{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:27:05Z","timestamp":1787027225723,"version":"build-2736575974"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Major depressive disorder is considered the most common comorbidity of anorexianervosa in adolescence. Some evidence argues against antidepressant use in this population. Moreover, the fear of being threatened with autonomy and of becoming dependent specific to this adolescent population and at the very core of the anorexic disease, make the proposal of such a treatment difficult to accept. This qualitative research aimed to explore the perspectives of view of adolescents with anorexia nervosa about antidepressants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted interviews with adolescents suffering from anorexia nervosa who had been treated with an antidepressant agent during their inpatient or outpatient care at Cochin Hospital. Adolescents were chosen by convenience sampling. Both verbal and written questions were asked to elicit their lived experiences. Interpretative Phenomenological Analysis was used to examine the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen adolescents (13 girls and two boys) were interviewed. We have reached total data saturation. The analysis found two meta-themes, each with two separate themes. (I) Reactions to the proposal of antidepressant with (i) an opposition phase (about the existence of depressive symptoms and about negative preconceptions) and (ii) need to share with family and other teenagers. (II) Reactions to antidepressant use with (iii) ambivalence and an initial perception of coercion, and (iv) effects of antidepressants (psychological effects, effects on the body and on anorexia nervosa and effects perceived through the eyes of others).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite positive effects, ambivalence toward the treatment remained present throughout the interviews: these adolescents still worry greatly about loss of control and weight gain. Depression as comorbidity seems to be entangled in the denial of disease, cognitive distortion and acquired fearlessness specific to AN. Its existence in adolescence can uncover transgenerational issues, sometimes previously hidden. An orodispersible\/drinkable form of antidepressants would facilitate adherence to treatment in this specific population. The intervention of a \u201cpatient-expert\u201d could reduce adolescents' anxiety about loss of control. A latency period seems necessary to allow them to understand the prescription at their own level and in the complexity of their anorexic illness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpsyt.2022.770903","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T02:24:20Z","timestamp":1649039060000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Subjective Experience of Antidepressant Prescription Among Adolescents With Anorexia Nervosa"],"prefix":"10.3389","volume":"13","author":[{"given":"Maude","family":"Ludot-Gr\u00e9goire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanille","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Carretier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lachal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Rose","family":"Moro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Blanchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"B1","year":"2013"},{"key":"B2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jpp.2004.06.006","article-title":"Donn\u00e9es \u00e9pid\u00e9miologiques: anorexie chez l'adolescent","volume":"17","author":"Godart","year":"2004","journal-title":"J P\u00e9diatrie Pu\u00e9riculture"},{"key":"B3","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.jad.2018.11.014","article-title":"Association between chronic somatic conditions and depression in children and adolescents: a retrospective study of 13,326 patients","volume":"245","author":"Kostev","year":"2019","journal-title":"J Affect Disord."},{"key":"B4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s40519-013-0020-4","article-title":"Prevalence, comorbidities and outpatient treatment of anorexia and bulimia nervosa in German children and adolescents","volume":"18","author":"Jaite","year":"2013","journal-title":"Eat Weight Disord."},{"key":"B5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/erv.2254","article-title":"Comorbid psychiatric disorders in female adolescents with first-onset anorexia nervosa: comorbidity in adolescent anorexia nervosa","volume":"22","author":"B\u00fchren","year":"2014","journal-title":"Eur Eat Disord Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"316","DOI":"10.2174\/1871530318666180213111637","article-title":"Anorexia Nervosa and Comorbid Psychopathology","volume":"18","author":"Marucci","year":"2018","journal-title":"Endocr Metab Immune Disord Drug Targets."},{"key":"B7","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/sltb.12235","article-title":"Anorexia nervosa, major depression, and suicide attempts: shared genetic factors","volume":"46","author":"Thornton","year":"2016","journal-title":"Suicide Life Threat Behav"},{"key":"B8","doi-asserted-by":"publisher","first-page":"504","DOI":"10.12688\/f1000research.17789.1","article-title":"Recent advances in understanding anorexia nervosa","volume":"8","author":"Frank","year":"2019","journal-title":"F1000Research."},{"key":"B9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/14656566.2020.1748600","article-title":"Pharmacotherapeutic strategies for the treatment of anorexia nervosa-too much for one drug?","volume":"21","author":"Frank","year":"2020","journal-title":"Expert Opin Pharmacother"},{"key":"B10","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.encep.2016.02.017","article-title":"Depressive symptoms during anorexia nervosa: state of the art and consequences for an appropriate use of antidepressants","volume":"43","author":"Lebl\u00e9","year":"2017","journal-title":"L'Enc\u00e9phale."},{"key":"B11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.psychres.2014.10.023","article-title":"Alexithymia in anorexia nervosa: the mediating role of depression","volume":"225","author":"Torres","year":"2015","journal-title":"Psychiatry Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/erv.2240","article-title":"Psychotropic drug treatment in anorexia nervosa. 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