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First, the GM may induce individuals to seek novel substances. Second, the gut microbiota is involved in the decomposition and absorption of drugs. Symptoms of individuals who suffer from DUDs are also related to intestinal microorganisms. Third, the effects of the GM and its metabolites on drug relapse are mainly reflected in the reward effect and drug memory. In conclusion, recent studies have preliminarily explored the relationship between GM and DUDs. This review deepens our understanding of the mechanisms of DUDs and provides important information for the future development of clinical treatment for DUDs.<\/jats:p>","DOI":"10.3389\/fpsyt.2022.1046804","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T06:44:30Z","timestamp":1670913870000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Potential roles of the gut microbiota in the manifestations of drug use 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