{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T01:55:57Z","timestamp":1771898157413,"version":"3.50.1"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychiatry"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Since the irruption of the coronavirus disease 2019 (COVID-19) the planet has submerged in a time of concern and uncertainty, with a direct impact on people's mental health. Moreover, the recurrent outbreaks that periodically harry different regions of the world constantly refocus people's concerns to the pandemic. Yet, each new wave heats the diverse countries in different situations, including the advances in their vaccination campaigns. In this research, we studied the levels of the general anxiety disorder (GAD) and depression in the Argentine population across the first and second waves of infections that occurred in our country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an on-line survey, within each peak of the pandemic. People were asked to self-report GAD and depression symptoms using the GAD-7 and PHQ-9 questioners, inform their vaccination status, the frequency they performed physical activity as well as working condition and modality. Here, we identified the more vulnerable groups and evaluated factors that could mitigate the rise of these mental disorders, focusing on vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our data shows that reported GAD and depression levels were higher during the second wave than during the first one. More importantly, vaccinated people were less depressed than non-vaccinated people, while GAD levels remained equivalent in both groups. Other factors directly associated with lower GAD and depression levels were performing frequent physical activity and being employed, regardless of the employment modality. These observations were replicated in different age ranges and genders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This work evidences GAD and depression in different pandemic waves in Argentina, as well the factors that may contribute to reducing the magnitude of these disorders, including vaccination.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.832352","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T05:16:19Z","timestamp":1655961379000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Second Wave of COVID-19 Pandemic in Argentinian Population: Vaccination Is Associated With a Decrease in Depressive Symptoms"],"prefix":"10.3389","volume":"13","author":[{"given":"Pedro","family":"Benedetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejo","family":"Barbuzza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Moscato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Reppucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celina","family":"Goyeneche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Katche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge H.","family":"Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haydee","family":"Viola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"Ballarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Moncada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"B1","unstructured":"Coronavirus (COVID-19) Deaths.2021"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/pubmed\/fdaa106","article-title":"Increased generalized anxiety, depression and distress during the COVID-19 pandemic: a cross-sectional study in Germany Alexander","author":"B\u00e4uerle","year":"2020","journal-title":"J Public Health."},{"key":"B3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/ijerph17103740","article-title":"Depression and Anxiety in Hong Kong during COVID-19","volume":"17","author":"Pui","year":"2020","journal-title":"Int J Environ Res Public Health."},{"key":"B4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jad.2020.07.133","article-title":"Psychological distress associated with COVID-19 quarantine: latent profile analysis, outcome prediction and mediation analysis","volume":"277","author":"Fern\u00e1ndez","year":"2020","journal-title":"J Affect Disord."},{"key":"B5","doi-asserted-by":"publisher","first-page":"112954","DOI":"10.1016\/j.psychres.2020.112954","article-title":"Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey","volume":"288","author":"Huang","year":"2020","journal-title":"Psychiatry Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/acps.13219","article-title":"Anxiety and depression in the Republic of Ireland during the COVID-19 pandemic","volume":"142","author":"Hyland","year":"2020","journal-title":"Acta Psychiatr Scand."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpsyt.2020.00821","article-title":"Psychological and behavioral responses to the COVID-19 pandemic in Greece","volume":"11","author":"Parlapani","year":"2020","journal-title":"Front Psychol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"110186","DOI":"10.1016\/j.jpsychores.2020.110186","article-title":"The effect of age, gender, income, work, and physical activity on mental health during coronavirus disease (COVID-19) lockdown in Austria","volume":"136","author":"Pieh","year":"2020","journal-title":"J Psychosom Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijerph17144924","article-title":"Prevalence and predictors of anxiety and depression symptoms during the COVID-19 pandemic and compliance with precautionary measures: age and sex matter","volume":"2","author":"Solomou","year":"2020","journal-title":"Int J Environ Res Public Health."},{"key":"B10","doi-asserted-by":"publisher","first-page":"113172","DOI":"10.1016\/j.psychres.2020.113172","article-title":"Factors associated with depression, anxiety, and PTSD symptomatology during the COVID-19 pandemic: Clinical implications for U. 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