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Psychiatry"],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Tobacco smoking and being overweight could lead to adverse health effects, which remain an important public health problem worldwide. Research indicates that overlapping pathophysiology may contribute to tobacco addiction and being overweight, but the neurobiological interaction mechanism between the two factors is still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current study used a mixed sample design, including the following four groups: (i) overweight long-term smokers (<jats:italic>n<\/jats:italic> = 24); (ii) normal-weight smokers (<jats:italic>n<\/jats:italic> = 28); (iii) overweight non-smokers (<jats:italic>n<\/jats:italic> = 19), and (iv) normal-weight non-smokers (<jats:italic>n<\/jats:italic> = 28), for a total of 89 male subjects. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI). Regional homogeneity (ReHo) was used to compare internal cerebral activity among the four groups. Interaction effects between tobacco addiction and weight status on ReHo were detected using a two-way analysis of variance, correcting for age, years of education, and head motion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant interaction effect between tobacco addiction and weight status is shown in right superior frontal gyrus. Correlation analyses show that the strengthened ReHo value in the right superior frontal gyrus is positively associated with pack-year. Besides, the main effect of tobacco addiction is specially observed in the occipital lobe and cerebellum posterior lobe. As for the main effect of weight status, the right lentiform nucleus, left postcentral gyrus, and brain regions involved in default mode network (DMN) survived.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results shed light on an antagonistic interaction on brain ReHo between tobacco addiction and weight status in the right superior frontal gyrus, which may be a clinical neuro-marker of comorbid tobacco addiction and overweight. Our findings may provide a potential target to develop effective treatments for the unique population of comorbid tobacco addiction and overweight people.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyt.2022.857479","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T05:30:30Z","timestamp":1654493430000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Weight Status Modulated Brain Regional Homogeneity in Long-Term Male 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