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In this perspective piece, we highlight the possibility to target specific functional territories within the cerebellum using non-invasive brain stimulation, potentially leading to the refinement of cerebellar-based therapeutics for precision psychiatry. Significant knowledge gap exists in our functional understanding of cerebellar systems. Intervening early, gauging severity of illness, developing intervention strategies and assessing treatment response, are all dependent on our understanding of the cerebello-cerebral networks underlying the pathology of psychotic disorders. A promising yet under-examined avenue for biomarker discovery is disruptions in cerebellar output circuitry. This is primarily because most 3T MRI studies in the past had to exclude cerebellum from the field of view due to limitations in spatiotemporal resolutions. Using recent technological advances in 7T MRI (e.g., parallel transmit head coils) to identify functional territories of the DN, with a focus on dentato-cerebello-thalamo-cortical (CTC) circuitry can lead to better characterization of brain-behavioral correlations and assessments of co-morbidities. Such an improved mechanistic understanding of psychiatric illnesses can reveal aspects of CTC circuitry that can aid in neuroprognosis, identification of subtypes, and generate testable hypothesis for future studies.<\/jats:p>","DOI":"10.3389\/fpsyt.2022.1021873","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T04:51:50Z","timestamp":1665982310000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Big contributions of the little brain for precision psychiatry"],"prefix":"10.3389","volume":"13","author":[{"given":"Sheeba","family":"Anteraper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Guell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Whitfield-Gabrieli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"9985","DOI":"10.1073\/pnas.93.18.9985","article-title":"Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry","volume":"93","author":"Andreasen","year":"1996","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1093\/oxfordjournals.schbul.a033321","article-title":"\u201cCognitive dysmetria\u201d as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?","volume":"24","author":"Andreasen","year":"1998","journal-title":"Schizophr Bull."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1001\/archneur.1991.00530230086029","article-title":"An emerging concept. 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