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Psychiatry"],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the changes in immunity and clinical infection events among patients with chronic insomnia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Forty-two patients with chronic insomnia (age = 64.44 \u00b1 10.53) and 47 normal controls (age = 67.08 \u00b1 7.822) were selected to determine differences in data, such as complete blood counts (CBCs), biochemical indices, lymphocyte subsets, immunoglobulin (Ig), complement C3 and C4 and interleukin-6 (IL-6), as well as to compare the incidence of clinical infection between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences in erythrocyte, hemoglobin, hematocrit, albumin, globulin, creatinine, IgG, IgG\/IgM ratio, CD4<jats:sup>+<\/jats:sup> T-lymphocytes, CD19-lymphocytes, CD4<jats:sup>+<\/jats:sup>\/CD8<jats:sup>+<\/jats:sup> ratio, platelet\/lymphocyte ratio, CD19\/CD3 ratio, and clinical infection events between the chronic insomnia group and the control group (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). There was no significant difference in neutrophil, lymphocyte, monocyte, and platelet counts; lymphocyte subsets CD8<jats:sup>+<\/jats:sup> T and CD56<jats:sup>+<\/jats:sup>; platelet-to-lymphocyte ratio (PLR); neutrophil-to-lymphocyte ratio (NLR); complement C3; complement C4; IgM; IgA; and IL-6 between the experimental group and their controls (<jats:italic>p<\/jats:italic> &amp;gt; 0.05). The systolic and diastolic blood pressures of the chronic insomnia group did not vary widely from those of the controls (<jats:italic>p<\/jats:italic> &amp;gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with chronic insomnia have immunological abnormalities, characterized by a higher incidence of clinical infection.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.1034405","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T08:06:37Z","timestamp":1666080397000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Research on the correlation of immunity in patients with chronic insomnia"],"prefix":"10.3389","volume":"13","author":[{"given":"Li","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-li","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-bao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Xian","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng-feng","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1378\/chest.14-0970","article-title":"International classification of sleep disorders-third edition: highlights and modifications","volume":"146","author":"Sateia","year":"2014","journal-title":"Chest."},{"key":"B2","first-page":"S347","article-title":"Characteristics of insomnia in the United States: results of the 1991 National Sleep Foundation Survey","volume":"22","author":"Ancoli-Israel","year":"1999","journal-title":"I Sleep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1053\/smrv.2002.0186","article-title":"Epidemiology of insomnia: what we know and what we still need to learn","volume":"6","author":"Ohayon","year":"2002","journal-title":"Sleep Med Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/sleep\/29.1.85","article-title":"Sex differences in insomnia: a meta-analysis","volume":"29","author":"Zhang","year":"2006","journal-title":"Sleep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1177\/1054773818806164","article-title":"Comparing the experience of and factors perpetuating chronic insomnia severity among young, middle-aged, and older adults","volume":"30","author":"Sidani","year":"2021","journal-title":"Clin Nurs Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1365-2869.2010.00822.x","article-title":"Prevalence of insomnia among Chinese adults in Hong Kong: a population-based study","volume":"20","author":"Wong","year":"2011","journal-title":"J Sleep Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3928\/00989134-20071001-07","article-title":"Sleep quality of older adults in nursing homes in Turkey: enhancing the quality of sleep improves quality of life","volume":"33","author":"Eser","year":"2007","journal-title":"J Gerontol Nurs."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e0170772","DOI":"10.1371\/journal.pone.0170772","article-title":"The prevalence of insomnia in the general population in China: A meta-analysis","volume":"12","author":"Cao","year":"2017","journal-title":"PLoS ONE."},{"key":"B9","first-page":"92","article-title":"Human immune system during sleep","volume":"6","author":"Asif","year":"2017","journal-title":"Am J Clin Exp Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1152\/physrev.00010.2018","article-title":"The sleep-immune crosstalk in health and disease","volume":"99","author":"Besedovsky","year":"2019","journal-title":"Physiol Rev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"zsy048","DOI":"10.1093\/sleep\/zsy048","article-title":"Assessment of sympathetic neural activity in chronic insomnia: evidence for elevated cardiovascular risk [published correction appears","volume":"41","author":"Carter","year":"2018","journal-title":"Sleep"},{"key":"B12","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.chest.2017.01.026","article-title":"Insomnia and risk of cardiovascular disease","volume":"152","author":"Javaheri","year":"2017","journal-title":"Chest."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.jacc.2021.07.023","article-title":"Manson JE, et al. 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