{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:36:55Z","timestamp":1780472215491,"version":"3.54.1"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:p>Empirical evidence and clinical observations suggest a strong -yet under acknowledged-link between anorexia nervosa (AN) and non-suicidal self-injurious behavior (NSSI). By reviewing the literature on the psychopathology and neurobiology of AN and NSSI, we shed light on their relationship. Both AN and NSSI are characterized by disturbances in affect regulation, dysregulation of the reward circuitry and the opioid system. By formulating a reward-centered hypothesis, we explain the overlap between AN and NSSI. We propose three approaches understanding the relationship between AN and NSSI, which integrate psychopathology and neurobiology from the perspective of self-destructiveness: (1) a nosographical approach, (2) a research domain (RDoC) approach and (3) a network analysis approach. These approaches will enhance our knowledge of the underlying neurobiological substrates and may provide groundwork for the development of new treatment options for disorders of self-destructiveness, like AN and NSSI. In conclusion, we hypothesize that self-destructiveness is a new, DSM-5-transcending concept or psychopathological entity that is reward-driven, and that both AN and NSSI could be conceptualized as disorders of self-destructiveness.<\/jats:p>","DOI":"10.3389\/fpsyt.2022.756238","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T05:22:01Z","timestamp":1652246521000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Psychopathological and Neurobiological Overlap Between Anorexia Nervosa and Self-Injurious Behavior: A Narrative Review and Conceptual Hypotheses"],"prefix":"10.3389","volume":"13","author":[{"given":"Marloes","family":"Oudijn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jara","family":"Linders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Mocking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Lok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"van Elburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Denys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"B1","author":"Claes","year":"2016","journal-title":"Non-suicidal Self-Injury in Eating Disorders."},{"key":"B2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/erv.2646","article-title":"Associations of food addiction and nonsuicidal self-injury among women with an eating disorder: a common strategy for regulating emotions?","volume":"26","author":"Carlson","year":"2018","journal-title":"Eur Eat Disord Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1016\/j.brs.2021.10.387","article-title":"Deep brain stimulation of the ventral anterior limb of the capsula interna in patients with treatment-refractory anorexia nervosa.","volume":"14","author":"Oudijn","year":"2021","journal-title":"Brain Stimul."},{"key":"B4","year":"2017","journal-title":"Practice Guideline for the Treatment of Etaing Disorders [Zorgstandaard Eetstoornissen]."},{"key":"B5","author":"Hemert","year":"2012","journal-title":"Multidisciplinaire Richtlijn Diagnostiek en Behandeling Van Su\u00efcidaal Gedrag."},{"key":"B6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-814449-7.00003-X","article-title":"Chapter 3 \u2013 Defining and analyzing the problem. 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