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However, the association between the decision-making deficit and resting-state brain activity of patients with OCD has not been examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty unmedicated patients with OCD and 55 matched control subjects completed IGT. Resting-state brain activity was examined using the fractional amplitude of low-frequency fluctuations (fALFFs). fALFF analysis focused on the slow-4 and 5 bands. Group comparisons were performed to determine the association between IGT performance and fALFFs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant group difference in the association between the IGT total net score and slow-4 fALFFs in the left putamen (voxel height threshold of <jats:italic>p<\/jats:italic> &amp;lt; 0.001; cluster size threshold of <jats:italic>p<\/jats:italic> &amp;lt; 0.05; family wise error-corrected). Higher putamen slow-4 fALFFs were correlated with lower IGT scores for OCD patients (<jats:italic>r<\/jats:italic> = \u22120.485; <jats:italic>p<\/jats:italic> &amp;lt; 0.0005) and higher IGT scores for control subjects (<jats:italic>r<\/jats:italic> = 0.402; <jats:italic>p<\/jats:italic> &amp;lt; 0.005). There was no group difference in the association between the IGT total net score and slow-5 fALFFs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings in unmedicated patients demonstrate the importance of resting-state putamen activity for decision-making deficit associated with OCD, as measured by IGT. The inverse correlation may be explained by the hypersensitive response of the putamen in patients with OCD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.836965","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T05:07:55Z","timestamp":1652418475000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control 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