":"2008","journal-title":"Pediatrics."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/sleep\/zsy102","article-title":"Restless sleep disorder in children: A pilot study on a tentative new diagnostic category","volume":"41","author":"Delrosso","year":"2018","journal-title":"Sleep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.sleep.2013.08.778","article-title":"Pediatric restless legs syndrome diagnostic criteria: An update by the international restless legs syndrome study group","volume":"14","author":"Picchietti","year":"2013","journal-title":"Sleep Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1176\/ajp.137.12.1630","article-title":"Diagnostic and statistical manual of mental disorders, 3rd ed","volume":"137","author":"KENDELL","year":"1980","journal-title":"Am J Psychiatry."},{"key":"B5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.sleep.2018.08.026","article-title":"Sleep phenotypes in attention deficit hyperactivity disorder","volume":"60","author":"Miano","year":"2019","journal-title":"Sleep Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.sleep.2009.04.003","article-title":"Sleep disorders in children with Attention-Deficit\/Hyperactivity Disorder (ADHD) recorded overnight by video-polysomnography","volume":"10","author":"Silvestri","year":"2009","journal-title":"Sleep Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"101613","DOI":"10.1016\/j.smrv.2022.101613","article-title":"Sleep as an outcome measure in ADHD randomized controlled trials: a scoping review","volume":"63","author":"McWilliams","year":"2022","journal-title":"Sleep Med Rev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"101643","DOI":"10.1016\/j.smrv.2022.101643","article-title":"Sleep and ADHD: a complex and bidirectional relationship","volume":"63","author":"Silvestri","year":"2022","journal-title":"Sleep Med Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00415-005-0604-7","article-title":"\u201cAnxietas Tibiarum\u201d: Depression and anxiety disorders in patients with restless legs syndrome","volume":"252","author":"Winkelmann","year":"2005","journal-title":"J Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e199966","DOI":"10.1001\/jamanetworkopen.2019.9966","article-title":"Association of restless legs syndrome with risk of suicide and self-harm","volume":"2","author":"Zhuang","year":"2019","journal-title":"JAMA Netw Open"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1177\/0883073811405852","article-title":"Pediatric restless legs syndrome: analysis of symptom descriptions and drawings","volume":"26","author":"Picchietti","year":"2011","journal-title":"J Child Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1016\/j.sleep.2015.07.016","article-title":"Leg kicking and rubbing as a highly suggestive sign of pediatric restless legs syndrome","volume":"16","author":"Bruni","year":"2015","journal-title":"Sleep Med."},{"key":"B13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/B978-0-12-800016-8.00006-4","article-title":"Pathways to overmedication and polypharmacy: Case examples from adolescents with fetal alcohol spectrum disorders","author":"Ipsiroglu","year":"2015","journal-title":"The Science and Ethics of Antipsychotic Use in Children"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.sleep.2008.11.008","article-title":"Cortical involvement in the sensory and motor symptoms of primary restless legs syndrome","volume":"10","author":"Tyvaert","year":"2009","journal-title":"Sleep Med."},{"key":"B15","article-title":"Understanding patient characteristics and medication prescriptions in children with mental health and neurodevelopmental disorders referred to a sleep clinic - a QIQA analysis","author":"Ipsiroglu","year":"","journal-title":"Rev Front Psychiatry"},{"key":"B16","doi-asserted-by":"publisher","first-page":"661","DOI":"10.5665\/sleep.2622","article-title":"Mirtazapine provokes periodic leg movements during sleep in young healthy men","volume":"36","author":"Fulda","year":"2013","journal-title":"Sleep."},{"key":"B17","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.smrv.2017.06.002","article-title":"The influence of antidepressants on restless legs syndrome and periodic limb movements: a systematic review","volume":"38","author":"Kolla","year":"2018","journal-title":"Sleep Med Rev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.pediatrneurol.2011.05.002","article-title":"Selective serotonin reuptake inhibitors and periodic limb movements of sleep","volume":"45","author":"Vendrame","year":"2011","journal-title":"Pediatr Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"zsab236","DOI":"10.1093\/sleep\/zsab236","article-title":"Leg movements during sleep in children treated with serotonergic antidepressants","volume":"45","author":"Ferri","year":"2022","journal-title":"Sleep"},{"key":"B20","doi-asserted-by":"publisher","first-page":"E62","DOI":"10.1176\/appi.neuropsych.12050128","article-title":"Clozapine-induced restless legs syndrome treated with aripiprazole","volume":"25","author":"Raveendranathan","year":"2013","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"B21","first-page":"183","article-title":"Exogenous melatonin in periodic limb movement disorder: an open clinical trial and a hypothesis","volume":"24","author":"Kunz","year":"2001","journal-title":"Sleep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/ana.10843","article-title":"Circadian rhythm of restless legs syndrome: relationship with biological markers","volume":"55","author":"Michaud","year":"2004","journal-title":"Ann Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/brainsci10070441","article-title":"Sleeping without prescription: Management of sleep disorders in children with autism with non-pharmacological interventions and over-the-counter treatments","volume":"10","author":"Esposito","year":"2020","journal-title":"Brain Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s41105-018-0158-6","article-title":"Magnitude and duration of acute-exercise intensity effects on symptoms of restless legs syndrome: A pilot study","volume":"16","author":"Cederberg","year":"2018","journal-title":"Sleep Biol Rhythms."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/j.sleep.2013.07.013","article-title":"Restless legs syndrome (Willis-Ekbom disease) and growing pains: are they the same thing? A side-by-side comparison of the diagnostic criteria for both and recommendations for future research","volume":"14","author":"Walters","year":"2013","journal-title":"Sleep Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e2020049880","DOI":"10.1542\/peds.2020-049880","article-title":"Cognitive behavioral therapy for autism spectrum disorders: a systematic review","volume":"147","author":"Wang","year":"2021","journal-title":"Pediatrics"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1001\/jama.2016.5453","article-title":"Treatment of attention-deficit\/hyperactivity disorder in adolescents: a systematic review","volume":"315","author":"Chan","year":"2016","journal-title":"JAMA."},{"key":"B28","doi-asserted-by":"publisher","first-page":"101274","DOI":"10.1016\/j.smrv.2020.101274","article-title":"Iron deficiency and sleep \u2013 a scoping review","volume":"51","author":"Leung","year":"2020","journal-title":"Sleep Med Rev"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1212\/WNL.54.8.1698","article-title":"Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome","volume":"54","author":"Earley","year":"2000","journal-title":"Neurology."},{"key":"B30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1365-2869.2004.00403.x","article-title":"CSF iron, ferritin and transferrin levels in restless legs syndrome","volume":"14","author":"Mizuno","year":"2005","journal-title":"J Sleep Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/s00381-017-3424-z","article-title":"Relationship of serum ferritin level and tic severity in children with Tourette syndrome","volume":"33","author":"Ghosh","year":"2017","journal-title":"Childs Nerv Syst."},{"key":"B32","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.smrv.2019.03.006","article-title":"Neurochemical features of idiopathic restless legs syndrome","volume":"45","author":"Jim\u00e9nez-Jim\u00e9nez","year":"2019","journal-title":"Sleep Med Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.sleep.2007.08.012","article-title":"Early manifestations of restless legs syndrome in childhood and adolescence","volume":"9","author":"Picchietti","year":"2008","journal-title":"Sleep Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1007\/s11064-007-9396-8","article-title":"Iron-deficiency anemia is associated with altered characteristics of sleep spindles in NREM sleep in infancy","volume":"32","author":"Peirano","year":"2007","journal-title":"Neurochem Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.sleep.2010.03.014","article-title":"Sleep alterations and iron deficiency anemia in infancy","volume":"11","author":"Peirano","year":"2010","journal-title":"Sleep Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.sleep.2020.05.037","article-title":"Restless legs syndrome in children and adolescents with attention-deficit\/hyperactivity disorder: prevalence, mimic conditions, risk factors, and association with functional impairment","volume":"73","author":"Srifuengfung","year":"2020","journal-title":"Sleep Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"S440","DOI":"10.1002\/mds.21607","article-title":"The role of iron in restless legs syndrome","volume":"22","author":"Allen","year":"2007","journal-title":"Move Disord."},{"key":"B38","doi-asserted-by":"publisher","first-page":"722","DOI":"10.3389\/fnins.2017.00722","article-title":"Pivotal role of adenosine neurotransmission in Restless Legs Syndrome","volume":"11","author":"Ferr\u00e9","year":"2018","journal-title":"Front Neurosci"},{"key":"B39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.sleep.2017.11.1126","article-title":"Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome\/Willis-Ekbom disease in adults and children: an IRLSSG task force report","volume":"41","author":"Allen","year":"2018","journal-title":"Sleep Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1080\/14656566.2019.1629418","article-title":"How does one choose the correct pharmacotherapy for a pediatric patient with restless legs syndrome and periodic limb movement disorder?: Expert Guidance.","volume":"20","author":"Dye","year":"2019","journal-title":"Expert Opin Pharmacother."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.sleep.2016.06.007","article-title":"Achievements, challenges, and future perspectives of epidemiologic research in restless legs syndrome (RLS)","volume":"31","author":"Picchietti","year":"2017","journal-title":"Sleep Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.sleep.2013.06.006","article-title":"Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose","volume":"14","author":"Grim","year":"2013","journal-title":"Sleep Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.sleep.2021.08.030","article-title":"Clinical efficacy and safety of intravenous ferric carboxymaltose treatment of pediatric restless legs syndrome and periodic limb movement disorder","volume":"87","author":"DelRosso","year":"2021","journal-title":"Sleep Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"zsaa155","DOI":"10.1093\/sleep\/zsaa155","article-title":"Comparison between oral ferrous sulfate and intravenous ferric carboxymaltose in children with restless sleep disorder","volume":"44","author":"DelRosso","year":"2021","journal-title":"Sleep"},{"key":"B45","doi-asserted-by":"publisher","first-page":"A224","DOI":"10.1093\/sleep\/zsac079.503","article-title":"Clinical efficacy of intravenous ferric carboxymaltose for restless legs symptoms and low serum ferritin in children with autism spectrum disorder","volume":"45","author":"DelRosso","year":"2022","journal-title":"Sleep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.smrv.2013.07.001","article-title":"The link between vitamin D metabolism and sleep medicine","volume":"18","author":"McCarty","year":"2014","journal-title":"Sleep Med Rev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.5664\/jcsm.8440","article-title":"Vitamin D and sleep in children","volume":"16","author":"Al-Shawwa","year":"2020","journal-title":"J Clin Sleep Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"953","DOI":"10.2147\/NDT.S63599","article-title":"Possible association between vitamin D deficiency and restless legs syndrome","volume":"10","author":"Oran","year":"2014","journal-title":"Neuropsychiatr Dis Treat."},{"key":"B49","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.33549\/physiolres.932367","article-title":"Ontogeny of the pain","volume":"61","author":"Rokyta","year":"2012","journal-title":"Physiol Res"},{"key":"B50","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/cns.12204","article-title":"Vitamin D as a potential therapy in amyotrophic lateral sclerosis","volume":"20","author":"Gianforcaro","year":"2014","journal-title":"CNS Neurosci Ther."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.1096\/fj.14-269811","article-title":"1,25-DihydroxyVitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: Implication for behavioral influences of Vitamin D","volume":"29","author":"Kaneko","year":"2015","journal-title":"FASEB J."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1096\/fj.13-246546","article-title":"Vitamin D hormone regulates serotonin synthesis. Part 1: Relevance for autism","volume":"28","author":"Patrick","year":"2014","journal-title":"FASEB J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1096\/fj.14-268342","article-title":"Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: Relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior","volume":"29","author":"Patrick","year":"2015","journal-title":"FASEB J."},{"key":"B54","doi-asserted-by":"publisher","first-page":"101379","DOI":"10.1016\/j.smrv.2020.101379","article-title":"Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway","volume":"55","author":"Huiberts","year":"2021","journal-title":"Sleep Med Rev"},{"key":"B55","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.yfrne.2012.07.001","article-title":"Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease","volume":"34","author":"Eyles","year":"2013","journal-title":"Front Neuroendocrinol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.pnpbp.2013.12.014","article-title":"Moderators of treatment response in adults with ADHD treated with a vitamin-mineral supplement","volume":"50","author":"Rucklidge","year":"2014","journal-title":"Prog NeuroPsychopharmacol Biol Psychiatry."},{"key":"B57","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/mnfr.201200418","article-title":"Vitamin D concentration and lateral cerebral ventricle volume in older adults","volume":"57","author":"Annweiler","year":"2013","journal-title":"Mol Nutr Food Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.biopsych.2008.07.031","article-title":"Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain","volume":"64","author":"Gilmore","year":"2008","journal-title":"Biol Psychiatry."},{"key":"B59","doi-asserted-by":"publisher","first-page":"393","DOI":"10.4103\/1673-5374.202936","article-title":"The impact of vitamin D deficiency on neurogenesis in the adult brain","volume":"12","author":"Groves","year":"2017","journal-title":"Neural Regen Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1097\/MED.0000000000000199","article-title":"Vitamin D and anemia: Insights into an emerging association","volume":"22","author":"Smith","year":"2015","journal-title":"Curr Opin Endocrinol Diabetes Obes."},{"key":"B61","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3345\/kjp.2012.55.6.206","article-title":"Prevalence and risk factors for vitamin D deficiency in children with iron deficiency anemia","volume":"55","author":"Yoon","year":"2012","journal-title":"Korean J Pediatr."},{"key":"B62","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/ajcn\/56.3.533","article-title":"Effect of iron on serum 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D concentrations","volume":"56","author":"Heldenberg","year":"1992","journal-title":"Am J Clin Nutr."},{"key":"B63","doi-asserted-by":"publisher","first-page":"70","DOI":"10.24953\/turkjped.2018.01.010","article-title":"Restless leg syndrome in children with celiac disease","volume":"60","author":"I\u015fikay","year":"2018","journal-title":"Turk J Pediatr."},{"key":"B64","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s11325-014-1049-y","article-title":"The effect of vitamin D supplements on the severity of restless legs syndrome","volume":"19","author":"Wali","year":"2015","journal-title":"Sleep Breath."},{"key":"B65","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1093\/ajcn\/72.3.690","article-title":"Decreased bioavailability of vitamin D in obesity","volume":"72","author":"Wortsman","year":"2000","journal-title":"Am J Clin Nutr."},{"key":"B66","doi-asserted-by":"publisher","first-page":"693","DOI":"10.5664\/jcsm.2266","article-title":"Vitamin D, race, and excessive daytime sleepiness","volume":"8","author":"McCarty","year":"2012","journal-title":"J Clin Sleep Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e103038","DOI":"10.1371\/journal.pone.0103038","article-title":"Autism and sensory processing disorders: Shared white matter disruption in sensory pathways but divergent connectivity in social-emotional pathways","volume":"9","author":"Chang","year":"2014","journal-title":"PLoS ONE"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.5664\/jcsm.8756","article-title":"Rethinking bedtime resistance in children with autism: Is restless legs syndrome to blame?","volume":"16","author":"Kanney","year":"2020","journal-title":"J Clin Sleep Med."}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.1003019\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T06:07:26Z","timestamp":1664172446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.1003019\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,26]]},"references-count":68,"alternative-id":["10.3389\/fpsyt.2022.1003019"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2022.1003019","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,26]]},"article-number":"1003019"}}