{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:34:51Z","timestamp":1793115291859,"version":"4.5.0"},"reference-count":249,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007048","name":"EEA Grants","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by communication and social interaction deficits, and by restricted interests and stereotyped, repetitive behavior patterns. ASD has a strong genetic component and a complex architecture characterized by the interplay of rare and common genetic variants. Recently, increasing evidence suggest a significant contribution of immune system dysregulation in ASD. The present paper reviews the latest updates regarding the altered immune landscape of this complex disorder highlighting areas with potential for biomarkers discovery as well as personalization of therapeutic approaches. Cross-talk between the central nervous system and immune system has long been envisaged and recent evidence brings insights into the pathways connecting the brain to the immune system. Disturbance of cytokine levels plays an important role in the establishment of a neuroinflammatory milieu in ASD. Several other immune molecules involved in antigen presentation and inflammatory cellular phenotypes are also at play in ASD. Maternal immune activation, the presence of brain-reactive antibodies and autoimmunity are other potential prenatal and postnatal contributors to ASD pathophysiology. The molecular players involved in oxidative-stress response and mitochondrial system function, are discussed as contributors to the pro-inflammatory pattern. The gastrointestinal inflammation pathways proposed to play a role in ASD are also discussed. Moreover, the body of evidence regarding some of the genetic factors linked to the immune system dysregulation is reviewed and discussed. Last, but not least, the epigenetic traits and their interactions with the immune system are reviewed as an expanding field in ASD research. Understanding the immune-mediated pathways that influence brain development and function, metabolism, and intestinal homeostasis, may lead to the identification of robust diagnostic or predictive biomarkers for ASD individuals. Thus, novel therapeutic approaches could be developed, ultimately aiming to improve their quality of life.<\/jats:p>","DOI":"10.3389\/fpsyt.2022.1006612","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T17:22:44Z","timestamp":1666200164000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Re-emerging concepts of immune dysregulation in autism spectrum disorders"],"prefix":"10.3389","volume":"13","author":[{"given":"Alina","family":"Erbescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorina Mihaela","family":"Papuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Budisteanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Arghir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Neagu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"B1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.ss6904a1","article-title":"Prevalence of autism spectrum disorder among children aged 8 years\u2014autism and developmental disabilities monitoring network, 11 sites, United States, 2016","volume":"69","author":"Maenner","year":"2020","journal-title":"MMWR Surveill Summ."},{"key":"B3","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s00787-020-01587-4","article-title":"ESCAP practice guidance for autism: a summary of evidence-based recommendations for diagnosis and treatment","volume":"30","author":"Fuentes","year":"2021","journal-title":"Eur Child Adolesc Psychiatry."},{"key":"B4","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(13)61539-1","article-title":"Autism","volume":"383","author":"Lai","year":"2014","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s12864-017-3667-9","article-title":"Cross-disorder comparative analysis of comorbid conditions reveals novel autism candidate genes","volume":"18","author":"Diaz-Beltran","year":"2017","journal-title":"BMC Genomics."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e20193447","DOI":"10.1542\/9781610024716-part01-ch002","article-title":"Identification, evaluation, and management of children with autism spectrum disorder","volume":"145","year":"2020","journal-title":"Pediatrics"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1017\/S2045796020000050","article-title":"Comorbidity and health services' usage in children with autism spectrum disorder: a nested case-control study","volume":"29","author":"Dizitzer","year":"2020","journal-title":"Epidemiol Psychiatr Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e0153329","DOI":"10.1371\/journal.pone.0153329","article-title":"Pathway network analyses for autism reveal multisystem involvement, major overlaps with other diseases and convergence upon MAPK and calcium signaling","volume":"11","author":"Wen","year":"2016","journal-title":"PLoS ONE."},{"key":"B9","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.tics.2011.07.003","article-title":"Genetics of autism spectrum disorders","volume":"15","author":"Geschwind","year":"2011","journal-title":"Trends Cogn Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/ng.3039","article-title":"Most genetic risk for autism resides with common variation","volume":"46","author":"Gaugler","year":"2014","journal-title":"Nat Genet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13229-017-0137-9","article-title":"Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia","volume":"8","year":"2017","journal-title":"Mol Autism"},{"key":"B12","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/s41588-019-0344-8","article-title":"Identification of common genetic risk variants for autism spectrum disorder","volume":"51","author":"Grove","year":"2019","journal-title":"Nat Genet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/978-3-030-30402-7_3","article-title":"Genomics of autism","volume":"24","author":"Fakhro","year":"2020","journal-title":"Adv Neurobiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/nature13772","article-title":"Synaptic, transcriptional and chromatin genes disrupted in autism","volume":"515","author":"De Rubeis","year":"2014","journal-title":"Nature."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.neuron.2015.09.016","article-title":"Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci","volume":"87","author":"Sanders","year":"2015","journal-title":"Neuron."},{"key":"B16","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nrn3992","article-title":"From the genetic architecture to synaptic plasticity in autism spectrum disorder","volume":"16","author":"Bourgeron","year":"2015","journal-title":"Nat Rev Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nm.4071","article-title":"Advancing the understanding of autism disease mechanisms through genetics","volume":"22","author":"de la Torre-Ubieta","year":"2016","journal-title":"Nat Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.cell.2019.12.036","article-title":"Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism","volume":"180","author":"Satterstrom","year":"2020","journal-title":"Cell."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.cell.2019.07.037","article-title":"Getting to the cores of autism","volume":"178","author":"Iakoucheva","year":"2019","journal-title":"Cell."},{"key":"B20","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13229-020-00370-1","article-title":"Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology","volume":"11","author":"Cheroni","year":"2020","journal-title":"Mol Autism."},{"key":"B21","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1289\/ehp.1002835","article-title":"Residential proximity to freeways and autism in the CHARGE study","volume":"119","author":"Volk","year":"2011","journal-title":"Environ Health Perspect."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e75510","DOI":"10.1371\/journal.pone.0075510","article-title":"Air pollution and newly diagnostic autism spectrum disorders: a population-based cohort study in Taiwan","volume":"8","author":"Jung","year":"2013","journal-title":"PLoS ONE."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","article-title":"Developmental neurotoxicity of industrial chemicals","volume":"368","author":"Grandjean","year":"2006","journal-title":"Lancet."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e360","DOI":"10.1038\/tp.2014.4","article-title":"Environmental toxicants and autism spectrum disorders: a systematic review","volume":"4","author":"Rossignol","year":"2014","journal-title":"Transl Psychiatry."},{"key":"B25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4321\/S1135-57272013000100008","article-title":"Trastornos del espectro autista y exposiciones ocupacionales de los progenitores [parental occupational exposures and autism spectrum disorder in children]","volume":"87","author":"Pino-L\u00f3pez","year":"2013","journal-title":"Rev Esp Salud Publica."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1002\/sim.5600","article-title":"Bayesian modeling of time-dependent vulnerability to environmental hazards: an example using autism and pesticide data","volume":"32","author":"Roberts","year":"2013","journal-title":"Stat Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.3390\/ijerph10094261","article-title":"Epigenetic findings in autism: new perspectives for therapy","volume":"10","author":"Siniscalco","year":"2013","journal-title":"Int J Environ Res Public Health."},{"key":"B28","doi-asserted-by":"publisher","first-page":"5136","DOI":"10.1038\/s41598-021-84573-3","article-title":"The association between gestational diabetes and ASD and ADHD: a systematic review and meta-analysis","volume":"11","author":"Rowland","year":"2021","journal-title":"Sci Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1001\/jamapediatrics.2020.6856","article-title":"Association between hypertensive disorders of pregnancy and neurodevelopmental outcomes among offspring","volume":"175","author":"Brand","year":"2021","journal-title":"JAMA Pediatr."},{"key":"B30","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nrn3978","article-title":"Immune mediators in the brain and peripheral tissues in autism spectrum disorder","volume":"16","author":"Estes","year":"2015","journal-title":"Nat Rev Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1152\/physrev.00039.2016","article-title":"Neuroimmune interactions: from the brain to the immune system and vice versa","volume":"98","author":"Dantzer","year":"2018","journal-title":"Physiol Rev."},{"key":"B32","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41380-018-0056-y","article-title":"The ASD living biology: from cell proliferation to clinical phenotype","volume":"24","author":"Courchesne","year":"2019","journal-title":"Mol Psychiatry."},{"key":"B33","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nature10110","article-title":"Transcriptomic analysis of autistic brain reveals convergent molecular pathology","volume":"474","author":"Voineagu","year":"2011","journal-title":"Nature."},{"key":"B34","doi-asserted-by":"publisher","first-page":"5748","DOI":"10.1038\/ncomms6748","article-title":"Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism","volume":"5","author":"Gupta","year":"2014","journal-title":"Nat Commun."},{"key":"B35","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/npp.2016.158","article-title":"The role of the immune system in autism spectrum disorder","volume":"42","author":"Meltzer","year":"2017","journal-title":"Neuropsychopharmacology."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1038\/nn.4373","article-title":"Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder","volume":"19","author":"Wu","year":"2016","journal-title":"Nat Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s12031-020-01658-w","article-title":"Integrated systems analysis explores dysfunctional molecular modules and regulatory factors in children with autism spectrum disorder","volume":"71","author":"Gao","year":"2021","journal-title":"J Mol Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"15867","DOI":"10.1038\/s41598-021-95447-z","article-title":"Understanding the impact of SNPs associated with autism spectrum disorder on biological pathways in the human fetal and adult cortex","volume":"11","author":"Golovina","year":"2021","journal-title":"Sci Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1177\/13623613211019547","article-title":"Potential role for immune-related genes in autism spectrum disorders: evidence from genome-wide association meta-analysis of autistic traits","volume":"26","author":"Arenella","year":"2022","journal-title":"Autism"},{"key":"B40","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.bbi.2010.08.003","article-title":"Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome","volume":"25","author":"Ashwood","year":"2011","journal-title":"Brain Behav Immun."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1002\/dneu.22044","article-title":"Immune system gene dysregulation in autism and schizophrenia","volume":"72","author":"Michel","year":"2012","journal-title":"Dev Neurobiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12974-021-02154-7","article-title":"Identification of aberrant innate and adaptive immunity based on changes in global gene expression in the blood of adults with autism spectrum disorder","volume":"18","author":"Horiuchi","year":"2021","journal-title":"J Neuroinflammation."},{"key":"B43","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.bbi.2017.09.010","article-title":"Activation of IL-17 receptor leads to increased oxidative inflammation in peripheral monocytes of autistic children","volume":"67","author":"Nadeem","year":"2018","journal-title":"Brain Behav Immun."},{"key":"B44","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.pnpbp.2018.12.002","article-title":"Oxidative and inflammatory mediators are upregulated in neutrophils of autistic children: role of IL-17A receptor signaling","volume":"90","author":"Nadeem","year":"2019","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"B45","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bbi.2009.08.001","article-title":"Differential monocyte responses to TLR ligands in children with autism spectrum disorders","volume":"24","author":"Enstrom","year":"2010","journal-title":"Brain Behav Immun."},{"key":"B46","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41398-021-01766-0","article-title":"Dysregulated gene expression associated with inflammatory and translation pathways in activated monocytes from children with autism spectrum disorder","volume":"12","author":"Hughes","year":"2022","journal-title":"Transl Psychiatry."},{"key":"B47","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1002\/aur.2284","article-title":"Neuroinflammatory gene expression alterations in anterior cingulate cortical white and gray matter of males with autism spectrum disorder","volume":"13","author":"Sciara","year":"2020","journal-title":"Autism Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann Neurol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jneuroim.2008.12.002","article-title":"Elevated immune response in the brain of autistic patients","volume":"207","author":"Li","year":"2009","journal-title":"J Neuroimmunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12974-017-0938-y","article-title":"Bridging autism spectrum disorders and schizophrenia through inflammation and biomarkers - pre-clinical and clinical investigations","volume":"14","author":"Prata","year":"2017","journal-title":"J Neuroinflammation."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1038\/mp.2016.103","article-title":"Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral de-fects","volume":"22","author":"Kim","year":"2017","journal-title":"Mol Psychiatry."},{"key":"B52","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.molimm.2021.12.009","article-title":"Imbalance in pro-inflammatory and anti-inflammatory cytokines milieu in B cells of children with autism","volume":"141","author":"Nadeem","year":"2022","journal-title":"Mol Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1742-2094-11-4","article-title":"Association of social and cognitive impairment and biomarkers in autism spectrum disorders","volume":"11","author":"Alabdali","year":"2014","journal-title":"J Neuroinflammation."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/bs6040029","article-title":"Peripheral inflammatory markers contributing to comorbidities in autism","author":"Inga J\u00e1come","year":"2016","journal-title":"Behav Sci"},{"key":"B55","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.molmed.2018.06.008","article-title":"The impact of systemic inflammation on neurodevelopment","volume":"24","author":"Jiang","year":"2018","journal-title":"Trends Mol Med"},{"key":"B56","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3389\/fped.2018.00394","article-title":"Modeling inflammation in autism spectrum disorders using stem cells","volume":"6","author":"Freitas","year":"2018","journal-title":"Front Pediatr."},{"key":"B57","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13229-016-0068-x","article-title":"From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition","volume":"7","author":"Young","year":"2016","journal-title":"Mol Autism."},{"key":"B58","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1479-7364-5-1-30","article-title":"Evolutionary divergence and functions of the human interleukin (IL) gene family","volume":"5","author":"Brocker","year":"2010","journal-title":"Hum Genomics."},{"key":"B59","doi-asserted-by":"publisher","first-page":"577066","DOI":"10.1016\/j.jneuroim.2019.577066","article-title":"Serum cytokine levels in children with spectrum autism disorder: differences in pro- and anti-inflammatory balance","volume":"337","author":"Kordulewska","year":"2019","journal-title":"J Neuroimmunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"552295","DOI":"10.3389\/fneur.2020.552295","article-title":"Plasma inflammatory cytokines are elevated in ALS","volume":"11","author":"Tortelli","year":"2020","journal-title":"Front Neurol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"155506","DOI":"10.1016\/j.cyto.2021.155506","article-title":"Cytokines in saliva as biomarkers of oral and systemic oncological or infectious diseases: a systematic review","volume":"143","author":"Diesch","year":"2021","journal-title":"Cytokine."},{"key":"B62","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s13073-021-00907-w","article-title":"Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses","volume":"13","author":"van Deuren","year":"2021","journal-title":"Genome Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/jid.2008.308","article-title":"Genetic variations in cytokines and cytokine receptors associated with psoriasis found by genome-wide association","volume":"129","author":"Duffin","year":"2009","journal-title":"J Invest Dermatol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13073-016-0329-5","article-title":"Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network","volume":"8","author":"Richard","year":"2016","journal-title":"Genome Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/hipo.10135","article-title":"Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity","volume":"13","author":"Avital","year":"2003","journal-title":"Hippocampus."},{"key":"B66","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/hipo.20542","article-title":"The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo","volume":"19","author":"Schmid","year":"2009","journal-title":"Hippocampus."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.psyneuen.2007.09.004","article-title":"A dual role for interleukin-1 in hippocampal-dependent memory processes","volume":"32","author":"Goshen","year":"2007","journal-title":"Psychoneuroendocrinology."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2398212820979802","DOI":"10.1177\/2398212820979802","article-title":"The role of cytokines in modulating learning and memory and brain plasticity","volume":"4","author":"Bourgognon","year":"2020","journal-title":"Brain Neurosci Adv."},{"key":"B69","first-page":"18","article-title":"The blood brain barrier and the role of cytokines in neuropsychiatry","volume":"6","author":"Yarlagadda","year":"2009","journal-title":"Psychiatry."},{"key":"B70","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jpsychires.2019.05.019","article-title":"A meta-analysis of pro-inflammatory cytokines in autism spectrum disorders: effects of age, gender, and latitude","volume":"115","author":"Saghazadeh","year":"2019","journal-title":"J Psychiatr Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1016\/j.bbamcr.2014.05.014","article-title":"Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease","volume":"1843","author":"Turner","year":"2014","journal-title":"Biochim Biophys Acta."},{"key":"B72","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s12264-017-0103-8","article-title":"The immune system, cytokines, and biomarkers in sutism spectrum disorder","volume":"33","author":"Masi","year":"2017","journal-title":"Neurosci Bull."},{"key":"B73","doi-asserted-by":"publisher","first-page":"531518","DOI":"10.1155\/2015\/531518","article-title":"Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders","volume":"2015","author":"Xu","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B74","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s12640-013-9393-4","article-title":"Altered cytokine and BDNF levels in autism spectrum disorder","volume":"24","author":"Ricci","year":"2013","journal-title":"Neurotox Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor necrosis factor-\u03b1 signaling in macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit Rev Eukaryot Gene Expr."},{"key":"B76","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.cyto.2018.03.034","article-title":"Cytokine profile in autistic patients","volume":"108","author":"Eftekharian","year":"2018","journal-title":"Cytokine."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.08.002","article-title":"Upregulation of IL-9 and JAK-STAT signaling pathway in children with autism","author":"Ahmad","year":"2017","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"B78","doi-asserted-by":"publisher","first-page":"6507","DOI":"10.3390\/ijms23126507","article-title":"IL-31: state of the art for an inflammation-oriented interleukin","volume":"23","author":"Borgia","year":"2022","journal-title":"Int J Mol Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"82390","DOI":"10.18632\/oncotarget.19326","article-title":"Immunological cytokine profiling identifies TNF-\u03b1 as a key molecule dysregulated in autistic children","volume":"8","author":"Xie","year":"2017","journal-title":"Oncotarget."},{"key":"B80","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s00213-018-5120-4","article-title":"Elevated IL-16 expression is associated with development of immune dysfunction in children with autism","volume":"236","author":"Ahmad","year":"2019","journal-title":"Psychopharmacology."},{"key":"B81","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/mp.2014.59","article-title":"Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis","volume":"20","author":"Masi","year":"2015","journal-title":"Mol Psychiatry."},{"key":"B82","doi-asserted-by":"publisher","first-page":"670200","DOI":"10.3389\/fpsyt.2021.670200","article-title":"Association of peripheral blood levels of cytokines with autism spectrum disorder: a meta-analysis","volume":"12","author":"Zhao","year":"2021","journal-title":"Front Psychiatry."},{"key":"B83","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.biopsych.2015.08.007","article-title":"Neonatal cytokine profiles associated with autism spectrum disorder","volume":"81","author":"Krakowiak","year":"2017","journal-title":"Biol Psychiatry."},{"key":"B84","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.biopsych.2019.04.037","article-title":"An exploratory examination of neonatal cytokines and chemokines as predictors of autism risk: the early markers for autism study","volume":"86","author":"Heuer","year":"2019","journal-title":"Biol Psychiatry."},{"key":"B85","doi-asserted-by":"publisher","first-page":"577119","DOI":"10.1016\/j.jneuroim.2019.577119","article-title":"Increased inflammasome activity in markedly ill psychiatric patients: an explorative study","volume":"339","author":"Hyl\u00e9n","year":"2020","journal-title":"J Neuroimmunol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"109999","DOI":"10.1016\/j.pnpbp.2020.109999","article-title":"Polymorphism of interleukin-1\u03b2 and interleukin-1 receptor antagonist genes in children with autism spectrum disorders","volume":"103","author":"Saad","year":"2020","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"B87","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S0165-5728(01)00421-0","article-title":"Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression","volume":"120","author":"Jyonouchi","year":"2001","journal-title":"J Neuroimmunol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jneuroim.2005.11.007","article-title":"Elevated cytokine levels in children with autism spectrum disorder","volume":"172","author":"Molloy","year":"2006","journal-title":"J Neuroimmunol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1742-2094-8-52","article-title":"Brown WT, Li X. IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation","volume":"8","author":"Wei","year":"2011","journal-title":"J Neuroinflamm."},{"key":"B90","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/jnc.15338","article-title":"Cerebrospinal fluid and serum protein markers in autism: a co-twin study","volume":"158","author":"Smedler","year":"2021","journal-title":"J Neurochem."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1056\/NEJMoa1610528","article-title":"Overexpression of the cytokine BAFF and autoimmunity risk","volume":"376","author":"Steri","year":"2017","journal-title":"N Engl J Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/schbul\/sbab106","article-title":"Plasma levels of the cytokines B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in schizophrenia, bipolar, and major depressive disorder: a cross sectional, multisite study","volume":"48","author":"Engh","year":"2022","journal-title":"Schizophr Bull"},{"key":"B93","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12974-015-0297-5","article-title":"Association of brain immune genes with social behavior of inbred mouse strains","volume":"12","author":"Ma","year":"2015","journal-title":"J Neuroinflammation."},{"key":"B94","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3390\/ph11020056","article-title":"Inflammation and neuro-immune dysregulations in autism spectrum disorders","volume":"11","author":"Siniscalco","year":"2018","journal-title":"Pharmaceuticals."},{"key":"B95","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/jhg.2008.5","article-title":"The HLA genomic loci map: expression, interaction, diversity and disease","volume":"54","author":"Shiina","year":"2009","journal-title":"J Hum Genet."},{"key":"B96","doi-asserted-by":"publisher","first-page":"6828","DOI":"10.1073\/pnas.0702023104","article-title":"Regulation of CNS synapses by neuronal MHC class I","volume":"104","author":"Goddard","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"B97","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S0074-7742(05)71013-8","article-title":"Immunological findings in autism","volume":"71","author":"Cohly","year":"2005","journal-title":"Int Rev Neurobiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.yfrne.2012.08.006","article-title":"The immune system and developmental programming of brain and behavior","volume":"33","author":"Bilbo","year":"2012","journal-title":"Front Neuroendocrinol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"7639","DOI":"10.1038\/s41598-018-25974-9","article-title":"HLA-class II haplotypes and autism spectrum disorders","volume":"8","author":"Bennabi","year":"2018","journal-title":"Sci Rep."},{"key":"B100","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.bbi.2020.09.033","article-title":"Understanding the genetic contribution of the human leukocyte antigen system to common major psychiatric disorders in a world pandemic context","volume":"91","author":"Tamouza","year":"2021","journal-title":"Brain Behav Immun."},{"key":"B101","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.pediatrneurol.2006.06.006","article-title":"HLA-DR4 in families with autism","volume":"35","author":"Lee","year":"2006","journal-title":"Pediatr Neurol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/YPG.0b013e32834915ae","article-title":"Association of HLA-DRB1 alleles and neuropsychological function in autism","volume":"22","author":"Chien","year":"2012","journal-title":"Psychiatr Genet."},{"key":"B103","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3389\/fnins.2016.00463","article-title":"Common genetic variants found in HLA and KIR immune genes in autism spectrum disorder","volume":"10","author":"Torres","year":"2016","journal-title":"Front Neurosci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/intimm\/dxu090","article-title":"IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration","volume":"27","author":"Makita","year":"2015","journal-title":"Int Immunol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1002\/ana.25610","article-title":"T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains","volume":"86","author":"DiStasio","year":"2019","journal-title":"Ann Neurol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"6804","DOI":"10.1523\/JNEUROSCI.20-18-06804.2000","article-title":"Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter","volume":"20","author":"Wender","year":"2000","journal-title":"J Neurosci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"18425","DOI":"10.1073\/pnas.0508621102","article-title":"Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes","volume":"102","author":"Pinkse","year":"2005","journal-title":"Proc Natl Acad Sci USA."},{"key":"B108","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/pedi.12597","article-title":"Genetics of type 1 diabetes","volume":"19","author":"Redondo","year":"2018","journal-title":"Pediatr Diabetes."},{"key":"B109","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1001\/archneurol.2011.2506","article-title":"Maternal autoantibodies in autism","volume":"69","author":"Braunschweig","year":"2012","journal-title":"Arch Neurol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.bbi.2010.11.017","article-title":"Autoantibodies to cerebellum in children with autism associate with behavior","volume":"25","author":"Goines","year":"2011","journal-title":"Brain Behav Immun."},{"key":"B111","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.neuro.2007.10.010","article-title":"Autism: maternally derived antibodies specific for fetal brain proteins","volume":"29","author":"Braunschweig","year":"2008","journal-title":"Neurotoxicology."},{"key":"B112","doi-asserted-by":"publisher","first-page":"e277","DOI":"10.1038\/tp.2013.50","article-title":"Autism-specific maternal autoantibodies recognize critical proteins in developing brain","volume":"3","author":"Braunschweig","year":"2013","journal-title":"Transl Psychiatry."},{"key":"B113","doi-asserted-by":"publisher","first-page":"9095284","DOI":"10.1155\/2020\/9095284","article-title":"Oxidative stress, folate receptor autoimmunity, and CSF findings in severe infantile autism","volume":"2020","author":"Ramaekers","year":"2020","journal-title":"Autism Res Treat."},{"key":"B114","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s10803-011-1260-7","article-title":"Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism","volume":"42","author":"Melnyk","year":"2012","journal-title":"J Autism Dev Disord."},{"key":"B115","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/bs.pmbts.2020.04.018","article-title":"Oxidative stress, metabolic and mitochondrial abnormalities associated with autism spectrum disorder","volume":"173","author":"Thorsen","year":"2020","journal-title":"Prog Mol Biol Transl Sci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/imr.12425","article-title":"Emerging roles for antigen presentation in establishing host-microbiome symbiosis","volume":"272","author":"Bessman","year":"2016","journal-title":"Immunol Rev"},{"key":"B117","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ridd.2017.10.009","article-title":"Increased stool immunoglobulin A level in children with autism spectrum disorders","volume":"82","author":"Zhou","year":"2018","journal-title":"Res Dev Disabil."},{"key":"B118","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.csbj.2020.12.012","article-title":"Virulence factor-related gut microbiota genes and immunoglobulin A levels as novel markers for machine learning-based classification of autism spectrum disorder","volume":"19","author":"Wang","year":"2020","journal-title":"Comput Struct Biotechnol J."},{"key":"B119","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/aur.1647","article-title":"A sexually dichotomous, autistic-like phenotype is induced by group B Streptococcus maternofetal immune activation","volume":"10","author":"Allard","year":"2017","journal-title":"Autism Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.bbi.2016.09.028","article-title":"Prenatal infection leads to ASD-like behavior and altered synaptic pruning in the mouse offspring","volume":"63","author":"Fern\u00e1ndez de Coss\u00edo","year":"2017","journal-title":"Brain Behav Immun."},{"key":"B121","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.biopsych.2016.08.024","article-title":"Emerging roles for the gut microbiome in autisms disorder","volume":"81","author":"Vuong","year":"2017","journal-title":"Biol Psychiatry."},{"key":"B122","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.neuroscience.2018.01.060","article-title":"Gut microbiota, inflammation, and probiotics on neural development in autism spectrum disorder","volume":"374","author":"Doenyas","year":"2018","journal-title":"Neuroscience."},{"key":"B123","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1002\/aur.2079","article-title":"Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice","volume":"12","author":"Wang","year":"2019","journal-title":"Autism Res."},{"key":"B124","doi-asserted-by":"publisher","first-page":"4625","DOI":"10.2741\/3028","article-title":"Cystatin protease inhibitors and immune functions","volume":"13","author":"Zavasnik-Bergant","year":"2008","journal-title":"Front Biosci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"e11419","DOI":"10.15252\/emmm.201911419","article-title":"Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy","volume":"12","author":"Di Matteo","year":"2020","journal-title":"EMBO Mol Med."},{"key":"B126","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3389\/fnmol.2019.00195","article-title":"Cystatin B involvement in synapse physiology of rodent brains and human cerebral organoids","volume":"12","author":"Penna","year":"2019","journal-title":"Front Mol Neurosci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"100323","DOI":"10.1016\/j.ebr.2019.100323","article-title":"Autistic features in Unverricht-Lundborg disease","volume":"12","author":"Tandon","year":"2019","journal-title":"Epilepsy Behav Rep."},{"key":"B128","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s10875-017-0433-3","article-title":"Adenosine deaminase (ADA)-deficient severe combined immune deficiency (SCID): molecular pathogenesis and clinical manifestations","volume":"37","author":"Bradford","year":"2017","journal-title":"J Clin Immunol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s100480000104","article-title":"Autism: evidence of association with adenosine deaminase genetic polymorphism","volume":"3","author":"Bottini","year":"2001","journal-title":"Neurogenetics."},{"key":"B130","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1002\/1096-8628(20001204)96:6<784::AID-AJMG18>3.0.CO;2-7","article-title":"Adenosine deaminase alleles and autistic disorder: case-control and family-based association studies","volume":"96","author":"Persico","year":"2000","journal-title":"Am J Med Genet."},{"key":"B131","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s10803-006-0354-0","article-title":"The G22A polymorphism of the ADA gene and susceptibility to autism spectrum disorders","volume":"38","author":"Hettinger","year":"2008","journal-title":"J Autism Dev Disord."},{"key":"B132","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1067\/mpd.2001.115023","article-title":"Cognitive and behavioral abnormalities in adenosine deaminase deficient severe combined immunodeficiency","volume":"139","author":"Rogers","year":"2001","journal-title":"J Pediatr."},{"key":"B133","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.neuint.2009.12.003","article-title":"Pediatric neurological syndromes and inborn errors of purine metabolism","volume":"56","author":"Camici","year":"2010","journal-title":"Neurochem Int."},{"key":"B134","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3389\/fendo.2018.00320","article-title":"Role of fibroblast growth factor-23 in innate immune responses","volume":"9","author":"Fitzpatrick","year":"2018","journal-title":"Front Endocrinol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s10803-008-0653-8","article-title":"Regulation of cerebral cortical size and neuron number by fibroblast growth factors: implications for autism","volume":"39","author":"Vaccarino","year":"2009","journal-title":"J Autism Dev Disord."},{"key":"B136","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.1038\/s41598-017-06033-1","article-title":"Whole exome sequencing reveals inherited and de novo variants in autism spectrum disorder: a trio study from Saudi families","volume":"7","author":"Al-Mubarak","year":"2017","journal-title":"Sci Rep."},{"key":"B137","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1440-169X.2009.01104.x","article-title":"Fibroblast growth factor signaling in development of the cerebral cortex","volume":"51","author":"Iwata","year":"2009","journal-title":"Dev Growth Differ."},{"key":"B138","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.semcdb.2015.10.003","article-title":"Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disorders","volume":"53","author":"Turner","year":"2016","journal-title":"Semin Cell Dev Biol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s11689-019-9268-y","article-title":"Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk","volume":"11","author":"Kumar","year":"2019","journal-title":"J Neurodev Disord."},{"key":"B140","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/humu.10257","article-title":"PTEN: one gene, many syndromes","volume":"22","author":"Eng","year":"2003","journal-title":"Hum Mutat."},{"key":"B141","doi-asserted-by":"publisher","first-page":"a036996","DOI":"10.1101\/cshperspect.a036996","article-title":"The role of PTEN in innate and adaptive immunity","volume":"9","author":"Taylor","year":"2019","journal-title":"Cold Spring Harb Perspect Med."},{"key":"B142","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/ng0597-64","article-title":"Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome","volume":"16","author":"Liaw","year":"1997","journal-title":"Nat Genet."},{"key":"B143","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ng0897-333","article-title":"Germline mutations in PTEN are present in Bannayan-Zonana syndrome","volume":"16","author":"Marsh","year":"1997","journal-title":"Nat Genet."},{"key":"B144","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/B978-0-444-62702-5.00009-3","article-title":"PTEN hamartoma tumor syndrome","volume":"132","author":"Mester","year":"2015","journal-title":"Handb Clin Neurol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1136\/jmg.2004.024646","article-title":"Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations","volume":"42","author":"Butler","year":"2005","journal-title":"J Med Genet."},{"key":"B146","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/GIM.0b013e31818fd762","article-title":"The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly","volume":"11","author":"Varga","year":"2009","journal-title":"Genet Med."},{"key":"B147","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.neuron.2006.03.023","article-title":"Pten regulates neuronal arborization and social interaction in mice","volume":"50","author":"Kwon","year":"2006","journal-title":"Neuron."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1053\/j.gastro.2012.01.011","article-title":"Autoimmunity, intestinal lymphoid hyperplasia, and defects in mucosal B-cell homeostasis in patients with PTEN hamartoma tumor syndrome","volume":"142","author":"Heindl","year":"2012","journal-title":"Gastroenterology."},{"key":"B149","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1136\/jmedgenet-2015-103266","article-title":"Cowden's syndrome with immunodeficiency","volume":"52","author":"Browning","year":"2015","journal-title":"J Med Genet."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/j.jaci.2016.03.055","article-title":"Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase \u03b4 syndrome-like immunodeficiency","volume":"138","author":"Tsujita","year":"2016","journal-title":"J Allergy Clin Immunol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.3390\/ijms20051166","article-title":"GeneAnalytics pathways and profiling of shared autism and cancer genes","volume":"20","author":"Gabrielli","year":"2019","journal-title":"Int J Mol Sci."},{"key":"B152","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13229-017-0182-4","article-title":"Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and\/or autism","volume":"8","author":"Yeung","year":"2017","journal-title":"Mol Autism."},{"key":"B153","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.mehy.2017.05.004","article-title":"Connecting the dots: overlaps between autism and cancer suggest possible common mechanisms regarding signaling pathways related to metabolic alterations","volume":"103","author":"Wen","year":"2017","journal-title":"Med Hypotheses."},{"key":"B154","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1016\/j.ygeno.2021.05.038","article-title":"Alternative splicing and gene co-expression network-based analysis of dizygotic twins with autism-spectrum disorder and their parents","volume":"113","author":"Okay","year":"2021","journal-title":"Genomics."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.bbrc.2004.10.183","article-title":"ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways","volume":"325","author":"Li","year":"2004","journal-title":"Biochem Biophys Res Commun."},{"key":"B156","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41586-019-0979-8","article-title":"Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction","volume":"567","author":"Liu","year":"2019","journal-title":"Nature."},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","author":"DeLuca","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1756284820923922","DOI":"10.1177\/1756284820923922","article-title":"The association between circulating levels of vitamin D and inflammatory markers in the first 2 years after colorectal cancer diagnosis","volume":"13","author":"Wesselink","year":"2020","journal-title":"Therap Adv Gastroenterol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.3390\/ijms19092736","article-title":"The anti-inflammatory effects of vitamin D in tumorigenesis","volume":"19","author":"Liu","year":"2018","journal-title":"Int J Mol Sci."},{"key":"B160","doi-asserted-by":"publisher","first-page":"904876","DOI":"10.1155\/2015\/904876","article-title":"25-OH Vitamin D and Interleukin-8: Emerging biomarkers in cutaneous melanoma development and progression","volume":"2015","author":"Ene","year":"2015","journal-title":"Mediators Inflamm"},{"key":"B161","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.psyneuen.2014.08.016","article-title":"Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood","volume":"50","author":"Grudet","year":"2014","journal-title":"Psychoneuroendocrinology."},{"key":"B162","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.encep.2019.02.005","article-title":"Vitamin D deficiency in a psychiatric population and correlation between vitamin D and CRP","volume":"45","author":"Faivre","year":"2019","journal-title":"Encephale."},{"key":"B163","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1432-1033.1997.00063.x","article-title":"1alpha,25-dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-kappaB-mediated interleukin-8 gene expression","volume":"250","author":"Harant","year":"1997","journal-title":"Eur J Biochem"},{"key":"B164","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0306-4522(03)00040-X","article-title":"Vitamin D3 and brain development","volume":"118","author":"Eyles","year":"2003","journal-title":"Neuroscience."},{"key":"B165","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/mp.2016.213","article-title":"Gestational vitamin D deficiency and autism-related traits: the generation R study","volume":"23","author":"Vinkhuyzen","year":"2018","journal-title":"Mol Psychiatry."},{"key":"B166","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1038\/s41380-019-0578-y","article-title":"Developmental vitamin D and autism spectrum disorders: findings from the Stockholm youth cohort","volume":"26","author":"Lee","year":"2021","journal-title":"Mol Psychiatry."},{"key":"B167","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1093\/oxfordjournals.epirev.a018033","article-title":"Molecular epidemiology of vitamin D receptor gene variants","volume":"22","author":"Zmuda","year":"2000","journal-title":"Epidemiol Rev."},{"key":"B168","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/s12883-019-1577-y","article-title":"Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis","volume":"19","author":"Imani","year":"2019","journal-title":"BMC Neurol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neulet.2005.01.018","article-title":"Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases","volume":"380","author":"Yan","year":"2005","journal-title":"Neurosci Lett."},{"key":"B170","doi-asserted-by":"publisher","first-page":"e3228","DOI":"10.7759\/cureus.3228","article-title":"Fok-I, Bsm-I, and Taq-I variants of vitamin D receptor polymorphism in the development of autism spectrum disorder: a literature review","volume":"10","author":"Biswas","year":"2018","journal-title":"Cureus."},{"key":"B171","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1002\/aur.2279","article-title":"Vitamin D receptor polymorphisms associated with autism spectrum disorder","volume":"13","author":"Guerini","year":"2020","journal-title":"Autism Res."},{"key":"B172","doi-asserted-by":"publisher","first-page":"8699","DOI":"10.3390\/ijms16048699","article-title":"Modulation of the genome and epigenome of individuals susceptible to autism by environmental risk factors","volume":"16","author":"Koufaris","year":"2015","journal-title":"Int J Mol Sci."},{"key":"B173","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/mp.2010.136","article-title":"Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis","volume":"17","author":"Rossignol","year":"2012","journal-title":"Mol Psychiatry."},{"key":"B174","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1002\/ajmg.b.30366","article-title":"Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism","author":"James","year":"2006","journal-title":"Am J Med Genet B Neuropsychiatr Genet."},{"key":"B175","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1089\/ars.2021.0040","article-title":"NADPH oxidases in the central nervous system: regional and cellular localization and the possible link to brain diseases","volume":"35","author":"Fang","year":"2021","journal-title":"Antioxid Redox Signal."},{"key":"B176","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1080\/08830185.2020.1768251","article-title":"Reactive oxygen species and immune regulation","volume":"39","author":"Yang","year":"2020","journal-title":"Int Rev Immunol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1007\/s12035-019-01742-2","article-title":"Oxidative stress in autism spectrum disorder","volume":"57","author":"Bj\u00f8rklund","year":"2020","journal-title":"Mol Neurobiol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"710","DOI":"10.3389\/fimmu.2019.00710","article-title":"The iNOS activity during an immune response controls the CNS pathology in experimental autoimmune encephalomyelitis","volume":"10","author":"Sonar","year":"2019","journal-title":"Front Immunol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"106555","DOI":"10.1016\/j.intimp.2020.106555","article-title":"Elevated expression of toll-like receptor 4 is associated with NADPH oxidase-induced oxidative stress in B cells of children with autism","volume":"84","author":"Al-Harbi","year":"2020","journal-title":"Int Immunopharmacol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.bbi.2016.12.024","article-title":"Toll-like receptor 4 signaling is associated with upregulated NADPH oxidase expression in peripheral T cells of children with autism","volume":"61","author":"Nadeem","year":"2017","journal-title":"Brain Behav Immun."},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218057","article-title":"The dual role of myeloperoxidase in immune response","author":"Arnhold","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B182","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1007\/s10803-020-04740-9","article-title":"Serum ischemia-modified albumin levels, myeloperoxidase activity and peripheral blood mononuclear cells in autism spectrum disorder (ASD)","volume":"51","author":"Ceylan","year":"2021","journal-title":"J Autism Dev Disord."},{"key":"B183","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.expneurol.2014.10.017","article-title":"The role of the nitric oxide pathway in brain injury and its treatment - from bench to bedside","volume":"263","author":"Garry","year":"2015","journal-title":"Exp Neurol."},{"key":"B184","doi-asserted-by":"crossref","DOI":"10.5772\/67494","article-title":"Neuronal nitric oxide synthase","volume-title":"Nitric Oxide Synthase\u2014Simple Enzyme-Complex Roles","author":"Arami","year":"2017"},{"key":"B185","doi-asserted-by":"publisher","first-page":"104554","DOI":"10.1016\/j.psyneuen.2019.104554","article-title":"Differential regulation of Nrf2 is linked to elevated inflammation and nitrative stress in monocytes of children with autism","volume":"113","author":"Nadeem","year":"2020","journal-title":"Psychoneuroendocrinology."},{"key":"B186","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/s12967-019-2076-z","article-title":"Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in autism spectrum disorder","volume":"17","author":"Abruzzo","year":"2019","journal-title":"J Transl Med."},{"key":"B187","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/aur.1345","article-title":"Rare single nucleotide polymorphisms in the regulatory regions of the superoxide dismutase genes in autism spectrum disorder","volume":"7","author":"Kova\u010d","year":"2014","journal-title":"Autism Res."},{"key":"B188","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.2337\/dc09-0852","article-title":"Genetic polymorphisms in genes encoding antioxidant enzymes are associated with diabetic retinopathy in type 1 diabetes","volume":"32","author":"Hovnik","year":"2009","journal-title":"Diabetes Care."},{"key":"B189","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3390\/cells8040367","article-title":"Alterations of mitochondrial biology in the oral mucosa of Chilean children with autism spectrum disorder (ASD)","volume":"8","author":"Carrasco","year":"2019","journal-title":"Cells."},{"key":"B190","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.pnpbp.2018.08.020","article-title":"Dysregulated enzymatic antioxidant network in peripheral neutrophils and monocytes in children with autism","volume":"88","author":"Nadeem","year":"2019","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"B191","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.biochi.2020.03.009","article-title":"Upregulation of enzymatic antioxidants in CD4+ T cells of autistic children","volume":"2","author":"Nadeem","year":"2020","journal-title":"Biochimie."},{"key":"B192","doi-asserted-by":"publisher","first-page":"675","DOI":"10.3389\/fpsyt.2019.00675","article-title":"Autism spectrum disorders and perinatal complications\u2014is oxidative stress the connection?","volume":"10","author":"Mandic-Maravic","year":"2019","journal-title":"Front Psychiatry."},{"key":"B193","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1186\/1479-7364-1-6-460","article-title":"Analysis of the glutathione S-transferase (GST) gene family","volume":"1","author":"Nebert","year":"2004","journal-title":"Hum Genomics."},{"key":"B194","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev.pharmtox.45.120403.095857","article-title":"Glutathione transferases","volume":"45","author":"Hayes","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","article-title":"Mitochondrial ROS signaling in organismal homeostasis","volume":"163","author":"Shadel","year":"2015","journal-title":"Cell."},{"key":"B196","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.3389\/fphys.2018.01487","article-title":"Mitochondria, oxidative stress and innate immunity","volume":"9","author":"Chen","year":"2018","journal-title":"Front Physiol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"102867","DOI":"10.1016\/j.autrev.2021.102867","article-title":"Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: potential role in Sj\u00f6gren's syndrome","volume":"20","author":"Barrera","year":"2021","journal-title":"Autoimmun Rev."},{"key":"B198","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3389\/fonc.2019.00348","article-title":"Inflammation and metabolism in cancer cell-mitochondria key player","volume":"9","author":"Neagu","year":"2019","journal-title":"Front Oncol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3390\/cells7120229","article-title":"Mitochondrial metabolism in major neurological diseases","volume":"7","author":"Zhou","year":"2018","journal-title":"Cells."},{"key":"B200","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.redox.2017.01.013","article-title":"Mitochondrial dynamics in type 2 diabetes: pathophysiological implications","volume":"11","author":"Rovira-Llopis","year":"2017","journal-title":"Redox Biol."},{"key":"B201","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3389\/fpsyt.2019.00269","article-title":"Mitochondrial dysfunction is inducible in lymphoblastoid cell lines from children with autism and may involve the TORC1 pathway","volume":"10","author":"Bennuri","year":"2019","journal-title":"Front Psychiatry."},{"key":"B202","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1146\/annurev-genet-110410-132529","article-title":"Fusion and fission: interlinked processes critical for mitochondrial health","volume":"46","author":"Chan","year":"2012","journal-title":"Annu Rev Genet."},{"key":"B203","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41398-019-0389-6","article-title":"Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review","volume":"9","author":"Liu","year":"2019","journal-title":"Transl Psychiatry."},{"key":"B204","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1854967","article-title":"Gene variations in autism spectrum disorder are associated with alteration of gut microbiota, metabolites and cytokines","volume":"13","author":"Liu","year":"2021","journal-title":"Gut Microbes."},{"key":"B205","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1016\/j.cell.2019.05.004","article-title":"Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice","volume":"177","author":"Sharon","year":"2019","journal-title":"Cell."},{"key":"B206","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3389\/fnins.2016.00601","article-title":"Variation in gene expression in autism spectrum disorders: an extensive review of transcriptomic studies","volume":"10","author":"Ansel","year":"2017","journal-title":"Front Neurosci."},{"key":"B207","doi-asserted-by":"publisher","first-page":"10093","DOI":"10.3748\/wjg.v22.i46.10093","article-title":"Can probiotics benefit children with autism spectrum disorders?","volume":"22","author":"Navarro","year":"2016","journal-title":"World J Gastroenterol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1007\/s10803-017-3409-5","article-title":"Association of autism spectrum disorders and inflammatory bowel disease","volume":"48","author":"Lee","year":"2018","journal-title":"J Autism Dev Disord."},{"key":"B209","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13229-016-0110-z","article-title":"Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders","volume":"7","author":"Fiorentino","year":"2016","journal-title":"Mol Autism."},{"key":"B210","doi-asserted-by":"publisher","first-page":"5987","DOI":"10.1038\/s41598-019-42568-1","article-title":"A molecular biomarker for prediction of clinical outcome in children with ASD, constipation, and intestinal inflammation","volume":"9","author":"Walker","year":"2019","journal-title":"Sci Rep."},{"key":"B211","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1743-7075-8-34","article-title":"Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity","volume":"8","author":"Adams","year":"2011","journal-title":"Nutr Metab."},{"key":"B212","doi-asserted-by":"publisher","first-page":"35820","DOI":"10.1038\/srep35820","article-title":"A putative blood-based biomarker for autism spectrum disorder-associated ileocolitis","volume":"6","author":"Walker","year":"2016","journal-title":"Sci Rep."},{"key":"B213","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.biopsych.2016.08.031","article-title":"Autoimmunity, autoantibodies, and autism spectrum disorder","volume":"81","author":"Edmiston","year":"2017","journal-title":"Biol Psychiatry."},{"key":"B214","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3390\/jpm11090901","article-title":"Interrogating epigenome toward personalized approach in cutaneous melanoma","volume":"11","author":"Dobre","year":"2021","journal-title":"J Pers Med."},{"key":"B215","doi-asserted-by":"publisher","first-page":"102685","DOI":"10.1016\/j.autrev.2020.102685","article-title":"Epigenetics, pregnancy and autoimmune rheumatic diseases","volume":"19","author":"Pacini","year":"2020","journal-title":"Autoimmun Rev."},{"key":"B216","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-981-15-3449-2_1","article-title":"Epigenetics in health and disease","volume":"1253","author":"Zhang","year":"2020","journal-title":"Adv Exp Med Biol."},{"key":"B217","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nrn.2016.41","article-title":"The landscape of DNA methylation amid a perfect storm of autism aetiologies","volume":"17","author":"Vogel Ciernia","year":"2016","journal-title":"Nat Rev Neurosci."},{"key":"B218","doi-asserted-by":"publisher","first-page":"5739","DOI":"10.1093\/cercor\/bhx250","article-title":"Dysregulation of cortical neuron DNA methylation profile in autism spectrum disorder","volume":"27","author":"Nardone","year":"2017","journal-title":"Cereb Cortex."},{"key":"B219","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1101\/gr.180273.114","article-title":"Methylomic trajectories across human fetal brain development","volume":"25","author":"Spiers","year":"2015","journal-title":"Genome Res."},{"key":"B220","doi-asserted-by":"publisher","first-page":"101409","DOI":"10.1016\/j.infbeh.2019.101409","article-title":"Leveraging epigenetics to examine differences in developmental trajectories of social attention: a proof-of-principle study of DNA methylation in infants with older siblings with autism","volume":"60","author":"Gui","year":"2020","journal-title":"Infant Behav Dev."},{"key":"B221","doi-asserted-by":"publisher","first-page":"612817","DOI":"10.3389\/fneur.2021.612817","article-title":"An epigenetically distinct subset of children with autism spectrum disorder resulting from differences in blood cell composition","volume":"12","author":"Jangjoo","year":"2021","journal-title":"Front Neurol."},{"key":"B222","doi-asserted-by":"publisher","first-page":"e1004402","DOI":"10.1371\/journal.pgen.1004402","article-title":"Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder","volume":"10","author":"Berko","year":"2014","journal-title":"PLoS Genet."},{"key":"B223","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3390\/children9040462","article-title":"Epigenome-wide analysis reveals DNA methylation alteration in ZFP57 and its target RASGFR2 in a Mexican population cohort with autism","volume":"9","author":"Aspra","year":"2022","journal-title":"Children."},{"key":"B224","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/mp.2013.114","article-title":"Common DNA methylation alterations in multiple brain regions in autism","volume":"19","author":"Ladd-Acosta","year":"2014","journal-title":"Mol Psychiatry."},{"key":"B225","doi-asserted-by":"publisher","first-page":"e433","DOI":"10.1038\/tp.2014.70","article-title":"DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways","volume":"4","author":"Nardone","year":"2014","journal-title":"Transl Psychiatry."},{"key":"B226","doi-asserted-by":"publisher","first-page":"907","DOI":"10.3389\/fgene.2019.00907","article-title":"Epigenetic delay in the neurodevelopmental trajectory of DNA methylation states in autism spectrum disorders","volume":"10","author":"Corley","year":"2019","journal-title":"Front Genet."},{"key":"B227","doi-asserted-by":"publisher","first-page":"e0253340","DOI":"10.1371\/journal.pone.0253340","article-title":"Placental DNmethylation changes and the early prediction of autism in full-term newborns","volume":"16","author":"Bahado-Singh","year":"2021","journal-title":"PLoS ONE."},{"key":"B228","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13059-022-02613-1","article-title":"Placental methylome reveals a 22q13","volume":"23","author":"Zhu","year":"2022","journal-title":"Genome Biol."},{"key":"B229","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13073-020-00785-8","article-title":"Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes","volume":"12","author":"Mordaunt","year":"2020","journal-title":"Genome Med."},{"key":"B230","doi-asserted-by":"publisher","first-page":"e1005442","DOI":"10.1371\/journal.pgen.1005442","article-title":"Early developmental and evolutionary origins of gene body DNA methylation patterns in mammalian placentas","volume":"11","author":"Schroeder","year":"2015","journal-title":"PLoS Genet."},{"key":"B231","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13229-016-0114-8","article-title":"Placental methylome analysis from a prospective autism study","volume":"7","author":"Schroeder","year":"2016","journal-title":"Mol Autism."},{"key":"B232","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s12031-021-01934-3","article-title":"Emerging role of non-coding RNAs in autism spectrum disorder","volume":"72","author":"Ghafouri-Fard","year":"2022","journal-title":"J Mol Neurosci."},{"key":"B233","doi-asserted-by":"publisher","first-page":"e660","DOI":"10.1038\/tp.2015.144","article-title":"Genome-wide differential expression of synaptic long noncoding RNAs in autism spectrum disorder","volume":"5","author":"Wang","year":"2015","journal-title":"Transl Psychiatry."},{"key":"B234","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s11011-019-00510-4","article-title":"IFNG\/IFNG-AS1 expression level balance: implications for autism spectrum disorder","volume":"35","author":"Fallah","year":"2020","journal-title":"Metab Brain Dis."},{"key":"B235","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3390\/genes7100076","article-title":"Impact of the autism-associated long noncoding RNA MSNP1AS on neuronal architecture and gene expression in human neural progenitor cells","volume":"7","author":"DeWitt","year":"2016","journal-title":"Genes."},{"key":"B236","doi-asserted-by":"publisher","first-page":"128ra40","DOI":"10.1126\/scitranslmed.3003479","article-title":"A noncoding RNA antisense to moesin at 5p14","volume":"4","author":"Kerin","year":"2012","journal-title":"Sci Transl Med."},{"key":"B237","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3389\/fgene.2019.00970","article-title":"The long noncoding RNA RPS10P2-AS1 is implicated in autism spectrum disorder risk and modulates gene expression in human neuronal progenitor cells","volume":"10","author":"Bilinovich","year":"2019","journal-title":"Front Genet."},{"key":"B238","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nature20612","article-title":"Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism","volume":"540","author":"Parikshak","year":"2016","journal-title":"Nature."},{"key":"B239","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1007\/s11011-021-00764-x","article-title":"MEG3 lncRNA is over-expressed in autism spectrum disorder","volume":"36","author":"Taheri","year":"2021","journal-title":"Metab Brain Dis."},{"key":"B240","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s12031-018-1240-x","article-title":"Aberrant expression of long non-coding RNAs in peripheral blood of autistic patients","volume":"67","author":"Sayad","year":"2019","journal-title":"J Mol Neurosci."},{"key":"B241","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1002\/jcb.27471","article-title":"Effect of the autism-associated lncRNA Shank2-AS on architecture and growth of neurons","volume":"120","author":"Luo","year":"2018","journal-title":"J Cell Biochem."},{"key":"B242","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3390\/jpm11090922","article-title":"MicroRNA expression profiles in autism spectrum disorder: role for miR-181 in immunomodulation","volume":"11","author":"Frye","year":"2021","journal-title":"J Pers Med."},{"key":"B243","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.cell.2016.10.031","article-title":"Histone acetylome-wide association study of autism spectrum disorder","volume":"167","author":"Sun","year":"2016","journal-title":"Cell."},{"key":"B244","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fpsyt.2014.00053","article-title":"Gene \u00d7 Environment interactions in autism spectrum disorders: role of epigenetic mechanisms","volume":"5","author":"Tordjman","year":"2014","journal-title":"Front Psychiatry."},{"key":"B245","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.molimm.2016.12.019","article-title":"Imbalance between the anti- and pro-inflammatory milieu in blood leukocytes of autistic children","volume":"82","author":"Ahmad","year":"2017","journal-title":"Mol Immunol"},{"key":"B246","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/1744666X.2020.1850273","article-title":"Autism spectrum disorders and natural killer cells: a review on pathogenesis and treatment","volume":"17","author":"Ebrahimi Meimand","year":"2021","journal-title":"Expert Rev Clin Immunol."},{"key":"B247","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.brainres.2004.11.018","article-title":"Interleukin-1beta enhances NMDA receptor-mediated current but inhibits excitatory synaptic transmission","volume":"1034","author":"Yang","year":"2005","journal-title":"Brain Res."},{"key":"B248","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.biopsych.2015.08.036","article-title":"Immune endophenotypes in children with autism spectrum disorder","volume":"81","author":"Careaga","year":"2017","journal-title":"Biol Psychiatry."},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.07.002","article-title":"Beyond infection - maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders","author":"Bilbo","year":"2018","journal-title":"Exp Neurol."}],"container-title":["Frontiers in Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.1006612\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T17:22:52Z","timestamp":1666200172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyt.2022.1006612\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,19]]},"references-count":249,"alternative-id":["10.3389\/fpsyt.2022.1006612"],"URL":"https:\/\/doi.org\/10.3389\/fpsyt.2022.1006612","relation":{},"ISSN":["1664-0640"],"issn-type":[{"value":"1664-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,19]]},"article-number":"1006612"}}